How can bypass grafting be made even more effective? Almost half of the veins transplanted to restore blood flow in the heart become clogged again within ten years after surgery. Gene therapy pre-treatment of the vein fragments that prevents the muscle cells from entering the vascular wall, might decrease the risk of this happening.
Literature:Kallenbach K., Salcher R, Bog A, Geveke S, Mörike C, Heim A, Cebotari S, Haverich A. Reduction of Neointima Formation in Autologous Vein Grafts in vivo by Overexpression of Matrix Metalloproteinase-3 (Stromeylsin-1). Circulation 2006; Suppl. II, Vol. 114,18:794