Haemochromatosis is not, as has been previously assumed, a disease of the small intestine but a disease of the liver. Scientists at the University Hospital of Heidelberg and the European Molecular Biology Laboratory (EMBL) have shown in the animal model that the disease is caused by a mutated gene.
Literature:Vujic Spasic M, Kiss J, Herrmann T, Galy B, Martinache S, Stolte J, Gröne HJ, Stremmel W, Hentze MW, Muckenthaler MU: Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab. 2008 Feb;7(2):173-8.