Jump to content
Powered by

World Asthma Day

Asthma is the most common chronic disease in children. One in ten children suffer from bronchial restriction and produce elevated amounts of lung mucus. On 02.05.2017 is "World Asthma Day" – the BIOPRO provides information about this topic.


In today’s world, not all asthma patients benefit from adequate treatment. There is no cure at all for people who suffer from COPD, chronic obstructive pulmonary disease. A group of researchers led by Dr. Marco Idzko at the Freiburg University Medical Centre are looking for new strategies to treat lung diseases such as these. They have already discovered that ATP, which is the major energy currency molecule in the body, has an effect on the inflammatory processes in the lung and therefore possibly contributes to the development of asthma or COPD. This leads to the question as to whether it would be possible to develop inhibitors to counteract defective ATP signalling and to use them as effective therapeutics.


Boehringer Ingelheim is hoping to find ways to use anti-inflammatory mechanisms of action to improve the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Clinical studies will show what kind of improvements patients can expect from the substances, which are currently at different stages of development. Drugs to widen the bronchia, marketed by Boehringer Ingelheim, will in the medium term become indispensable in the treatment of chronic obstructive pulmonary diseases and asthma.


Many genes are known to play a role in the development of the chronic lung disease bronchial asthma. Dr. Andrea Heinzmanns team at the University Medical Centre Freiburg has investigated some of these genes and is also interested in epigenetic factors. It is known that asthma is not only caused by genetic factors but can also be triggered by mechanisms that affect the genes without changing the genetic code.


At its 3rd International Research & Development (R&D) press conference, Boehringer Ingelheim gave journalists insights into its R&D pipeline. Around 200 scientists at the company’s site in Biberach are investigating new treatment options for patients with COPD (chronic obstructive pulmonary disease), asthma, idiopathic lung fibrosis, lung cancer and other respiratory diseases. In addition, the researchers are also focusing on the R&D of compounds for the treatment of cardiometabolic and neurological disorders.


HOT Screen GmbH from Reutlingen Germany develops human organotypical HOT cell culture models related to the human immune system for the assessment of drug activity profiles and the selection of suitable drug candidates. The sophisticated models are made with differentiated cells and can be adapted to a broad range of different diseases - including rheumatoid arthritis osteoarthritis Crohns disease neurodermatitis COPD asthma and many others.


Gene therapy currently offers the only chance of curing genetic diseases such as cystic fibrosis and beta thalassaemia. Gene therapy is the replacement or correction of a mutated gene with DNA that encodes a functional gene. Intensive research has been going on in this field for many years however only a handful gene therapies are available at this point in time. Dr. Michael Kormann junior professor at the Childrens Hospital at the University of Tübingen and his team of researchers deal with genes that have the potential to cure disease their work focuses on gene therapy techniques and on the correction of genes that lead to severe hereditary lung diseases. They were able to prolong the life of mice suffering from surfactant protein B deficiency using modified ribonucleic acids.


Many of us have known the Bosch Group mainly as a technology company that is active in the automotive sector. Now, the multinational company is opening up a whole new field of business and is entering the medical technology market with a new subsidiary. Bosch Healthcare Solutions GmbH, which is headquartered in the city of Waiblingen, has developed an innovative breath analysis device that allows asthmatics to measure the severity of airway inflammation from their own home.

Website address: https://www.gesundheitsindustrie-bw.de/en/article/news/world-asthma-day