Dr. Alexander Bürkle from the University of Konstanz was awarded the GT-Toxicology Prize by the Society of Toxicology (part of the German Society of Experimental and Clinical Pharmacoloy and Toxicology) and the journal “Toxicology” for his work on DNA repair mechanisms. Bürkle’s research centres on the enzyme poly[ADP-ribose]polymerase (PARP). The reduced activity of PARP is known to cause the incomplete or delayed repair of continuously occurring DNA damage.
Alexander Bürkle, professor of molecular toxicology in the Faculty of Biology at the University of Konstanz, is investigating the correlation between DNA repair function, ageing processes and the development of cancer. “I am delighted with the prize which was awarded for work done by my research group,” said Alexander Bürkle. In January 2011, Bürkle and his colleague Dr. María Moreno-Villanueva were awarded the Ursula M. Händel Animal Welfare Prize by the DFG (German Research Foundation) for the development of a method that helps reduce the number of animal experiments in research.Bürkle’s research centres on the enzyme poly[ADP-ribose]polymerase (PARP), and includes work on the enzyme’s biochemical function. “PARP is a protein that is involved in numerous cellular processes. One of its purposes, and I believe that this is the enzyme’s major function, is the repair of DNA damage,” said Bürkle pointing out that reduced PARP function leads to the incomplete or delayed repair of continuously occurring DNA damage. Over time, this leads to the accumulation of cell damage, which in turn causes the death of cells as well as mutations and eventually also leads to cancer.
The GT-Toxicology Prize, which comes with a purse of 1,000 euros, is awarded by the Society of Toxicology and the journal “Toxicology” on the basis of publications by researchers who have achieved outstanding research results in the field of toxicology. Bürkle received the prize at the annual meeting of the German Society of Experimental and Clinical Pharmacology and Toxicology held in Frankfurt on 31st March 2011.
Prof. Dr. Alexander BürkleUniversitiy of KonstanzDepartment of Molecular ToxicologyUniversitätsstraße 1078464 KonstanzPhone: +49 (0)7531 / 88-4035E-mail: Alexander.Buerkle[at]uni-konstanz.de