Dossier - 09/03/2015

Advances in the study and treatment of liver diseases

Liver diseases are often underestimated despite being quite common and potentially having serious and even life-threatening consequences, especially in chronic cases. The most common causes of liver diseases are hepatitis viruses, excessive alcohol consumption, and obesity; congenital or autoimmune liver diseases are quite rare. Thanks to advances in medical research, diseases such as hepatitis B and C can be treated effectively.

Her ground-breaking research studies on the regulation of gene activity have earned Dr Angelika Feldmann the Hella Bühler Prize for 2026, which is endowed with 100,000 euros.

A research group led by the Central Institute of Mental Health in Mannheim has confirmed for the first time within the German National Cohort an association between cigarette consumption and depression. The findings show that depression occurs more frequently over the lifetime of current and former smokers than among those who have never smoked.

Article - 10/06/2021

New study: vaccine therapy for treating patients with chronic leukaemia

Personalised peptide vaccination is expected to improve the treatment of patients with chronic lymphocytic leukaemia. A research team from Tübingen has started a Phase I clinical trial with CLL patients who will undergo ibrutinib treatment. Other leukaemia sufferers as well as cancer patients in general are also expected to benefit in the long term.

ngredients of our daily diet – including caffeine – can influence the resistance of bacteria to antibiotics. This has been shown in a new study by a team of researchers at the Universities of Tübingen and Würzburg. They discovered bacteria such as E. coli orchestrate complex regulatory cascades to react to chemical stimuli from their direct environment which can influence the effectiveness of antimicrobial drugs.

A new method allows stem cells and cancer stem cells to be studied at the single cell level and the resulting cell clones to be traced directly. Studying thousands of individual cells in parallel, the researchers combined the analysis of the genomic cancer mutations with the associated expression profiles.

Young patients suffering from two aggressive sarcoma types can now participate in the innovative PAMSARC therapy study at the NCT Heidelberg. The study uses molecular biological methods and tests the extent to which a new drug can improve the poor prognosis for these tumours.

EMBL scientists created SDR-seq, a tool for single-cell DNA-RNA-sequencing that studies both DNA and RNA simultaneously, linking coding and non-coding genetic variants to gene expression in the same single cell.

Hummingbird Diagnostics GmbH, a pioneer in harnessing blood-based small RNAs for early disease detection and characterization, today announced the publication of a new study in Nature Communications Medicine introducing an Oxford Nanopore Technologies (ONT)-based method for detecting small RNA modifications in blood.

Led by researchers from Heidelberg Faculty of Medicine at Heidelberg University and the University of California, San Francisco (USA), an international research team has evaluated a novel approach for the diagnosis of pulmonary tuberculosis. The method enables detection of Mycobacterium tuberculosis without laboratory infrastructure, within a markedly shorter time frame than conventional diagnostics, and using a simple swab.

A study by researchers at the University of Freiburg investigates how the scent of one’s partner influences stress reactions. The study participants showed that the subconsciously perceived scent of their respective partners increased their subjective perception of stress and caused their heart rate to rise, especially when the scent was perceived as sexually attractive.

Phase 1 part of combined Phase 1/2 study initiated as part of pandemic preparedness against highly pathogenic avian influenza (H5N1) virus, considered to be potential future pandemic threat. Study will assess monovalent vaccine candidate, encoding an influenza A H5-antigen using proprietary second-generation mRNA backbone.

Dossier - 01/07/2013

Electrophysiology from cardiac pacemakers to drug discovery

Electrochemical reactions are involved in many processes in the human organism. Electrophysiology is the study of the central processes of electrical and chemical interaction and communication between neurons and muscle cells, including the transmission and processing of signals in the nerves and the subsequent contraction of the muscles. For example, electrophysiology studies examine the rhythm which which our heart pumps blood through the body.

Researchers of the Heidelberg University, Heidelberg University Hospital (UKHD) and Heidelberg Institute for Theoretical Studies (HITS) have developed a synthetic peptide based on the natural protein S100A1, a nearly universal “fuel” for weakened hearts. The researchers combined computer-aided methods with lab studies to investigate the therapeutic effect of the so called S100A1ct peptide molecule.

Researchers at Heidelberg Faculty of Medicine at Heidelberg University, in collaboration with partners from 29 German study centers, have found evidence of a potential biomarker for personalized therapy of acute myeloid leukemia (AML) in a Phase II study. Analyses showed that certain patients could benefit from additional treatment with the drug Motixafortide in addition to standard chemotherapy.

Dossier - 09/07/2012

Bachelors and masters under scrutiny has the new study system stood the test?

More practical relevance, shorter courses and courses that are compatible across Europe – when the decision to implement the bachelor’s and master’s system was made in Germany in 1999, there were high expectations and hopes for the positive changes to come. The question is, have these expectations been met?

As the sun rises higher in the sky this spring, UV exposure increases. This should be addressed with proper sun protection. New data shows that people who work outdoors frequently are at a significantly higher risk of developing melanoma on their faces. At the same time, many affected individuals lack awareness of the risks and fail to use systematic sun protection.

CureVac N.V. (Nasdaq: CVAC), a clinical-stage biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced results of the second interim analysis of its international pivotal Phase 2b/3 study in approximatively 40,000 subjects (the HERALD study) of CureVac’s first-generation COVID-19 vaccine candidate, CVnCoV.

The cellular environment of a tumor can either support or sabotage recovery. The most comprehensive study to date on the tumor microenvironment in low-grade gliomas, conducted by KiTZ, Jena University Hospital, the DKFZ, and Heidelberg University Hospital, shows what a supportive or obstructive “neighborhood” looks like in childhood brain tumors. The study also provides clues as to how tumor communication might be blocked.

An environmental bacterium could protect against the effects of stress right through to the next generation. Evidence of this emerged in a study using a mouse model carried out by researchers from Ulm and Frankfurt, the results of which were published in the journal `Molecular Psychiatry´. According to the study, the offspring of treated mothers were better protected against the effects of stress in adulthood than control animals.

Study led by the University of Tübingen: many non-antibiotics weaken the natural protective function of the intestine – with consequences for the colonization with pathogenic bacteria

Microorganisms can increase their host’s ability to adapt to the environment and reproduce – evolutionary biologists are now studying the underlying molecular mechanisms. A research team headed by Dr. Fabian Staubach and Yun Wang from the Institute of Biology I at the University of Freiburg has now studied the relationship of Gluconobacter bacteria and fruit flies. They have found that specific Gluconobacter variants supply the flies with vitamin…

More and more data from various European countries prove: Vaccination against human papillomavirus not only prevents precancerous lesions, but also reliably protects against cervical cancer. On the occasion of the International HPV Awareness Day on March 4, Nobel laureate Harald zur Hausen hopes that many more parents will recognize this unique opportunity to protect their children from preventable cancers by vaccinating against HPV.

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions have hardly been studied to date. Researchers from the German Cancer Research Center, the Mannheim Medical Faculty and Columbia University have now published that hepatic stellate cells control liver metabolism as well as liver regeneration and size. The results of the study could contribute to new therapeutic approaches for liver diseases.

In a joint study conducted by the DZHK sites in Heidelberg, Munich and Göttingen, researchers are deciphering how the spatial organisation of the genome in the heart determines genetic disease risks.