The Technology Licensing Office TLB works in partnership with science and industry and is continuously coming up with new ways to ensure the economic success of inventions from all the key fields of technology. Dr. Frank Schlotter head of Life Sciences at the Karlsruhe-based TLB provides insights into the work that his office does taking as examples innovations from the fields of regenerative medicine and diagnostics.
For quite a number of illnesses, patients need to have the concentrations of the medications they are taking and their blood metabolites checked on a regular basis, which can make life rather difficult. Researchers at the Max Planck Institute for Medical Research in Heidelberg have now developed a test based on the firefly enzyme luciferase. This enzyme can be used to quickly and cheaply measure parameters of interest.
Paul Dietl talks around the subject before coming to the point yes lung research has a very long tradition. And yes the breathing mechanism and structure of the lungs have been known for many years. We have also known for quite some time that gases diffuse and are not actively absorbed in the lungs. Are lung researchers now concentrating on the precise details? Nothing could be further from the truth said the Ulm professor for general physiology Prof. Paul Dietl The most essential aspects are still unclear.
The Comprehensive Infectious Diseases Centre at the University of Ulm was recently presented to the public. The centre is responsible for coordinating the cooperation between specialists in the diagnosis and therapy of complex infectious diseases.
In order to counteract the increase in the number of diabetics it is necessary to take into account the entire psychosocial environment of the patients states Prof. Dr. Peter Nawroth a physician from Heidelberg University Hospital. The prevention of late complications must be a major goal of any treatment and patient consultation. By focusing on the development and investigation of the RAGE-dependent reaction system Nawroth and his team have succeeded in significantly driving forward the understanding of the molecular relationships of late diabetes-related damage.
With the establishment of the BioRN Innovation Center in the Rhine-Neckar Life Science Cluster, a professional, specialist and neutral intermediary between science and industry will be available to support the transfer of technologies in all of the cluster’s research institutions. In addition, the BioRN Innovation Center acts as a partner for strategic alliances set up to reinforce the competitiveness of the institutions on the European and international levels.
Intensive cooperation between the engineering-driven sectors and the biotechnology sector is a prerequisite for driving forward automation in the field of biotechnology. The Engineering – Life Sciences – Automation (ELSA) cluster initiative of BioRegio STERN Management GmbH aims to promote cross-industry cooperation. A study entitled ‘Biotech meets Autotech’, which was carried out as part of the ELSA project, provides insights into the current status of cooperation and the potential offered by closer collaboration.
Vesicles form naturally in cells and can do many things including transporting pharmaceutically active substances to tumours. However natural vesicles only have a short lifespan which can lead to the premature release of the drug enclosed within them. Alexander Wittemann a chemist at Konstanz University has successfully developed artificial biocompatible polymer vesicles with a much longer lifespan.
A research consortium was established at the Stuttgart Research Center Systems Biology SRCSB at the University of Stuttgart in January 2013 with the goal of establishing models that help predict the action of targeted therapeutics. The scientists combine molecular biology experiments with complex mathematical models in order to achieve a holistic understanding of disease and therapy.
The NMI Natural and Medical Sciences Institute in Reutlingen organised its biannual MEA conference from 8 to 11 July 2008. More than 200 developers and microelectrode array users from 18 countries came together in Reutlingen to present their latest developments and results.
amcure GmbH has identified a new compound with a new efficacy profile against pancreatic cancer. Animal experiments have shown promising results: the drug candidate successfully prevents tumour growth and destroys existing metastases. The company, which was spun out from the Karlsruhe Institute of Technology (KIT) in 2011, is now working on its first financing round and is looking for new investors. At the same time it is carefully planning its future with the aim of developing the new angiogenesis inhibitor in a structured and precise way.
Boehringer Ingelheim is hoping to find ways to use anti-inflammatory mechanisms of action to improve the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Clinical studies will show what kind of improvements patients can expect from the substances, which are currently at different stages of development. Drugs to widen the bronchia, marketed by Boehringer Ingelheim, will in the medium term become indispensable in the treatment of chronic obstructive pulmonary diseases and asthma.
Trying to get a second opinion from a medical colleague who is at home preparing dinner may be quite a challenge, especially when the colleague does not have access to the necessary image data. This has now become easier in the field of radiology thanks to a mobile app called mRay, which provides a reliable way for radiologists to share medical images on mobile devices.
The NMI in Reutlingen is one of the most prestigious research institutes in Germany, “a beacon of applied research” as the Minister of Economic Affairs recently called the institute. This success is no accident: for 25 years now, the institute with its interdisciplinary team has been working efficiently and actively towards this achievement. Moreover, it greatly succeeded in bridging science and industry.
Spectroscopic methods have been used for many decades in scientific research to obtain a wealth of information about chemical substances, substance mixtures and their reaction processes. Micro-biolytics GmbH from Esslingen have successfully developed a spectroscopic method that combines innovative technologies. The method enables the highly accurate and sensitive measurement of aqueous samples.
The impact of digital health applications on public health is not yet well documented despite the growing number of health apps on the market. In a report called “Digital-Health-Anwendungen für Bürger: Kontext, Typologie und Relevanz aus Public-Health-Perspektive”, the Bertelsmann Foundation has developed a classification system to facilitate further research and evaluation of digital health applications.
Lena Maier-Hein from the German Cancer Research Center (DKFZ) helps physicians get better vision during minimally-invasive surgery. Using novel methods of image analysis, she wants to provide additional image information for surgeons. Thus, they can better differentiate tumors from healthy tissue and execute safer surgical tumor therapies. Maier-Hein now receives the Prize of the Berlin-Brandenburg Academy of Sciences and Humanities, which is donated by the Monika Kutzner Foundation.
Scientists at the University Hospital in Heidelberg have discovered a hepatitis B virus peptide that can prevent viral infections in a mouse model. A team led by Professor Stephan Urban is developing a virus blocker against hepatitis B infections. Despite vaccinations every year about 750000 people die from the consequences of hepatitis B infections.
What causes stress for some, actually speeds others like extremophilic bacteria up. They love it hot, sour or salty, toxic substances like heavy metals also do them good and even give them energy. As molecular and systems biology techniques get better and better, industry is also becoming increasingly interested in these exotic organisms. What potential does knowing the biochemistry of extremophilic bacteria have for the pharmaceutical, cosmetics and sanitary articles industries? Whatever the answer might turn out to be, there is certainly a growing trend towards using extremophilic microbes in academic and industrial research.
The speed dating format is no longer just a popular and simple dating method for lonely hearts, but has also become a rewarding way for establishing new business contacts and connections quickly and efficiently. BIOPRO Baden-Württemberg chose speed networking, as speed dating is called in the corporate world, for its recent Meet & Match event on pharmaceutical process technology, which took place on 15th March 2016 with the support of Bosch Packaging Technology in Crailsheim.
The field of medicine often requires materials that need to be sterile at the same time as having low thermal stability. The Institute of Plasma Research at the University of Stuttgart has developed a dry-heat plasma sterilisation method that is a faster, more effective and less dangerous alternative to previously used methods.
First aid at the site of an accident can save many lives. Initial assistance is very often given by non-experts. In order to help these first-aiders in what are difficult circumstances, Karl Küfner GmbH & Co. KG from Albstadt and the HSG-IMIT (Institut für Mikro- und Informationstechnik) from Villingen-Schwenningen have developed a respiratory flow sensor for first-aiders which gives visual and acoustic information during resuscitation.
Researchers have discovered two new TBE transmission pathways: the first related to the consumption of raw milk and raw milk cheese that can cause encephalitis, and the second is another tick species that can pass on the TBE virus, thus increasing the risk of contracting the disease even in winter.
It is difficult to imagine how Ochsenhausen-based Labor Dr. Merk und Kollegen (LMK) would be able to develop, produce and test medical products for bacterial and viral contaminations without using cell cultures. The medium-sized company also produces viruses for testing and has stored more than 80 different viruses – enveloped and non-enveloped ones, animal and human pathogens – at -80˚C.
Sleep-related breathing problems can in the long term even lead to cardiac infarction or stroke. A new technology from TNI medical AG puts a stop to the discomforts of a mask by giving people a seminal solution.