Signal transduction is one of the most innovative fields of research in the life sciences. A book entitled “Molecular Biology of the Cell” is clear evidence of this. When the first edition of the mighty tome was published in the 1980s, Bruce Alberts and his co-authors only devoted a few paragraphs to signal processing and cellular communication. A lot was still unknown and unclear at the time. The current 5th edition devotes a complete chapter to the “Mechanisms of Cellular Communication”. Although the scientists are far from being able to understand and decipher everything, the signal researchers nevertheless have a good deal of knowledge about the transduction of signals and the different signalling pathways.