It has long been suspected that endothelial cells play a key role in determining how the body’s immune system responds to tumors. Researchers at the DKFZ and the Medical Faculty Mannheim of Heidelberg University have now identified, in mouse studies, a specialized population of blood vessel lining endothelial cells that enable an effective immune defense against cancer metastases in the liver.

The Friends of the German Cancer Research Center (DKFZ) support the DKFZ and aim to help strengthen its position in the international arena. With the DKFZ Innovation Award, presented at this year’s annual reception, the association honors Helmut Salih, a researcher whose innovative work bridges the gap between immunological research and patient care.

The University of Freiburg is strengthening its European collaboration in the field of Artificial Intelligence by having been accepted into the Virtual Centre of Excellence of the European AI initiative ELIAS. The Freiburg researchers contribute their expertise to the European network in areas including machine learning, computer vision, robot learning, automated reasoning, intelligent systems and neurotechnologies, as well as responsible AI.

Robots that can learn and adapt require not only data, AI tools, and algorithms but also direct communication with their users. Jens Kober would like to improve this interaction and as the new head of a research team at Fraunhofer IPA, he is focusing in particular on construction robotics.

The European Research Council (ERC) supports visionary projects in basic research through its “Advanced Grants.” This year, the Council awarded a grant to cancer researcher and physician Dieter Saur from the DKTK Munich* site, and Aurelio Teleman, a metabolism expert at the German Cancer Research Center (DKFZ).

Prof. Dr Fred Hamprecht from the Interdisciplinary Center for Scientific Computing of Heidelberg University is receiving valuable funding from the ERC, which will support a project in the field of computational quantum chemistry. An ERC Advanced Grant also goes to Prof. Dr Andreas Meyer-Lindenberg, Director of the Central Institute of Mental Health and professor at the Medical Faculty Mannheim of Ruperto Carola.

In order to further strengthen Heidelberg University as an internationally recognized location of infection research, Prof. Dr Mathias Lichterfeld has been selected for an Alexander von Humboldt Professorship endowed with 7.8 million euros. Leading international academics are granted this most valuable of German research awards to enable them to conduct long-term, cutting-edge research at German universities.

Gelatin is a versatile natural material. To tailor its properties specifically to the various applications in medicine, diagnostics, and cosmetics, the Fraunhofer IGB has developed a toolbox for chemical functionalization. With the help of automated processes, the modifications can now be scaled under defined conditions, and reproducible batches of modified gelatin can be produced on a scale ranging from grams to kg for customer sampling.

The German Research Foundation (DFG) funds continuation of Research Training Group (RTG) 2727 “Checkpoints of Innate Immunity in Cancer and Tissue Damage”, with around €5,8 million.

Joint press release of the Heidelberg Faculty of Medicine at Heidelberg University and the German Center for Infection Research: With the FDA approval of Hepcludex (bulevirtide), a therapy for chronic hepatitis D developed at the Heidelberg Faculty of Medicine at Heidelberg University, Heidelberg University Hospital, and the German Center for Infection Research (DZIF) has now reached the world’s most important pharmaceutical market.

AI is transforming science and does not stop at neuroscience. In this interview, we speak to Gabriele Lohmann about her research at the intersection of the brain and algorithms. She talks about the use of artificial intelligence as a research tool, the decoding of brain activity, and why large language models do not understand what they are doing.

Prof. Dr Simon Elsässer will be awarded one of this year’s Alexander von Humboldt Professorships in Berlin on 12 May 2026. With funding of five million euros, Elsässer will strengthen Freiburg’s research focus ‘Signals of Life’ over the next five years. In this interview, he discusses complex decision-making processes in cells, the significance of signals and what makes the research environment in Freiburg so special.

Konstanz molecular biologist Elke Deuerling has been admitted to the German National Academy of Sciences, the "Leopoldina". By selecting Elke Deuerling as a member, the Academy recognizes her outstanding contributions to the field of life sciences, particularly to proteostasis research.

From May 15–16, 2026, the 3rd International Symposium “Frontiers in Skin Immunity” will bring leading experts in dermatology and immunology to Heidelberg. Organized by the SFB Transregio 156 “The Skin as Sensor and Initiator of Local and Systemic Immunity” and the Medical Faculty of Heidelberg University the meeting highlights advances in understanding skin immune responses and marks the conclusion of the consortium’s third funding period.

A new technique based on labelled sugar molecules is providing previously unknown insights into the inner ear. A study by the University of Konstanz and Charité-Universitätsmedizin Berlin shows that the cupula in the inner ear of zebrafish completely regenerates within approximately two months. These findings open up a new avenue for research into sudden hearing loss and acute disorders of the sense of balance.

Brain metastases are among the most serious complications of breast cancer. Researchers at Heidelberg University, DKFZ, and UKHD have concluded an investigation of the immune cells in the brain tissue surrounding these breast cancer brain metastases. Their findings: spatial distribution patterns of immune cells are associated with prolonged patient survival. These findings could help to guide use of immunotherapies for breast cancer patients.

The cities of Heidelberg and Mainz want to work closely together in the future: Their aim is to further develop the Neckar-Rhine-Main region as an international innovation and biotech region. To this end, Heidelberg Mayor Würzner and Mainz Mayor Haase signed a MoU at Heidelberg City Hall on Friday, April 24, 2026. Those responsible for the central innovation and development structures of both cities also took part in the signing.

Not only actual chronological age, but also individual aging at the molecular level is a key factor in the development of cancer. This was discovered by scientists at the DKFZ and the Saarland Cancer Registry. If the so-called “epigenetic clocks” indicate accelerated biological aging, the likelihood of a cancer diagnosis increases. This finding could help identify at-risk groups and make early detection screenings more targeted

Genome duplication probably gave biodiversity a decisive evolutionary boost. A Chinese-German research team led by Axel Meyer from the University of Konstanz has now investigated the early phases of the process known as re-diploidization. The results show that the fusion of chromosome sets is asynchronous.

Can Aztekin and his team have discovered how oxygen-sensing explains why amphibians regenerate limbs and mammals do not.

How does sugar affect relaxation exercises? A new study carried out by researchers from the University of Konstanz provides revealing insights into the connection between blood glucose and the autonomic nervous system: The intake of sugar counteracts relaxation.

In ovarian cancer, immunotherapies using checkpoint inhibitors have so far been effective in only a small number of patients. Researchers at the HI-TRON Mainz* have now discovered that lipid metabolism processes in the tumor microenvironment play a decisive role in how well such therapies work. The findings open up new avenues for using immunotherapies in a more targeted manner, increasing their effectiveness, and overcoming resistance.

The German Center for Mental Health (DZPG) conducts nationwide research on individualized treatments for depression, anxiety disorders, and addiction. Its approach combines established therapeutic methods with innovative strategies to enhance overall treatment efficacy. The primary beneficiaries are patients for whom conventional therapies have so far proven insufficiently effective.

Protein activity can be precisely regulated via subtle changes in temperature using heat-sensitive switches. Underlying this capability is a novel modular design strategy developed by researchers at the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University. The strategy allows the integration of sensory domains in various proteins regardless of function or spatial structure.