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  • Press release - 10/01/2022

    Algorithm identifies cancer drivers

    Genetic alterations that promote the development and spread of tumors are difficult to identify. This is especially true for mutations in the non-protein-coding regions of the genome, which include all important regulatory sequences. Scientists at the German Cancer Research Center have now published an algorithm that detects cancer drivers in both the protein-coding and non-coding regions of the genome.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/algorithm-identifies-cancer-drivers
  • Press release - 26/07/2021

    Vaccination against hereditary colorectal cancer successful in mice

    Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug increased the protective effect.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/vaccination-against-hereditary-colorectal-cancer-successful-mice
  • Cancer immunotherapy - 06/09/2018 Schematic showing the so-called breakthrough event as well as the expansion and invasion stages of cells during carcinogenesis.

    The immunogenicity of tumours and the development of new cancer medicines

    Microsatellite-unstable cancers are characterised by a large number of mutations within short repetitive DNA sequence regions, and can form novel peptides that the human immune system recognises as neoantigens. These cancers represent a starting point for the development of vaccines to prevent them appearing at an early stage of development. Microsatellite instability is particularly frequent in colon and cervical cancers.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-immunogenicity-of-tumours-and-the-development-of-new-cancer-medicines
  • Article - 27/02/2017 Prof-Michael-Baumann.jpg

    Michael Baumann – the new man at the helm of the DKFZ

    On 1st November 2016, Professor Michael Baumann, a radiation oncologist from Dresden, became the new chairman and scientific director of the German Cancer Research Center in Heidelberg. Michael Baumann has the perfect background when it comes to combining basic and applied cancer research. This enables scientific findings to be used more quickly and effectively for preventing, diagnosing and treating cancer, and patients’ individual needs to be…

    https://www.gesundheitsindustrie-bw.de/en/article/news/michael-baumann-the-new-man-at-the-helm-of-the-dkfz
  • Article - 30/06/2016 Fettfaerbung_in_der_Leber_HZ_Mchn.jpg

    Why fasting is good for health

    A protein in the nucleus of liver cells is produced in greater quantities when we go hungry; it limits fatty acid uptake and adjusts the metabolism in the liver. However in people with metabolic disorders, the abnormal expression of this protein (GADD45β), which was previously only known to be involved in the regulation of cell division and DNA repair, leads to a dysregulated fat and sugar metabolism. Scientists from the DKFZ and Helmholtz…

    https://www.gesundheitsindustrie-bw.de/en/article/news/why-fasting-is-good-for-health
  • Overview

    Basic research

    The latest articles, press releases and dossiers on basic research in Baden-Württemberg

    https://www.gesundheitsindustrie-bw.de/en/article/research
  • Article - 23/02/2015 Photo of a young woman smiling into the camera.

    Miriam Erlacher: apoptosis research – balancing clinical work and research

    Programmed cell death plays an important role in embryonic development and has also been identified as the cause of a range of diseases. It also plays a key role in the development and survival of higher organisms. Its regulation is based on a sophisticated system of interacting antagonistic signals in a network that is still largely unknown. Disturbances in this delicate balance promote the development of diseases such as cancer. Dr. Miriam…

    https://www.gesundheitsindustrie-bw.de/en/article/news/miriam-erlacher-apoptosis-research-balancing-clinical-work-and-research
  • Article - 08/09/2014 Dr. Maria Moreno-Villanueva, University of Konstanz

    Molecular effects of traumatic stress

    After a traumatic experience, people often suffer not only mental, but also physical effects. Dr. María Moreno-Villanueva from the University of Konstanz has investigated the molecular effects of traumatic stress in people and has found a higher than normal number of DNA strand breaks. In the worst cases this can lead to diseases such as cancer. However, her study also shows that successful psychotherapy can reverse DNA damage. Her findings will…

    https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-effects-of-traumatic-stress
  • Article - 25/11/2013 20671_de.jpg

    Elisa May: a sharp, microscopic look at DNA damage

    DNA damage is part of our everyday life. Every day, tens of thousands of DNA single-strand breaks occur in every cell, but we have a variety of sophisticated genome maintenance mechanisms to protect ourselves against such problems. However, serious diseases can result in cases where the cellular repair system fails. Amongst other things, there is a close relationship between the failure of DNA repair mechanisms and the development of cancer.…

    https://www.gesundheitsindustrie-bw.de/en/article/news/elisa-may-a-sharp-microscopic-look-at-dna-damage
  • Article - 08/08/2013 20110_de.jpg

    Innovative measurement of cellular stress allows development of new cancer drugs

    The chemical attachment of PolyADP-ribose a biopolymer with chemical similarities to nucleic acids to cellular proteins is part of the cellular DNA repair machinery. To investigate this process in more detail Dr. Aswin Mangerich and colleagues from the University of Konstanz and the MIT have developed a bioanalytical platform based on isotope dilution mass spectrometry to quantify PAR levels with high specificity and sensitivity. The results…

    https://www.gesundheitsindustrie-bw.de/en/article/news/innovative-measurement-of-cellular-stress-allows-development-of-new-cancer-drugs
  • Article - 29/07/2013 20141_de.jpg

    ‘Go back to start’ in the field of meiosis

    Researchers have long thought they knew exactly how meiosis, meiosis regulators and the complex that forms between homologous chromosomes during meiosis work. The research group headed by Dr. Andrea Pichler from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has now discovered a new mechanism that plays an important role in meiosis. The study carried out by Pichler and her colleague Dr. Helene Klug has shown why it is…

    https://www.gesundheitsindustrie-bw.de/en/article/news/go-back-to-start-in-the-field-of-meiosis
  • Article - 25/02/2013 19274_de.jpg

    Frauke Melchior and the SUMO wrestling match between proteins

    Fifteen years ago, molecular biologist Frauke Melchior discovered a new mechanism of posttranslational protein modification that controls a variety of processes in eukaryotic cells. A small protein called SUMO is covalently bound to target proteins by specific enzymes and cleaved by other enzymes. This discovery has shaped Melchior’s scientific career.

    https://www.gesundheitsindustrie-bw.de/en/article/news/frauke-melchior-and-the-sumo-wrestling-match-between-proteins
  • Article - 28/12/2012 18958_de.jpg

    When cells go out of control – researchers to unveil the secret of cell ageing

    The process of ageing appears, at least at first sight, to be fairly tangible and is visible both at individual and societal level. Nevertheless, science has not yet come up with detailed insights into the physiology of ageing. Jörg Bergemann, Professor of Biomedical Engineering at the Albstadt-Sigmaringen University of Applied Sciences, is studying the processes of ageing in skin cells in a project that has recently been granted funding by the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/when-cells-go-out-of-control-researchers-to-unveil-the-secret-of-cell-ageing
  • Article - 23/04/2012 16983_de.jpg

    Iris-Tatjana Kolassa – extreme stress takes a toll on cells

    Molecular psychology has huge potential for the future. The discipline has used imaging methods for diagnostic purposes for a long time, but Iris-Tatjana Kolassa, a 33-year-old psychologist from Ulm, is convinced that in future it will increasingly use molecular biology and medicine methods. The idea of remaining blinkered in her own discipline is a notion that is utterly foreign to Kolassa; whenever she senses synergies, whether it be with…

    https://www.gesundheitsindustrie-bw.de/en/article/news/iris-tatjana-kolassa-extreme-stress-takes-a-toll-on-cells
  • Article - 16/04/2012 The photo shows a blossom with white petals and yellow stamina.

    DNA recombination for targeted plant breeding

    Did evolution invent games of chance? During the development of sperm and egg cells, maternal and paternal genes are mixed at random, thus giving rise to new combinations of traits. What are the molecular mechanisms of this process known as DNA recombination? How can it be used to breed plants with higher yields? Prof. Dr. Holger Puchta and his team at the Karlsruhe Institute of Technology (KIT) are investigating the processes associated with the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/dna-recombination-for-targeted-plant-breeding
  • Article - 05/03/2012 The photo shows nine people standing on a staircase.

    Ubiquitin and related molecules do more than just degrade and recycle cellular waste

    The proteins of the ubiquitin family have long been regarded as cellular Post-its with to be discarded written on them. However over the last ten years it has become increasingly clear that the proteins of the ubiquitin family that cells use to label defective or unneeded proteins also regulate a broad range of important cellular processes. It has also been found that they are involved in the pathogenesis of cancer and neurodegenerative diseases…

    https://www.gesundheitsindustrie-bw.de/en/article/news/ubiquitin-and-related-molecules-do-more-than-just-degrade-and-recycle-cellular-waste
  • Article - 23/01/2012 16240_de.jpg

    Peter Rodemann – a career in radiobiology

    Prof. Dr. H. Peter Rodemann has been head of the Division of Radiobiology and Molecular Environmental Research at Tübingen University Hospital for around 20 years. He has been awarded numerous prizes for his outstanding achievements, particularly during the second half of 2011 when he was awarded the Ulrich Hagen Prize by the German Society for Biological Radiation Research as well as being elected member of the German Academy of Sciences…

    https://www.gesundheitsindustrie-bw.de/en/article/news/peter-rodemann-a-career-in-radiobiology
  • Press release - 04/11/2011 Logo DKFZ, blue letters "DKFZ"

    Alternate ending – living on without telomerase

    Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have discovered an alternative mechanism for the extension of the telomere repeat sequence by DNA repair enzymes.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/alternate-ending-living-on-without-telomerase
  • Dossier - 22/08/2011 Volcanic crater in the Yellowstone National Park: The lake is surrounded by an orange ring consisting of algae and bacteria which have become adapted to the extremely high temperatures.<br />

    Stress and molecular defence mechanisms

    Organisms can experience stress from exposure to bacteria and pathogenic fungi; in fact, stress can arise from exposure to any type of environmental influence. As they have evolved, biological cells have developed numerous molecular mechanisms that enable them to survive even in inhospitable conditions. What kind of effects do abiotic stress factors have on plants and human beings? How do cells protect themselves? Are researchers able to increase…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/stress-and-molecular-defence-mechanisms
  • Article - 27/06/2011 The photo shows a magnetic resonance image of a human head. A walnut-size structure can be seen inside the brain.

    New therapeutic approaches: nitric oxide for the treatment of brain tumours

    Researchers led by neurosurgeon Dr. Astrid Weyerbrock from the Freiburg University Medical Centre are working on the improvement of therapies for the effective treatment of glioblastomas that involve deciphering the biological mechanisms that lead to these complex brain tumours. They are using a volatile molecule that is also found in the earths atmosphere.

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-therapeutic-approaches-nitric-oxide-for-the-treatment-of-brain-tumours
  • Press release - 09/04/2011 Prof. Dr. Alexander Bürkle, scientist from the University of Konstanz

    Alexander Bürkle receives award for research into DNA repair

    Dr. Alexander Bürkle from the University of Konstanz was awarded the GT-Toxicology Prize by the Society of Toxicology (part of the German Society of Experimental and Clinical Pharmacoloy and Toxicology) and the journal “Toxicology” for his work on DNA repair mechanisms. Bürkle’s research centres on the enzyme poly[ADP-ribose]polymerase (PARP). The reduced activity of PARP is known to cause the incomplete or delayed repair of continuously…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/alexander-buerkle-receives-award-for-research-into-dna-repair
  • Article - 21/03/2011 13966_de.jpg

    Andrea Hartwig – trace elements, toxic metals and the thin line in between

    For more than 25 years Prof. Dr. Andrea Hartwig has been investigating the quantities of metal compounds that have a beneficial or toxic effect on human health. As a basic researcher the new chair of the Department of Food Chemistry and Toxicology at the Karlsruhe Institute of Technology KIT has managed to clarify many mechanisms of action of toxic metals including on the molecular level.

    https://www.gesundheitsindustrie-bw.de/en/article/news/andrea-hartwig-trace-elements-toxic-metals-and-the-thin-line-in-between
  • Article - 07/02/2011 13564_de.jpg

    The discovery of the individual as business model

    The move towards personalised medicine has made considerable progress, in particular in the field of oncology, where it is leading to the close integration of diagnostics and therapy as well as to the development of profitable new business models, some of which have controversial exclusive legal claims.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-discovery-of-the-individual-as-business-model
  • Article - 15/03/2010 10212_de.jpg

    Cornelia Ulrich: Cancer prevention through food and sports

    The appointment of Cornelia Ulrich as professor and head of the Departments of Preventive Oncology at the National Centre for Tumour Diseases and the German Cancer Research Centre shows that Heidelberg is expanding its research priorities in the prevention and early diagnosis of cancer. Ulrichs main focus has been on the folic acid metablism C1 compounds and inflammation.

    https://www.gesundheitsindustrie-bw.de/en/article/news/cornelia-ulrich-cancer-prevention-through-food-and-sports
  • Article - 28/10/2009 09928_de.jpg

    Worn down and financially exhausted, but more popular than ever

    When academic toxicologists in a German state join forces, it is virtually headline news. This is because the discipline is on the red list. Only in Baden-Württemberg does the number of toxicologists at university institutes justify the joining of forces. The ironic thing about this is that the competence of the rare species ”toxicologicus” is in greater demand than ever.

    https://www.gesundheitsindustrie-bw.de/en/article/news/worn-down-and-financially-exhausted-but-more-popular-than-ever

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