Article - 20/12/2007 Viruses are the major cause of myocardial diseases About 500000 people in Germany suffer from dilatative cardiomyopathy DCM. Viral infections are the major cause of this myocardial disease. Its molecular and cellular mechanisms are being investigated in a transregional SFB project at the University of Tübingen.https://www.gesundheitsindustrie-bw.de/en/article/news/viruses-are-the-major-cause-of-myocardial-diseases
Article - 13/05/2008 Just follow your nose Sharks can sense a few drops of blood in water. In fact they are able to smell blood in dilutions of as little as one to 10 billion. Is it just sharks or piranhas that have such an acute sense of smell? The answer is no - all fish have a highly developed sense of smell.https://www.gesundheitsindustrie-bw.de/en/article/news/just-follow-your-nose
Press release - 30/11/2011 Researchers are challenging a common model of immunology Up to now, scientists have assumed that mast cells, a certain type of immune cells, play a central role in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Current studies conducted at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now provided evidence to refute this assumption. Now it is only the mast cells’ central function in allergies that remains undisputed.https://www.gesundheitsindustrie-bw.de/en/article/press-release/researchers-are-challenging-a-common-model-of-immunology
Press release - 12/10/2011 Dioxin-like Chemical Messenger Makes Brain Tumors More Aggressive Scientists from German Cancer Research Center and Heidelberg University have discovered a new dioxin receptor-coupled metabolic pathway which weakens the immune system and promotes the growth of malignant gliomas. Glioma is the most frequent and most malignant brain tumor in adults. In Germany, about 4,500 people are newly diagnosed with glioma every year.https://www.gesundheitsindustrie-bw.de/en/article/press-release/dioxin-like-chemical-messenger-makes-brain-tumors-more-aggressive
Article - 29/05/2012 Intestinal bacteria and human gut types The type of bacteria that colonize the human gut does not just influence our digestion and well-being. Metagenome sequencing has provided an international consortium involving scientists from the European Molecular Biology Laboratory at the University Hospital of Heidelberg with evidence that certain individuals have different gut types with different types of bacteria. Such individuals not only differ in their predisposition to disease, but also…https://www.gesundheitsindustrie-bw.de/en/article/news/intestinal-bacteria-and-human-gut-types
Press release - 16/11/2021 Cystic fibrosis & COPD: Mucus reprograms immune cells and promotes airway inflammation Scientists of the Translational Lung Research Center Heidelberg (TLRC) and the German Cancer Research Center (DKFZ) have discovered a new link between excessive airway mucus and chronic airway inflammation that is characteristic of cystic fibrosis and chronic obstructive pulmonary disease (COPD). The researchers showed that mucus in the airways reprograms certain cells of the immune system.https://www.gesundheitsindustrie-bw.de/en/article/press-release/cystic-fibrosis-copd-mucus-reprograms-immune-cells-and-promotes-airway-inflammation
Article - 28/02/2011 Development of food allergies Allergic reactions to certain types of food can, in extreme cases, lead to life-threatening anaphylactic shock. People with peanut allergies are particularly at risk. Allergic reactions can also gradually develop into chronic intolerances such as coeliac disease, for example. The causes of food allergies nearly always originate in early childhood. https://www.gesundheitsindustrie-bw.de/en/article/news/development-of-food-allergies
Article - 20/10/2014 Michael Schindler: HI virus and host interactions Prof. Dr. Michael Schindler explores the interaction between viruses and their human host cells on the molecular level. His specific interest is HI virus infections and the mechanisms the virus uses to attack the human immune system. Schindler’s eventual aim is to identify a new target for the therapy of HIV infections. In April 2014, Schindler was appointed head of the Department of Molecular Virology of Human Infectious Diseases at the…https://www.gesundheitsindustrie-bw.de/en/article/news/michael-schindler-hi-virus-and-host-interactions
Article - 07/03/2011 Thomas Brunner: steroid synthesis in the intestine A research team led by Prof. Dr. Thomas Brunner at the University of Konstanz has found out that intestinal epithelial cells are able to synthesise anti-inflammatory steroids glucocorticoids following immunological stress which makes a considerable contribution to the maintenance of local immune homoeostasis. Brunner plans to use his findings to develop a therapeutic approach for the treatment of inflammatory bowel diseases.https://www.gesundheitsindustrie-bw.de/en/article/news/thomas-brunner-steroid-synthesis-in-the-intestine
Article - 19/01/2016 Innate immune defence: using peptides against fungi and bacteria Part of the human immune defence relies on antimicrobial peptides. These peptides, so-called defensins, are present in the gastrointestinal tract where they play a role in the pathogenesis of Crohn’s disease. Prof. Jan Wehkamp and his team of researchers at the University Hospital in Tübingen study how this knowledge can be put to good use for the treatment of Crohn’s and other diseases.https://www.gesundheitsindustrie-bw.de/en/article/news/innate-immune-defence-using-peptides-against-fungi-and-bacteria
Overview Pharmaceutics The latest articles, press releases and dossiers on pharmaceutics in Baden-Württemberghttps://www.gesundheitsindustrie-bw.de/en/article/pharma
Macrophages interacting with cytomegaloviruses - 22/02/2022 Cytomegaloviruses subvert macrophage identity Cytomegaloviruses are basically harmless. However, if they occur along with other pathogens, they can trigger serious diseases. They can manipulate our immune system and encourage resident defence cells to migrate. Researchers at the Centre for Chronic Immunodeficiency (CCI) at the Freiburg University Medical Centre have discovered which mechanisms underlie the behavioural changes in macrophages that make it easier for other pathogens to attack.https://www.gesundheitsindustrie-bw.de/en/article/news/cytomegaloviruses-subvert-macrophage-identity
Press release - 02/09/2021 Award-winning science: Cancer-promoting metabolic pathways as targets of new therapies Christiane Opitz, scientist at the German Cancer Research Center, is being awarded this year's Ita Askonas Prize of the European Federation of Immunological Societies. Opitz has discovered how tumor cells use certain metabolites to protect themselves against the immune system. Her research findings may provide important clues for the development of new therapeutic concepts.https://www.gesundheitsindustrie-bw.de/en/article/press-release/award-winning-science-cancer-promoting-metabolic-pathways-targets-new-therapies
Article - 19/11/2015 Immune cells are reprogrammed in Alzheimer’s brains Scientists from the Hertie Institute for Clinical Brain Research at the University of Tübingen are pursuing an innovative treatment approach for Alzheimer’s disease using immune cells to eliminate the protein deposits that are the hallmark of Alzheimer’s. Dr. Jonas Neher and his team tested whether exchanging brain-specific immune cells with fresh, more active cells has a positive effect on the disease. https://www.gesundheitsindustrie-bw.de/en/article/news/immune-cells-are-reprogrammed-in-alzheimers-brains
Article - 18/03/2011 Allergen research – present and future An allergy is a hypersensitivity disorder of the immune system. It is an exaggerated immune reaction to external stimuli such as pollen and is associated with symptoms that range in degree from uncomfortable (hay fever, asthma) to life-threatening (anaphylactic shock). Dr. Thomas Bethke, Medical Director of Nycomed Germany, explains in the following interview how a drug manufacturer approaches the research and development of anti-allergy…https://www.gesundheitsindustrie-bw.de/en/article/news/allergen-research-present-and-future
Article - 03/07/2010 Erbasens: Using the power of nature Before setting up her own company biologist Dr. Elke Schulz amassed a wealth of knowledge in the pharmaceutical industry. Now she harnesses the power of plants to develop and sell dietary supplements and natural cosmetics. Her company Erbasens specialises in combining high-quality oils and plant essences to create products such as Paramirum that safeguards the effectiveness of the immune system and promotes the bodys defence systems.https://www.gesundheitsindustrie-bw.de/en/article/news/erbasens-using-the-power-of-nature
Press release - 21/05/2010 The road to individualized tumour vaccines What are the typical cancer cell characteristics that our immune system is directed against? Using a new biochemical method, scientists from the Neurosurgery Department of the Heidelberg University Hospital and the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ) are now able to answer this question for each individual patient. The method is expected to help identify new target structures for individualized tumour vaccines. https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-road-to-individualized-tumour-vaccines
Press release - 14/09/2021 Bridging antibodies plus enhancer can destroy breast cancer cells Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have developed antibodies that have two antigen-binding sites and can couple cancer cells with effector cells of the immune system. In laboratory tests, these bridging antibodies, together with an enhancer antibody, were able to specifically mobilize the body's own immune defenses and destroy breast cancer cells.https://www.gesundheitsindustrie-bw.de/en/article/press-release/Bridging-antibodies-plus-enhancer-can-destroy-breast-cancer-cells
Article - 11/06/2010 Recycling of bacterial cell wall constituents Bacterial cells are focused on growth and proliferation. These processes are initiated by cellular enzymes that break up the cell wall material murein introduce new material and degrade material that is no longer needed. And all this in large amounts about 50 per cent of murein are degraded and newly formed turnover per cell generation. Dr. Christoph Mayer and his team from the University of Constance have shown that the cells carry out effective…https://www.gesundheitsindustrie-bw.de/en/article/news/recycling-of-bacterial-cell-wall-constituents
Article - 12/06/2010 Correcting enzyme defects using stem cells Bone marrow transplantation was originally developed for the treatment of leukaemias and other malignant diseases of the haemotopoietic system. Thanks to increasing technological process it has been possible to considerably expand the treatment spectrum over the last few years. Dr. Ingo Müller paediatrician at the University Hospital in Tübingen now uses bone marrow transplantation for the therapy of genetic metabolic diseases with highly…https://www.gesundheitsindustrie-bw.de/en/article/news/correcting-enzyme-defects-using-stem-cells
Press release - 26/07/2021 Vaccination against hereditary colorectal cancer successful in mice Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug increased the protective effect.https://www.gesundheitsindustrie-bw.de/en/article/press-release/vaccination-against-hereditary-colorectal-cancer-successful-mice
Article - 02/07/2012 Together against liver failure Medicines that are usually effective in treating diseases can sometimes be associated with severe adverse effects. This can occur when the liver which normally metabolizes drugs and renders them harmless becomes overburdened and even collapses completely. Prof. Dr. Jens Timmer from the University of Freiburg and Prof. Dr. Ursula Klingmüller from the German Cancer Research Center DKFZ in Heidelberg have joined forces in a huge European research…https://www.gesundheitsindustrie-bw.de/en/article/news/together-against-liver-failure
Press release - 21/07/2010 One Million for Cancer Research from Manfred Lautenschläger Foundation When Harald zur Hausen was awarded the Nobel Prize for Medicine in 2008, Manfred Lautenschläger spontaneously offered to support the Nobel laureate’s scientific work by funding a new research team. These funds will now go to Angelika Riemer, a young scientist who plans to advance the development of a vaccine which is able to cure existing infections with carcinogenic human papillomaviruses at the German Cancer Research Center (Deutsches…https://www.gesundheitsindustrie-bw.de/en/article/press-release/one-million-for-cancer-research-from-manfred-lautenschlaeger-foundation
Press release - 12/07/2021 Hijacked immune activator promotes growth and spread of colorectal cancer Through a complex, self-reinforcing feedback mechanism, colorectal cancer cells make room for their own expansion by driving surrounding healthy intestinal cells to death - while simultaneously fueling their own growth. This feedback loop is driven by an activator of the innate immune system. Researchers from the German Cancer Research Center (DKFZ) and the University of Heidelberg discovered this mechanism in the intestinal tissue of fruit…https://www.gesundheitsindustrie-bw.de/en/article/press-release/hijacked-immune-activator-promotes-growth-and-spread-colorectal-cancer
Article - 10/02/2014 HOT Screen GmbH - models for studying diseases HOT Screen GmbH from Reutlingen Germany develops human organotypical HOT cell culture models related to the human immune system for the assessment of drug activity profiles and the selection of suitable drug candidates. The sophisticated models are made with differentiated cells and can be adapted to a broad range of different diseases - including rheumatoid arthritis osteoarthritis Crohns disease neurodermatitis COPD asthma and many others. https://www.gesundheitsindustrie-bw.de/en/article/news/hot-screen-gmbh-models-for-studying-diseases