Organ failure due to fatty liver - 24/09/2020 HepaRegeniX develops an active substance for liver regeneration When the liver stops regenerating on its own, it might be possible in future for doctors to intervene with a chemical agent. Tübingen-based HepaRegeniX GmbH is developing a promising candidate with the aim of improving the treatment of both acute and chronic liver failure. https://www.gesundheitsindustrie-bw.de/en/article/news/heparegenix-develops-active-substance-liver-regeneration
Press release - 04/07/2018 Phase-I-trial approved for novel stem cell therapy for patients with ischemic cardiomyopathy Viscofan BioEngineering, the biomedical business unit of the world market leader for collagenous sausage casings Viscofan announced today that the Spanish Agency for Medicines (AEMPS) has given green light to carry out a clinical phase-I-trial with Viscofan BioEngineering’s first product for regenerative medicine. The novel therapy consisting of stem cells on a collagenous carrier membrane can now be tested on ten patients suffering from severe…https://www.gesundheitsindustrie-bw.de/en/article/press-release/phase-i-trial-approved-for-novel-stem-cell-therapy-for-patients-with-ischemic-cardiomyopathy
Article - 19/03/2018 Regenerative medicine: curing rather than simply treating diseases Some scientists refer to the latest developments in the field of regenerative medicine as the "next revolution in medicine". With the help of gene therapies or stem cells, regenerative medicine aims not only to treat disease symptoms, but to cure them at source. Some approaches are already being used to treat patients and several others are close to application.https://www.gesundheitsindustrie-bw.de/en/article/news/regenerative-medicine-curing-rather-than-simply-treating-diseases
Article - 21/02/2018 HepaRegeniX – a start-up is taking it up a step! HepaRegeniX, a biotech company founded in 2016, specialises in developing drugs that restore the regenerative capacity of diseased livers. The three founders of the biotech start-up, Prof. Dr. Lars Zender, Prof. Dr. Stefan Laufer and Dr. Wolfgang Albrecht, anticipate starting clinical testing of the first drug candidate in 2019.https://www.gesundheitsindustrie-bw.de/en/article/news/heparegenix-a-start-up-is-taking-it-up-a-step
Press release - 12/12/2017 BRAIN AG and Mannheim University develop 3D skin models for health care and cosmetics Research collaboration in project M2Aind for new real-time and high-resolution screening technologies of 3D skin spheroids. Mannheim University of Applied Sciences builds on expertise in 3D cell culture and advanced live cell imaging. BRAIN contributes unique skin reporter cells, screening compound libraries and market knowledge. Review article in Journal of Cellular Biotechnology. https://www.gesundheitsindustrie-bw.de/en/article/press-release/brain-ag-and-mannheim-university-develop-3d-skin-models-for-health-care-and-cosmetics
Press release - 05/09/2017 Cell marking opens up a window into the body A new and particularly reliable method for marking cells can simplify research into diseases such as myocardial infarction, diabetes or Alzheimer's and reduce the use of test animals: Scientists from the University of Tübingen have developed a method by which they can target specific cell types in mice and monitor their behavior using positron emission tomography (PET). PET-based cell tracking allows scientists to observe complex life…https://www.gesundheitsindustrie-bw.de/en/article/press-release/cell-marking-opens-up-a-window-into-the-body
Article - 26/01/2017 Freiburg researchers transform skin cells into renal cells A team of researchers from Freiburg has used direct programming to successfully produce kidney-like cells very similar to natural renal tubular cells in terms of appearance and function. These cells are thus a promising alternative to kidney cells isolated from animals and cells differentiated from embryonic stem cells. The reprogrammed kidney cells can be used, for example, for pharmacological and toxicological tests and investigating the…https://www.gesundheitsindustrie-bw.de/en/article/news/freiburg-researchers-transform-skin-cells-into-renal-cells
Article - 27/06/2016 A nasal spray for treating neurodegenerative diseases Neuroscientists from Heidelberg have created the scientific foundations for a nasal spray that can stabilise the dendrites of nerve cells, thus reducing nerve damage and brain function losses following a stroke. Prof. Dr. Hilmar Bading and his team received the 2016 German BioRegions Innovation Prize for their invention and have set up a company called FundaMental Pharma to further accelerate the development of a marketable medicinal product.https://www.gesundheitsindustrie-bw.de/en/article/news/a-nasal-spray-for-treating-neurodegenerative-diseases
Article - 21/03/2016 Shock wave therapy gives hope to many men Although the approval of vasodilatory drugs made available an effective medicine for treating erectile dysfunction, not all men respond to this type of treatment. MTS Medical UG from Konstanz has developed a therapeutic device that means that these men can now get help too. What's more, the device has no adverse health effects.https://www.gesundheitsindustrie-bw.de/en/article/news/shock-wave-therapy-gives-hope-to-many-men
Article - 17/12/2015 Inhibition of bromodomain affects stem cell differentiation DNA methylation and histone modification are epigenetic mechanisms that affect gene transcription. Moreover, protein complexes can regulate gene expression by modifying chromatin structure and function. Dr. Thomas Günther and his team from the Center for Clinical Research at the Freiburg University Medical Center are studying the effect of the inhibitor PFI-3 on the BAF complex. This protein complex modifies chromatin structure and controls the…https://www.gesundheitsindustrie-bw.de/en/article/news/nhibition-of-bromodomain-affects-stem-cell-differentiation
Press release - 16/11/2015 The Baden-Württemberg healthcare industry – a strong economic power (Stuttgart – 16th November 2015) BIOPRO Baden-Württemberg has just published its latest analysis of the Baden-Württemberg healthcare industry including comprehensive facts and figures. Baden-Württemberg continues to be one of the top locations for medical technology, pharma and biotechnology in Germany. https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-baden-wuerttemberg-healthcare-industry-a-strong-economic-power
Article - 03/09/2015 Pattern formation: How undifferentiated cell clusters develop orderly structures Dr. Patrick Müller explores cellular signalling pathways that turn undifferentiated cell clusters into orderly structures as embryos develop. Supported by an ERC grant, the Max Planck researcher from Tübingen uses a broad range of methods from the fields of genetics, biophysics, mathematics and the computer sciences for his investigations. Regenerative medicine is one field that particularly stands to benefit from Müller’s findings. https://www.gesundheitsindustrie-bw.de/en/article/news/pattern-formation-how-undifferentiated-cell-clusters-develop-orderly-structures
Article - 01/06/2015 High-tech fibres for organ and tissue regeneration Biologically degradable polymers can be electrically spun into a type of fleece that can be used as a scaffold and growth matrix for living cells. This fleece can be used to replace diseased or damaged tissue. In the field of cardiovascular medicine, the fleece can be used to produce new heart valves and tissue.https://www.gesundheitsindustrie-bw.de/en/article/news/high-tech-fibres-for-organ-and-tissue-regeneration
Dossier - 09/03/2015 Advances in the study and treatment of liver diseases Liver diseases are often underestimated despite being quite common and potentially having serious and even life-threatening consequences, especially in chronic cases. The most common causes of liver diseases are hepatitis viruses, excessive alcohol consumption, and obesity; congenital or autoimmune liver diseases are quite rare. Thanks to advances in medical research, diseases such as hepatitis B and C can be treated effectively. Fewer advances…https://www.gesundheitsindustrie-bw.de/en/article/dossier/advances-in-the-study-and-treatment-of-liver-diseases
Article - 22/12/2014 Large-scale urology project: cell therapy for the treatment of stress incontinence The first and so far only clinical DFG research group on urology is being coordinated by a team from Tübingen. The team is developing a cell-based therapy for the regeneration of the urethral sphincter. Clinicians, life scientists and engineers are working together to try and find a causal therapy of stress incontinence. https://www.gesundheitsindustrie-bw.de/en/article/news/large-scale-urology-project-cell-therapy-for-the-treatment-of-stress-incontinence
Dossier - 10/11/2014 Cell and gene therapies: from bench to bedside While cell therapy has become standard treatment for a number of blood cancers, most cell and gene therapy approaches for the treatment of hereditary and metabolic diseases, neurodegenerative disorders and cancer are still in the experimental phases or early clinical trials. However, recent successes give rise to the hope that cell and gene therapies will in future make important contributions to previously incurable diseases.https://www.gesundheitsindustrie-bw.de/en/article/dossier/cell-and-gene-therapies-from-bench-to-bedside
Article - 19/05/2014 Amedrix establishes new collagen and implant production technology Amedrix GmbH, which is based in the Life Science Center in Esslingen and currently has a staff of eight people, develops innovative acellular medical products on the basis of animal collagen. The company's ChondroFiller products have the advantage over existing cartilage treatment options such as microfracture surgery, OCT (osteochondral transplant) surgery or ACT (autologous chondrocyte transplantation) in that they can be produced without…https://www.gesundheitsindustrie-bw.de/en/article/news/amedrix-establishes-new-collagen-and-implant-production-technology
Article - 05/05/2014 Michael Doser brings together biomedicine and textile research Textile products used for the treatment of wounds are increasingly being coupled with bioactive functions. A growing number of biocompatible and absorbable high-tech materials are used on and in the human body for therapy, diagnosis and measurements. Michael Doser, Director of Medical Engineering/Biomedical Process Engineering at the ITV Denkendorf, is working on innovative wound management products and processes.https://www.gesundheitsindustrie-bw.de/en/article/news/michael-doser-brings-together-biomedicine-and-textile-research
Article - 31/03/2014 Lsd1 – a gatekeeper for differentiation onset of embryonic mouse stem cells Epigenetics is an emerging field of research that studies heritable changes in gene expression that are not caused by changes in the underlying DNA sequence. Prof. Dr. Roland Schüle, Director of Central Clinical Research at the Freiburg University Medical Centre, and his team are specifically focused on epigenetic modifiers that regulate the timely development of placental mouse tissue. Schüle and his team have discovered in mouse embryos that a…https://www.gesundheitsindustrie-bw.de/en/article/news/lsd1-a-gatekeeper-for-differentiation-onset-of-embryonic-mouse-stem-cells
Article - 03/03/2014 TETEC – the cartilage makers What you need is patient cells. The certified laboratories of TETEC AG use autologous cells to produce biological cartilage replacement for degenerated joints and intervertebral discs. The company considers itself the global market leader in the knee cartilage market. This means that the rapidly growing company is excellently placed for introducing new products to the regenerative medicine market.https://www.gesundheitsindustrie-bw.de/en/article/news/tetec-the-cartilage-makers
Article - 24/02/2014 Enhanced feeling of well-being triggers regeneration New biomaterials are all the rage – especially in the Department of Oral Biotechnology, which was established at the Dental School and Hospital at the Freiburg University Medical Centre in 2008. The department’s laboratory manager, Prof. Dr. Thorsten Steinberg, takes an approach that is inspired by clinical application and aimed at developing biomaterials that support the wound healing process. This approach must, of necessity, include basic…https://www.gesundheitsindustrie-bw.de/en/article/news/enhanced-feeling-of-well-being-triggers-regeneration
Article - 28/06/2013 A world champion of regeneration Planarians can be cut into pieces, and each piece can regenerate into a complete organism. The flatworms are able to do this as they have a huge pool of adult totipotent stem cells that can differentiate into any body cell whatsoever, including germ cells. Scientists from the Heidelberg Institute for Theoretical Studies are using new algorithms to analyse the complex planarian genome structures with the aim of obtaining insights into the genetic…https://www.gesundheitsindustrie-bw.de/en/article/news/a-world-champion-of-regeneration
Article - 11/02/2013 REGiNA – the health region for regenerative medicine REGiNA is a users’ centre for regenerative medicine in the area bordered by the cities of Stuttgart and Tübingen and the Neckar-Alb region. It was established with the aim of translating a variety of advanced regenerative methods into broad clinical application. Providing a diverse and broad range of information, REGiNA is focused on making new treatment possibilities and the opportunities created by regenerative medicine known to doctors,…https://www.gesundheitsindustrie-bw.de/en/article/news/regina-the-health-region-for-regenerative-medicine
Article - 31/12/2012 siRNA for the regeneration of tissue and nerves Regenerative medicine is increasingly making use of siRNA to turn off proteins that prevent the application of regenerative therapies. Researchers at the NMI in Reutlingen develop siRNA technologies that have the potential to prevent the development of fibroses, the encapsulation of implants and improve the regeneration of nerves. https://www.gesundheitsindustrie-bw.de/en/article/news/sirna-for-the-regeneration-of-tissue-and-nerves