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  • Press release - 28/02/2025

    Early Excellence in Science Award für Ivana Winkler

    The Bayer Foundation's Early Excellence in Science Award 2024 in the category of Data Science goes to Ivana Winkler of the German Cancer Research Center (DKFZ). Winkler's work uncovered the unexpected effect of female reproductive capacity: the constantly recurring remodeling of the organs of the female reproductive tract during the sexual cycle leads to fibrosis and chronic inflammation over the years.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/early-excellence-science-award-fuer-ivana-winkler
  • Press release - 25/02/2025

    Self-healing hearts How Zebrafish regenerate heart muscle cells

    Zebrafish can completely replace damaged heart muscle cells: The affected organ becomes fully functional again. Researchers at Ulm University have discovered that a specific cell-to-cell communication signal helps them to cope better with replication stress. This stress inhibits tissue regeneration in humans and mammals as they age. In Zebrafish a signalling protein ensures that the cells of the damaged organ continue to divide and thus multiply.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/self-healing-hearts-how-zebrafish-regenerate-heart-muscle-cells
  • Controllable microcatheters - 20/02/2025 Logo_EndoSurge.png

    Robot-assisted control of surgical instruments using magnetic resonance imaging

    Catheter-based examinations and surgical procedures are severely limited by the restricted controllability of conventional instruments and harmful radiation exposure to both patients and medical staff caused by prolonged exposure to radiation during fluoroscopy. EndoSurge, a Stuttgart-based start-up, has developed innovative robotic microcatheters that can be precisely controlled using the magnetic field of an MRI device.

    https://www.gesundheitsindustrie-bw.de/en/article/news/robot-assisted-control-surgical-instruments-using-magnetic-resonance-imaging
  • Press release - 13/02/2025

    Guardian molecule keeps cells on track – new perspectives for the treatment of liver cancer

    A guardian molecule ensures that liver cells do not lose their identity. The discovery is of great importance for cancer medicine because a change of identity of cells has come into focus as a fundamental principle of carcinogenesis for several years. The research team was able to show that the newly discovered guardian is so powerful that it can slow down highly potent cancer drivers and cause malignant liver tumors to regress in mice.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/guardian-molecule-keeps-cells-track-new-perspectives-treatment-liver-cancer
  • Press release - 07/02/2025

    Spliceosome: How cells avoid errors when manufacturing mRNA

    The spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins. Researchers at the Heidelberg University Biochemistry Center (BZH) have succeeded for the first time in depicting a faultily “blocked” spliceosome at high resolution and reconstructing how it is recognized and eliminated in the cell.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/spliceosome-how-cells-avoid-errors-when-manufacturing-mrna
  • Project REVeyeVE - 06/02/2025 Es ist eine einzelne gedrehte, helle Struktur vor schwarzem Hintergrund zu sehen.

    Targeted, virus-free gene therapy for the eye using degradable nanopropellers

    Eye diseases that result in blindness in young people are primarily caused by genetic mutations. An interdisciplinary team of researchers from the Universities of Tübingen and Heidelberg is developing an innovative gene therapy method using biodegradable, magnetic nanopropellers. These innovative nanopropellers can effectively deliver intact genes into the affected cells, offering a potential solution for treating genetic disorders of this kind.

    https://www.gesundheitsindustrie-bw.de/en/article/news/Targeted-virus-free-gene-therapy-for-the-eye-using-degradable-nanopropellers
  • Press release - 23/01/2025

    How the Ebola virus replicates in cells

    Like all viruses, the Ebola virus is dependent on host cells in order to replicate. Researchers at Heidelberg University Hospital, in collaboration with colleagues from the Friedrich Loeffler Institute, have been able to show for the first time using state-of-the-art imaging techniques how the replication compartments of the Ebola virus change during replication in infected cells.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-ebola-virus-replicates-cells
  • Press release - 23/01/2025

    ERC Funding for „EmbryoNet-AI“

    Konstanz biologist Patrick Müller receives a Proof of Concept Grant from the European Research Council for his project "EmbryoNet-AI". Its goal is the further development of an AI-supported platform for the automated evaluation of experiments – for example, in drug development.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/erc-funding-embryonet-ai
  • Press release - 15/01/2025

    Similarities discovered between vascular calcification and bone growth

    University of Tübingen research team observes biochemical process in living cells – indications of new approach to preventing heart attacks and strokes

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/similarities-discovered-between-vascular-calcification-and-bone-growth
  • Press release - 14/01/2025

    Epigenetics ensures placenta functioning

    If the development of blood vessels in the placenta is impaired, fetal growth retardation may result. Scientists from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University discovered that the correct development of functioning blood vessels in the mouse placenta is controlled epigenetically: One of the enzymes that modify gene activity using methyl groups is responsible.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/epigenetics-ensures-placenta-functioning
  • Press release - 03/01/2025

    New approaches against metastatic breast cancer: mini-tumors from circulating cancer cells

    Tumor cells circulating in the blood are the "germ cells" of breast cancer metastases. They are rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult. A team from the DKFZ, the Heidelberg Stem Cell Institute HI-STEM and the NCT Heidelberg has now succeeded for the first time in cultivating stable tumor organoids directly from blood samples of breast cancer patients.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-approaches-against-metastatic-breast-cancer-mini-tumors-circulating-cancer-cells
  • Press release - 19/12/2024

    Antibody that neutralizes inhibitory factors involved in nerve regeneration leads to enhanced motor function after acute spinal cord injury

    Antibodies can improve the rehabilitation of people with acute spinal cord injury. Researchers at 13 clinics in Germany, Switzerland, the Czech Republic and Spain have investigated this with promising results. For the first time, it was possible to identify patient groups that displayed a clinically relevant treatment effect. A follow-up study will start in December 2024.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/antibody-neutralizes-inhibitory-factors-involved-nerve-regeneration-leads-enhanced-motor-function-after-acute-spinal-cord-injury
  • Press release - 13/12/2024

    Schizophrenia: NMI observes processes in nerve cells

    Up to now, schizophrenia has mainly been treated symptomatically, as little is known about the exact underlying processes. Researchers at the NMI Natural and Medical Sciences Institute in Reutlingen have succeeded in gaining a better understanding of the driving mechanisms of the disease. This offers opportunities for the development of new drugs. They have published their findings in the journal BMC Psychiatry.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/schizophrenia-nmi-observes-processes-nerve-cells
  • Dossier: Innovative animal-free research in Baden-Württemberg - 05/12/2024 A watercolour painting depicts a rhesus monkey wearing a surgical mask sitting at a laboratory bench, with two white mice looking up at him. He sticks his thumb up in the air. In the foreground is a petri dish with a bean-shaped organoid. There are microscopes in the background and a poster on the wall with the words ‘No more Animal Testing’.

    Mini-organs and multi-organ chips - where lab mice may soon retire

    Farewell to animal testing? Life sciences researchers in BW are pioneering innovative methods to replace animal experiments, reduce the number of animals used and refine the procedures and conditions under which animals are kept. These are the guiding principles of the 3Rs principle. Developing cutting-edge models and establishing a robust 3R network, not only shapes the future of research but also improves the quality of scientific outcomes.

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/mini-organs-and-multi-organ-chips-where-lab-mice-may-soon-retire
  • Press release - 28/11/2024

    Molecular biology: New interdisciplinary Research Training Group investigates cellular regulation

    Cell division, cell differentiation, cell repair and cell death play fundamental roles in the human organism, its development, health and reproduction. Cellular transformation processes are governed by two regulatory mechanisms: chromatin modifications and cell signaling networks. The EpiSignal Research Training Group sheds light on the hitherto little-researched interplay between these two complex systems.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/molecular-biology-new-interdisciplinary-research-training-group-investigates-cellular-regulation
  • Press release - 26/11/2024

    Collaborative research centres on kidney and brain prolonged

    On 25 November, the German Research Foundation (DFG) announced the continued funding of two existing Collaborative Research Centres (CRC) at the University of Freiburg’s Faculty of Medicine. In CRC 1453 Nephrogenetics (NephGen), doctors and researchers are using genetic information to search for mechanisms underlying kidney diseases.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/collaborative-research-centres-kidney-and-brain-prolonged
  • Press release - 20/11/2024

    New bioengineering approaches for the automated production of complex organoids

    The reproducible and precise production of complex organoid models to simulate human organ malfunctions is the focus of an interdisciplinary research project at Heidelberg University. A research team from the life and engineering sciences is looking to combine the engineering of molecular systems with machine learning and automated production methods.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/neue-ansaetze-des-bio-engineering-fuer-die-automatisierte-herstellung-komplexer-organoide
  • Press release - 14/11/2024

    Novel method for fighting tumors

    Making existing cancer therapy more efficient while significantly reducing the side effects on healthy tissue - this is the aim of a project at Aalen University. It is being funded with one million euros from the Carl Zeiss Foundation. The biophysicist and his team are developing innovative nanoparticles made of gold. The particles use radiotherapy and chemotherapy simultaneously and kill the cancer cells in a targeted manner.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/novel-method-for-fighting-tumors
  • Press release - 16/10/2024

    Sensitive Arm Prostheses

    A quantum sensor that can register nerve impulses without contact opens up new possibilities in prosthetics. Researchers at Fraunhofer IPA are developing together with the industrial partner Q.ANT the prototype of one Prosthetic arm that is controlled by neural commands like healthy limbs.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/sensitive-arm-prostheses
  • Press release - 01/10/2024

    Reporter Skin: In-vitro Skin Makes Cell Reaction to Test Substance Measurable in Real Time

    At the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, a three-dimensional skin model has now been set up for the first time that directly displays the skin's reaction to substances: The reporter skin. Thanks to the built-in reporter, the cellular response can be measured precisely and quickly – using a living model.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/reporter-skin-vitro-skin-makes-cell-reaction-test-substance-measurable-real-time
  • Press release - 25/09/2024

    How do rare genetic variants affect health? AI provides more accurate predictions

    Whether we are predisposed to particular diseases depends to a large extent on the countless variants in our genome. However in the case of genetic variants the influence on the presentation of certain pathological traits has been difficult to determine. Researchers have introduced an algorithm based on deep learning that can predict the effects of rare genetic variants.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-do-rare-genetic-variants-affect-health-ai-provides-more-accurate-predictions
  • Chronic inflammatory bowel diseases - 25/09/2024 Vor schwarzem Hintergrund sind kugelförmige Zellansammlungen zu sehen.

    Proinflammatory regulatory T lymphocytes as a therapeutic target in Crohn's disease

    Chronic inflammatory bowel diseases are very stressful for those affected and increase the risk of bowel cancer. PD Dr. Robyn Laura Kosinsky from the Bosch Health Campus in Stuttgart, together with researchers from the USA, identified disfunctional regulatory T cells as important drivers of inflammation in Crohn's disease. They also found that with the help of an epigenetically active drug, it was possible to restore the cells’ original…

    https://www.gesundheitsindustrie-bw.de/en/article/news/proinflammatory-regulatory-t-lymphocytes-therapeutic-target-crohns-disease
  • Press release - 25/09/2024

    How developmental signals can contribute to Genomic Mosaicism

    Certain developmental signals play a significant role in maintaining our genetic blueprints. They prevent alterations in the genome, known as mosaicism. The underlying biological mechanism helps the DNA to produce an identical copy of itself during cell division using the original genetic blueprint. However, it can also contribute to genomic mosaicism during nerve cell development.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-developmental-signals-can-contribute-genomic-mosaicism
  • Press release - 19/09/2024

    Quality standards for looking into the tumor genome

    Personalized medicine with individually tailored therapies is becoming more a reality in cancer. This requires a look into the genetic material of tumors, a molecular diagnostic tumor profile. A research group from the German Network for Personalized Medicine (DNPM) has recorded the quality standards according to which genome analyses are carried out in Germany. The data is a prerequisite for integrating gene sequencing into routine care.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/quality-standards-looking-tumor-genome
  • Press release - 17/09/2024

    Five new cross-border doctoral networks at Universität Heidelberg

    Five transnational and cross-institutional doctoral networks at Heidelberg University are being funded as part of the “Marie Skłodowska-Curie Actions”. They work together on current scientific topics with high innovation potential. Ruperto Carola coordinates an MSCA Doctoral Network on artificial intelligence in physics, two networks in medicine, life sciences and engineering.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/five-new-cross-border-doctoral-networks-universitat-heidelberg

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