Press release - 03/04/2018 Double success for Heidelberg stem cell researchers Two awards at once, both carrying high monetary prizes, go to young researchers from the Heidelberg Institute for Stem Cell Research and Experimental Medicine (HI-STEM) at the German Cancer Research Center (DKFZ): Simon Raffel will receive the 2018 Walter Schulz Prize. Simon Haas will share the 2018 Otto Schmeil Prize with his colleague Lars Velten from EMBL. https://www.gesundheitsindustrie-bw.de/en/article/press-release/double-success-for-heidelberg-stem-cell-researchers
Article - 07/11/2011 Daniel Gebhard – a new chapter in the mitochondrial theory of aging It has been known for quite some time that skin aging and skin cancer are connected with UV radiation. It is believed that mutations in the mitochondrial DNA are major contributors to aging and cancer, which is why in-depth knowledge about the repair mechanisms of skin cells is essential. Daniel Gebhard, doctoral student at Albstadt-Sigmaringen University, is investigating the repair capacity of mtDNA in different human skin cell types. He is…https://www.gesundheitsindustrie-bw.de/en/article/news/daniel-gebhard-a-new-chapter-in-the-mitochondrial-theory-of-aging
Dossier - 14/06/2016 CRISPR/Cas – genome editing is becoming increasingly popular The number of publications and patents that involve the CRISPR/Cas system has been increasing exponentially since the technique was first described a few years ago. The increase in funding for projects involving CRISPR/Cas also demonstrates how powerful this new method is. The targeted modification of genomes (also called gene editing or genome editing) using CRISPR/Cas is extraordinarily accurate and also has the potential to cure hereditary…https://www.gesundheitsindustrie-bw.de/en/article/dossier/crisprcas-genome-editing-is-becoming-increasingly-popular
Press release - 10/12/2012 Sex hormone induces elongation of stem cell telomeres The telomere ends of chromosomes become shorter with any cell division round. This is why the lifespan of most cells is limited. One of several exceptions to this rule is the haematopoietic stem cells of the bone marrow. The enzyme telomerase enables them compensate telomere attrition. However defective telomerase function can cause bone marrow failure disorders such as aplastic anaemia amongst others. Prof. Dr. Uwe Martens from the SLK Hospital…https://www.gesundheitsindustrie-bw.de/en/article/press-release/sex-hormone-induces-elongation-of-stem-cell-telomeres
Article - 19/12/2011 Lenhard Rudolph prepares four biomarkers for clinical application Lenhard Rudolph’s biomarker quartet is extremely promising in terms of progressing medical and clinical treatment in ageing societies. The quartet - EF-1 alpha, Chi3L3, CRAMP and OP 18 – is made up of four proteins that can potentially be used as biomarkers. Specific concentrations of these molecules in human blood provide information on the biological age and renewal capacity of the tissue and organs of patients. The biomarker quartet also…https://www.gesundheitsindustrie-bw.de/en/article/news/lenhard-rudolph-prepares-four-biomarkers-for-clinical-application
Press release - 17/04/2008 BioLux GmbH - from the hen to the egg and then to the clients It began as a service laboratory for DNA sequencing and within a few years became a worldwide network of highly specialised biotech companies for molecular biology products. Investments in platform technologies play a key role in this development. Since then the team at Stuttgart-based BioLux GmbH has found that the production of antibodies is its highest revenue business activity.https://www.gesundheitsindustrie-bw.de/en/article/press-release/biolux-gmbh-from-the-hen-to-the-egg-and-then-to-the-clients
Press release - 05/08/2009 New test for safer biomedical research results In biomedical research with living cells in the culture dish, contamination with bacteria, viruses or other fast-growing cells is always a problem. Scientists of the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ) have now developed a test system for the fast and cost-effective detection of such contaminations. The new method will contribute to making biomedical research results safer and reproducible. https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-test-for-safer-biomedical-research-results
Article - 20/06/2011 Molecular biologists to celebrate 50th anniversary of Jacob and Monod’s operon model Leading molecular biologists from around the world came together at a conference jointly organized by the European Molecular Biology Organisation (EMBO) and the Institut Pasteur in Paris between 17th and 20th May to celebrate the 50th anniversary of the operon concept published by François Jacob and Jacques Monod in 1961. The scientists discussed concepts and research results influenced by the operon model, which have led to our present…https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-biologists-to-celebrate-50th-anniversary-of-jacob-and-monod-s-operon-model
Article - 16/04/2012 Endosymbiosis and horizontal gene transfer Mitochondria and plastids, which evolved by way of symbiogenesis, have over time come under the control of nuclear genes. It is still not known how the expression of genes encoded in the nucleus and mitochondrion is coordinated to make them functional. Model systems such as highly specialized plastid-incorporating marine slugs can be used to help clarify such issues. https://www.gesundheitsindustrie-bw.de/en/article/news/endosymbiosis-and-horizontal-gene-transfer
Press release - 08/06/2011 TagCyx Biotechnologies TagCyx is a research based company located in Yokohama Kanagawa Prefecture. The core technologies of TagCyx are unnatural base pair technologies and nucleic acids stabilization technology.https://www.gesundheitsindustrie-bw.de/en/article/press-release/tagcyx-biotechnologies
Press release - 01/08/2012 Micro-Copier for genome analysis The scientists Jochen Hoffmann, Dr. Guenther Roth, and Prof. Dr. Roland Zengerle from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg can copy simultaneously 100.000 different DNA sequences in a so called picowell array that has the size of a one cent coin. The new method holds promise to advance the personalised medicine.https://www.gesundheitsindustrie-bw.de/en/article/press-release/micro-copier-for-genome-analysis
Article - 12/06/2010 Reliable evidence of efficacy using skin models and assays In the molecular biology laboratory at the Albstadt-Sigmaringen University of Applied Sciences a team led by Prof. Dr. Jörg Bergemann is developing and optimising assays that enable the quantitative determination of DNA damage and the investigation of repair mechanisms. The researchers exclusively use in vitro test systems. Using tissue engineering methods the researchers are developing a skin model for pharmacological efficacy and…https://www.gesundheitsindustrie-bw.de/en/article/news/reliable-evidence-of-efficacy-using-skin-models-and-assays
Article - 08/09/2016 A diamond might make sequencing more accurate DNA sequencing techniques have been developed along the lines of faster, further, cheaper. State-of-the-art methods make it possible to handle large projects in a relatively short period of time. However, the error rate is still very high. Dr. Maria Fyta and her team at the Institute for Computational Physics at the University of Stuttgart have carried out quantum-transport calculations which suggested that specific chemical modifications in the…https://www.gesundheitsindustrie-bw.de/en/article/news/a-diamond-might-make-sequencing-more-accurate
Press release - 21/02/2012 Ring-like protein complex helps ensure accurate protein production In fairy tales, magic rings endow their owners with special abilities: the ring makes the wearer invisible, fulfils his wishes, or otherwise helps the hero on the path to his destiny. Similarly, a ring-like structure found in a protein complex called ‘Elongator’ has led researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg,…https://www.gesundheitsindustrie-bw.de/en/article/press-release/ring-like-protein-complex-helps-ensure-accurate-protein-production
Article - 06/12/2010 Bioplastics – materials that have the potential to be used in medical technology At the recent International Symposium on Biopolymers ISBP in Stuttgart scientists discussed the use of biobased plastics for applications in the field of medical technology. The majority of strategies presented at the symposium will only be ready for market in a few years time. However they give an idea as to why bioplastics are likely to be applied to a greater extent in the field of medical technology.https://www.gesundheitsindustrie-bw.de/en/article/news/bioplastics-materials-that-have-the-potential-to-be-used-in-medical-technology
Dossier - 22/08/2011 Stress and molecular defence mechanisms Organisms can experience stress from exposure to bacteria and pathogenic fungi; in fact, stress can arise from exposure to any type of environmental influence. As they have evolved, biological cells have developed numerous molecular mechanisms that enable them to survive even in inhospitable conditions. What kind of effects do abiotic stress factors have on plants and human beings? How do cells protect themselves? Are researchers able to increase…https://www.gesundheitsindustrie-bw.de/en/article/dossier/stress-and-molecular-defence-mechanisms
Press release - 27/11/2009 Gene Mutations Underlying Risk for Parkinson's Disease Two genes containing mutations known to cause rare familial forms of parkinsonism are also associated with the more common, sporadic form of the disease where there is no family history, researchers have found. The finding came in the largest genome-wide association study (GWAS) reported to date involving Parkinson's disease.https://www.gesundheitsindustrie-bw.de/en/article/press-release/gene-mutations-underlying-risk-for-parkinson-s-disease
Press release - 16/11/2009 No-Entry Zones for AIDS Virus The AIDS virus (HIV) inserts its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that the virus almost entirely spares particular sites in the human genetic material in this process. This finding may be useful for developing new, specific AIDS drugs. https://www.gesundheitsindustrie-bw.de/en/article/press-release/no-entry-zones-for-aids-virus
Press release - 29/04/2009 febit Receives European Patent for Gene Extraction Procedure febit holding gmbh announced today, that the company has been granted the first European patent (EP1436609) for a microarray-based nucleic acid extraction procedure. In conjunction with the US patent US7320862, febit now holds a unique patent position in the dynamic market of sample preparation for second-generation sequencers. https://www.gesundheitsindustrie-bw.de/en/article/press-release/febit-receives-european-patent-for-gene-extraction-procedure
Article - 22/02/2013 Malte Drescher provides insights into cells Electron spin resonance (ESR) spectroscopy can deliver information about the structure and dynamics of large molecules and was used by Dr. Malte Drescher from the University of Konstanz to develop a method for the structural analysis of biological macromolecules inside cells. It provides insights into the complex structure of molecules under physiological conditions and is a promising approach for the development of cancer drugs.https://www.gesundheitsindustrie-bw.de/en/article/news/malte-drescher-provides-insights-into-cells
Press release - 04/03/2010 New German-Austrian project for breast cancer therapy Hope for breast cancer patients under the leadership of the Vorarlberg Institute for Vascular Investigation and Treatment VIVIT a cross border cooperation is to start between hospitals and bioanalytical laboratories of the Rhine Valley and Lake Constance region. It is aimed at exploring the influence genetic material DNA has on the progression of breast cancer and the response to breast cancer treatment. A collaboration which became possible…https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-german-austrian-project-for-breast-cancer-therapy
Article - 10/01/2011 Review: What does the cell factory of the future look like? A symposium on “Cell Factories of the Future” was held at the Laupheim-based company Rentschler Biotechnologie on 14th and 15th October 2010. The event attracted around 70 scientists from academia and industry and will now take place every two years. The symposium focused on new biomanufacturing developments and technologies, and included lectures on (animal) cells, cell factories and the future of recombinant protein production. https://www.gesundheitsindustrie-bw.de/en/article/news/review-what-does-the-cell-factory-of-the-future-look-like
Article - 11/02/2013 Johannes Krause examines historical pathogens: old pathogens in a new light Palaeogeneticist Johannes Krause is drawn to ancient DNA. His work on the evolution of human pathogens shows that his findings are not purely of historical interest, but also enable conclusions to be made on future disease outbreaks and epidemics. In autumn 2012, Krause was awarded an ERC Starting Grant. Krause uses the grant to expand his research into plague and other historical pathogens that continue to be a threat to human health. https://www.gesundheitsindustrie-bw.de/en/article/news/johannes-krause-examines-historical-pathogens-old-pathogens-in-a-new-light
Article - 21/08/2009 Patenting and clinical trials go hand in hand Back when he was doing his degree thesis at the German Cancer Research Centre in Heidelberg the immunologist Prof. Peter Öhlschläger who now works at the University of Constance laid down the basic principles for developing an artificial gene for the treatment of cervical cancer. Prof. Öhlschläger is currently in the process of filing a patent for DNA vaccines for HPV. In the following interview the scientist says that the greatest challenges are…https://www.gesundheitsindustrie-bw.de/en/article/news/patenting-and-clinical-trials-go-hand-in-hand