Gene regulation as a starting point for cancer therapies - 02/12/2021 New investigation method for deciphering complex epigenetic networks The development and maintenance of uncontrolled cell division in tumours is often due to the unbalanced, complex interplay of regulatory epigenetic networks. Researchers at the Institute of Biochemistry and Technical Biochemistry in Stuttgart have developed a new screening system to identify essential components that can serve as targets for anticancer drugs.https://www.gesundheitsindustrie-bw.de/en/article/news/new-investigation-method-deciphering-complex-epigenetic-networks
Gene regulation - 20/07/2021 The many faces of the epigenetic regulator MOF Epigenetic modifications play a crucial role in coordinated gene transcription, and are required for a fertilised egg cell to be able to develop into an organism with different cell types. Dr. Asifa Akhtar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been studying the essential epigenetic regulator protein MOF for 20 years.https://www.gesundheitsindustrie-bw.de/en/article/news/die-vielen-gesichter-des-epigenetischen-regulators-mof
Article - 17/03/2021 Epigenetic switches in bacteria as biosensors The analysis of pathogen biomarkers and biomarkers for the diagnosis of diseases can be crucial for health. However, the detection of pathogens and diseases depends on a sensitive and reliable method that delivers rapid results. Biosensors have such properties. Researchers at the Institute of Biochemistry and Technical Biochemistry (IBTB) at Stuttgart University have constructed an epigenetic circuit composed of plasmids that might make it…https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetic-switches-bacteria-biosensors
Press release - 02/11/2020 Juvenile myelomonocytic leukemia: International classification model allows for customized treatment Juvenile myelomonocytic leukemia (JMML) is a rare blood cancer of early childhood. Previous research activities have shown that JMML patients can be divided into three groups based on certain genetic markers, DNA methylation. Depending on the subgroup, statements can be made about the course of the disease. https://www.gesundheitsindustrie-bw.de/en/article/press-release/juvenile-myelomonocytic-leukemia-international-classification-model-allows-customized-treatment
Press release - 15/10/2020 Pancreatic cancer: Subtypes with different aggressiveness discovered Tumors of the pancreas are particularly feared. They are usually discovered late and mortality is high. Until now, no targeted and personalized therapies exist. Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* (HI-STEM) have now succeeded for the first time in defining two differently aggressive molecular subtypes of pancreatic carcinoma.https://www.gesundheitsindustrie-bw.de/en/article/press-release/pancreatic-cancer-subtypes-different-aggressiveness-discovered
Press release - 03/04/2018 Double success for Heidelberg stem cell researchers Two awards at once, both carrying high monetary prizes, go to young researchers from the Heidelberg Institute for Stem Cell Research and Experimental Medicine (HI-STEM) at the German Cancer Research Center (DKFZ): Simon Raffel will receive the 2018 Walter Schulz Prize. Simon Haas will share the 2018 Otto Schmeil Prize with his colleague Lars Velten from EMBL. https://www.gesundheitsindustrie-bw.de/en/article/press-release/double-success-for-heidelberg-stem-cell-researchers
Article - 28/03/2018 New method for analysing epigenetic modifications - in the service of medical progress It is not just genetic factors that influence developmental processes and diseases; it is becoming increasingly evident that epigenetic changes play a major role too. Thanks to a new method developed at the University of Stuttgart, epigenetic processes can now be investigated in living cells.https://www.gesundheitsindustrie-bw.de/en/article/news/new-method-for-analysing-epigenetic-modifications-in-the-service-of-medical-progress
Article - 11/12/2017 KDM4 – an efficient target for the therapy of triple-negative breast cancer While breast cancer survival has clearly improved in recent years, women with triple-negative breast cancer have benefitted very little from progress in cancer medicine. Targeted therapies aimed at inhibiting epigenetic regulators might offer a potential new option for the treatment of breast cancer. Prof. Dr. Roland Schüle and Dr. Jochen Maurer have discovered an epigenetic enzyme called KDM4 and come up with a new cell model that significantly…https://www.gesundheitsindustrie-bw.de/en/article/news/kdm4-an-efficient-target-for-the-therapy-of-triple-negative-breast-cancer
Transregional research cooperation - 11/10/2017 New research consortium to develop new liver cancer treatments The causes, signs and symptoms of liver cancer are extremely complex. Investigating them requires the collaboration of many experts across university and regional boundaries. A new transregional research group is now studying the complex overall mechanisms at the cellular, genetic and molecular level in order to develop new concepts and drugs for treating liver and bile duct cancers.https://www.gesundheitsindustrie-bw.de/en/article/news/new-research-consortium-to-develop-new-liver-cancer-treatments
Article - 04/07/2016 Epigenetic modifications for the treatment of oesophageal cancer Oesophageal cancer is a rare but highly aggressive type of cancer with a rather poor prognosis. Dr. Theresa Ahrens, a researcher in a group led by Prof. Dr. Silke Laßmann and Prof. Dr. Martin Werner at the Institute of Clinical Pathology at the Freiburg University Medical Centre, has tested a variety of epigenetic drugs that can interfere with the development of oesophageal cancer. https://www.gesundheitsindustrie-bw.de/en/article/news/modifikation-epigenetic-modifications-for-the-treatment-of-oesophageal-cancer-als-therapie-bei-speiseroehrenkrebs
Article - 17/12/2015 Inhibition of bromodomain affects stem cell differentiation DNA methylation and histone modification are epigenetic mechanisms that affect gene transcription. Moreover, protein complexes can regulate gene expression by modifying chromatin structure and function. Dr. Thomas Günther and his team from the Center for Clinical Research at the Freiburg University Medical Center are studying the effect of the inhibitor PFI-3 on the BAF complex. This protein complex modifies chromatin structure and controls the…https://www.gesundheitsindustrie-bw.de/en/article/news/nhibition-of-bromodomain-affects-stem-cell-differentiation
Epigenetics - 10/08/2015 Reading domains detect and identify histone modifications Prof. Dr. Albert Jeltsch from the Institute of Biochemistry at the University of Stuttgart and his team of researchers have now presented an alternative method to detect and identify changes in the post-translational modifications of histones. They envisage that their new method, which uses parts of natural proteins, so-called reading domains, will make such tests cheaper and simpler, and experimental data more reliable. https://www.gesundheitsindustrie-bw.de/en/article/news/reading-domains-detect-and-identify-histone-modifications
Article - 15/12/2014 Heart muscle cell 1.0 and 2.0 – two epigenetic programmes in one cell All the cells in an organism have to adapt to changing requirements as they develop and grow - including muscle cells in the heart. Crucial to this process are the cells’ growth in size and epigenetic factors that play a role in modulating the expression of various genes. The role of epigenetics in cancer development has been the focus of research for quite some time. The question is, what role do epigenetic factors play in the development of the…https://www.gesundheitsindustrie-bw.de/en/article/news/heart-muscle-cell-1-0-and-2-0-two-epigenetic-programmes-in-one-cell
Article - 30/06/2014 Targeting epigenetic DNA modifications for the diagnosis of cancer Epigenetic DNA modifications have been shown to play a role in carcinogenesis and are therefore a promising target for the early detection of cancer. Dr. Daniel Summerer and his research group at the University of Konstanz have developed a method that enables the direct and site-specific identification of epigenetic changes. The method represents a new approach in the field of epigenetic analysis as well as a major step towards simpler cancer…https://www.gesundheitsindustrie-bw.de/en/article/news/targeting-epigenetic-dna-modifications-for-the-diagnosis-of-cancer
Article - 25/03/2013 Epigenetics for personalised cancer care for women Every year in the EU, 45,300 women are diagnosed with ovarian cancer and 330,000 with breast cancer. Ovarian cancer has a mortality rate of around 64% and breast cancer around 27%*. The EU-funded research project EpiFemCare aims at improving cancer detection and subsequent patient care. The research project aims to develop blood tests based on epigenetic DNA modifications, i.e. the methylation of the base cytosine, for the identification of…https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-for-personalised-cancer-care-for-women
Article - 12/12/2011 Comprehensive Biomarker Center GmbH – next-generation biomarkers Biomarker research has moved on from proteins to nucleic acids where one of the main priorities is the use of microRNA expression profiles. The Heidelberg-based biotech company Comprehensive Biomarker Center GmbH (CBC, formerly febit) has state-of-the-art technologies and the skills and knowledge to advance the development of new nucleic acid biomarkers for complex diseases in cooperation with partners from research and industry. https://www.gesundheitsindustrie-bw.de/en/article/news/comprehensive-biomarker-center-gmbh-next-generation-biomarkers
Article - 20/06/2011 Molecular biologists to celebrate 50th anniversary of Jacob and Monod’s operon model Leading molecular biologists from around the world came together at a conference jointly organized by the European Molecular Biology Organisation (EMBO) and the Institut Pasteur in Paris between 17th and 20th May to celebrate the 50th anniversary of the operon concept published by François Jacob and Jacques Monod in 1961. The scientists discussed concepts and research results influenced by the operon model, which have led to our present…https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-biologists-to-celebrate-50th-anniversary-of-jacob-and-monod-s-operon-model
Article - 28/11/2010 Genedata facilitates search for biomarkers Biomarkers play a key role in testing the efficacy of a new drug or finding out adverse reactions to it. For reliable and quick results, modern laboratory methods are used to generate huge amounts of highly complex molecular data. The data then need to be efficiently analysed. The company Genedata, with headquarters in Basel (Switzerland) and offices throughout Europe, including a base in Konstanz (Germany), has developed the software system…https://www.gesundheitsindustrie-bw.de/en/article/news/genedata-facilitates-search-for-biomarkers
Article - 31/07/2010 Christian Riedel – an outstanding bifidobacteria researcher The 37-year-old microbiologist Christian Riedel was recently awarded the Science Prize of the city of Ulm for his basic research on bifidobacteria. Riedel who is the head of a group of 12 junior researchers at the University of Ulm has shown that bifidobacteria exert an inhibitory effect on chronic bowel inflammation. The researcher hopes to have identified the underlying molecular mechanisms within the next 12 months.https://www.gesundheitsindustrie-bw.de/en/article/news/christian-riedel-an-outstanding-bifidobacteria-researcher
Press release - 07/08/2009 Silenced genes as a warning sign of blood cancer Important growth inhibitors are often switched off in the genetic material of cancer cells by specific chemical DNA modifications. Scientists of the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ), in collaboration with colleagues from Ohio State University in the United States, have investigated how this happens. They discovered, in mice, that cancer-typical DNA methylation occurs long before the first symptoms of…https://www.gesundheitsindustrie-bw.de/en/article/press-release/silenced-genes-as-a-warning-sign-of-blood-cancer
Article - 16/11/2008 Looking for a formula to determine biological age The Europe-wide MARK-AGE project involving scientists from 14 countries commenced on the 1st April 2008. Scientists have joined forces to investigate the factors involved in ageing. They are using standardised questionnaires and analysing data acquired from physical and biochemical examinations of the blood and urine from 3700 volunteers. The team of experts includes the medical expert Professor Alexander Bürkle and the mathematician Prof.…https://www.gesundheitsindustrie-bw.de/en/article/news/looking-for-a-formula-to-determine-biological-age
Article - 20/04/2008 varionostic develops test systems for tumour markers The Ulm-based company varionostic GmbH has received a research grant from the German Ministry of Economics and Technology. Details on the level of the grant were not disclosed. The company will research tumour markers and develop detection systems for DNA methylations.https://www.gesundheitsindustrie-bw.de/en/article/news/varionostic-develops-test-systems-for-tumour-markers