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  • Press release - 23/06/2023

    The molecular control centre of our protein factories

    Researchers from Konstanz and Zurich have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in protein sorting.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/molecular-control-centre-our-protein-factories
  • Press release - 28/01/2022

    Artificial Muscles Made of Proteins

    Dr. Stefan Schiller and Dr. Matthias Huber from the University of Freiburg’s livMatS Cluster of Excellence have succeeded in developing a muscle solely on the basis of natural proteins. The autonomous contractions of the material, which the researchers presented in the journal Advanced Intelligent Systems, can be controlled with the help of pH and temperature changes.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/artificial-muscles-made-proteins
  • Press release - 17/11/2022

    New target for Alzheimer's therapies found

    DZNE researchers discover link between the protein medin and Alzheimer's disease. The protein medin is deposited in the blood vessels of the brains of Alzheimer's patients along with the protein amyloid-β. DZNE Researchers have discovered this so-called co-aggregation. They have now published their observation in the renowned journal Nature.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-target-alzheimers-therapies-found
  • Press release - 05/09/2024

    Cohesion at the cellular level: flexible yet stable

    Research teams from the Universities of Konstanz and Potsdam are analyzing how proteins work together to enable our cells to both stick and move. The marker protein paxillin is at the centre of their interest.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cohesion-cellular-level-flexible-yet-stable
  • Press release - 31/05/2024

    Toolkit makes protein design faster and more accessible

    The Damietta Server broadens the accessibility to protein design research and its applications in various biotechnological and biomedical fields. Researchers at the Max Planck Institute for Biology Tübingen, the University of Tübingen, and the University Hospital Tübingen have developed a web-based toolkit to accelerate and simplify protein design without needing powerful computers or extensive protein design expertise on the user’s end.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/toolkit-makes-protein-design-faster-and-more-accessible
  • Press release - 25/02/2025

    Protein with contradictory properties: secret revealed

    A protein with contradictory properties: Despite its large negative surface charge, it has a strong tendency to take up electrons, which are also negatively charged. The researchers discovered positively charged calcium ions inside the protein very near the electrons, counteracting their charge. They see this as a natural way of handling opposing electrical charges and allowing the protein to optimally fulfill its biological function.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/protein-contradictory-properties-secret-revealed
  • Press release - 06/05/2024

    Research under high pressure

    Why 3,000 bars are needed to take a comprehensive look at a protein: Konstanz researchers Frederic Berner and Michael Kovermann present a new high-pressure spectroscopy method to unravel the properties of proteins' native structures.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/research-under-high-pressure
  • Press release - 09/05/2023

    New strategy for clinically relevant protein sequencing

    Proteins have characteristic amino acid sequences, the analysis of which is fundamental for research and medicine. These can be decoded; however, so-called protein sequencing is expensive and time-consuming. A large-scale research project led by Prof. Dr. Jan Behrends from the Institute of Physiology at the University of Freiburg now aims to establish a new technology for protein sequencing using nanopores, which will be rapid and cost-effective.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-strategy-clinically-relevant-protein-sequencing
  • Press release - 02/08/2023

    Freiburg research team casts light on signal-dependent formation of mitochondria

    Known as the power plant of the cell, mitochondria are essential to human metabolism. Human mitochondria consist of 1,300 different proteins and two fatty biomembranes. The vast majority of mitochondrial proteins are produced with a cleavable transport signal and have to be actively transported into the mitochondria.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/freiburger-forschungsteam-klaert-signalabhaengige-bildung-von-mitochondrien-auf
  • Press release - 24/04/2023

    Hidden RNA repair mechanism discovered in humans

    Konstanz researchers discover the function of a previously unexplored protein: In three characteristic steps, "C12orf29" links the ends of RNA strands. Proteins that perform this kind of RNA ligation were previously unknown in humans. The results of the study suggest that it is important for RNA repair during cellular stress.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/hidden-rna-repair-mechanism-discovered-humans
  • Trenzyme GmbH - 20/05/2020 Coronavirus im Elektronenmikroskop

    The SARS-CoV spike protein and its receptor

    The SARS-CoV-2 coronavirus uses a spike protein to bind to the ACE2 receptor on the cell surfaces of lung tissue. Additional cofactors are needed to allow the virus genome to penetrate human cells and multiply. Knowing these relationships can help understand the course of the infection and develop counterstrategies. To this end, the Constance-based company Trenzyme has produced a recombinant spike protein to support coronavirus research.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-sars-cov-spike-protein-and-its-receptor
  • Press release - 09/07/2024

    Unique characteristics of previously unexplored protein discovered

    Freiburg-Prague research collaboration achieves scientific breakthrough in understanding cell division. The international research collaboration has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/unique-characteristics-previously-unexplored-protein-discovered
  • Microorganisms produce nutrients in bioreactors - 12/03/2025 A bioreactor in a laboratory with a glass vessel containing a liquid with harvested yeast.

    CO2 and H2 as starting materials for proteins and vitamins

    Agricultural land needed to sustain the world's growing population is becoming increasingly scarce. To help address this challenge, researchers from the Environmental Biotechnology Group at the University of Tübingen have developed an innovative and sustainable power-to-vitamin technology. This breakthrough enables protein- and vitamin-rich foods to be produced with the help of microorganisms in a bioreactor using carbon dioxide and…

    https://www.gesundheitsindustrie-bw.de/en/article/news/co2-and-h2-starting-materials-proteins-and-vitamins
  • Press release - 18/01/2021

    How a protein variant could explain resistance to sleeping sickness drug

    A specific variant of the surface protein VSG of African trypanosomes, the causative agents of sleeping sickness, is associated with resistance to the important drug Suramin. Scientists at the German Cancer Research Center have now been able to find a possible explanation for the formation of resistance based on the crystal structure of this protein variant.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-protein-variant-could-explain-resistance-sleeping-sickness-drug
  • Press release - 09/09/2022

    Breaking down proteins: How starving cancer cells switch food sources

    Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food". Building on genetic screens, an international team of scientists could identify the protein LYSET as part of a pathway that allows cancer cells to make this switch. Their findings are now published in the journal Science.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/neu-identifiziertes-protein-ermoeglicht-krebszellen-auf-alternative-nahrungsquellen-auszuweichen
  • Press release - 10/01/2022

    Algorithm identifies cancer drivers

    Genetic alterations that promote the development and spread of tumors are difficult to identify. This is especially true for mutations in the non-protein-coding regions of the genome, which include all important regulatory sequences. Scientists at the German Cancer Research Center have now published an algorithm that detects cancer drivers in both the protein-coding and non-coding regions of the genome.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/algorithm-identifies-cancer-drivers
  • Elastin as artificial muscle material - 02/03/2022 A small rectangular piece of protein consisting of a beige and a brown layer in a metal container that bends to one side in one picture and to the other side in a second picture.

    Artificial muscle from proteins for diverse future applications

    As far as diversity and complexity are concerned, proteins are nature's smallest marvels. Biotechnologists have already used natural proteins as a basis for the development, bespoke design and production of artificial systems. This is what the livMatS cluster of excellence at the University of Freiburg has been doing. Researchers in the cluster have successfully produced an artificial muscle from elastin that functions autonomously.

    https://www.gesundheitsindustrie-bw.de/en/article/news/artificial-muscle-proteins-diverse-future-applications
  • Press release - 20/06/2022

    Protein changes in the liquor indicate inflammatory processes in the brain

    Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain. German researchers have succeeded in identifying a group of proteins in the liquor that could provide information about such inflammatory processes. As so-called biomarkers, the proteins could help to better understand disease processes in the future and to test the effect of potential drugs against brain inflammation.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/protein-changes-liquor-indicate-inflammatory-processes-brain
  • Press release - 15/11/2024

    Selenium proteins as a possible new target for cancer research

    An important enzyme helps the body produce selenium proteins – this discovery could open up new strategies for treating cancer in children. This has been published by scientists from the University of Würzburg, the University Sao Paolo, the German Cancer Research Center (DKFZ) and the Heidelberg Stem Cell Institute HI-STEM*.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/selenium-proteins-possible-new-target-cancer-research
  • Press release - 28/03/2025

    Quality Assurance in the Cell: Preventing Defective Protein Blueprints

    Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA – a prerequisite for protein synthesis in the cell. The poorly characterized factors are crucial to ensuring that the molecular machine responsible for splicing is working correctly. A research team has deciphered how the two cellular quality inspectors work.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/quality-assurance-cell-preventing-defective-protein-blueprints
  • Press release - 28/01/2022

    New insights into predicting the efficacy of active ingredients in drug development

    Drugs consist of molecules developed in the drug laboratory that bind to their target, usually a protein, and thus exert their effect. The actual duration of binding of a drug molecule to its target protein varies depending on the drug. The lifetime of the drug-target complex can play a critical role in the efficacy of a drug, as a long residence time at the target can be crucial for the drug's action in some cases.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-insights-predicting-efficacy-active-ingredients-drug-development
  • Press release - 28/08/2023

    Innovative computational approach helps design proteins for cancer treatment

    The computational design of new proteins for biomedical or other applications involves long computing times on powerful servers. A joint team of researchers from the Max Planck Institute for Biology Tübingen and the University Hospital Tübingen has now developed and tested a new computational method to greatly speed up the necessary energy calculations. Their framework allows for a precise and efficient design of functional proteins.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/innovative-computational-approach-helps-design-proteins-cancer-treatment
  • Press release - 21/08/2024

    A molecular control hub maintains order

    How are proteins in our cells modified while they are still being synthesized? An international team of researchers from the University of Konstanz, Caltech, and ETH Zurich has deciphered the molecular mechanism of this vital process.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/molecular-control-hub-maintains-order
  • Press release - 24/03/2021

    Vaccination against mutated protein tested in brain tumor patients for the first time

    Tumor vaccines can help the body fight cancer. Mutations in the tumor genome often lead to protein changes that are typical of cancer. A vaccine can alert the patients' immune system to these mutated proteins. For the first time, physicians and cancer researchers from Heidelberg and Mannheim have now carried out a clinical trial to test a mutation-specific vaccine against malignant brain tumors.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/vaccination-against-mutated-protein-tested-brain-tumor-patients-first-time
  • Press release - 06/03/2025

    NMI TT in Reutlingen and Düsseldorf University Women's Hospital develop high-precision method for analyzing individual circulating tumor cells

    Researchers have developed a new method that enables a more precise analysis of individual tumor cells circulating in the blood. This allows not only the previously possible genomic investigation of such tumor cells, but also the focused analysis of single-cell signaling pathways at the functional protein level. The combined analysis of the mutated genome and signaling proteins opens up new avenues for more targeted treatment methods.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/nmi-tt-reutlingen-and-duesseldorf-university-womens-hospital-develop-high-precision-method-analyzing-individual-circulating-tumo

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