3R-Center - 18/08/2021

Putting alternatives to animal testing into practice

Animal experiments are still central to biomedical research. However, it has become increasingly clear that not all of them are absolutely necessary. Alternative techniques exist. The new 3R-Netzwerk Baden-Württemberg is now seeking to promote these more vigorously - and improve animal welfare in cases where alternatives to animal testing are not available.

So far, 4.2 million animal tests under the REACH chemical regulation: A study from Konstanz and Baltimore quantifies the number of animals that died for the hazard assessment of chemicals in the chemical industry.

Why 3,000 bars are needed to take a comprehensive look at a protein: Konstanz researchers Frederic Berner and Michael Kovermann present a new high-pressure spectroscopy method to unravel the properties of proteins' native structures.

In the current selection round, the German Research Foundation (DFG) has granted funding for two new Collaborative Research Centres at the University of Konstanz. Over the next four years, the research teams will be working intensively on trigger signals in biological cells as well as on "silence" and "noise" in human speech.

Technology impulse for the Lake Constance region: The new Single Cell Centre at the University of Konstanz offers technology and expertise to study cells individually and at high resolution – for applications in medical diagnostics, medication development and basic research at universities.

Konstanz molecular biologist Elke Deuerling has been admitted to the German National Academy of Sciences, the "Leopoldina". By selecting Elke Deuerling as a member, the Academy recognizes her outstanding contributions to the field of life sciences, particularly to proteostasis research.

Chemical building blocks from plastic waste; Reducing the risk of falls using virtual orientation aids: Konstanz chemists Manuel Häußler and Lukas Odenwald as well as sport scientist Lorenz Assländer receive Baden-Württemberg prototype funding for their transfer projects "Waste2DCA" and "Augmented Balance".

Ageing is a highly individual process. An international consortium coordinated by researchers in Konstanz has developed a method that uses biomarkers to determine a person's biological age – a valuable tool for research on ageing and the development of new approaches in preventive medicine.

Toxicologists from the University of Konstanz have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes.

Research teams from the Universities of Konstanz and Potsdam are analyzing how proteins work together to enable our cells to both stick and move. The marker protein paxillin is at the centre of their interest.

Which cellular processes ensure that immune responses are controlled precisely? A new study by the Institute of Cell Biology and Immunology Thurgau (BITG) and the University of Konstanz decodes a decisive signalling pathway.

Do infectious disease outbreaks breed political mistrust? Ore Koren, Indiana University Bloomington (USA), and Nils Weidmann, University of Konstanz (Germany), have found out that they do. Their study was recently published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS).

Researchers at the University of Konstanz publish image analysis software that automatically detects and classifies defects of animal development. Thanks to artificial intelligence, "EmbryoNet" outperforms human experts in terms of speed, accuracy and sensitivity.

How are proteins in our cells modified while they are still being synthesized? An international team of researchers from the University of Konstanz, Caltech, and ETH Zurich has deciphered the molecular mechanism of this vital process.

In a virtual reality study involving zebrafish, researchers from the University of Konstanz and King’s College London have discovered that the development of the eye is influenced by what the fish see during the early stages of life – and this, in turn, alters their behaviour.

A new technique based on labelled sugar molecules is providing previously unknown insights into the inner ear. A study by the University of Konstanz and Charité-Universitätsmedizin Berlin shows that the cupula in the inner ear of zebrafish completely regenerates within approximately two months. These findings open up a new avenue for research into sudden hearing loss and acute disorders of the sense of balance.

Inhibition of a protein complex in cells of the immune system prevents rejection of transplanted organs – this has been shown in a study by immunologists from the University of Konstanz, the Biotechnology Institute Thurgau (BITg) and Chongqing Cancer University Hospital.

Researchers from the universities in Konstanz and Vienna discover a new class of antibiotic that selectively targets Neisseria gonorrhoeae, the bacterium that causes gonorrhoea. These substances trigger a self-destruction program, which also operates in multi-resistant variants of the pathogen. The novel findings are published in the current issue of Nature Microbiology.

How does sugar affect relaxation exercises? A new study carried out by researchers from the University of Konstanz provides revealing insights into the connection between blood glucose and the autonomic nervous system: The intake of sugar counteracts relaxation.

Using artificial intelligence to revolutionize drug development is the aim of the start-up "EmbryoNet AI Technologies" led by Konstanz biologist Patrick Müller. Müller and his team have now been awarded the start-up prize by the Federal Ministry for Economic Affairs and Climate Action (BMWK) for their business concept.

Scientists have been working on the artificial production of blood for several decades. Making a new discovery, researchers from the Institute for Cellular Biology and Immunology Thurgau at the University of Konstanz, in collaboration with Queen Mary University of London, have come an important step closer to this goal.

Genome duplication probably gave biodiversity a decisive evolutionary boost. A Chinese-German research team led by Axel Meyer from the University of Konstanz has now investigated the early phases of the process known as re-diploidization. The results show that the fusion of chromosome sets is asynchronous.

Dossier - 09/02/2015

Chemical tools for biological applications

The boundaries between traditional scientific disciplines are becoming less and less distinct. Interdisciplinary cooperation is often required to study complex processes and biomolecular issues. Interdisciplinary cooperation is central to chemical biology.

Konstanz researchers discover the function of a previously unexplored protein: In three characteristic steps, "C12orf29" links the ends of RNA strands. Proteins that perform this kind of RNA ligation were previously unknown in humans. The results of the study suggest that it is important for RNA repair during cellular stress.

Augmented reality for visual orientation - 15/11/2023

Fall prevention with the help of balance-enhancing AR glasses

As we age, our eyesight deteriorates and we have increasing difficulties with orientation. This can lead to balance problems and fatal falls. A team led by Dr. Lorenz Assländer from the University of Konstanz is currently developing a prototype of augmented reality (AR) glasses that use superimposed patterns to facilitate visual orientation in space, thereby helping to improve balance control and prevent falls.