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  • Article - 01/03/2016 Tubiom_ab.jpg

    Tübiom – the gut flora’s role in human health and disease

    It’s the mix that makes it work: a large number of different bacteria live in our intestine and ensure proper digestive functioning. CeMeT GmbH has launched the Tübiom project to explore bacterial gut flora and how it alters with lifestyle, diet and disease. The long-term objective is to derive recommendations for intestinal health.

    https://www.gesundheitsindustrie-bw.de/en/article/news/tuebiom-the-gut-floras-role-in-human-health-and-disease
  • Article - 15/02/2016 Rolf Backofen sitting in front of his PC.

    Bacteria – a treasure box for genetic engineers

    Bacteria have developed a versatile defence system to protect themselves against viral infections. One of these defence tools, known as CRISPR/Cas9 system, is currently hogging the headlines as it promises to revolutionise the way genetic material can be modified. Prof. Rolf Backofen from the Institute of Bioinformatics at the University of Freiburg has managed to classify the defence system of all bacterial species sequenced to date. This will…

    https://www.gesundheitsindustrie-bw.de/en/article/news/bacteria-a-treasure-box-for-genetic-engineers
  • Article - 30/11/2015 The figure shows a model of the active centre of MccA.

    Bacterial MccA is better than other enzymes when it comes to reducing sulphites

    Dr. Bianca Hermann from the University of Freiburg specialises in multi-haem enzymes, and investigates the enzymes’ structure and reaction mechanisms. She has clarified the enzymes’ crystal structure and reaction mechanisms and found out why the bacterial MccA enzyme complex can reduce sulphur-containing substances such as sulphites up to a hundred times faster than other enzymes.

    https://www.gesundheitsindustrie-bw.de/en/article/news/bacterial-mcca-is-better-than-other-enzymes-when-it-comes-to-reducing-sulphites
  • Article - 11/11/2015 Three-dimensional representation of the active centre of the Geobacter enzyme.

    A metal enzyme that can cleave benzene rings

    Aromatic rings are extremely stable and very difficult to break apart. Prof. Dr. Matthias Boll from the University of Freiburg’s Faculty of Biology and his team work with Geobacter metallireducens, a bacterium that can completely degrade aromatic compounds under strictly anaerobic conditions. While the biological degradation of aromatic hydrocarbons is of global relevance, the chemical resulting from the reduction of benzene rings could also be…

    https://www.gesundheitsindustrie-bw.de/en/article/news/a-metal-enzyme-that-can-cleave-benzene-rings
  • Article - 19/10/2015 Electron microscope image of MRSA bacteria: four green spheres surrounded by grey cellular material.

    New compound that may kill hospital germs is close to clinical testing

    Bacteria's increasing resistance to antibiotics is a very serious medical issue. An infection with pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) bacteria can be life-threatening for hospital patients because MRSA has become resistant to the most commonly used antibiotics. Although reserve antibiotics are available in cases where others have lost their ability to control or kill bacterial growth effectively, they do not…

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-compound-that-may-kill-hospital-germs-is-close-to-clinical-testing
  • Article - 17/08/2015 AG_Papatheodorou.jpg

    CDT – a bacterial toxin that mediates its own delivery into cells

    Clostridium difficile is totally harmless in healthy people. However, in combination with antibiotics it can cause severe diarrhoea and intestinal inflammation in elderly and debilitated people. But how does the spore-forming, rod-shaped bacterium deploy its power? And how does it enter the cell? Dr. Panagiotis Papatheodorou and his colleagues from the Institute of Experimental and Clinical Pharmacology and Toxicology (Director: Prof. Dr. Klaus…

    https://www.gesundheitsindustrie-bw.de/en/article/news/cdt-a-bacterial-toxin-that-mediates-its-own-delivery-into-cells
  • Article - 11/05/2015 B/w electron microscope image of a Lactobacillus rhamnosus bacterium that is in contact with a keratinocyte (measuring bar = 0.1).

    How Lactobacillus bacteria fight Candida albicans infections

    Fungal infections of skin and mucous membranes are relatively common. Around 75 percent of the human population lives with Candida albicans, a fungus that has no harmful effects in people with an intact immune system that can fight off systemic infections. However, in people with immune systems that have been weakened by antibiotics or radiotherapy for example C. albicans infections can lead to sepsis which may even be life-threatening. Prof. Dr.…

    https://www.gesundheitsindustrie-bw.de/en/article/news/how-lactobacillus-bacteria-fight-candida-albicans-infections
  • Article - 16/02/2015 Model of the protein complex.

    The cellular power station of the cholera pathogen – from the structure to new antibiotics

    The bacterium Vibrio cholerae causes cholera, a severe disease that affects up to 3.5 million people a year. A team of scientists from the universities of Freiburg, Hohenheim and Konstanz have now gained new insights into the way the bacterium produces energy. They have elucidated the structure and function of the bacterium’s energy-production machinery. The research results provide new insights into biochemical energy production and the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-cellular-power-station-of-the-cholera-pathogen-from-the-structure-to-new-antibiotics
  • Article - 24/11/2014 Three-dimensional microscopic representation of a synthetic vesicle that is invaded by bacteria.

    Lipid zipper triggers bacterial invasion

    Millions of people die each year from infections both in developing and industrial countries. There is still no effective treatment for a large number of diseases caused by pathogens. In order to treat infectious diseases effectively, we need to understand the mechanisms that bacteria use to infect human cells. The cytoskeleton of the host cell usually plays a key role in this process. Researchers at the University of Freiburg have discovered a…

    https://www.gesundheitsindustrie-bw.de/en/article/news/lipid-zipper-triggers-bacterial-invasion
  • Article - 18/08/2014 The photo shows 7 staff members of VAXIMM GmbH.

    VAXIMM: Vaccines that impede cancer growth

    VAXIMM GmbH, a young biotechnology company from Mannheim, Germany, specialises in the development of vaccines for cancer treatment. The company’s first product candidate, VXM01, is a live oral vaccine that targets the VEGFR-2 receptor and hence the blood supply of tumours. VXM01 is currently undergoing clinical testing in pancreatic cancer patients.

    https://www.gesundheitsindustrie-bw.de/en/article/news/vaximm-vaccines-that-impede-cancer-growth
  • Article - 06/07/2014 The photo shows Dr. Böttcher and one of his colleagues assessing bacterial culture plates.<br />

    Behaviour-changing signalling molecules as alternative to antibiotics

    Bacteria display group behaviours when they form biofilms or cause infections. These group behaviours protect them against adverse environmental conditions. Thomas Böttcher from the University of Konstanz studies the signalling molecules that control this behaviour. His work involves identifying and characterising natural substances that can prevent bacteria from forming biofilms and from swarming. The substances’ medically relevant effect makes…

    https://www.gesundheitsindustrie-bw.de/en/article/news/behaviour-changing-signalling-molecules-as-alternative-to-antibiotics
  • Article - 02/06/2014 The photo shows the Konstanz researchers Dieter Spiteller, Michael Weiss, Ann-Katrin Felux, Alasdair Cook, Thomas Huhn, Karin Denger and David Schleheck in a laboratory.

    Researchers shed light on important metabolic pathway

    A research team led by microbiologist Dr. David Schleheck, in cooperation with chemists from the University of Konstanz, has discovered how sulpho-glucose is degraded in Escherichia coli bacteria. As this sulphurous glucose analogue is produced by all photosynthetically active organisms, the researchers’ discovery is of great importance for our understanding of the global sulphur cycle.

    https://www.gesundheitsindustrie-bw.de/en/article/news/researchers-shed-light-on-important-metabolic-pathway
  • Article - 22/04/2014 False-colour representation clearly reveals the presence of a biofilm consisting of a substance matrix (yellow) produced by Staphylococcus aureus bacteria (grey).

    Sugar code and hygiene in the fight against multi-resistant pathogens

    Horizontal gene transfer between bacteria is a major reason for the spread of bacterial antibiotic resistance. It is the transfer of bacterial DNA from one bacterium to another, even distantly related species, by bacteriophages, viruses that infect bacteria. Microbiologists from the University of Tübingen are investigating these mechanisms with the aim of finding new strategies that would effectively combat bacteria such as methicillin-resistant…

    https://www.gesundheitsindustrie-bw.de/en/article/news/sugar-code-and-hygiene-in-the-fight-against-multi-resistant-pathogens
  • Article - 25/01/2014 20891_de.jpg

    Call for responsible antibiotics prescription

    Heidelberg University Hospital and the University Medical Centre in Mannheim are working hard to counteract the increase of antibiotic resistance. Strategies include a European-wide system for infection surveillance, the training of health professionals in the responsible use of antibiotics and the search for novel antibiotic substances in unconventional organisms.

    https://www.gesundheitsindustrie-bw.de/en/article/news/call-for-responsible-antibiotics-prescription
  • Article - 20/01/2014 20602_de.jpg

    Curetis AG: Miniaturised laboratory for the simple, rapid and reliable diagnosis of serious infections

    Acute pneumonia usually leaves doctors with no choice the situation can quickly become life threatening requiring doctors to act quickly. Instead of waiting for laboratory results they often prescribe an antibiotic that is effective against numerous bacterial species in the hope that it will also work against the bacterium that has caused the inflammation in the lung tissue. Curetis AG from Holzgerlingen close to Stuttgart has developed a…

    https://www.gesundheitsindustrie-bw.de/en/article/news/curetis-ag-miniaturised-laboratory-for-the-simple-rapid-and-reliable-diagnosis-of-serious-infections
  • Article - 13/01/2014 20817_de.jpg

    Mechanisms of membrane protein insertion

    Prof. Dr. Irmgard Sinning, biochemist and structural biologist at the University of Heidelberg, will be awarded the 2014 Leibniz Prize from the German Research Foundation (DFG) for her work on the structure and function of complexes that transport different membrane proteins to the correct cellular compartments in the appropriate target membranes. Her research is primarily focussed on the co-translational SRP pathway mediated by signal…

    https://www.gesundheitsindustrie-bw.de/en/article/news/mechanisms-of-membrane-protein-insertion
  • Dossier - 09/09/2013 Immunofluorescence image of two dendritic mouse cells with MHC complexes (labelled with red-fluorescent antibodies) on their surface.

    New trends in the field of immunology

    B- and T- lymphocytes along with macrophages have long been regarded as the most important cells of the human immune system and have thus been a major focus of research. This has now changed and it is now the dendritic cells that are regarded as the major components of the adaptive immune system and have become a major focus of scientific interest. Research into innate immune defence mechanisms has also become more important due to the discovery…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/new-trends-in-the-field-of-immunology
  • Article - 12/08/2013 Three-dimensional structure of the Sec translocase. The helper protein YidC, a membrane insertase, binds specifically to the lateral gate of the channel (binding sites shown in red) through which the membrane protein enters the lipid layer of the membrane.

    A doorman in the bacterial membrane

    We are fortunate to have membranes; they separate the interior of cells from the exterior and ensure that precious substances do not leave the cell and toxic substances cannot enter. Membrane proteins do an amazing job in transporting substances from one side of the membrane to the other. This process occurs in bacteria and in humans in much the same way. Prof. Dr. Hans-Georg Koch and his team at the Institute for Biochemistry and Molecular…

    https://www.gesundheitsindustrie-bw.de/en/article/news/a-doorman-in-the-bacterial-membrane
  • Article - 18/05/2013 19744_de.jpg

    Biofilm research aims at fighting hospital germs

    Pseudomonas aeruginosa is a common bacterium that can be found in many different places – soil, water, washing basins, toilets and washing machines, to name but a few examples. Due to its resistance to antibiotic treatment, P. aeruginosa is mainly known as the cause of hospital-acquired infections. David Schleheck, a biologist from Konstanz University, deals specifically with the bacterium’s presence in biofilms. His research could open up new…

    https://www.gesundheitsindustrie-bw.de/en/article/news/biofilm-research-aims-at-fighting-hospital-germs
  • Article - 11/02/2013 Schematic with two artificial liposomes. The membrane on the left contains phospholipids and the receptors are positioned far away from each other. The membrane of the liposome on the right also contains cholesterol and sphingomyelin, which makes the receptors aggregate into clusters.<br />

    Cholesterol boosts the memory of the immune system

    Cholesterol has been demonised for a long time as high cholesterol levels are seen as major risk factors for atherosclerosis myocardial infarction and gallstones. However cholesterol is an essential component of mammalian cell membranes and is required for proper membrane function. It exists in huge quantities in the human body. In addition to being essential for cell survival and hence all animal life in general cholesterol also plays a crucial…

    https://www.gesundheitsindustrie-bw.de/en/article/news/cholesterol-boosts-the-memory-of-the-immune-system
  • Press release - 15/11/2012 18690_de.jpg

    How bacteria attack their host cells with sticky lollipops

    Yersinia enterocolitica, a pathogenic bacterium, causes fever and diarrhea. By help of a protein anchored in its membrane, Yersinia attaches to its host cells and infects them. Scientists of the Max Planck Institute for Developmental Biology in Tübingen and the Leibniz-Institut fuer Molekulare Pharmakologie in Berlin have determined the structure of an important component of the membrane protein and have gained insight into its biogenesis. The…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-bacteria-attack-their-host-cells-with-sticky-lollipops
  • Press release - 09/10/2012 18335_de.jpg

    Bacterium in a Laser Trap

    Scientists from the Department of Microsystems Engineering IMTEK of the University of Freiburg have constructed an innovative new optical trap that can grab and scan tiny elongated bacteria with the help of a laser. Optical tweezers could previously only be used to grab bacteria at one point not to manipulate their orientation. The Freiburg researchers have now succeeded in using a quickly moving focused laser beam to exert an equally distributed…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/bacterium-in-a-laser-trap
  • Article - 10/09/2012 18040_de.jpg

    Jan Wehkamp to investigate the causes of chronic inflammatory bowel diseases

    It takes a great deal of courage to question a common scientific doctrine especially for scientists at the very beginning of their careers. But around ten years ago Dr. Jan Wehkamp did not shy away from doing just that and as a result he and his scientific partner Professor Dr. Eduard Stange came up with a new explanation for the pathogenesis of chronic inflammatory bowel diseases.

    https://www.gesundheitsindustrie-bw.de/en/article/news/jan-wehkamp-to-investigate-the-causes-of-chronic-inflammatory-bowel-diseases
  • Press release - 21/08/2012 17950_de.jpg

    Freiburg research team sheds light on important metabolite in bacteria

    Scientists from the research groups of Prof. Dr. Susana Andrade and Prof. Dr. Oliver Einsle, members of the Institute of Organic Chemistry and BIOSS Centre for Biological Signalling Studies, Cluster of Excellence of the University of Freiburg, have collected the first precise data ever on the function of a transport protein for formate – an important metabolite in bacteria. The findings could potentially lead to the development of new antibiotic…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/freiburg-research-team-sheds-light-on-important-metabolite-in-bacteria
  • Dossier - 23/07/2012 17728_de.jpg

    Extremophilic bacteria

    What causes stress for some, actually speeds others like extremophilic bacteria up. They love it hot, sour or salty, toxic substances like heavy metals also do them good and even give them energy. As molecular and systems biology techniques get better and better, industry is also becoming increasingly interested in these exotic organisms. What potential does knowing the biochemistry of extremophilic bacteria have for the pharmaceutical, cosmetics…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/extremophilic-bacteria

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