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  • Dossier - 27/08/2012 17919_de.jpg

    Evo-devo - the synthesis of developmental biology and evolution

    Evo-devo research has led to completely new ideas concerning the evolution of animals, their tissues and organs. The huge variety of animals on the planet is the result of changes in the activity of a limited number of master genes that control early embryonic development. These master genes have been highly conserved throughout evolution, which is why their analysis allows conclusions to be drawn concerning the evolution of multicellular animals…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/evo-devo-the-synthesis-of-developmental-biology-and-evolution
  • Press release - 26/01/2009

    Parasites in the genome - A molecular parasite could play an important role in human evolution

    Researchers at the Max Planck Institute for Developmental Biology in Tübingen Germany determined the structure of a protein L1ORF1p which is encoded by a parasitic genetic element and which is responsible for its mobility.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/parasites-in-the-genome-a-molecular-parasite-could-play-an-important-role-in-human-evolution
  • Article - 24/10/2011 The photo shows four pictures: the picture on the left shows a grey sphere with a y-shaped furrow on its surface. The picture on the right shows a grey sphere with a linear furrow. The photo on the bottom right shows a y-shaped worm-like structure and the picture on the left a line-shaped worm-like structure.<br /> <br />

    Cadherins and Wnt signals – cell adhesion or growth and dispersion?

    The proteins of the cadherin family form a kind of molecular zip that binds cells closely together thereby preventing cancer cells from migrating for example. Prof. Dr. Doris Wedlich and her team from the Karlsruhe Institute of Technology KIT were involved in the discovery that cadherins are not only involved in cell adhesion but also have other functions.

    https://www.gesundheitsindustrie-bw.de/en/article/news/cadherins-and-wnt-signals-cell-adhesion-or-growth-and-dispersion
  • Article - 29/03/2008

    Artificial micro RNAs in plant breeding

    Scientists from the Max Planck Institute for Developmental Biology in Tübingen and their colleagues from the International Rice Research Institute in the Philippines succeeded in accelerating rice plant breeding by using artificial small RNA molecules.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/artificial-micro-rnas-in-plant-breeding
  • Article - 22/09/2008

    Insight into the evolution of parasitism

    Scientists at the Max Planck Institute for Developmental Biology together with American colleagues have decoded the genome of the Pristionchus pacificus nematode. It consists of a large number of genes. The scientists gain insight into the evolution of parasitism.

    https://www.gesundheitsindustrie-bw.de/en/article/news/insight-into-the-evolution-of-parasitism
  • Article - 27/08/2012 17920_de.jpg

    The discovery of homeotic genes

    Research into the genes that cause erroneous developments in fruit flies have led to one of the most exciting discoveries in the field of developmental biology: the same type of gene that controls early embryonic development in Drosophila, also controls early embryogenesis of other organisms, including humans. These homeotic genes are lined up on the DNA in exactly the same order as they are expressed along the body axis during embryogenesis.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-discovery-of-homeotic-genes
  • Press release - 11/11/2009

    Deciphering the regulatory code

    Thanks to scientists at the European Molecular Biology Laboratory EMBL in Heidelberg Germany it is now possible to accurately predict when and where different cis-regulatory modules CRMs will be active. The study published today in Nature is a first step towards forecasting the expression of all genes in a given organism and demonstrates that the genetic regulation that is crucial for correct embryonic development is more flexible than previously…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/deciphering-the-regulatory-code
  • Press release - 21/09/2011 15391_de.jpg

    Epigenetic changes don’t last

    First comprehensive inventory of epigenetic changes over several generations shows that these often do not last and therefore probably have limited effects on long-term evolution. The team around Detlef Weigel, director of the Department for Molecular Biology, focused on one of the most important epigenetic marks, methylation of DNA.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/epigenetic-changes-don-t-last
  • Press release - 14/01/2010 Different Arabidopsis plants (Photo: Max Planck Society)

    Evolution caught in the act

    Mutations are the raw material of evolution. Charles Darwin already recognized that evolution depends on heritable differences between individuals: those who are better adapted to the environment have better chances to pass on their genes to the next generation. A species can only evolve if the genome changes through new mutations, with the best new variants surviving the sieve of selection. Scientists at the Max Planck Institute for…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/evolution-caught-in-the-act
  • Article - 20/02/2008 Scanning electron microscope image of Caenorhabditis elegans and Pristionchus pacificus.

    Threadworms throughout time

    Threadworms are versatile research objects and are excellent models for investigating fundamental evolutionary principles. Researchers at the Max Planck Institute for Developmental Biology use the Caenorhabditis and Pristionchus threadworm genera to study the molecular mechanisms of biodiversity.

    https://www.gesundheitsindustrie-bw.de/en/article/news/threadworms-throughout-time
  • Press release - 17/08/2012 17915_de.jpg

    Max Planck scientist investigates the evolutionary model of Muller’s ratchet

    Especially in small asexual populations unfavourable mutations can accumulate. This process is known as Mullers ratchet in evolutionary biology. The ratchet predicts that the genome deteriorates irreversibly leaving populations on a one-way street to extinction. In collaboration with colleagues from the US Richard Neher from the Max Planck Institute for Developmental Biology has shown mathematically how Mullers ratchet operates and he has…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/max-planck-scientist-investigates-the-evolutionary-model-of-muller-s-ratchet
  • Press release - 14/01/2009 07818_de.jpg

    Looking for the Achilles’ heel of parasites

    Researchers have identified a hormone that controls whether nematode larvae turn into parasites or not.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/looking-for-the-achilles-heel-of-parasites
  • Article - 26/10/2011 15720_de.jpg

    Simple nerve cells regulate swimming depth of marine plankton

    Scientists of the Max Planck Institute for Developmental Biology in Tübingen Germany have identified some signaling substances in the nervous system of larvae of the marine annelid Platynereis regulating the swimming depth. These substances influence the ciliary beating and thus hold the larvae in the preferred water depth. The scientists discovered a very simple circuitry of nerve cells underlying this regulation reflecting an early evolutionary…

    https://www.gesundheitsindustrie-bw.de/en/article/news/simple-nerve-cells-regulate-swimming-depth-of-marine-plankton
  • Article - 14/03/2008

    Elisa Izaurralde, a prominent RNA scientist, receives Leibniz Prize

    The directors of the Tübingen Max Planck Institute MPI for Developmental Biology are pleased to have a Leibniz prizewinner in their ranks for the second year running. Dr. Elisa Izaurralde and her colleague Dr. Elena Conti have both been awarded the 2008 prize for their outstanding work in the field of RNA research.

    https://www.gesundheitsindustrie-bw.de/en/article/news/elisa-izaurralde-a-prominent-rna-scientist-receives-leibniz-prize
  • Article - 31/03/2014 Microscopic image in which the nuclei and cytoskeleton are strained.

    Lsd1 – a gatekeeper for differentiation onset of embryonic mouse stem cells

    Epigenetics is an emerging field of research that studies heritable changes in gene expression that are not caused by changes in the underlying DNA sequence. Prof. Dr. Roland Schüle, Director of Central Clinical Research at the Freiburg University Medical Centre, and his team are specifically focused on epigenetic modifiers that regulate the timely development of placental mouse tissue. Schüle and his team have discovered in mouse embryos that a…

    https://www.gesundheitsindustrie-bw.de/en/article/news/lsd1-a-gatekeeper-for-differentiation-onset-of-embryonic-mouse-stem-cells
  • Press release - 02/08/2011 15061_de.jpg

    How the modular structure of proteins permits evolution to move forward

    Changes in a short protein domain can alter a whole signaling network involved in organ development – this is the key result of a comparative study of the development of the egg laying organ in two species of nematodes. However, the outward appearance of the organ remains the same in both species.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-the-modular-structure-of-proteins-permits-evolution-to-move-forward
  • Article - 17/03/2014 Schematic drawing of Drosophila. The Hox genes, which are critical for the differentiation of the fly’s body segments, are located very close to one another and are expressed in the developing embryo in the order of the segments.

    Hox gene found to influence germline stem cell niche

    Prof. Dr. Ingrid Lohmann and her team at the Centre for Organismal Studies COS at the University of Heidelberg are studying the effect of Hox proteins on the early development of Drosophila using genomic genetic molecular and biochemical methods along with complex computer analyses and simulations. They have cast light on a basic regulatory mechanism of stem cell differentiation. They were able to show that the Hox transcription factor Abd-B is…

    https://www.gesundheitsindustrie-bw.de/en/article/news/hox-gene-found-to-influence-germline-stem-cell-niche
  • Article - 25/01/2010 The photo shows a cross-section through a mutated fish larve eye. The cells are blue and the lens transparent. The cells behind the cells have a chaotic structure.

    The two sides of a cell

    Almost all cells are asymmetric – this is why for example the intestines, the brain and lungs function so well. Tumour diseases show why it is so important for a cell to have two different sides, a “head” and a “foot”. In cancer, genes that are responsible for the correct development of cell polarity are often defective. Dr. Felix Loosli from the Karlsruhe Institute of Technology investigates epithelial cells in the retina of the small Japanese…

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-two-sides-of-a-cell
  • Article - 05/05/2010 11243_de.jpg

    The Hydra genome

    The genome of the freshwater cnidarian Hydra, a model organism used in evo-devo research, was recently deciphered by an international group of researchers including Prof. Thomas Holstein’s group from the University of Heidelberg. The sequencing of the Hydra genome sheds light on the early evolutionary lines and the development of the complexity of multicellular animals.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-hydra-genome
  • Article - 10/06/2009 Portrait of Dr Dirk Linke

    Dirk Linke - a vaccine is ready - just in case

    There is a well-known saying: travel broadens the mind. This is not the only consequence of travel – the biochemist Dr. Dirk Linke from Tübingen travelled to India on holiday and brought back an idea for a new scientific project. Since his return, his idea, the possibility of developing a vaccine with a wide-ranging effect against some of the most frequent diarrhoea pathogens, has even generated financial backing from prominent supporters.

    https://www.gesundheitsindustrie-bw.de/en/article/news/dirk-linke-a-vaccine-is-ready-just-in-case
  • Article - 27/08/2012 17923_de.jpg

    A worm that turned

    The body plan of vertebrates resembles an earthworm turned on its back. Unsurprisingly, this radical idea initially met with great criticism but modern evo-devo research supports this idea of inversion. An evolutionarily conserved gene cassette determines the dorsoventral axis in the developing embryo. It does so in both vertebrates and invertebrates. However, the body plans of vertebrates and invertebrates are dorsoventrally inverted with…

    https://www.gesundheitsindustrie-bw.de/en/article/news/a-worm-that-turned
  • Press release - 12/09/2012 18102_de.jpg

    Allegedly Useless Parts of the Human Genome Fulfil Regulatory Tasks

    The international ENCODE project aims to assemble an encyclopedia of all functional DNA elements in the human genome. The Heidelberg scientists were able to confirm in a showcase with the model organism Medaka fish that surprisingly many of the analysed elements in the non-protein-coding part of the DNA can actually regulate gene activity in a very specific way.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/allegedly-useless-parts-of-the-human-genome-fulfil-regulatory-tasks
  • Article - 05/06/2012 17261_de.jpg

    Max Planck Director Izaurralde honored for groundbreaking research

    Professor Dr. Elisa Izaurralde has made important contributions to the field of RNA biology in recent years. The managing director of the Max Planck Institute for Developmental Biology in Tübingen explores the complex mechanisms of cellular gene regulation. For her work on mRNA regulation she has now been honored with the prestigious Ernst Jung Prize for Medicine.

    https://www.gesundheitsindustrie-bw.de/en/article/news/max-planck-director-izaurralde-honored-for-groundbreaking-research
  • Article - 08/06/2015 Schematic representation showing how the combination of two fragments (kidney-shaped green and orange, top right and left) makes it possible to design proteins with new functions (bottom, horseshoe-shaped, in this case by binding of an irregularly shaped, grey molecule that is not bound by the original proteins.

    New construction kit for designing new proteins

    Protein building blocks with well-defined properties that can be assembled into new molecules with desired structures and functions are highly sought after in biotechnology and medicine. Birte Höcker, a biologist at the Max Planck Institute for Developmental Biology in Tübingen, is currently working on this in a project she calls “Protein Lego”.

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-construction-kit-for-designing-new-proteins
  • Press release - 12/11/2012 18647_de.jpg

    Phosphate switch to fine-tune the protein production in cells

    MicroRNAs are essential regulators of the genetic program in multicellular organisms. Because of their potent effects the production of these small regulators has itself to be tightly controlled. That is the key finding of a new study performed by Tübingen scientists at the Max Planck Institute for Developmental Biology. They identified a new component that modulates the production of microRNAs in thale cress by the removal of phosphate residues…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/phosphate-switch-to-fine-tune-the-protein-production-in-cells

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