Press release - 12/11/2012 Searching for new strategies against prostate cancer The European Research Council (ERC) has announced that Roland Schüle, Scientific Director at the Department of Urology, University of Freiburg Medical Centre has been awarded an ERC Advanced Grant. Professor Schüle will receive €2.5 million for a period of 5 years for his research proposal to identify and characterize the molecular and physiological functions of the epigenetic enzyme LSD1 and to explore its role in prostate cancer.https://www.gesundheitsindustrie-bw.de/en/article/press-release/searching-for-new-strategies-against-prostate-cancer
Dossier - 05/11/2012 Cancer – basic research, successes and trends Science is approaching cancer treatment by using new systems biology approaches and setting up large-scale multidisciplinary projects such as the International Cancer Genome Consortium. Progress in genome, epigenome and gene expression analyses of cancer cells, new insights into the regulation and interaction of cells gained in cooperation with stem cell research and virus research contributes to gaining a causal understanding of cancer. This…https://www.gesundheitsindustrie-bw.de/en/article/dossier/cancer-basic-research-successes-and-trends
Article - 15/10/2012 ERC Starting Grants 2012: Baden-Württemberg achieves above-average success On September 10th 2012, the European Research Council (ERC) announced the results of the fifth funding round of its Starting Grants. Baden-Württemberg was awarded 13 grants, and is the state with the largest number of a total of 34 grants awarded to German life sciences researchers. Baden-Württemberg life sciences researchers will be receiving Starting Grants worth around 20 million euros.https://www.gesundheitsindustrie-bw.de/en/article/news/erc-starting-grants-2012-baden-wuerttemberg-achieves-above-average-success
Article - 17/09/2012 Biochemisty and the assembly of ammonium machines Researchers who intend to build enzymes in the laboratory need detailed knowledge about the function of the respective enzymes. Using modern biochemistry methods researchers led by Prof. Dr. Oliver Einsle from the University of Freiburg have in the last few years clarified the atomic structure of a complex bacterial protein that converts atmospheric nitrogen into a form that can be readily used by other organisms. The researchers have recently…https://www.gesundheitsindustrie-bw.de/en/article/news/biochemisty-and-the-assembly-of-ammonium-machines
Article - 06/08/2012 varionostic: specialist in epigenetic analyses Ulm-based varionostic helps epigenetics researchers to obtain information on gene activity. The company is specifically focused on the analysis of methyl groups (-CH3) that are attached to DNA and turn genes on and off. Just as the field of epigenetics, previously only known to insiders, has emerged as a biomedical area of research, the University of Ulm spin-off has matured and grown over the past six years since it was set up.https://www.gesundheitsindustrie-bw.de/en/article/news/varionostic-specialist-in-epigenetic-analyses
Press release - 03/08/2012 Dosage compensation in male flies: Balance between sexes The sex of many organisms is determined by the number of X chromosomes. In humans women have two X chromosomes whereas men have only one but also have an additional Y chromosome. Why this does not result in an imbalance in the expression of important genes on the X chromosome is what researchers at the Max Planck Institute in Freiburg have examined in collaboration with researcher in Cambridge UK. They have been able to show that the initiation…https://www.gesundheitsindustrie-bw.de/en/article/press-release/dosage-compensation-in-male-flies-balance-between-sexes
Press release - 04/06/2012 DFG establishes 20 new Collaborative Research Centres The support ranges from new therapies for multiple sclerosis via the heroic tradition in ancient time to functional microgels. Attached is a selection of research approaches in science in Baden-Württemberg.https://www.gesundheitsindustrie-bw.de/en/article/press-release/dfg-establishes-20-new-collaborative-research-centres
Article - 21/05/2012 Interactions between the genome and the environment Parental neglect appears to lead to epigenetic changes in children, which result in behavioural problems in later years. This is one issue amongst the many that were addressed at the colloquium “Gene und Umwelt – Wie wir werden, was wir sind” (Genes and the environment – how we become what we are) recently organized by the Daimler and Benz Foundation in Berlin.https://www.gesundheitsindustrie-bw.de/en/article/news/interactions-between-the-genome-and-the-environment
Article - 23/04/2012 Iris-Tatjana Kolassa – extreme stress takes a toll on cells Molecular psychology has huge potential for the future. The discipline has used imaging methods for diagnostic purposes for a long time, but Iris-Tatjana Kolassa, a 33-year-old psychologist from Ulm, is convinced that in future it will increasingly use molecular biology and medicine methods. The idea of remaining blinkered in her own discipline is a notion that is utterly foreign to Kolassa; whenever she senses synergies, whether it be with…https://www.gesundheitsindustrie-bw.de/en/article/news/iris-tatjana-kolassa-extreme-stress-takes-a-toll-on-cells
Article - 05/03/2012 Ubiquitin and related molecules do more than just degrade and recycle cellular waste The proteins of the ubiquitin family have long been regarded as cellular Post-its with to be discarded written on them. However over the last ten years it has become increasingly clear that the proteins of the ubiquitin family that cells use to label defective or unneeded proteins also regulate a broad range of important cellular processes. It has also been found that they are involved in the pathogenesis of cancer and neurodegenerative diseases…https://www.gesundheitsindustrie-bw.de/en/article/news/ubiquitin-and-related-molecules-do-more-than-just-degrade-and-recycle-cellular-waste
Press release - 01/02/2012 Defects in the packaging of genetic material in malignant brain tumors Glioblastomas are regarded as particularly aggressive brain tumors. In children with glioblastoma, Heidelberg scientists have now discovered genetic alterations that affect the function of DNA packaging proteins known as histones. In a cell, histones serve as coils around which the DNA wraps. At the same time, histones regulate gene activity. Mutations in histone genes have never before been tied to a disease. The group comprising scientists of…https://www.gesundheitsindustrie-bw.de/en/article/press-release/defects-in-the-packaging-of-genetic-material-in-malignant-brain-tumors
Article - 16/01/2012 Manfred Jung: drug discovery and the epigenetic code Prof. Dr. Manfred Jungs team at the University of Freiburg are chemical epigeneticists whose research involves the development of methods that enable them to identify and optimise new therapeutic drugs which are able to alter the epigenetic code of cancer and other cell types. The team use a perfidious worm for their research.https://www.gesundheitsindustrie-bw.de/en/article/news/manfred-jung-drug-discovery-and-the-epigenetic-code
Article - 19/12/2011 Patrick Heun: The DNA tangle and how it is organised Dr. Patrick Heun and his group of researchers at the Max Planck Institute MPI of Immunobiology and Epigenetics in Freiburg are working on elucidating the spatial organisation of cell nuclei and how the structure of chromosomes is passed on to daughter cells during the division of cells. The researchers have come up with clear proof that the formation of centromeres depends on a single molecule. https://www.gesundheitsindustrie-bw.de/en/article/news/patrick-heun-the-dna-tangle-and-how-it-is-organised
Article - 12/12/2011 Comprehensive Biomarker Center GmbH – next-generation biomarkers Biomarker research has moved on from proteins to nucleic acids where one of the main priorities is the use of microRNA expression profiles. The Heidelberg-based biotech company Comprehensive Biomarker Center GmbH (CBC, formerly febit) has state-of-the-art technologies and the skills and knowledge to advance the development of new nucleic acid biomarkers for complex diseases in cooperation with partners from research and industry. https://www.gesundheitsindustrie-bw.de/en/article/news/comprehensive-biomarker-center-gmbh-next-generation-biomarkers
Press release - 05/12/2011 Cellzome founder wins EU women innovators award Cellzome announces 5 December 2011 that Dr. Gitte Neubauer has received the highly esteemed EU Women Innovators Award. The award recognizes her outstanding contribution in translating academic research into a commercial venture through the foundation of Cellzome. The prize value of 100.000 euros awarded by the European Commission Innovation Union was presented by Jos Manuel Barroso in a ceremony as part of the Innovation Convention 2011 in…https://www.gesundheitsindustrie-bw.de/en/article/press-release/cellzome-founder-wins-eu-women-innovators-award
Article - 14/11/2011 Marina Freudenberg and Chris Galanos – more than 40 years of bacterial defence research This years Nobel Prize in Medicine or Physiology was awarded to three renowned scientists one of whom is the American Bruce Beutler who was instrumental in clarifying the structure of the mammalian Toll-like 4 TLR4 receptor. Prof. Dr. med. Marina Freudenberg and Dr. Dr. h.c. Chris Galanos from the Freiburg-based Max Planck Institute MPI of Immunobiology and Epigenetics have co-authored the key publication that led to the award of the Nobel Prize…https://www.gesundheitsindustrie-bw.de/en/article/news/marina-freudenberg-and-chris-galanos-more-than-40-years-of-bacterial-defence-research
Press release - 21/09/2011 Epigenetic changes don’t last First comprehensive inventory of epigenetic changes over several generations shows that these often do not last and therefore probably have limited effects on long-term evolution. The team around Detlef Weigel, director of the Department for Molecular Biology, focused on one of the most important epigenetic marks, methylation of DNA.https://www.gesundheitsindustrie-bw.de/en/article/press-release/epigenetic-changes-don-t-last
Article - 25/07/2011 Silke Brüderlein has “green fingers” for cell cultures Many researchers in the biosciences work with cell cultures, but not all of them seem to understand them at a deeper level. The biologist Silke Brüderlein from the Institute of Pathology in Ulm is a specialist in cell culture and is well aware of the problems that might arise when working with cell cultures.https://www.gesundheitsindustrie-bw.de/en/article/news/silke-bruederlein-has-green-fingers-for-cell-cultures
Press release - 13/07/2011 Kinetochores prefer the “silent” DNA sections of the chromosome The centromere is a specialized region of the chromosome, on which a protein complex known as the kinetochore is assembled. During cell division, the kinetochore provides a point of attachment for molecules of the cytoskeleton, thereby mediating the segregation of chromosomes to the two opposing cell poles. Scientists from the Max Planck Institute of Immunobiology and Epigenetics and BIOSS in Freiburg have investigated the factors that play an…https://www.gesundheitsindustrie-bw.de/en/article/press-release/kinetochores-prefer-the-silent-dna-sections-of-the-chromosome
Article - 27/06/2011 The EURAT project at the Marsilius Kolleg in Heidelberg Bioinformaticians, human geneticists, molecular biologists, oncologists, pathologists, lawyers and theologians are all participating in the project “Ethical and legal aspects of the total sequencing of the human genome” (EURAT) being carried out at Heidelberg University’s Marsilius Kolleg. The project partners are developing a common viewpoint and working out solutions for problems arising from the possibilities of total genome sequencing. https://www.gesundheitsindustrie-bw.de/en/article/news/the-eurat-project-at-the-marsilius-kolleg-in-heidelberg
Article - 20/06/2011 Molecular biologists to celebrate 50th anniversary of Jacob and Monod’s operon model Leading molecular biologists from around the world came together at a conference jointly organized by the European Molecular Biology Organisation (EMBO) and the Institut Pasteur in Paris between 17th and 20th May to celebrate the 50th anniversary of the operon concept published by François Jacob and Jacques Monod in 1961. The scientists discussed concepts and research results influenced by the operon model, which have led to our present…https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-biologists-to-celebrate-50th-anniversary-of-jacob-and-monod-s-operon-model
Article - 14/06/2011 Retinitis pigmentosa: a new form of cell death What form of cell death do the photoreceptors of people suffering from retinitis pigmentosa undergo and how can their degeneration be prevented or delayed with pharmaceutical substances? Dr. Paquet-Durand from the Institute for Ophthalmic Research in Tübingen is working to resolve these questions.https://www.gesundheitsindustrie-bw.de/en/article/news/retinitis-pigmentosa-a-new-form-of-cell-death
Article - 30/04/2011 More efficient ways to erase cell memory Around five years ago for the first time ever regeneration biologists successfully turned back fully differentiated body tissue into pluripotent stem cells using a specific mixture of transcription factors. However the idea that it may one day become possible to create organ tissue is still a distant dream. The quantity of stem cells that can be obtained with current methods is still far too low. Dr. Maria Manukyan from the Centre for Biological…https://www.gesundheitsindustrie-bw.de/en/article/news/more-efficient-ways-to-erase-cell-memory
Article - 30/04/2011 The DKFZ-ZMBH Alliance The strategic alliance between the cell and tumour biology research priority at the German Cancer Research Center and the Center for Molecular Biology at Universität Heidelberg has led to the development of one of the largest centres of basic biomedical research in Germany. The top international profile of this interdisciplinary institution located at the interface between molecular and cellular biology tumour biology and biomedicine is reflected…https://www.gesundheitsindustrie-bw.de/en/article/news/the-dkfz-zmbh-alliance
Press release - 15/02/2011 Cellzome Announces Achievement of Second Milestone in Epigenetics Collaboration with GSK Cellzome announced today that it has achieved the second milestone in its epigenetics alliance with GlaxoSmithKline. The milestone triggers a payment of an undisclosed amount from GSK and follows only two months after the first milestone was achieved. https://www.gesundheitsindustrie-bw.de/en/article/press-release/cellzome-announces-achievement-of-second-milestone-in-epigenetics-collaboration-with-gsk