Article - 19/07/2016 Licence to kill – the enormous potential of CAR T cells With 6 million euros of EU funding, the CARAT project aims to optimise a technology called CAR T that is used to equip T cells with antibody fragments and specifically direct them to destroy cancer cells. The CARAT consortium comprises a multinational team of experts from the Institute for Cell- and Gene Therapy at the Freiburg University Medical Center led by Prof. Dr. Toni Cathomen and seven partner institutions. Cathomen’s team is developing…https://www.gesundheitsindustrie-bw.de/en/article/news/licence-to-kill-the-enormous-potential-of-car-t-cells
Article - 29/11/2008 The worm in humans Caenorhabditis elegans has a lifespan of 20 days. The worm is as small as a comma and consists of only 959 cells. Caenorhabditis elegans is very different from Homo sapiens who might at least in Germany live for as long as 79 years or more. Nevertheless the tiny worm is the most important model organism for researchers into ageing who use it to study the development of age-related diseases and the ageing process itself.https://www.gesundheitsindustrie-bw.de/en/article/news/the-worm-in-humans
Article - 13/10/2014 Personalised cancer therapy based on microRNA analysis microRNAs are not just required for the regulation of gene expression, their expression signatures also allow conclusions to be drawn on the type and progression of cancer. Sensovation AG is therefore working with partners from industry and clinical research to develop an automated microRNA analysis platform that can detect and evaluate microRNA signatures faster than has previously been possible. The system is designed to make it easier to…https://www.gesundheitsindustrie-bw.de/en/article/news/personalised-cancer-therapy-based-on-microrna-analysis
Press release - 04/04/2012 Insilico on the fast track: Supercomputer breaks into new high performance dimensions Starting today, Insilico Biotechnology will use Europe’s very fastest civil computer – going by the name of “Hermit“ – for its modeling and simulating processes. Hermit will cut computing time radically allowing metabolic predictions over several orders of magnitude. In the near future, predictions on the toxic effects of drugs across scales from cellular to organ level will be feasible.https://www.gesundheitsindustrie-bw.de/en/article/press-release/insilico-on-the-fast-track-supercomputer-breaks-into-new-high-performance-dimensions
Article - 29/07/2013 Genetic fingerprinting - a useful method in fruit production Genetic fingerprinting is a well-known technique used for paternity testing and in forensic science. However, the technique is also used in the field of agriculture. Molecular genetics makes it possible to develop and apply new research and breeding methods to the field of fruit production in order to improve production and quality standards. Dr. Haibo Xuan from the Competence Centre for Fruit Production (KOB) at Lake Constance has been working…https://www.gesundheitsindustrie-bw.de/en/article/news/genetic-fingerprinting-a-useful-method-in-fruit-production
Article - 30/04/2011 The DKFZ-ZMBH Alliance The strategic alliance between the cell and tumour biology research priority at the German Cancer Research Center and the Center for Molecular Biology at Universität Heidelberg has led to the development of one of the largest centres of basic biomedical research in Germany. The top international profile of this interdisciplinary institution located at the interface between molecular and cellular biology tumour biology and biomedicine is reflected…https://www.gesundheitsindustrie-bw.de/en/article/news/the-dkfz-zmbh-alliance
Article - 12/07/2010 Vesicular transport in cells – from analysis to biogenesis COPI vesicles, one of the three major types of intracellular transport vesicles, are an excellent example of how the molecular analysis of individual vesicle components can lead to an understanding of the biogenesis and transport mechanisms of membrane vesicles as a whole. The research carried out by Dr. Felix T. Wieland’s team at the University of Heidelberg has made a decisive contribution to such detailed insights.https://www.gesundheitsindustrie-bw.de/en/article/news/vesicular-transport-in-cells-from-analysis-to-biogenesis
Article - 18/02/2013 AIDS researchers from Ulm to shed light on the success of the HIV-1 M group Frank Kirchhoff AIDS researcher at the University of Ulm has come up with a plausible explanation for the pandemic spread of the human immunodeficiency virus 1 HIV-1 M group and its ability to adapt to the human immune system. In a recent study with colleagues from Germany and abroad Kirchhoff used molecular biology methods to investigate the group and compare it with the relatively rare HIV-1 N group. Kirchhoff hopes that the molecular…https://www.gesundheitsindustrie-bw.de/en/article/news/aids-researchers-from-ulm-to-shed-light-on-the-success-of-the-hiv-1-m-group
Article - 21/02/2012 How do toxins, viruses and bacteria invade cells? For a long time researchers believed that cells more or less invite Trojan Horses to invade them and this is what standard textbooks say. This all changed when Dr. Winfried Römer showed during his postdoctoral period what really happened when toxins invade cells. This has led to new ways of looking at the processes associated with intoxication and the infection of human cells with viruses and bacteria. Today junior professor Dr. Winfried Römer…https://www.gesundheitsindustrie-bw.de/en/article/news/how-do-toxins-viruses-and-bacteria-invade-cells
Article - 22/03/2019 Personalised therapies for treating metastasing breast cancer Breast cancer is characterised by broad genetic diversity. Successful treatment is made even more difficult by the fact that, in advanced breast cancer, the properties of metastases often differ significantly from the primary tumour. The Heidelberg CATCH study is now collecting genetic profiles from patients' metastasis tissue samples, which can be used to tailor therapy to individual requirements.https://www.gesundheitsindustrie-bw.de/en/article/news/personalisierte-therapieansaetze-bei-metastasiertem-brustkrebs
Press release - 01/10/2008 Virtual database screening saves time and money In order to be able to manage the growing amount of information in the life sciences the international research community has developed numerous electronic databases over the last few years. Supported by sophisticated software programmes the stored information can now be analysed effectively. In parallel with work-intensive screening methods which involve many laboratory experiments scientists are increasingly relying on computer-based methods. https://www.gesundheitsindustrie-bw.de/en/article/press-release/virtual-database-screening-saves-time-and-money
Press release - 26/03/2009 Sygnis Pharma AG increases capital SYGNIS Pharma AG reported its financial results for the first nine months of the fiscal year 20082009. The company improved its cash position significantly as a result of a successful capital increase. Following the capital increase the stake of dievini Hopp BioTech in SYGNIS Pharma AG increased to approximately 44.90 of the total share capital. The preparations for the phase II efficacy trial of its lead candidate AX200 in acute ischemic stroke…https://www.gesundheitsindustrie-bw.de/en/article/press-release/sygnis-pharma-ag-increases-capital
Article - 28/04/2014 Sciomics: antibody microarrays and their broad range of applications Sciomics GmbH is a start-up biotech from Heidelberg with a special focus on protein microarrays. Sciomics produces complex, high-density antibody microarrays for cancer-relevant proteins and offers services for medical research, diagnostics and the industry, including biomarker screening, the verification of biomarker candidates, the analysis and localization of drug targets and their signalling pathways as well as the characterization of…https://www.gesundheitsindustrie-bw.de/en/article/news/sciomics-antibody-microarrays-and-their-broad-range-of-applications
Article - 12/03/2012 Q-bios provides client-specific biotechnology services Q-bios GmbH, a spin-off from the Mannheim University of Applied Sciences, is a biotechnology company that provides services related to the production and purification of diagnostic and therapeutic proteins as well as the development and amplification of suitable cell lines. The company offers its services, which are based on state-of-the-art technologies, to clients from the biotechnology, diagnostic and pharmaceutical industries.https://www.gesundheitsindustrie-bw.de/en/article/news/q-bios-provides-client-specific-biotechnology-services
Article - 12/01/2011 How milk, cheese, yoghurt and curd cheese can be kept free from “genetic engineering” Bacteriophages introduce their DNA into bacteria where they quickly reproduce and eventually destroy the host organism. Phages are omnipresent in nature and some can be dangerous for humans. They also represent a huge contamination risk in the production of fermented food. Canadian researchers Lvesque et al. 2005 estimate that phages cause around 10 per cent of all production losses in the diary industry where they infest bacteria such as…https://www.gesundheitsindustrie-bw.de/en/article/news/how-milk-cheese-yoghurt-and-curd-cheese-can-be-kept-free-from-genetic-engineering
Article - 06/08/2009 PEPperPRINT wins award for its peptide chips PEPperPRINT GmbH, a spin-off of the German Cancer Research Centre, has won the Science4Life Venture Cup, a German start-up contest that comes with the most prize money. The Heidelberg-based start-up company was previously awarded the renowned research prize by the German Stifterverband and was chosen as a “Landmark in the Land of Ideas” competition run by the German government in 2009.https://www.gesundheitsindustrie-bw.de/en/article/news/pepperprint-wins-award-for-its-peptide-chips
Press release - 18/10/2021 More precise characterization of brain tumors improves diagnosis and therapy An international study with about 3000 patients confirms the validity of a new classification system for meningiomas. It combines tissue characteristics (histology) with molecular analyses and thus improves therapy planning.https://www.gesundheitsindustrie-bw.de/en/article/press-release/more-precise-characterization-brain-tumors-improves-diagnosis-and-therapy
Press release - 17/11/2009 iGEM team Freiburg: a standing order for gold medals The Bioware team from Freiburg, an important part of the bioss cluster of excellence, has once again achieved resounding success: one gold medal and two special prizes at the iGEM competition (international Genetically Engineered Machine), the largest event for up-and-coming scientists focusing on synthetic biology. It was the turn of the research group heads, junior professor Dr. Kristian Müller and Dr. Katja Arndt, to participate in the…https://www.gesundheitsindustrie-bw.de/en/article/press-release/igem-team-freiburg-a-standing-order-for-gold-medals
Press release - 11/11/2009 Hematopoietic stem cell treatment with a new gene therapy vector: A first success treating a brain disease Two children with adrenoleukodystrophy (ALD), a fatal brain disease, have been successfully treated with a new gene therapy vector. Two years after treatment, the disease evolution has been stopped, and no adverse effect of the gene therapy has been observed so far. The results of this clinical trial conducted by Drs Nathalie Cartier and Patrick Aubourg (Inserm, France) in collaboration with European partners have just been published in Science…https://www.gesundheitsindustrie-bw.de/en/article/press-release/hematopoietic-stem-cell-treatment-with-a-new-gene-therapy-vector-a-first-success-treating-a-brain-di
Press release - 01/05/2009 Gaining insights into potato cells Viruses and bacteria are the lifeblood of GATC a family-run biotechnology company that is continuing to grow in spite of the current economic downturn. At the moment GATC is working on the sequence of one particular vegetable - and the company has submitted a building application to add another 1000 square metres to the existing 800.https://www.gesundheitsindustrie-bw.de/en/article/press-release/gaining-insights-into-potato-cells
Article - 14/07/2014 Andreas Marx – “Chemical Biology” of DNA polymerases Whether inside the cell or in molecular biology laboratories, the synthesis of DNA would not be possible without DNA polymerases. The regulation and application of this versatile enzyme family is the subject of research carried out by Prof. Dr. Andreas Marx at the University of Konstanz in Southern Germany. In addition to basic research into naturally occurring DNA polymerases, Marx deals with the development of novel polymerases that can be used…https://www.gesundheitsindustrie-bw.de/en/article/news/andreas-marx-chemical-biology-of-dna-polymerases
Dossier - 22/08/2011 Stress and molecular defence mechanisms Organisms can experience stress from exposure to bacteria and pathogenic fungi; in fact, stress can arise from exposure to any type of environmental influence. As they have evolved, biological cells have developed numerous molecular mechanisms that enable them to survive even in inhospitable conditions. What kind of effects do abiotic stress factors have on plants and human beings? How do cells protect themselves? Are researchers able to increase…https://www.gesundheitsindustrie-bw.de/en/article/dossier/stress-and-molecular-defence-mechanisms
Article - 12/09/2011 Claudia Stürmer: the growth and regeneration of nerve fibres Axons are the long, slender projections of nerve cells whose growth is governed by the intrinsic properties of neurons as well as by growth-promoting and growth-inhibiting molecules present in the neurons’ environment. In fish, the injured axons of the central nervous systems are able to regenerate. This is not the case in mammals, and therefore humans. A group of researchers led by Prof. Dr. Claudia Stürmer at the University of Konstanz is…https://www.gesundheitsindustrie-bw.de/en/article/news/claudia-stuermer-the-growth-and-regeneration-of-nerve-fibres
Article - 16/12/2013 An RNA switch for protein mutations RNA is a family of biological molecules with multiple roles, including the transmission of information and the catalysis of chemical reactions in a similar way to enzyme action. Ribozymes (ribonucleic acid enzymes) of this kind function for example within the ribosome where they link amino acids during protein synthesis. Professor Jörg Hartig from the University of Konstanz has developed a new ribozyme-based method that enables him to control the…https://www.gesundheitsindustrie-bw.de/en/article/news/an-rna-switch-for-protein-mutations
Press release - 30/06/2011 Cancer treatments: New information from fission yeast When a cell divides the genetic information in the chromosomes must be passed on error-free to the daughter cells. Researchers at the Friedrich Miescher Laboratory in Tübingen are studying this process using fission yeast as a model organism. In cooperation with researchers at the University of Tübingen they succeeded in attributing additional tasks to the Aurora enzymes which were already recognized as important cellular tools for the reliable…https://www.gesundheitsindustrie-bw.de/en/article/press-release/cancer-treatments-new-information-from-fission-yeast