Article - 01/06/2015 A protein complex that maintains order in the cell Researchers believe that the defective transport of proteins can be linked with diseases such as Alzheimer’s. Prof. Dr. Elke Deuerling and Dr. Martin Gamerdinger, molecular biologists from the University of Konstanz, have now discovered what is necessary to prevent erroneous protein transport.https://www.gesundheitsindustrie-bw.de/en/article/news/a-protein-complex-that-maintains-order-in-the-cell
Overview Basic research The latest articles, press releases and dossiers on basic research in Baden-Württemberghttps://www.gesundheitsindustrie-bw.de/en/article/research
Article - 16/03/2015 Heike Brötz-Oesterhelt - searching for novel antibiotics in bacteria Microbial metabolic products can be used in the fight against dangerous pathogens such as multidrug-resistant bacteria. Since summer 2014, microbiologist Prof. Dr. Heike Brötz-Oesterhelt has been investigating the mechanisms of action of bacterial substances at the University of Tübingen with the aim of paving the way for new antibiotics. Interesting candidates have already been identified.https://www.gesundheitsindustrie-bw.de/en/article/news/heike-broetz-oesterhelt-searching-for-novel-antibiotics-in-bacteria
Article - 16/02/2015 The cellular power station of the cholera pathogen – from the structure to new antibiotics The bacterium Vibrio cholerae causes cholera, a severe disease that affects up to 3.5 million people a year. A team of scientists from the universities of Freiburg, Hohenheim and Konstanz have now gained new insights into the way the bacterium produces energy. They have elucidated the structure and function of the bacterium’s energy-production machinery. The research results provide new insights into biochemical energy production and the…https://www.gesundheitsindustrie-bw.de/en/article/news/the-cellular-power-station-of-the-cholera-pathogen-from-the-structure-to-new-antibiotics
Article - 02/02/2015 Rentschler Biotechnologie invests in new production plant The Laupheim-based contract manufacturer Rentschler Biotechnologie GmbH is greatly expanding its production capacities. The company is investing €24 million in the construction of two 3,000 litre stainless steel bioreactors, which should be operational in early 2017 and will more than double the production capacities for cell culture-derived proteins. Rentschler also announced recently that it was adding a new 2,000 litre single-use bioreactor…https://www.gesundheitsindustrie-bw.de/en/article/news/rentschler-biotechnologie-invests-in-new-production-plant
Article - 30/06/2014 Scale is key: biodata for optimising bioproduction Biotech research is aimed at improving industrial-scale microbial production, making it more profitable and more competitive. However, laboratory-scale data cannot easily be transferred one to one to large-scale production. New systems biology concepts for the simulation of large-scale production are now set to make this possible.https://www.gesundheitsindustrie-bw.de/en/article/news/scale-is-key-biodata-for-optimising-bioproduction
Article - 10/06/2014 Ribosome assembly as target for innovative antibiotics Although bacterial ribosomes are a popular target of common antibiotics, there are no drugs that specifically target ribosome assembly. To date, there is simply no screening method that would be suitable for assaying inhibitors of ribosomal subunit assembly. Prof. Dr. Elke Deuerling and Dr. Rainer Nikolay from the University of Konstanz have now achieved a breakthrough. They have developed a method that enables the high-throughput identification…https://www.gesundheitsindustrie-bw.de/en/article/news/ribosome-assembly-as-target-for-innovative-antibiotics
Article - 02/06/2014 Researchers shed light on important metabolic pathway A research team led by microbiologist Dr. David Schleheck, in cooperation with chemists from the University of Konstanz, has discovered how sulpho-glucose is degraded in Escherichia coli bacteria. As this sulphurous glucose analogue is produced by all photosynthetically active organisms, the researchers’ discovery is of great importance for our understanding of the global sulphur cycle. https://www.gesundheitsindustrie-bw.de/en/article/news/researchers-shed-light-on-important-metabolic-pathway
Article - 28/04/2014 New ways to interfere with bacterial strategies Bacteria themselves provide the key to their destruction. New insights into the growth and interaction between different pathogens are used in microbial genetics to develop new methods and active substances for combatting multidrug-resistant bacterial strains.https://www.gesundheitsindustrie-bw.de/en/article/news/new-ways-to-interfere-with-bacterial-strategies
Article - 22/04/2014 Sugar code and hygiene in the fight against multi-resistant pathogens Horizontal gene transfer between bacteria is a major reason for the spread of bacterial antibiotic resistance. It is the transfer of bacterial DNA from one bacterium to another, even distantly related species, by bacteriophages, viruses that infect bacteria. Microbiologists from the University of Tübingen are investigating these mechanisms with the aim of finding new strategies that would effectively combat bacteria such as methicillin-resistant…https://www.gesundheitsindustrie-bw.de/en/article/news/sugar-code-and-hygiene-in-the-fight-against-multi-resistant-pathogens
Article - 17/02/2014 Soil bacteria explored as source of new antibiotics Two scientists from the Interfaculty Institute of Microbiology and Infection Medicine IMIT at the University of Tübingen PD Dr. Evi Stegmann and Dr. Yvonne Mast are exploring the biosynthesis of antibiotic substances with the aim of modifying them to make them suitable for application in the fight against multidrug-resistant bacteria.https://www.gesundheitsindustrie-bw.de/en/article/news/soil-bacteria-explored-as-source-of-new-antibiotics
Article - 25/01/2014 Call for responsible antibiotics prescription Heidelberg University Hospital and the University Medical Centre in Mannheim are working hard to counteract the increase of antibiotic resistance. Strategies include a European-wide system for infection surveillance, the training of health professionals in the responsible use of antibiotics and the search for novel antibiotic substances in unconventional organisms.https://www.gesundheitsindustrie-bw.de/en/article/news/call-for-responsible-antibiotics-prescription
Article - 16/09/2013 Infrared light as an indicator of wine quality Guaranteeing the quality of wines is becoming increasingly important so that they are able to compete in the international market. However, the quality control methods currently used are often rather time-consuming and costly. In addition, it is difficult to detect microbial grape contaminations that might jeopardise the quality of the wines. Researchers at the National Training and Research Institute for Viticulture and Horticulture in…https://www.gesundheitsindustrie-bw.de/en/article/news/infrared-light-as-an-indicator-of-wine-quality
Article - 27/06/2013 Annegret Wilde – jetlagged cyanobacteria Sleep-deprived bacteria? Prokaryotes that move towards the light? Yes, they actually exist, as demonstrated by Prof. Dr. Annegret Wilde from the Institute of Molecular Genetics at the University of Freiburg. For the past 15 years Wilde has been studying the requirements and capabilities of cyanobacteria and she was appointed chair for molecular genetics at the University of Freiburg in August 2012.https://www.gesundheitsindustrie-bw.de/en/article/news/annegret-wilde-jetlagged-cyanobacteria
Article - 17/06/2013 EHEC prevention: mission ‘safe salad’ Raw fruit and vegetables are popular and healthy, at least as long as they are not contaminated with pathogens such as those that caused the EHEC outbreak in 2011 where sprouted foods were identified as the source of the E. coli outbreak. Researchers from the University of Hohenheim are looking into how the risk of consumers being infected by ready-to-eat vegetables and salads can be minimised. https://www.gesundheitsindustrie-bw.de/en/article/news/ehec-prevention-mission-safe-salad
Dossier - 03/06/2013 Food analytics – applied consumer protection Consumers – in other words, all of us – rightly expect to be supplied with healthy, high-quality and safe foods. However, over the past few years, food scandals have frequently hit the headlines. They are brought to light in laboratories that have a huge arsenal of methods and procedures to analyse food. Although the media would have us believe otherwise, the vast majority of foods are safe and very rarely hazardous to human health. This is in…https://www.gesundheitsindustrie-bw.de/en/article/dossier/food-analytics-applied-consumer-protection
Guest article - 25/03/2013 Shanghai – a city that never sleeps Between September 2012 to February 2013 I spent six months of practical training in Prof. Weihong Jiangs group at the Shanghai Institute for Biological Sciences of the Chinese Academy of Sciences. A grant from the Baden-Württemberg Ministry of Science Research and the Arts enabled me not only to gain valuable practical experience but also gave me an in-depth view into Chinese culture and life in Shanghai.https://www.gesundheitsindustrie-bw.de/en/article/news/shanghai-a-city-that-never-sleeps
Article - 18/02/2013 Biotechnology in Biberach: a success story that breaks new ground At its New Year reception Biberach University of Applied Sciences outlined the universitys success the establishment of its biotechnology programme is going smoothly and student interest remains steady. Biberach also has a successful track record of acquiring third-party funding and has established new national and international cooperations.https://www.gesundheitsindustrie-bw.de/en/article/news/biotechnology-in-biberach-a-success-story-that-breaks-new-ground
Press release - 17/12/2012 Curetis AG initiates clinical trial in the U.S. towards FDA clearance Curetis AG announced the start of a clinical trial of its Unyvero™ System and the corresponding LRT (lower respiratory tract) application in the U.S. The company expects enrollment completion within the next 12-15 months, followed by a 510(k) submission to the FDA in 2014. The prospective, multicenter trial will include samples collected from more than 2,000 hospitalized patients suspected to have a lower respiratory tract infection and several…https://www.gesundheitsindustrie-bw.de/en/article/press-release/curetis-ag-initiates-clinical-trial-in-the-u-s-towards-fda-clearance
Article - 10/12/2012 MicroMol GmbH and “the fine art of life science” MicroMol GmbH carries out microbiological, molecular and cell biological analyses, is active in research and development, performs validations and produces and sells laboratory products for the life sciences industry. This brief description reflects a broad product and service portfolio that addresses a wide range of different clients, including companies in the pharmaceutical and chemical industries and in the medical technology, industrial…https://www.gesundheitsindustrie-bw.de/en/article/news/micromol-gmbh-and-the-fine-art-of-life-science
Article - 15/10/2012 ERC Starting Grants 2012: Baden-Württemberg achieves above-average success On September 10th 2012, the European Research Council (ERC) announced the results of the fifth funding round of its Starting Grants. Baden-Württemberg was awarded 13 grants, and is the state with the largest number of a total of 34 grants awarded to German life sciences researchers. Baden-Württemberg life sciences researchers will be receiving Starting Grants worth around 20 million euros.https://www.gesundheitsindustrie-bw.de/en/article/news/erc-starting-grants-2012-baden-wuerttemberg-achieves-above-average-success
Article - 15/10/2012 Vegetables help fend off bacteria in the intestines Their discovery in the human intestines came as quite a surprise up until a few years ago LTi lymphoid tissue inducer - cells were only known to be involved in the embryonic development of the immune system. A team of researchers led by Prof. Dr. Andreas Diefenbach from the University of Freiburg Medical Centre has since been able to show the protective role played by LTi cells in fortifying the intestinal wall as a reaction to nutrients found…https://www.gesundheitsindustrie-bw.de/en/article/news/vegetables-help-fend-off-bacteria-in-the-intestines
Article - 15/10/2012 gerbion®: hunting down pathogens Detecting viruses, bacteria or parasites in human, animal, food and environmental samples is routine for the staff of gerbion GmbH & Co. KG. The company has been using virological, microbiological and serological methods for many years, but is now also using cutting-edge molecular biology methods for detecting pathogens. The founders of the Kornwestheim-based diagnostics company have concentrated on own research work and the development of…https://www.gesundheitsindustrie-bw.de/en/article/news/gerbion-hunting-down-pathogens
Press release - 01/08/2012 With broccoli against infections The microbiologist and immunologist Prof. Dr. Andreas Diefenbach, Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Centre, has been awarded a European Research Council "Starting Grant" for his project "NutrImmune". The ERC Starting Grant is one of Europe’s most prestigious grants for young investigators.https://www.gesundheitsindustrie-bw.de/en/article/press-release/with-broccoli-against-infections
Article - 29/05/2012 Exploring special antibiotics synthesis pathways Kirromycin, an antibiotic produced by soil bacteria, reveals unusual steps for biosynthesis that might also be of interest for biotechnological applications. Dr. Ewa Maria Musiol was the first to shed light on the functions of specific acyltransferases involved in the biosynthesis of the antibiotic. She also received the 2012 DECHEMA PhD Award for Natural Products Research for these achievements.https://www.gesundheitsindustrie-bw.de/en/article/news/exploring-special-antibiotics-synthesis-pathways