Article - 31/03/2017 A novel mechanism of cancer development Epstein-Barr virus (EBV) infections occur in almost all adults worldwide and are a high risk factor for some types of cancer. Researchers from Heidelberg have now come up with a novel mechanism that promotes carcinogenesis involving an EBV protein rather than the genome of the virus. The EBV protein BNRF1 induces the excessive amplification of the centrosomes of the spindle apparatus, and leads to chromosomal instability and inaccurate…https://www.gesundheitsindustrie-bw.de/en/article/news/a-novel-mechanism-of-cancer-development
Press release - 02/05/2016 2015 call - ERC Advanced Grants granted to Baden-Württemberg researchers The main goal of the European Research Council (ERC) is to fund Europe’s brightest minds and thus encourage the highest quality research. In April 2016, the ERC announced the awarding of its prestigious Advanced Grants, and three life sciences researchers from Baden-Württemberg were among the recipients.https://www.gesundheitsindustrie-bw.de/en/article/press-release/2015-call-erc-advanced-grants-granted-to-baden-wuerttemberg-researchers
Dossier - 18/04/2016 Epigenetics – heritable traits without changing the DNA sequence Epigenetics, i.e. the inheritance of traits that does not involve a change in the DNA sequence, was once a controversial subject that has since become a central focus of biological research. Epigenetic inheritance is now studied by numerous national and international research programmes. Many cellular regulatory and differentiation processes are controlled by epigenetic mechanisms that take place on different levels, including the DNA, histone,…https://www.gesundheitsindustrie-bw.de/en/article/dossier/epigenetics-heritable-traits-without-changing-the-dna-sequence
Article - 24/02/2014 Chemical tools for exploring cell division The cell cycle, consisting of interphase and mitosis, forms the basis for eukaryotic growth and reproduction. Numerous control and regulatory mechanisms guarantee that the separation and distribution of the chromosomes happens synchronously with the formation of the daughter cells. Amongst other things, the two daughter cells only form when the chromosomes are far enough apart from each other. Professor Dr. Thomas Mayer from the University of…https://www.gesundheitsindustrie-bw.de/en/article/news/chemical-tools-for-exploring-cell-division
Article - 25/02/2013 Frauke Melchior and the SUMO wrestling match between proteins Fifteen years ago, molecular biologist Frauke Melchior discovered a new mechanism of posttranslational protein modification that controls a variety of processes in eukaryotic cells. A small protein called SUMO is covalently bound to target proteins by specific enzymes and cleaved by other enzymes. This discovery has shaped Melchior’s scientific career. https://www.gesundheitsindustrie-bw.de/en/article/news/frauke-melchior-and-the-sumo-wrestling-match-between-proteins
Press release - 19/08/2011 Trial-and-error mechanism might be a reason for female infertility When an egg cell is being formed, the cellular machinery which separates chromosomes is extremely imprecise at fishing them out of the cell’s interior, scientists at EMBL Heidelberg have discovered. The findings, published online in Cell, could explain why errors in the number of chromosomes in the egg cell are the leading cause of miscarriages and severe congenital diseases like Down's syndrome, as well as causing female infertility. https://www.gesundheitsindustrie-bw.de/en/article/press-release/trial-and-error-mechanism-might-be-a-reason-for-female-infertility
Article - 06/06/2011 Review: “DKFZ-ZMBH Alliance Forum on Aging & Cancer” in Heidelberg At the DKFZ-ZMBH Alliance Forum 2011 recently held in Heidelberg internationally leading molecular and cell biologists cancer researchers and epidemiologists presented their latest results on the ageing of cells and organisms and the development of cancer.https://www.gesundheitsindustrie-bw.de/en/article/news/review-dkfz-zmbh-alliance-forum-on-aging-cancer-in-heidelberg
Press release - 26/01/2011 ‘Complexes Matter’ in How Epigenetic Inhibitors Interact with Their Drug Targets Cellzome Scientists Publish First Chemoproteomic Characterization of HDAC Inhibitors in Nature Biotechnology. Results of the first ever chemoproteomic study of inhibition of HDAC Histone Deacetylase complexes opens up the potential for a new way of studying potency and selectivity for inhibitors of epigenetic drug targets such as HDACs. https://www.gesundheitsindustrie-bw.de/en/article/press-release/complexes-matter-in-how-epigenetic-inhibitors-interact-with-their-drug-targets
Press release - 17/04/2009 Who is pulling the threads in the cell? Cell division i.e. mitosis is key in the development of multicellular organisms be these dogs cats mice humans or plants. This process is controlled by specific proteins that interact closely with each other. Prof. Thomas U. Mayer a molecular geneticist at the University of Constance has gained new insights into the function of two of these proteins namely the CPC and Mklp2 proteins. He has discovered that a protein known as cyclin-dependent…https://www.gesundheitsindustrie-bw.de/en/article/press-release/who-is-pulling-the-threads-in-the-cell
Press release - 05/09/2008 Thomas U. Mayer - research for aesthetes Mayers major interest is cell division which he sees as an interesting and also a beautiful aesthetic process. Prof. Dr. Thomas U. Mayer occupies the chair of molecular genetics at the University of Constance where he enjoys working in close contact with colleagues from the field of chemistry.https://www.gesundheitsindustrie-bw.de/en/article/press-release/thomas-u-mayer-research-for-aesthetes