Individuals with a genetic predisposition to Alzheimer’s disease show altered blood levels indicating damaged neuronal contacts as early as 11 years before the expected onset of dementia symptoms. This is evident in the levels of the protein “beta-synuclein”. An international team report these findings in the journal “Alzheimer’s & Dementia”. The biomarker studied here could potentially help to detect neurodegeneration at an early stage.

The human brain continuously processes sensory impulses that compete for our attention. Our ability to select enables us to process specific information and ignore irrelevant stimuli. In this way, we can recognize a familiar face in a large crowd of people. But how is this made possible?

Contact with pets reduces the risk of developing stress-related disorders in adult life in urban children. This is the conclusion of a study conducted by the Section for Molecular Psychosomatic Medicine at Ulm University Hospital together with other researchers from Germany and the USA. Living with animals is said to alleviate inflammatory stress reactions.

Melanie Börries, Professor of Medical Bioinformatics at the Medical Faculty of the University of Freiburg and Director of the Institute of Medical Bioinformatics and Systems Medicine at the Medical Center – University of Freiburg, is being honoured for her pioneering work in personalised cancer therapy.

The Medical Faculty Heidelberg of Heidelberg University and Mannheim University of Applied Sciences are combining their expertise in infectious disease research, mass spectrometry, and bioinformatics to overcome resistance in malaria vectors. The project is supported by funding from the Gates Foundation.

Metastatic breast cancer requires complex and lengthy treatment, the side effects of which affect the quality of life of patients. These often include sexual problems. In a large international randomized exercise intervention trial, researchers have now shown that women who received a nine-month supervised exercise program reported significantly fewer symptoms than women who did not participate in the training program.

Germany's most important award for young scientists honors the development of immunotherapies against malignant brain tumors.

Researchers from the universities in Konstanz and Vienna discover a new class of antibiotic that selectively targets Neisseria gonorrhoeae, the bacterium that causes gonorrhoea. These substances trigger a self-destruction program, which also operates in multi-resistant variants of the pathogen. The novel findings are published in the current issue of Nature Microbiology.

84 percent of Germans consciously consider their diet. For the majority, nutrition is a central topic, but many perceive the public debate as divisive and patronising. According to the latest nutrition study by the Robert Bosch Stiftung and the More in Common, citizens want policies that promote healthy, regional, and affordable food – without regulations or bans. At the same time, they are calling for more say in shaping the food system.

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA – a prerequisite for protein synthesis in the cell. The poorly characterized factors are crucial to ensuring that the molecular machine responsible for splicing is working correctly. A research team has deciphered how the two cellular quality inspectors work.

Researchers at the German Cancer Research Center (DKFZ) have succeeded in identifying a resistance mechanism that often occurs in a specific targeted therapy against chronic lymphocytic leukemia (CLL). The drug ibrutinib is effective in many cases, but therapy resistance often develops during the course of treatment. In cell culture experiments and in mice, the resistance mechanism was successfully overcome using a second drug.

A recent article by Prof. Dr. Martin Haimerl and Prof. Dr. Christoph Reich of Furtwangen University shows that machine learning (ML) in medicine is often evaluated without a comprehensive risk assessment. The authors investigated the extent to which current scientific papers include risk-based metrics in the evaluation of AI models for medical devices.