Pancreatic cancer is one of the deadliest types of cancers in humans. Chemotherapies attack not only the tumor cells but also healthy cells throughout the body. Innovative nanoparticles could be a new approach to treat cancer more precisely. The approach was developed by a research team from the Max Planck Institute (MPI) for Multidisciplinary Sciences, the University Medical Center Göttingen (UMG), and the Karlsruhe Institute of Technology.

Augmented reality for visual orientation - 15/11/2023

Fall prevention with the help of balance-enhancing AR glasses

As we age, our eyesight deteriorates and we have increasing difficulties with orientation. This can lead to balance problems and fatal falls. A team led by Dr. Lorenz Assländer from the University of Konstanz is currently developing a prototype of augmented reality (AR) glasses that use superimposed patterns to facilitate visual orientation in space, thereby helping to improve balance control and prevent falls.

All cancer cells - even those within the same tumor - differ from each other and change over the course of a cancer disease. Scientists at Heidelberg University Hospital, the Medical Faculty in Heidelberg and the German Cancer Research Center discovered molecular changes in multiple myeloma that help individual cancer cells to survive therapy.

Nanoparticles as drug carriers - 09/11/2023

Inhalation of nanocarriers for antibiotics against resistant tuberculosis pathogens

Around ten million people worldwide still contract tuberculosis every year. With an estimated 1.4 million deaths a year, tuberculosis was the world’s deadliest infectious disease until COVID-19. The high mortality rate is down to the sophisticated biology of the pathogen Mycobacterium tuberculosis. A team of researchers from the KIT and the Research Centre Borstel (FZB) has developed a method that aims to outsmart the bacterium once and for all.

Climate-neutral wastewater treatment plants thanks to patented real-time analytics - 08/11/2023

Using AI to reduce greenhouse gases in wastewater companies

The wastewater industry is responsible for global greenhouse gas emissions equivalent to those of global aviation. The start-up Variolytics has found a way to significantly reduce greenhouse gases in wastewater treatment plants using real-time analytics. The patented sensor technology and AI-supported process optimisation offer multiple benefits: in addition to reducing nitrous oxide, the system helps to reduce energy costs and resources.

CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments are unsuccessful. A limiting factor of this very effective and safe therapy is that the cells used in the process quickly reach a state of exhaustion. Researchers at the University of Freiburg have now been able to prevent this exhaustion and thus significantly improve the effect of the therapy in a preclinical animal model.

The Sustainability Innovation Campus (ICN) initiated by the University of Freiburg and the Karlsruhe Institute of Technology (KIT), which will begin its work in January 2024, has announced a two-year funding programme for start-up projects. Scientists from the University of Freiburg, KIT and cooperating universities and research institutions are invited to submit their project outlines by 30 November 2023.

Wasser 3.0: #detect|remove|reuse - 31/10/2023

How to sustainably remove and recycle microplastics from water

We all pollute our water with things we use in our everyday lives. In the process, microplastics and micropollutants accumulate in sometimes significant quantities and are difficult to remove. This has increasingly devastating consequences for our health and the environment. Wasser 3.0, a non-profit start-up from Karlsruhe, has declared war on this problem by developing a customisable process to detect, remove and even recycle these pollutants.

An interdisciplinary research group combining mechanical engineering and biotechnology has taken up its work at the Institute for Molecular Systems Engineering and Advanced Materials (IMSEAM) of Heidelberg University. The team under the direction of Dr Kai Melde will pursue an innovative approach to biofabrication – 3D cell culture using ultrasound. Tools are being developed that can be used as an alternative to or enhancement for 3D printing.

Textiles are a given in civil engineering. Until now, textiles made of resistant synthetic fibers have been used for this purpose, having a long lifetime. For some applications, however, it would not only be sufficient but even desirable for the auxiliary textile to degrade when it has done its job. Natural fibers, in contrast, often decompose too quickly. The DITF are developing a bio-based protective coating that extends their service life.

High-resolution microscopy technology bypassing the diffraction limit - 26/10/2023

From micro- to nanoscope

It has long been impossible to distinguish objects closer than 200 nanometres using light microscopes. However, novel devices developed by a company called abberior Instruments GmbH, which use technology developed by Nobel Prize winner Prof. Dr. Stefan Hell and his teams in Heidelberg and Göttingen, are now able to bypass this resolution limit and provide detailed insights into living cells in the lower nanometre range.

Jun.-Prof. Dr. Priscilla Briquez, junior professor at the Department of General and Visceral Surgery at the Freiburg University Medical Center and member of the Medical Faculty at the University of Freiburg, has received a European Research Council (ERC) Starting Grant from the European Commission. Her DRESSCODE project will receive a total of 1.5 million euros funding for five years.

Epigenetically active drugs enable the cell to read parts of the genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the University Hospital Tübingen have now published. These "therapy-induced epitopes" could help the immune system recognize cancer cells.

Epigenetically active drugs enable the cell to read parts of the genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the University Hospital Tübingen have now published. These "therapy-induced epitopes" could help the immune system recognize cancer cells.

A researcher team from Ecole Polytechnique Federal de Lausanne led by Dr. Vivek Thacker now group leader at the Department of Infectious Diseases at Heidelberg University Hospital have studied why tuberculosis bacteria form long strands and how this affects their infectivity. Their findings could lead to new therapies and have now been published in the journal Cell.

Why are severe courses of SARS-CoV-2 infection less common in children and adolescents than in adults? Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered that the immune system in the upper respiratory tract is much more alert and active in children before infection than in adults and is therefore better equipped to fight the virus.

Microorganisms degrade biobased turf infill - 17/10/2023

Eco-friendly artificial turf: a sports pitch that’s good for people and the environment

There are thousands of artificial turf pitches in Germany. They are extremely practical, but often not at all environmentally friendly. When it rains or the pitch is used, plastic particles from the rubber granules can be released into the envronment, where they remain. Researchers at the University of Stuttgart along with the company TECNARO are now developing an artificial turf with an infill that biodegrades as soon as it leaves the pitch.

The development of highly specific T-cell engagers directed against pHLA tumor targets will be quick and easy. BioCopy's innovative pHLA screening technology characterizes drug candidates in great depth for their specific binding against the desired pHLA tumor target. YUMAB develops highly specific antibodies with their advanced antibody technologies.

The new Center for Bionic Intelligence Tübingen Stuttgart aims to optimize the interaction between humans and technical systems in a fundamentally new way. Scientists from the Universities of Stuttgart and Tübingen, the Max Planck Institute for Intelligent Systems and the Max Planck Institute for Biological Cybernetics are conducting research on intelligent bionic systems that will aid understanding and treatment of certain diseases of the CNS.

Doubling food production, saving water, and increasing carbon storage capacity – this may sound paradoxical, but would be theoretically feasible. Reaching this goal, however, would require a radical spatial reorganization of land use. This is the conclusion of researchers from Karlsruhe Institute of Technology (KIT) and the Heidelberg Institute for Geoinformation Technology (HeiGIT) of Heidelberg University.

Dossier - 11/10/2023

The quantum revolution in the healthcare industry

From ultra-fast quantum computers to highly sensitive sensors - quantum technologies could take medicine a giant step forward. Possible areas of application range from drug development and early cancer detection to reading brain waves to control prostheses or exoskeletons. The German state of Baden-Württemberg plays a key role in the development of sensors in particular.

The demand for skilled workers in Germany is high - especially in the healthcare sector. But the procedure for hiring and recognising qualifications is complex. In Baden-Württemberg, the Welcome Center Sozialwirtschaft Baden-Württemberg is one of the contact points for companies and professionals seeking advice on the process.

Researchers at the University of Hohenheim are working on an alternative to fish consisting of microalgae. Advantage: Microalgae have high quality ingredients and also contribute to carbon storage.

Preventing waste from instant meals - 05/10/2023

EDGGY: edible packaging film made from eggshell waste

Many instant meals such as ramen soups have both a protective outer packaging and individual ingredients in small plastic sachets. To prevent this environmentally harmful waste, five students at the University of Hohenheim have developed a sustainable film based on eggshells and plant proteins that dissolves in hot water and is edible.

A phase I clinical trial is now starting at Tuebingen University Hospital in the Clinical Collaboration Unit (CCU) Translational Immunology, in collaboration with the Department of Internal Medicine I, which is investigating the therapeutic cancer peptide vaccine Fusion-VAC-XS15 in combination with immune checkpoint blockade by atezolizumab (Tecentriq®).

A research team of scientists from the Fraunhofer IPA, the Bosch Digital Innovation Hub at Bosch Health Campus and the Institute of Image-Guided Surgery (IHU) of Strasbourg has jointly launched the DAIOR project. Within the framework of the project, the project partners are working on realizing the operating room of the future with help of artificial intelligence and robot assisted telemedicine.

The European Parliament’s amendments to the proposal for a Regulation on Artificial Intelligence (AI) may be defined as a socio-ecological turnaround compared to the European Commission’s existing draft. The parliamentary draft proposes a series of environmental and climate-related provisions which, in the Oeko-Institut’s view, are feasible and technically achievable. The Oeko-Institut has reviewed these proposals in a Policy Paper.

Researchers at the University of Freiburg quantify the amount of material needed to enable people to live without poverty. 1.2 billion people live in poverty. To lift them out of it, an average of about six tons of raw materials are needed per person and year – in particular minerals, fossil fuels, biomass and metal ores. This is the result of a study by researchers from the Chair of Sustainable Energy and Material Flow Management.

Help with osteoarthritis of the knee - 27/09/2023

Individualised knee-joint cartilage: artificial tissue that fits

Knee joints are subject to considerable stress throughout our lives. The natural shock absorber cartilage wears out over a lifetime, so many people develop knee osteoarthritis. Treatment is available in the form of artificial cartilage. This "off-the-shelf" tissue often does not grow well. Researchers are developing an individualised cartilage replacement made from biomaterial that is produced by 3D printing based on MRI images.

Mobile units for processing fruit and vegetables on-site may play an important role in food supply in 2035. The EU’s FOX project investigated the form that such local food chains might take. To this end, Fraunhofer ISI developed future scenarios that could be used to test the viability of business models for regional food processing and distribution.

Autonomous and robust navigation is an essential capability for agricultural robots or machines that are to reach a new level of autonomy to manoeuver safely and reliably in their environment. Fraunhofer IPA will showcase what is currently technologically and economically feasible with live demos at agritechnica, the agricultural trade fair taking place in Hanover from November 12 to 18, 2023.

Tumor vaccines can help the body fight cancer. These vaccines alert the patient's immune system to proteins that are harbouring cancer-typical alterations. Physicians and cancer researchers from Heidelberg and Mannheim have now treated adult patients with advanced midline gliomas, difficult-to-treat brain tumors, with a peptide vaccine for the first time.

Current diagnostic methods do not always reliably distinguish between chronic inflammation of the pancreas and pancreatic cancer. About one third of all diagnoses are inconclusive. Scientists from the German Cancer Research (DKFZ) and from Heidelberg University Hospital (UKHD) therefore searched for molecular markers that could specify this diagnosis.

The Cultivated B (TCB) began discussions with the European Food Safety Authority (EFSA) and officially entered the pre-submission process for novel food approval of a novel or non-farmed sausage product. Subsequent to the official submission, TCB will emerge as world’s first biotech company to apply for EFSA certification for cultivated meat. This is a pivotal first step in the evolution of the cultivated meat market.

Project SMARTGAIT - 13/09/2023

Safe and cost-effective analysis of neurological gait disorders with AI

Stroke, Parkinson's disease and multiple sclerosis often resulting in gait disorders in those affected. Gait analyses play a crucial role in the successful evaluation and therapy of such disorders. Current measurement methods are costly and time-consuming. The SMARTGAIT project is therefore developing an innovative AI-based system aimed at performing meaningful gait analyses with the help of simple smartphone video recordings.

Food of the future: new production methods - 06/09/2023

NewFoodSystems: innovation space for tomorrow’s food

A rapidly growing world population and simultaneously rapidly shrinking arable land – these are just some of the major challenges facing the food industry. But how can solutions be found? Answers are being sought by the bioeconomy innovation space NewFoodSystems. Funded by the German Federal Ministry of Education and Research (BMBF), it is a network where science and industry can come together to develop sustainable food systems of the future.

Sustainability report - 31/08/2023

ReKlimaMed: how effective is the German healthcare sector when it comes to sustainability?

Hospitals, care facilities and the healthcare industry, together with laboratories, private practices and pharmacies, ensure our medical care, but in so doing they produce enormous amounts of greenhouse gases and consume many resources. The ReKlimaMed report prepared by the viamedica foundation presents an inventory of current sustainable activities, and provides stakeholders with information and recommendations for action.

Rising sea levels due to climate change and artificial irrigation cause soil salinity to increase. This has a negative impact on agriculture, including viticulture. The plants die, yields decrease. Researchers of Karlsruhe Institute of Technology (KIT) have therefore studied a wild grapevine of higher salt tolerance. Their goal is to identify the genetic factors that make the grapevine resilient.

The computational design of new proteins for biomedical or other applications involves long computing times on powerful servers. A joint team of researchers from the Max Planck Institute for Biology Tübingen and the University Hospital Tübingen has now developed and tested a new computational method to greatly speed up the necessary energy calculations. Their framework allows for a precise and efficient design of functional proteins.

DNA nanotechnology - 25/08/2023

Artificial cytoskeleton made of DNA for synthetic cells

The physicists Prof. Dr. Kerstin Göpfrich and Prof. Dr. Laura Na Liu want to understand life from the bottom up. They intend to do this by constructing an artificial cell. However, rather than natural protein building blocks, they are using 3D-DNA structures as construction material. The first step involved creating an artificial cell skeleton that dynamically assembles and disassembles like the biological model and can transport vesicles.

TÜV SÜD has received approval as a UK Approved Body (UKAB) for medical devices. With this approval, medical device manufacturers can implement UKCA certification for the UK market and CE certification for the European market in a time- and cost-efficient manner with TÜV SÜD.

Scientists from the German Cancer Research Center (DKFZ) and the Cambridge Stem Cell Institute have developed an AI system that recognizes and characterizes white and red blood cells in microscopic images of blood samples. The algorithm can help physicians diagnose blood disorders and is available as an open source method for research purposes.

Germany has the most active market, Southern Europe wants more variety, and people in Poland find dairy substitutes too expensive, according to a recent study by the University of Hohenheim.

Germany has the most active market, Southern Europe wants more variety, and people in Poland find dairy substitutes too expensive, according to a recent study by the University of Hohenheim.

Project BlindZero - 03/08/2023

Hope for patients with eye diseases: human cornea from 3D printers

Thousands of cornea transplants are performed every year. However, donors are rare and the procedure is not always without complications. Researchers at the University of Heidelberg are developing an innovative technique in the project BlindZero. It involves ‘printing’ human corneas directly onto patients’ eyes using 3D bioprinting. The reprogrammed genetically engineered cells used for this purpose are not expected to cause a rejection reaction.

Known as the power plant of the cell, mitochondria are essential to human metabolism. Human mitochondria consist of 1,300 different proteins and two fatty biomembranes. The vast majority of mitochondrial proteins are produced with a cleavable transport signal and have to be actively transported into the mitochondria.

Konstanz chemists develop mineral plastics with numerous positive properties from sustainable basic building blocks and, together with biologists, demonstrate the material's excellent microbiological degradability.

Industrial biocatalysis with enzymes is deemed to be a “game changer” in the development of a sustainable chemical industry. Enzymes can be used to synthesize an impressive range of complex molecules. Researchers of KIT have now developed a new class of materials by producing enzyme foams of tremendous stability and activity. The researchers have already filed a patent application on the process to produce enzyme foams.

NeuroQ project - 26/07/2023

Quantum sensors for exoskeletons: can quantum physics beat paralysis?

Could people suddenly be able to move again decades after being paralysed? State-of-the-art quantum sensors integrated in exoskeletons could make this possible. Technology being developed as part of the BMBF-funded NeuroQ beacon project by researchers from organisations including the Fraunhofer IAF, the Charité in Berlin and the University of Stuttgart might achieve even more: besides facilitating movement, it could also help cure paralysis.

What impacts do agrochemicals have on the ongoing global insect decline? Biologists at the University of Konstanz have found out that aversive learning is impaired in bumblebees exposed to glyphosate. Their study is published in the journal Science of the Total Environment.

Molecular biologist Professor Holger Puchta from KIT is granted funding within a Reinhart Koselleck Project by the German Research Foundation (DFG) for work on specific restructuring of plant genomes. Puchta, a pioneer of green genetic engineering, has used molecular scissors in plants for 30 years now. His new project is aimed at using the CRISPR/Cas method to freely combine genes in crops, thus making Gregor Mendel’s dream come true.

Can biosurfactants increase microbiological oil degradation in North Sea seawater? An international research team from the universities of Stuttgart und Tübingen, together with the China West Normal University and the University of Georgia, have been exploring this question and the results have revealed the potential for a more effective and environmentally friendly oil spill response.

So far, 4.2 million animal tests under the REACH chemical regulation: A study from Konstanz and Baltimore quantifies the number of animals that died for the hazard assessment of chemicals in the chemical industry.

A new study published in Nature Medicine, July 2023 has identified two novel markers for screening high-grade squamous intraepithelial lesions (HSIL), a precursor to anal cancer, from the anal microbiome of people with HIV (PWH). PWH are at a significantly higher risk of developing anal cancer. Current screening methods, such as anal cytology, have low specificity for detecting HSIL, which hinders the prevention of anal cancer.

Tumour organoids facilitate drug discovery - 20/07/2023

Drug screening for children with cancer using patient-specific miniature tumours

Standard drugs often don’t work in children and adolescents with recurrent cancer. Researchers from the Hopp Children's Tumour Centre (KITZ) and the German Cancer Research Center (DKFZ) in Heidelberg have been looking to open up new therapy options for those affected, and have cultivated individual miniature tumours from biopsy samples to test the effectiveness of a variety of drugs within a few weeks.

On Tuesday, July 18, 2023, the Tübingen AI Center held a symposium to celebrate its permanent establishment as a national AI center. Since July 1, 2022, it has received 20 million euros a year in funding from the federal government and the state.

As the world's population continues to grow, the construction industry faces the challenge of using fewer resources and switching to sustainable materials. Scientists from the Universities of Stuttgart and Freiburg are developing new interdisciplinary approaches to construction for the future.

Wearable medical devices, such as soft exoskeletons that provide support for stroke patients or controlled drug delivery patches, have to be made of materials that can adapt intelligently and autonomously to the wearer's movements and to changing environmental conditions. These are the type of autonomously switchable polymer materials that have recently been developed by researchers at the University of Stuttgart and the University of…

Insightful study with participation from the University of Konstanz warns of human-induced impacts on the marine ecosystem.

The function of mast cells, which are part of the immune system, is still a mystery. Scientists at the German Cancer Research Center (DKFZ) have now shown in mice: mast cells function as a sensor that signals the animals to avoid antigens, including harmful allergens, and thereby protect themselves from health-threatening inflammatory reactions. The findings were published in the journal Nature.

7591 red deer, 3443 roe deer, 4876 wild boar, 36 wolves, 16 lynxes and 227 red foxes: These are the results of the first standardised monitoring of wildlife populations in ten large protected areas in Germany. It was carried out by scientists at the University of Freiburg led by Prof. Dr. Marco Heurich and Dr. Christian Fiderer from the Faculty of Environment and Natural Resources.