Article - 12/05/2016 Novel method for predicting the spatial structure of biomolecules Biomolecules can only fulfil their functions in the cell when they fold into a characteristic native three-dimensional structure. Knowing this structure is not only of paramount importance for basic research, but also for medicine and pharmacology. Scientists from the Karlsruhe Institute of Technology (KIT) have therefore developed a simple method to predict the three-dimensional structure of biomolecules from the analysis of readily available…https://www.gesundheitsindustrie-bw.de/en/article/news/novel-method-for-predicting-the-spatial-structure-of-biomolecules
Article - 24/02/2014 Chemical tools for exploring cell division The cell cycle, consisting of interphase and mitosis, forms the basis for eukaryotic growth and reproduction. Numerous control and regulatory mechanisms guarantee that the separation and distribution of the chromosomes happens synchronously with the formation of the daughter cells. Amongst other things, the two daughter cells only form when the chromosomes are far enough apart from each other. Professor Dr. Thomas Mayer from the University of…https://www.gesundheitsindustrie-bw.de/en/article/news/chemical-tools-for-exploring-cell-division
Article - 14/10/2013 Online-tool predicts functions of regulatory RNAs Metabolism stress response and gene expression are all controlled by regulatory networks in living systems. Well-known regulators are proteins which function as enzymes chaperones or transcription factors to regulate numerous processes. Less well-known are RNA-molecules which also regulate a multitude of processes small RNAs or sRNAs. Dr. Jens Georg from the Department of Genetics and Experimental Bioinformatics at the University of Freiburg has…https://www.gesundheitsindustrie-bw.de/en/article/news/online-tool-predicts-functions-of-regulatory-rnas
Article - 07/10/2013 Hans Kestler brings order to biological data Hans Kestler works on the borders between the faculties, administration and different disciplines at Ulm University. Molecular biologists and life scientists at Ulm University fight over the lively engineer who is in his late forties. They all need the assistance of the systems biologist who knows how to deal with the enormous amounts of data they produce using mathematical models and algorithms.https://www.gesundheitsindustrie-bw.de/en/article/news/hans-kestler-brings-order-to-biological-data
Article - 09/09/2013 Karsten Borgwardt, a specialist in data mining The use of cutting-edge genomics, proteomics and metabolomics methods generates ever-increasing amounts of data in ever decreasing timescales. Special mathematical and computational methods are required for deducing relevant information from specific patterns. The data mining specialist Karsten Borgwardt from Tübingen is developing such methods for specific application in the life sciences. https://www.gesundheitsindustrie-bw.de/en/article/news/karsten-borgwardt-a-specialist-in-data-mining
Article - 28/06/2013 A world champion of regeneration Planarians can be cut into pieces, and each piece can regenerate into a complete organism. The flatworms are able to do this as they have a huge pool of adult totipotent stem cells that can differentiate into any body cell whatsoever, including germ cells. Scientists from the Heidelberg Institute for Theoretical Studies are using new algorithms to analyse the complex planarian genome structures with the aim of obtaining insights into the genetic…https://www.gesundheitsindustrie-bw.de/en/article/news/a-world-champion-of-regeneration
Article - 03/06/2013 Laser light for the diagnosis of stroke Stroke is one of the most common causes of death in the Western world and in Germany the most common cause of moderate to severe disabilities. Besides effective prevention, the rapid and specific diagnosis of impaired blood circulation in the brain is key in the effective treatment of stroke patients. PD Dr. Thomas Gisler from the University of Konstanz has developed CereFLux, a method that allows the flow of blood in the human brain to be…https://www.gesundheitsindustrie-bw.de/en/article/news/laser-light-for-the-diagnosis-of-stroke
Article - 22/10/2012 syneed imaging: precise visualisation of functional tissue properties Functional medical imaging modalities are of great significance in modern medical diagnostics. Existing ways of diagnosing diseases are now being expanded with the arrival of the innovative parameter imaging method. syneed imaging uses proprietary highly sensitive software for the analysis of dynamic image data. This software complements standard methods such as computed tomography and magnetic resonance imaging and increases the significance of…https://www.gesundheitsindustrie-bw.de/en/article/news/syneed-imaging-precise-visualisation-of-functional-tissue-properties
Article - 24/09/2012 20 millilitres of blood to diagnose Down syndrome Down syndrome, or trisomy 21, occurs when there is an extra copy of chromosome 21. LifeCodexx AG has developed PraenaTest®, an innovative diagnostic test that is able to reliably confirm or exclude trisomy 21 from a blood sample of a pregnant woman. The non-invasive test developed by the Konstanz-based biotech company has recently been placed on the market as an alternative to current invasive tests which result in up to 700 miscarriages per year…https://www.gesundheitsindustrie-bw.de/en/article/news/20-millilitres-of-blood-to-diagnose-down-syndrome
Article - 06/08/2012 Database instead of a book – software facilitates diagnosis of liver diseases The bachelor’s theses of Matthias Hillert and Pascal Laube, students at the Konstanz University of Applied Sciences (HTWG), involved the development of a computer programme that facilitates the analysis of computed tomography images of the liver by comparing them to similar images stored in a database. It is a tool that has the potential to be used in other areas, such as the identification of bone tumours.https://www.gesundheitsindustrie-bw.de/en/article/news/database-instead-of-a-book-software-facilitates-diagnosis-of-liver-diseases
Press release - 30/01/2012 New Modeling Platform for Industrial Bioproduction Insilico Biotechnology is one of the partners in atransnational EU-project out to find a common, easy-to-use computer-based platform for modeling metabolic processes in organisms which are of interest for biotechnological applications. The main advantage of this approach is that it will shorten the time from concept to marketable European biotechnology product considerably for all involved.https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-modeling-platform-for-industrial-bioproduction
Article - 01/09/2011 Quality by Design – a paradigm change in bioprocess development Bioprocess technology has undergone a fundamental change with regard to the criteria used for validating product quality: around ten years ago, the U.S. Food and Drug Administration (FDA) revised the 1987 process validation guidance and the subsequent establishment of the Process Analytical Technology (PAT) initiative heralded a paradigm change in bioprocess understanding and control. The FDA’s guidance underwent a paradigm shift from what was…https://www.gesundheitsindustrie-bw.de/en/article/news/quality-by-design-a-paradigm-change-in-bioprocess-development
Press release - 29/07/2011 The brain’s connectome – from branch to branch The human brain is the most complex of all organs, containing billions of neurons with their corresponding projections, all woven together in a highly complex, three-dimensional web. To date, mapping this vast network posed a practically insurmountable challenge to scientists. Now, however, a research team from the Heidelberg-based Max Planck Institute for Medical Research has developed a method for tackling the mammoth task. Using two new…https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-brain-s-connectome-from-branch-to-branch
Press release - 21/04/2011 Mathematical Methods for Investigating the Hepatitis C Virus An international research project coordinated at Heidelberg University revolves around the development of new mathematical methods for investigating the interaction between virus and host cell as exemplified by the hepatitis C virus. The integrated “PathoSys” project assembles ten research groups of virologists, systems biologists, mathematicians, computer scientists, bioinformaticians and molecular biologists from Germany, France, Cyprus,…https://www.gesundheitsindustrie-bw.de/en/article/press-release/mathematical-methods-for-investigating-the-hepatitis-c-virus
Article - 29/11/2010 Adverse skin reactions - more than just skin deep Severe skin reactions such as toxic epidermal necrolysis TEN and Stevens-Johnson syndrome SJS are caused by drugs that have originally been developed for the treatment or alleviation of other diseases. In some cases the consumption of these drugs can be fatal. The Centre for Documentation of Severe Skin Reactions dZh in Freiburg has been collecting information on rare skin diseases for around 20 years.https://www.gesundheitsindustrie-bw.de/en/article/news/adverse-skin-reactions-more-than-just-skin-deep
Article - 28/11/2010 Genedata facilitates search for biomarkers Biomarkers play a key role in testing the efficacy of a new drug or finding out adverse reactions to it. For reliable and quick results, modern laboratory methods are used to generate huge amounts of highly complex molecular data. The data then need to be efficiently analysed. The company Genedata, with headquarters in Basel (Switzerland) and offices throughout Europe, including a base in Konstanz (Germany), has developed the software system…https://www.gesundheitsindustrie-bw.de/en/article/news/genedata-facilitates-search-for-biomarkers
Press release - 18/11/2010 A Code for evolutionary biology Alexandros (Alexis) Stamatakis heads the new research group “Scientific Computing” at the Heidelberg Institute for Theoretical Studies (HITS) – Software and supercomputing for large-scale biological data analysis. https://www.gesundheitsindustrie-bw.de/en/article/press-release/a-code-for-evolutionary-biology
Article - 08/11/2010 Molecular biology assisted by information theory What do the Internet and mobile communication have in common with the division of yeast cells and viruses? Quite a lot, says Martin Bossert, professor at the Institute of Telecommunication Technology and Applied Information Theory in Ulm. The 55-year-old engineer coordinates an interdisciplinary priority programme of the German Research Foundation (DFG, SPP 1395 Information and Communication Theory in Molecular Biology) that applies information…https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-biology-assisted-by-information-theory
Article - 04/11/2010 Stefan Günther – Software for text and cell jungles Junior professor Dr. Stefan Günther from the Institute for Pharmaceutical Sciences at the University of Freiburg has a long-standing interest in computer sciences and is now developing software to model three-dimensional protein structures. This enables him to predict interaction mechanisms between therapeutic substances and cellular enzymes.https://www.gesundheitsindustrie-bw.de/en/article/news/stefan-guenther-software-for-text-and-cell-jungles
Article - 25/10/2010 Angelika Rück visualises the dance of molecules Angelika Rück measures the luminescence time of molecules in order to find out whether proteins are speaking with each other. She hopes that she will soon be able to differentiate inflammation from tumours. Rück who is head of microscopy at the Ulm-based ILM has worked hard with her colleagues to make the Eselsberg-based Ulm University location one of southern Germanys leading life cell imaging centres.https://www.gesundheitsindustrie-bw.de/en/article/news/angelika-rueck-visualises-the-dance-of-molecules
Article - 18/10/2010 Abigail Morrison – How does the brain learn? The physicist and neuroscientist Prof. Dr. Abigail Morrison from the Bernstein Center for Computational Neuroscience BCCN in Freiburg has always been interested in theoretical questions relating to thinking and remembering. She now works on the development of computer models of different brain areas. Is it possible to untangle the complexities of neural networks in the brain using mathematics and informatics?https://www.gesundheitsindustrie-bw.de/en/article/news/abigail-morrison-how-does-the-brain-learn
Dossier - 09/08/2010 Molecular design made to measure and the requirements Biomolecules such as peptides and nucleic acids can nowadays be synthesised relatively quickly and inexpensively. In addition, great progress has been made in the development of methods enabling the directed mutagenesis in microorganisms. These two developments have boosted the design of new, and the reorganisation of known, molecules. Moreover, these help in the utilisation of certain molecule functions in research and in the industrial…https://www.gesundheitsindustrie-bw.de/en/article/dossier/molecular-design-made-to-measure-and-the-requirements
Press release - 17/11/2009 More precise radiation therapy with real-time movement detection The innovative tracking technology designed to increase the precision and efficiency of radiotherapy treatment that was developed by mediri GmbH (Heidelberg), winner of the BMBF’s Medical Technology Innovation Competition in 2006, has now been used for the first time. The technology has been integrated into a specifically developed ultrasound system belonging to the Fraunhofer Institute for Biomedical Technology (IBMT, St. Ingbert). https://www.gesundheitsindustrie-bw.de/en/article/press-release/more-precise-radiation-therapy-with-real-time-movement-detection
Article - 18/09/2009 Patents promote creativity and motivation The protection of innovations and patents is an important issue for Stockach- based Sensovation AG in terms of the companys proprietary developments. According to Paul Hing Chief Technology Officer of the company which develops and manufactures intelligent detection systems Sensovation has already filed three patents and further ideas for potential patents are currently being evaluated. But how does a medium-sized medical device company such as…https://www.gesundheitsindustrie-bw.de/en/article/news/patents-promote-creativity-and-motivation
Press release - 08/01/2009 ILM - Microscopy There are many different light microscopy methods for dealing with biological and medical issues on the cellular level. In many cases, this also involves the use of lasers either for the manipulation of cells or for the laser-assisted microscopic investigation of cells. A number of different confocal laser microscopy methods have proved to be particularly successful in such investigations to the extent that they have become virtually…https://www.gesundheitsindustrie-bw.de/en/article/press-release/ilm-microscopy-1