Article - 19/12/2011 Lenhard Rudolph prepares four biomarkers for clinical application Lenhard Rudolph’s biomarker quartet is extremely promising in terms of progressing medical and clinical treatment in ageing societies. The quartet - EF-1 alpha, Chi3L3, CRAMP and OP 18 – is made up of four proteins that can potentially be used as biomarkers. Specific concentrations of these molecules in human blood provide information on the biological age and renewal capacity of the tissue and organs of patients. The biomarker quartet also…https://www.gesundheitsindustrie-bw.de/en/article/news/lenhard-rudolph-prepares-four-biomarkers-for-clinical-application
Press release - 08/01/2011 Sense2care - new dimension of blood gas analysis systems Established in August 2010 at the Natural and Medical Sciences Institute at the University of Tübingen (NMI) in Reutlingen, sense2care is an innovative medical technology company. The High-Tech Foundation Fund has now awarded sense2care a total of €500,000 for investing in the development of miniaturised systems to monitor critically ill patients in the operating theatre and in intensive care. https://www.gesundheitsindustrie-bw.de/en/article/press-release/sense2care-new-dimension-of-blood-gas-analysis-systems
Article - 30/03/2015 How psychological stress weakens the immune system Too much stress makes you sick – this is the widely held opinion. But exactly how chronic psychological stress affects our body is not yet fully understood. This is the question Dr. Annette Sommershof and her team from the University of Konstanz are trying to answer. The scientists are exploring stress-related changes in the immune system and have found evidence for the observation that long-term stress weakens the immune system, resulting in…https://www.gesundheitsindustrie-bw.de/en/article/news/how-psychological-stress-weakens-the-immune-system
Dossier - 01/07/2013 Electrophysiology – from cardiac pacemakers to drug discovery Electrochemical reactions are involved in many processes in the human organism. Electrophysiology is the study of the central processes of electrical and chemical interaction and communication between neurons and muscle cells, including the transmission and processing of signals in the nerves and the subsequent contraction of the muscles. For example, electrophysiology studies examine the rhythm which which our heart pumps blood through the…https://www.gesundheitsindustrie-bw.de/en/article/dossier/electrophysiology-from-cardiac-pacemakers-to-drug-discovery
Press release - 12/07/2011 Cortisol Controls Recycling of Bile Acids Scientists of the German Cancer Research Center DKFZ have made a discovery in mice whose liver cells are unable to receive cortisol signals This hormone is responsible for a process in which the liver recycles bile acids from the blood. If this recycling is disrupted the animals develop gallstones and lose weight because they are no longer able to digest dietary fats.https://www.gesundheitsindustrie-bw.de/en/article/press-release/cortisol-controls-recycling-of-bile-acids
Press release - 02/04/2011 Nanosensor detects pathogens Researchers from the Stuttgart-based Max Planck Institute of Solid State Research have succeeded in detecting tiny traces of DNA using sensors made from carbon nanotubes. The sensors are highly selective for specific DNA sequences and it is envisaged that they will be used for the rapid examination of blood samples.https://www.gesundheitsindustrie-bw.de/en/article/press-release/nanosensor-detects-pathogens
Article - 05/02/2009 Cutting off the supply of nutrients and oxygen to tumours Is it possible to cut cancer cells off from the supply infrastructure of the body and bring them to their knees? Dr. Jochen Rößlers research group from the Childrens Hospital at the Freiburg Medical School is investigating how tumours establish contacts with blood and lymph vessels and are hoping to find new ways of treating tumours.https://www.gesundheitsindustrie-bw.de/en/article/news/cutting-off-the-supply-of-nutrients-and-oxygen-to-tumours
Article - 14/12/2009 Clever surveillance system keeps yeast in check The spectrum of human diseases (mycoses) caused by fungi ranges from trivial nail infections to life-threatening systemic infections. The latter are mainly caused by Candida albicans. The dermatologist Prof. Dr. med. Martin Schaller from Tübingen is investigating how this fungus, which is actually part of the normal microbial flora of humans, becomes a pathogen. At the same time, he is looking into the role the patient’s immune system plays in…https://www.gesundheitsindustrie-bw.de/en/article/news/clever-surveillance-system-keeps-yeast-in-check
Article - 07/04/2009 Sick hearts as instructors In a joint project with heart surgeons from Freiburg pharmacologist Professor Dr. Lutz Hein and his team at the University of Freiburg are working to uncover the mystery of spontaneous self-healing in the case of chronic cardiac insufficiency. Initial results suggest the involvement of genetic mechanisms amongst other things.https://www.gesundheitsindustrie-bw.de/en/article/news/sick-hearts-as-instructors
Article - 04/07/2013 Experimental evidence of stem cells for metastasis For the first time, scientists from Heidelberg have characterised cancer cells that initiate metastasis in the blood of breast cancer patients using an in-vivo xenograft mouse model. These cells have the properties of cancer stem cells and are characterised by three surface molecules that can be used as biomarkers for disease progression. https://www.gesundheitsindustrie-bw.de/en/article/news/experimental-evidence-of-stem-cells-for-metastasis
Article - 18/08/2014 VAXIMM: Vaccines that impede cancer growth VAXIMM GmbH, a young biotechnology company from Mannheim, Germany, specialises in the development of vaccines for cancer treatment. The company’s first product candidate, VXM01, is a live oral vaccine that targets the VEGFR-2 receptor and hence the blood supply of tumours. VXM01 is currently undergoing clinical testing in pancreatic cancer patients.https://www.gesundheitsindustrie-bw.de/en/article/news/vaximm-vaccines-that-impede-cancer-growth
Article - 06/07/2015 Blood stem cells deliver drugs to brain tumours The brain is the central switchboard in our body. Professor Ghazaleh Tabatabai’s work focuses specifically on the brain and the fight against uncontrolled proliferation of brain tumours. In May 2014, she was appointed professor in the newly established Interdisciplinary Division of Neuro-Oncology at the University of Tübingen and head of the Clinical and Experimental Neuro-Oncology research group at the Hertie Institute for Clinical Brain…https://www.gesundheitsindustrie-bw.de/en/article/news/blood-stem-cells-deliver-drugs-to-brain-tumours
Press release - 23/06/2008 Doubts about TNF-alpha blockers Results obtained by scientists at the Department of Orthopaedic Surgery at the University Hospital of Heidelberg show that in contrast to previous assumptions the tumour necrosis factor alpha TNF-alpha has no influence on pain and mobility.https://www.gesundheitsindustrie-bw.de/en/article/press-release/doubts-about-tnf-alpha-blockers
Press release - 16/04/2008 Effective Cancer Immune Therapy Through Order in the Blood Vessels Researchers at the German Cancer Research Center have discovered a key molecule that is responsible for the immature structure of blood vessels in malignant tumors. If this molecule is switched off in mice vessels normalize so that immune cells are better able to get to the tumor tissue.https://www.gesundheitsindustrie-bw.de/en/article/press-release/effective-cancer-immune-therapy-through-order-in-the-blood-vessels
Article - 23/04/2009 Cancer therapy targets angiogenesis The idea of starving tumours by interrupting their blood supply has despite initial drawbacks generated the production of blockbuster drugs and is now a major RD focus for biotechnology and pharmaceutical companies. But the biological effects are more complicated than originally expected.https://www.gesundheitsindustrie-bw.de/en/article/news/cancer-therapy-targets-angiogenesis
Press release - 09/09/2010 China Medical City, Taizhou Taizhou is a commercial and industrial city of around 5 million inhabitants located in the Yantze River Delta about half way between Nanjing and Suzhou. Within the Taizhou city boundaries on a total area of 25 square kilometers China Medical City CMC a national-level pharmaceutical high-tech park is currently under construction. https://www.gesundheitsindustrie-bw.de/en/article/press-release/china-medical-city-taizhou
Article - 12/12/2011 Comprehensive Biomarker Center GmbH – next-generation biomarkers Biomarker research has moved on from proteins to nucleic acids where one of the main priorities is the use of microRNA expression profiles. The Heidelberg-based biotech company Comprehensive Biomarker Center GmbH (CBC, formerly febit) has state-of-the-art technologies and the skills and knowledge to advance the development of new nucleic acid biomarkers for complex diseases in cooperation with partners from research and industry. https://www.gesundheitsindustrie-bw.de/en/article/news/comprehensive-biomarker-center-gmbh-next-generation-biomarkers
Article - 30/05/2016 The unknown dark spot of the microcosm The world of microorganisms is still largely unknown. Researchers such as Kai Sohn from the Fraunhofer IGB in Stuttgart are working on decoding, analysing and gradually gaining a better understanding of the microbial genome. In their search for new enzymes and other biomolecules, both biotechnologists and pharmacologists are interested in micoorganisms, and physicians are hoping that detailed insights into the microbial genome will lead to the…https://www.gesundheitsindustrie-bw.de/en/article/news/the-unknown-dark-spot-of-the-microcosm
Article - 14/05/2009 A multicentred approach for the treatment and prevention of diabetes In order to counteract the increase in the number of diabetics it is necessary to take into account the entire psychosocial environment of the patients states Prof. Dr. Peter Nawroth a physician from Heidelberg University Hospital. The prevention of late complications must be a major goal of any treatment and patient consultation. By focusing on the development and investigation of the RAGE-dependent reaction system Nawroth and his team have…https://www.gesundheitsindustrie-bw.de/en/article/news/a-multicentred-approach-for-the-treatment-and-prevention-of-diabetes
Article - 04/07/2017 Ruxolitinib – successful graft-versus-host disease treatment Graft-versus-host disease is a serious complication in leukaemia patients who have been given a blood stem cell transplant from a genetically different person. Prof. Dr. Nikolas von Bubnoff and Prof. Dr. Robert Zeiser from the Department of Haematology, Oncology and Stem Cell Transplantation at Freiburg University Medical Centre initiated a Germany-wide study to show that an active substance called ruxolitinib has a promising therapeutic effect.…https://www.gesundheitsindustrie-bw.de/en/article/news/ruxolitinib-successful-graft-versus-host-disease-treatment
Article - 08/09/2014 Molecular effects of traumatic stress After a traumatic experience, people often suffer not only mental, but also physical effects. Dr. María Moreno-Villanueva from the University of Konstanz has investigated the molecular effects of traumatic stress in people and has found a higher than normal number of DNA strand breaks. In the worst cases this can lead to diseases such as cancer. However, her study also shows that successful psychotherapy can reverse DNA damage. Her findings will…https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-effects-of-traumatic-stress
Telemedicine - 19/10/2015 Medical apps – potential helpers for physicians and patients Can smartphones become health counsellors for patients or diagnostic tools for doctors? The answer is yes, at least technically. However, health apps that comply with valid medical device regulations are still rather rare in Germany. Many health insurance companies are reluctant to pay for the use of these modern tools because the legal framework is inadequate and doctors are not yet fully capable of using them. Nevertheless, the use of such…https://www.gesundheitsindustrie-bw.de/en/article/news/medical-apps-potential-helpers-for-physicians-and-patients
Article - 18/08/2014 The use of human genes as medical products In contrast to medications used for treating disease, gene therapy does not use chemical agents to alleviate or cure disease symptoms. Instead, it involves the introduction of a normal copy of a mutated gene to restore the function of a protein. Gene therapy could also be described as a way of restoring the body’s self-healing process. It is an extremely smart idea that enables the sustainable treatment of diseases which cannot usually be…https://www.gesundheitsindustrie-bw.de/en/article/news/the-use-of-human-genes-as-medical-products
Article - 30/04/2012 German Cardiac Society meeting 2012 - Medicine for sick hearts The recent German Cardiac Society meeting in Mannheim in April 2012 focused on the latest findings related to the prognosis, diagnosis and therapy of heart diseases. While great progress has been made in the therapy of disease symptoms, it will still take a long time before gene and stem cell therapies that target the causes of disease find their way into clinical application. The conference also presented the new German Centre for Cardiovascular…https://www.gesundheitsindustrie-bw.de/en/article/news/german-cardiac-society-meeting-2012-medicine-for-sick-hearts
Assay to support the diagnosis of autoimmune diseases - 22/06/2022 Tracking down pathogenic immune complexes Soluble complexes of antibodies and their target structures circulating in the blood can trigger serious systemic inflammations. Dr. Philipp Kolb and Haizhang Chen from the Institute of Virology at the Freiburg University Medical Centre have developed a sensitive, cell-based test system for detecting these immune complexes. The system can be used to diagnose systemic autoimmune diseases, and also severe cases of COVID-19.https://www.gesundheitsindustrie-bw.de/en/article/news/tracking-down-pathogenic-immune-complexes