Healthcare industry

Press release - 10/07/2009

How to make tumour cells undergo suicide?

How to make tumour cells undergo suicide? The pathologist Dr. Wilfried Roth was awarded the Rudolf Virchow Prize and a cheque of 5000 euros for his work on inducing apoptosis in tumour cells.

Article - 01/08/2010

Manfred Kist – 25 years of fascination for a stomach bacterium

Helicobacter pylori is a genus of bacteria that inhabits the human stomach. The bacteria can cause duodenal and gastric ulcers and are also linked to the development of gastric cancer. Prof. Dr. Manfred Kist from the Freiburg University Medical Centre has spent around 25 years of his scientific career on investigating H. pylori a bent rod-shaped bacterium.

New method for analysing blood samples - 26/11/2020

Personalised therapy monitoring for malignant melanomas

Immunotherapy has greatly improved the survival chances of patients with malignant melanoma. A study has now begun at the Department of Dermatology at the University Hospital of Tübingen to develop a way to monitor the course of treatment as effectively as possible. It involves personalised monitoring using liquid biopsies in addition to conventional PET/CT examinations. This analysis procedure of blood samples could enable closer monitoring of…

Dossier - 12/12/2011

Development of new molecular biomarkers

Biomarkers are playing an increasing role in drug discovery and development. They can be used as molecular indicators for diseases and disease risks as well as for monitoring the effectiveness of therapy. Highly specific molecular biomarkers are being identified using state-of-the-art technologies from the fields of genomics, proteomics and metabolomics.

Article - 31/03/2008

First biosimilar from Ulm close to approval

ratiopharm Germanys second largest generics producer received a positive assessment from the EU regulatory body EMEA in London for the first filgrastim biosimilar. The company expects to receive marketing authorisation for its first biosimilar by mid to end April.

Article - 30/05/2011

From bench to bedside to bench

The term translational medicine does not always refer to the concept “from bench to bedside and back”, and indeed is often used to refer to many other, somewhat distant, concepts. However, the new translation centres and translational research consortia do correspond to the original meaning. These new centres and consortia have become effective structures in health research in Germany whose goal is the continuous improvement of the diagnostic and…

Article - 21/07/2014

Predicting the efficiency of cancer drugs using mathematical models

A research consortium was established at the Stuttgart Research Center Systems Biology SRCSB at the University of Stuttgart in January 2013 with the goal of establishing models that help predict the action of targeted therapeutics. The scientists combine molecular biology experiments with complex mathematical models in order to achieve a holistic understanding of disease and therapy.

Article - 04/02/2013

G protein-coupled receptors and their importance for research and development

Brian Kobilka and Robert Lefkowitz were awarded the 2012 Nobel Prize in Chemistry for their groundbreaking discoveries of the inner workings of G protein-coupled receptors (GPCRs). These transmembrane receptors play a key role in the processing of odours and the recognition of hormones. The work of the two American scientists has had an impact on many researchers around the world. In the following interview, Professor Dr. Daniel Legler, head of…

Press release - 28/01/2010

Boehringer and Priaxon to collaborate in cancer treatment research and development

The pharmaceutical company Boehringer Ingelheim and the young Munich-based company Priaxon have entered into a collaborative project to research and develop mdm2/p53 inhibitors for the treatment of cancer. Priaxon is contributing its expertise in the inhibition of protein-protein interactions, while Boehringer will take on the development and commercialisation of potential products.

Article - 13/09/2010

Molecules adapted to the environment

For many years Prof. Dr. Klaus Kümmerer from the University Medical Centre Freiburg has been investigating how the chemical structures of drugs and other chemicals can be modified in order to enable them to be degraded more quickly in rivers and soils. There has to be a new way of thinking said Kümmerer going on to add the appropriate methods are already in place.

Dossier - 10/11/2014

Cell and gene therapies: from bench to bedside

While cell therapy has become standard treatment for a number of blood cancers, most cell and gene therapy approaches for the treatment of hereditary and metabolic diseases, neurodegenerative disorders and cancer are still in the experimental phases or early clinical trials. However, recent successes give rise to the hope that cell and gene therapies will in future make important contributions to previously incurable diseases.

Neuroblastoma can spread relentlessly or shrink spontaneously. Scientists from the Hopp Children’s Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg and the National Center for Tumor Diseases (NCT) Heidelberg have shown that some malignant neuroblastomas employ a trick to avoid cell death: they use a special mechanism to lengthen the telomeres at the end of their chromosomes.

Press release - 24/01/2011

Synimmune - Close cooperation cuts new cancer drug development time

A development project from Synimmune GmbH, founded in July 2010, made a big impression on the panel of assessors at the German Federal Ministry of Education and Research (BMBF). So much so, that the company was awarded EUR 2.5 million as part of the GO-Bio biotechnology start-up scheme.

Article - 25/04/2016

Pancreatic cancer and its resistance to therapy

Pancreatic tumours are among the cancers with the worst prognosis. In many cases they are resistant to treatment. Prof. Dr. Andreas Trumpp and his colleagues from the DKFZ and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI-STEM have discovered that the reason why some pancreatic tumours are so resistant to treatment is down to larger quantities of the enzyme CYP3A5 in subtypes of pancreatic cancer. Molecular…

Article - 15/12/2009

Arming the immune system against cancer

The theory that immune cells are able to attack tumours has long been a theory with only a minority of supporters. However, this theory is currently experiencing a renaissance. In the future, it might even be possible to specifically alter T-lymphocytes in order to improve their ability to identify and destroy certain tumour types. Prof. Dr. Hanspeter Pircher and his team at the Freiburg University Medical Centre are focusing on the development…

Affimed GmbH - 01/07/2020

"Innate cell engagers" to fight cancer

In the fight against tumour cells, d Affimed GmbH from Heidelberg relies entirely on the weapons of the innate immune system. Affimed has developed special innate cell engagers, which are bispecific antibodies that recognise tumour cells and bring them together with natural killer cells and macrophages of the innate immune system, which then kill the tumour cells. Clinical trials using the AFM13 molecule are ongoing.

Press release - 10/12/2012

Cocktail boosts immune cells in fighting cancer

Natural killer cells (or NK cells), as part of the body´s immune system, can effectively fight cancer. Unfortunately, they quickly lose their aggressiveness and hence are unable to reject solid tumors. Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now discovered a cocktail consisting of three different immune mediators that leaves NK killer cells active over a long period of time. In mice,…

Press release - 12/11/2012

Searching for new strategies against prostate cancer

The European Research Council (ERC) has announced that Roland Schüle, Scientific Director at the Department of Urology, University of Freiburg Medical Centre has been awarded an ERC Advanced Grant. Professor Schüle will receive €2.5 million for a period of 5 years for his research proposal to identify and characterize the molecular and physiological functions of the epigenetic enzyme LSD1 and to explore its role in prostate cancer.

Press release - 19/12/2011

Aldevron to generate antibodies for erythropoietin research consortium

Aldevron is pleased to announce its participation in a new three year, €3.9 million research project to study the long-term risks of erythropoietin (EPO) and its derivatives (epoetins) in cancer patients.

Stem cell research - 12/07/2018

The role of stem cell dormancy in regeneration and cancer

Scientists at the HI-STEM stem cell institute in Heidelberg have shown that the stem cells responsible for replenishing blood cells have the greatest potential of self-renewal of any other stem cells. However, they are normally in a dormant state, and only become active upon exposure to certain stress factors. An oncogene called MYC controls the stem cells' transition from dormancy to active self-renewal.

Article - 29/11/2010

Against chronic liver inflammation and liver cancer

Chronic hepatitis B and C are the major causes of liver cancer. In contrast to hepatitis B viruses, there is no hepatitis C virus vaccination available. New research carried out by Professor Bartenschlager and his colleagues from Heidelberg might give rise to new strategies for the development of vaccines and medications for the prevention and treatment of chronic hepatitis C virus infections.

Article - 03/03/2016

Liquid biopsies – beacons of hope for cancer diagnosis?

Researchers around the world, including researchers from the Freiburg University Medical Center, are working on developing simple blood tests, so-called liquid biopsies, that can be used to obtain accurate information about tumour staging and the progress of therapy. An international liquid biopsy symposium was held in Freiburg in October 2015 and has produced valuable insights.

Scientists at the EMBL and the University of Heidelberg have shown how stressed cells boost the production of the blood-clotting protein thrombin and how cancer cells may be taking advantage of this process. This research could lead to new therapies.

Article - 21/02/2011

Hope for more effective brain tumour therapy

Glioblastoma is the most common and most aggressive type of brain tumour in humans. It has a tendency to recur and it carries a bad prognosis. Intensive research into the molecular reaction chains involved in its pathogenesis has led to promising and effective treatment strategies.