Press release - 02/10/2012 One- or two-way transcription depends on gene loops In certain toy racecar tracks sneaky players can flip a switch trapping their opponents vehicles in a loop of track. Cells employ a less subtle approach they change the tracks layout. In a study scientists at the European Molecular Biology Laboratory EMBL and Oxford University discovered that by forming or undoing gene loops cells manipulate the path of the transcription machinery which reads out instructions from DNA controlling whether it…https://www.gesundheitsindustrie-bw.de/en/article/press-release/one-or-two-way-transcription-depends-on-gene-loops
Article - 05/05/2010 The Hydra genome The genome of the freshwater cnidarian Hydra, a model organism used in evo-devo research, was recently deciphered by an international group of researchers including Prof. Thomas Holstein’s group from the University of Heidelberg. The sequencing of the Hydra genome sheds light on the early evolutionary lines and the development of the complexity of multicellular animals.https://www.gesundheitsindustrie-bw.de/en/article/news/the-hydra-genome
Big Data - 14/12/2017 Looking at the whole genome raises new questions Research laboratories around the world have long focused on studying the whole human genome. It is hoped that knowing the whole human genome will improve diagnostics and enable more specific therapies. Although genome analysis has not yet reached routine clinical application, whole genome sequencing has already raised many ethical and legal issues - for researchers, physicians and patients.https://www.gesundheitsindustrie-bw.de/en/article/news/looking-at-the-whole-genome-raises-new-questions
Article - 02/06/2008 Genome vagabonds Mobile DNA elements are able to change their position in the genome and mobilise entire gene groups as well as switch genes on and off. Professor Bodo Rak and his team at the University of Freiburg are investigating the effect of mobile DNA fragments on the evolution of E. coli bacteria.https://www.gesundheitsindustrie-bw.de/en/article/news/genome-vagabonds
Press release - 30/06/2009 The genome as glue Many engineers who need to work with structured materials with small pores most likely dream of a glue that not only holds the tiny particles together, but also automatically brings them into contact at the correct distance from each other. Scientists under the leadership of Prof. Clemens Richert and Prof. Stefan Bräse at the Karlsruhe Institute of Technology (KIT) have now developed a “bioglue” using a process that is summarised in the journal…https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-genome-as-glue
Press release - 07/03/2015 Genome Analysis of Cancer Cells: Germany’s Biggest Sequencing Unit Established in Heidelberg Thorough examination of the genome of cancer cells is essential for a better understanding of the disease and to improve treatment. Therefore, the German Cancer Research Center (DKFZ), with the support of the German Cancer Consortium (DKTK), will invest in the Illumina HiSeq X Ten Sequencing System, the world’s first and only platform to deliver full coverage human whole genome for less than 1000 Euros per genome with the power to sequence more…https://www.gesundheitsindustrie-bw.de/en/article/press-release/genome-analysis-of-cancer-cells-germany-s-biggest-sequencing-unit-established-in-heidelberg
Article - 25/02/2013 Computomics: unlocking the secrets of plant genome sequences Thanks to the latest generation of sequencing technology, the deciphering of the complete genome of organisms is becoming faster and cheaper. The challenge is to compile the book of life from millions of DNA fragments and unlock the secrets of the human and other organisms. The young bioinformatics company Computomics in Tübingen is doing just this for crops. In contrast to the human genome, the genome of the majority of plants is still a book…https://www.gesundheitsindustrie-bw.de/en/article/news/computomics-unlocking-the-secrets-of-plant-genome-sequences
Article - 12/08/2013 A complete exome sequence in one week The exome is the part of the genome that is formed by exons i.e. the DNA regions that code for proteins and other functional products. Though comprising only about 1 of the total genome the majority of disease-causing mutations occur in the exome. Selectively sequencing the coding regions of the genome is quicker than whole-genome sequencing. Therefore exome sequencing plays an important role in the diagnosis of genetic diseases and cancer.…https://www.gesundheitsindustrie-bw.de/en/article/news/a-complete-exome-sequence-in-one-week
Article - 08/11/2010 Individual genome sequencing – for whom? Next-generation sequencing technologies are fast and effective. This is exactly the reason why the International Cancer Genome Consortium, of which the German Cancer Research Center is part, has set itself the goal of sequencing thousands of individual cancer genomes. Private companies also offer the possibility of sequencing genomes for private clients. It looks as if the problematic vision of “googling your genes” might become reality.https://www.gesundheitsindustrie-bw.de/en/article/news/individual-genome-sequencing-for-whom
Press release - 04/02/2010 MicroRNA: a glimpse into the past Scientists at the European Molecular Biology Laboratory EMBL in Heidelberg Germany have discovered that microRNAs are found in the exact same tissues in animals as diverse as sea anemones worms and humans hinting at an early origin of these tissues in animal evolution. https://www.gesundheitsindustrie-bw.de/en/article/press-release/microrna-a-glimpse-into-the-past
Press release - 20/04/2010 The ZMBH mourns the death of Heinz Schaller The Centre for Molecular Biology at the University of Heidelberg ZMBH is in mourning following the death of Prof. Dr. Heinz Schaller at the age of 78 on April 10 2010 after a short illness. Heinz Schaller was not only the driving force behind the foundation and development of the ZMBH at the University of Heidelberg he was also one of the founding fathers of molecular biological research and molecular virology in Germany. His scientific…https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-zmbh-mourns-the-death-of-heinz-schaller
Press release - 21/01/2010 Resequencing: HybSelect from febit in use The Molecular Genetics Core Facility (MGCF) at Children’s Hospital Boston chose febit’s HybSelect technology which will enable genetics researchers to conduct the highly economic targeted enrichment of genes of interest for resequencing. In January the core facility will be receiving the Geniom RT Analyzer® from febit to perform HybSelect.https://www.gesundheitsindustrie-bw.de/en/article/press-release/resequencing-hybselect-from-febit-in-use
Press release - 01/12/2009 Stefan Wiemann elected new spokesman of the German Genome Research Network Associate Professor (PD) Dr. Stefan Wiemann of the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ) has been elected spokesman of the Project Committee of the National Genome Research Network. This funding programme supports projects in medical genome research aimed at fighting relevant widespread diseases. https://www.gesundheitsindustrie-bw.de/en/article/press-release/stefan-wiemann-elected-new-spokesman-of-the-german-genome-research-network
Press release - 04/02/2020 CeGaT Brings New Dimension to Exome Diagnostics CeGaT aims to solve all genetically-caused cases of disease to help physicians state a diagnosis. To pursue this goal, CeGaT incorporated its long-term expertise and latest scientific knowledge in an innovative diagnostic tool: CeGaT Exome Xtra is the most powerful genetic diagnostic option for patients with complex, unspecific, and rare diseases.https://www.gesundheitsindustrie-bw.de/en/article/press-release/cegat-ermoeglicht-neue-dimension-der-exom-diagnostik
Press release - 23/04/2010 febit Receives European Union (EU) Patent for Synthesis of Minimal Genomes febit announced the receipt of an EU patent EP 1 728 860B1 for its technology to synthesize minimal genomes. The new patent protects febits technology for combining genes to construct a minimal functional genome or parts of it. The EU patent complements earlier patents on the synthesis of oligonucleotides for gene-assembling. https://www.gesundheitsindustrie-bw.de/en/article/press-release/febit-receives-european-union-eu-patent-for-synthesis-of-minimal-genomes
Press release - 13/07/2009 Genome-wide study on the development of schizophrenia Numerous research centres around the world have been working together in order to clarify the genetic basis of schizophrenia. The Central Institute of Mental Health (ZI) in Mannheim was also involved in the study, which was recently published online in the scientific journal Nature.https://www.gesundheitsindustrie-bw.de/en/article/press-release/genome-wide-study-on-the-development-of-schizophrenia
Press release - 09/02/2011 The human genome’s breaking points A detailed analysis of data from 185 human genomes sequenced in the course of the 1000 Genomes Project, by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in collaboration with researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, as well as the University of Washington and Harvard Medical School, both in the USA, has identified the genetic sequence of an unprecedented 28.000 structural…https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-human-genome-s-breaking-points
Press release - 17/05/2021 New findings in genome research The working group around Dr. Philipp Rathert at the Institute for Biochemistry and Technical Biochemistry investigates the regulation of epigenetic networks of certain cancers and ways of treating them. The working group published its new findings in April. https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-findings-genome-research
Article - 21/05/2012 Interactions between the genome and the environment Parental neglect appears to lead to epigenetic changes in children, which result in behavioural problems in later years. This is one issue amongst the many that were addressed at the colloquium “Gene und Umwelt – Wie wir werden, was wir sind” (Genes and the environment – how we become what we are) recently organized by the Daimler and Benz Foundation in Berlin.https://www.gesundheitsindustrie-bw.de/en/article/news/interactions-between-the-genome-and-the-environment
Press release - 01/08/2012 Micro-Copier for genome analysis The scientists Jochen Hoffmann, Dr. Guenther Roth, and Prof. Dr. Roland Zengerle from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg can copy simultaneously 100.000 different DNA sequences in a so called picowell array that has the size of a one cent coin. The new method holds promise to advance the personalised medicine.https://www.gesundheitsindustrie-bw.de/en/article/press-release/micro-copier-for-genome-analysis
Press release - 14/01/2010 Evolution caught in the act Mutations are the raw material of evolution. Charles Darwin already recognized that evolution depends on heritable differences between individuals: those who are better adapted to the environment have better chances to pass on their genes to the next generation. A species can only evolve if the genome changes through new mutations, with the best new variants surviving the sieve of selection. Scientists at the Max Planck Institute for…https://www.gesundheitsindustrie-bw.de/en/article/press-release/evolution-caught-in-the-act
Press release - 03/08/2012 Dosage compensation in male flies: Balance between sexes The sex of many organisms is determined by the number of X chromosomes. In humans women have two X chromosomes whereas men have only one but also have an additional Y chromosome. Why this does not result in an imbalance in the expression of important genes on the X chromosome is what researchers at the Max Planck Institute in Freiburg have examined in collaboration with researcher in Cambridge UK. They have been able to show that the initiation…https://www.gesundheitsindustrie-bw.de/en/article/press-release/dosage-compensation-in-male-flies-balance-between-sexes
Press release - 10/05/2012 FANCM gene plays key role in inheritance Scientists of KIT and the University of Birmingham have identified relevant new functions of a gene that plays a crucial role in Fanconi anemia, a life-threatening disease. The FANCM gene is known to be important for the stability of the genome. Now, the researchers found that FANCM also plays a key role in the recombination of genetic information during inheritance. For their studies, the scientists used thale cress as a model plant. Their…https://www.gesundheitsindustrie-bw.de/en/article/press-release/fancm-gene-plays-key-role-in-inheritance
Article - 31/10/2008 Genome of the diatom Phaeodactylum sequenced A large international group of researchers including researchers from the University of Constance has succeeded in sequencing the genome of a marine alga. Microalgae which belong to the phytoplankton are the basis of the marine food chain.https://www.gesundheitsindustrie-bw.de/en/article/press-release/genome-of-the-diatom-phaeodactylum-sequenced
Article - 07/10/2015 Call for a moratorium on germ line experiments in humans Modern genetic engineering tools enable genes to be modified in a genomic context in living cells. Genome surgery unlocks enormous potential for the treatment of genetic diseases, but it could also be misused for the uncontrolled manipulation of the human genome. An interdisciplinary working group of German scientists is calling for a moratorium on human germ line experiments to provide a space to define the opportunities and risks of this new…https://www.gesundheitsindustrie-bw.de/en/article/news/call-for-a-moratorium-on-germ-line-experiments-in-humans