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  • Press release - 21/12/2021

    Cochlear implant as a sensor

    The cochlear implant (CI) is the most successful neural prosthesis worldwide. Thanks to direct stimulation of the auditory nerve, it enables more than half a million people worldwide to hear, even though those affected were born deaf or deafened.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cochlear-implant-sensor
  • Press release - 27/10/2021

    Disordered brain activity in Rolandic epilepsy can be influenced by brief sounds during sleep

    Rolandic epilepsy is a common form of epilepsy in children which occurs primarily during sleep. Short sounds played during sleep can partially suppress the neuronal discharges characteristic of epilepsy. That’s according to a research team from the University of Tübingen and Tübingen University Hospitals. The team is headed by Dr. Hong-Viet Ngo and Professor Jan Born from the Institute of Medical Psychology and Behavioral Neurobiology.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/disordered-brain-activity-rolandic-epilepsy-can-be-influenced-brief-sounds-during-sleep
  • Article - 22/06/2021 Ausschnitt aus der Software von living brain. Patienten erlernen anhand von Übungen mit VR im kritischen Zeitfenster Alltagsaufgaben effektiv.

    Using virtual reality in the clinic to rehabilitate patients with cognitive disorders

    Outdated and inadequate methods of neurological rehabilitation are still being used for patients with neurological diseases or injuries – and what’s more, the treatment is usually too late. This is because cognitive training is especially important in the critical phases when the brain is particularly plastic. The Heidelberg-based company living brain proves that early treatment is possible using an extremely innovative method – with concentrated…

    https://www.gesundheitsindustrie-bw.de/en/article/news/using-virtual-reality-clinic-rehabilitate-patients-cognitive-disorders
  • Press release - 17/06/2021

    To fear or not - how does the brain switch?

    Which neurons in the brain mediate fear responses - and how do they flip the switch when the danger is over? The research team of Prof. Ingrid Ehrlich at the Institute of Biomaterials and Biomolecular Systems (IBBS), Department of Neurobiology studies these questions. Their latest results obtained in collaboration with scientists at the Friedrich Miescher Institute in Basel (Switzerland), the National Institute of Health (USA), and Innsbruck…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/fear-or-not-how-does-brain-switch
  • Press release - 08/10/2020

    New class of highly effective inhibitors protects against neurodegeneration

    Heidelberg neurobiologists decode central mechanism of degenerative processes in the brains of mouse models and develop new principle for therapeutic agents.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-class-highly-effective-inhibitors-protects-against-neurodegeneration
  • Article - 21/08/2018 Cells stained blue and red.

    Parkinson's disease: vitamin B3 has a positive effect on nerve cells

    Parkinson's disease is one of the most common neurodegenerative diseases in the world. There are around 4.1 million sufferers worldwide. It is characterised by motor impairments that result from the death of certain nerve cells in the brain. Researchers at the University of Tübingen have now discovered that vitamin B3 has a positive effect on damaged nerve cells and can boost their energy metabolism.

    https://www.gesundheitsindustrie-bw.de/en/article/news/parkinsons-disease-vitamin-b3-has-a-positive-effect-on-nerve-cells
  • Article - 01/02/2018 The photo shows the dentate gyrus of a rat (part of the hippocampus). The nuclei of the nerve cells that run like a ribbon from the left-hand to the right-hand side of the photo, are stained red; immature, newly formed nerve cells are white.

    Combined test systems to advance the development of drugs for treating Alzheimer’s

    Which substances are suitable for treating neurodegenerative diseases such as Alzheimer's? Due to complex biochemical relationships, testing suitable drug candidates is difficult, especially in the early drug development phase. Many predictive test systems only cover individual aspects. A team from Baden-Württemberg and France is now combining different models to develop a new approach.

    https://www.gesundheitsindustrie-bw.de/en/article/news/combined-test-systems-to-advance-the-development-of-drugs-for-treating-alzheimers
  • Article - 05/09/2016 Glioblastom_MRT.jpg

    Apogenix: immuno-oncological protein drugs for the treatment of malignant diseases

    Apogenix AG, a biopharmaceutical company from Heidelberg that specialises in immuno-oncology, develops protein drugs that target central signalling pathways involved in regulating the growth, migration and apoptosis of malfunctioning cells and thus offer novel treatment options for cancer and other malignant diseases.

    https://www.gesundheitsindustrie-bw.de/en/article/news/apogenix-immunonkologische-proteinwirkstoffe-gegen-maligne-erkrankungen
  • Article - 13/01/2016 Drawing from the book "Max and Moritz" showing teacher Lämpel about to go to bed. A prohibition sign is    drawn across the bed.

    New approach for treating depression

    Depression is the most common mental health condition; it must be taken seriously and requires treatment. Exactly how and where therapies work is still unclear. Prof. Dr. Dietrich van Calker and Prof. Dr. Knut Biber from Freiburg University Medical Center have been looking into mechanisms of action and have discovered a molecule that appears to be implicated in numerous neuropsychiatric disorders and the effect of various anti-depression…

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-approach-for-treating-depression
  • Article - 29/06/2015 15921_de.jpg

    The transition from acute to chronic pain

    Prof. Dr. Rohini Kuner and fellow scientists from Heidelberg have shown that a protein that inhibits an enzyme produced by immune cells protects nerve cells from chronic hypersensitivity to neuropathic pain. Kuner is also the spokesperson of a new collaborative research centre in Heidelberg that is receiving funding from the German Research Foundation totalling over 12 million euros. The centre is seeking to find the reasons why acute pain…

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-transition-from-acute-to-chronic-pain
  • Overview

    Basic research

    The latest articles, press releases and dossiers on basic research in Baden-Württemberg

    https://www.gesundheitsindustrie-bw.de/en/article/research
  • Article - 01/12/2014 22507_de.jpg

    Stem cell research for preventing radiation-induced developmental damage

    Although ionizing radiation is known to cause cell damage and genetic modifications, its effects on embryonic development are still poorly understood. This is why Prof. Dr. Suzanne Kadereit from the Albstadt-Sigmaringen University of Applied Sciences is involved in a cooperative project that uses human embryonic stem cells for studying the effects of ionizing radiation on prenatal brain development. She heads up the only university of applied…

    https://www.gesundheitsindustrie-bw.de/en/article/news/stem-cell-research-for-preventing-radiation-induced-developmental-damage
  • Article - 17/11/2014 Microscope image of two nerve cells that are connected with each other.<br />

    About synapses and learning

    You can’t teach an old dog new tricks – the old proverb is not totally true. It is now known that the modulation of synaptic functions, including the formation of new neurons, still takes place in old age, although to a lesser extent than in childhood. The human brain stores memories in the form of neural activity patterns. Structural plasticity appears to be the basis for all learning processes. Physician Thomas Hainmüller and Prof. Dr. Marlene…

    https://www.gesundheitsindustrie-bw.de/en/article/news/about-synapses-and-learning
  • Dossier - 30/06/2014 Cocaine and cigarette.

    Addiction: new concepts for resolving old problems

    Addictive substances and behaviours are as varied as their effects on an addict’s health and personality. However, modern neurobiological research has revealed common principles in the development and continuation of addiction, which can be used as an approach for new prevention and therapy strategies including the prevention of relapses. This dossier presents some of the latest research results in the field.

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/addiction-new-concepts-for-resolving-old-problems
  • Article - 19/05/2014 21459_de.jpg

    Alcoholism: the molecular basis of addiction and deprivation

    Scientists at the Central Institute of Mental Health in Mannheim use rats and mice to study the genetic basis and neurobiological mechanisms of alcohol addiction, the changes that occur during alcohol deprivation and the factors that favour a relapse. In translational research, the results from animal experiments are reviewed using alcohol-dependent patients in order to turn them quickly into preventive strategies and therapies.

    https://www.gesundheitsindustrie-bw.de/en/article/news/alcoholism-the-molecular-basis-of-addiction-and-deprivation
  • Article - 13/01/2014 20779_de.jpg

    Stefan Liebau: using iPS cells for studying neural development

    With the appointment of Stefan Liebau as professor of neuroanatomy, iPS cell research has found its way into the Institute of Anatomy at the University of Tübingen. The physician and neuroscientist explores the development of human nerve cells and specialises in working with stem cells. Liebau and his team are currently dealing with the question as to how neural stem cells develop into retinal precursor cells. The researchers are also studying…

    https://www.gesundheitsindustrie-bw.de/en/article/news/stefan-liebau-using-ips-cells-for-studying-neural-development
  • Article - 16/12/2013 Network with red glowing neurons.

    Tools of the future

    Optogenetics is a relatively new technique that enables scientists to manipulate nature with light. Light-sensitive proteins coupled to enzymes or channelrhodopsins embedded in membranes that guide ions across plasma membranes all of these can be used to modulate cell behaviour. Researchers around the world are working on the emerging technique in order to refine and optimise it for application in their research projects. Optogenetics seems to…

    https://www.gesundheitsindustrie-bw.de/en/article/news/tools-of-the-future
  • Article - 23/09/2013 Drosophila brain with yellow mushroom bodies, which are the flies’ association and learning centres.

    Calcium and memory

    Calcium in the nuclei of neurons controls the transcription of genes that play a role in the structural changes that are responsible for the formation of long-term memory. Neurobiologists at Heidelberg University have identified this cellular “switch” in Drosophila melanogaster and have used sensational experiments to analyse its function in the formation of the long-term memory of flies.

    https://www.gesundheitsindustrie-bw.de/en/article/news/calcium-and-memory
  • Article - 22/07/2013 20103_de.jpg

    Marcus Fändrich strengthens protein biochemistry at Ulm University

    After quite a long vacancy the directors post of the Institute for Pharmaceutical Biotechnology at the University of Ulm has finally been filled. Marcus Fändrich and his team moved into the laboratories and offices of the new life sciences building on the Oberer Eselsberg Ulm University campus in November 2012. Fändrich fills a gap in the Ulm Bioregions biopharmaceutical education activities as he will not only be teaching biochemistry…

    https://www.gesundheitsindustrie-bw.de/en/article/news/marcus-faendrich-strengthens-protein-biochemistry-at-ulm-university
  • Article - 08/04/2013 19474_de.jpg

    Top position for German placebo research

    Placebo research at Tübingen University is part of a German network that is a world leader in the field. One of the research priorities relates to the perception of pain and the underlying neurobiological mechanisms.

    https://www.gesundheitsindustrie-bw.de/en/article/news/top-position-for-german-placebo-research
  • Article - 25/03/2013 19421_de.jpg

    Ralf Baumeister – tinkering, constructing and switching off genes

    The focus of Ralf Baumeisters research a small nematode that is known as Caenorhabditis elegans is a rather simple organism. Nevertheless the worm can be used to study complicated behaviour including associated learning. This is how Prof. Dr. Ralf Baumeister from the Institute of Biology III at the University of Freiburg describes the animal that he works with on a daily basis. The worm has now got very little left to hide. And the genetic…

    https://www.gesundheitsindustrie-bw.de/en/article/news/ralf-baumeister-tinkering-constructing-and-switching-off-genes
  • Article - 25/02/2013 The figure shows a neuron whose membrane contains two channel proteins. The proteins can be stimulated with different wavelengths and enable different ions to enter the cell.

    How can light be used to control the behaviour of neurons?

    The control of the behaviour of individual neurons simply by switching light stimuli on and off sends neuroscientists into raptures as it reveals insights into as yet hidden and complicated processes in the brain. Thanks to optogenetics this particular science fiction became reality a few years ago. Working with researchers from the Bernstein Center at the University of Freiburg and the Friedrich Miescher Institute for Biomedical Research in…

    https://www.gesundheitsindustrie-bw.de/en/article/news/how-can-light-be-used-to-control-the-behaviour-of-neurons
  • Article - 19/12/2012 19022_de.jpg

    Interpretation affects visual perception

    Dr. Hendrikje Nienborg is investigating how visual information is processed in the brain. Her most important finding is that the way we interpret visual information influences visual processing and perception. The neuroscientist uses awake mammals to investigate the mechanisms in the visual cortex that underlie visual perception. Dr. Nienborg was awarded an ERC Starting Grant worth 1.9 million euros for her research into the neural foundations of…

    https://www.gesundheitsindustrie-bw.de/en/article/news/interpretation-affects-visual-perception
  • Article - 08/10/2012 18286_de.jpg

    Epilepsy changes brain architecture

    Epileptic fits, i. e. abnormal excessive neuronal activity in the hippocampus, severely affects nerve cells and can lead to permanent damage. A team of researchers led by Prof. Dr. Carola Haas from the Neurocenter at the University of Freiburg is focusing on changes in the brain anatomy of patients suffering from temporal lobe epilepsy as well as on the molecular and cellular processes underlying the disease. The team’s research focuses on stem…

    https://www.gesundheitsindustrie-bw.de/en/article/news/epilepsy-changes-brain-architecture
  • Article - 27/08/2012 17960_de.jpg

    Why don't dogs talk?

    Humans have developed a unique ability to communicate through speech and language. Research focusing on the development of human language and its genetic basis focuses specifically on the developmental gene FOXP2. Evo-devo research has shown that a human-specific FOXP2 variant is key for the human ability to talk. It is likely that the human variant of the rather common FOXP2 protein was already present in Neanderthals.

    https://www.gesundheitsindustrie-bw.de/en/article/news/why-don-t-dogs-talk

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