Press release - 25/01/2021 Protein anchors as a newly discovered key molecule in cancer spread and epilepsy Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases. They published their results in the journal Cell.https:////www.gesundheitsindustrie-bw.de/en/article/press-release/protein-anchors-newly-discovered-key-molecule-cancer-spread-and-epilepsy
Press release - 08/10/2020 New class of highly effective inhibitors protects against neurodegeneration Heidelberg neurobiologists decode central mechanism of degenerative processes in the brains of mouse models and develop new principle for therapeutic agents.https:////www.gesundheitsindustrie-bw.de/en/article/press-release/new-class-highly-effective-inhibitors-protects-against-neurodegeneration
Press release - 29/11/2018 Hattrick in Freiburg Three researchers at the MPI for Immunobiology and Epigenetics receive millions in funding from the European Research Council. Dominic Grün, Nicola Iovino and Ritwick Sawarkar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg will each be awareded one of the prestigious Consolidator Grants of the European Research Council. This means that 6 million euros in funding will go to fundamental research in Freiburg over the next…https:////www.gesundheitsindustrie-bw.de/en/article/press-release/hattrick-in-freiburg
Article - 21/08/2018 Parkinson's disease: vitamin B3 has a positive effect on nerve cells Parkinson's disease is one of the most common neurodegenerative diseases in the world. There are around 4.1 million sufferers worldwide. It is characterised by motor impairments that result from the death of certain nerve cells in the brain. Researchers at the University of Tübingen have now discovered that vitamin B3 has a positive effect on damaged nerve cells and can boost their energy metabolism.https:////www.gesundheitsindustrie-bw.de/en/article/news/parkinsons-disease-vitamin-b3-has-a-positive-effect-on-nerve-cells
Article - 14/12/2016 Transcranial brain stimulation to counteract chronic tiredness You may well be familiar with the ”leaden” feeling associated with lack of sleep. However, chronic tiredness lasting many months might be a sign of a serious disease. Dr. Lukas Frase, together with Prof. Dr. Christoph Nissen’s team at the Freiburg University Medical Center’s Department of Psychiatry and Psychotherapy, has come up with a method to help patients with abnormally high sleep needs. The method uses weak electrostimulation and has the…https:////www.gesundheitsindustrie-bw.de/en/article/news/transcranial-brain-stimulation-to-counteract-chronic-tiredness
Article - 02/08/2016 Can the ticking Huntington clock be stopped? An early phase clinical study involving thirty-six Huntington’s disease (HD) patients is currently underway to investigate whether a method called gene silencing can cure the disease. If the gene that causes the disease can be turned off, it would be the first step towards a treatment that not only fights symptoms but actually treats the causes of HD, hence providing a cure. https:////www.gesundheitsindustrie-bw.de/en/article/news/can-the-ticking-huntington-clock-be-stopped
Company profile - 14/07/2016 neuroloop GmbH: how the manipulation of neuronal information can lower blood pressure Millions of people worldwide suffer from high blood pressure. However, taking medicines to control high blood pressure does not work for everyone. Dr. Dennis Plachta and Prof. Dr. Thomas Stieglitz from IMTEK have now developed a neurostimulator to control blood pressure. Together with Dr. Michael Lauk, an experienced company founder, the two researchers set up a company called neuroloop, which is funded by Aesculap AG and aims to turn the…https:////www.gesundheitsindustrie-bw.de/en/article/news/neuroloop-gmbh-how-the-manipulation-of-neuronal-information-can-lower-blood-pressure
Article - 27/06/2016 A nasal spray for treating neurodegenerative diseases Neuroscientists from Heidelberg have created the scientific foundations for a nasal spray that can stabilise the dendrites of nerve cells, thus reducing nerve damage and brain function losses following a stroke. Prof. Dr. Hilmar Bading and his team received the 2016 German BioRegions Innovation Prize for their invention and have set up a company called FundaMental Pharma to further accelerate the development of a marketable medicinal product.https:////www.gesundheitsindustrie-bw.de/en/article/news/a-nasal-spray-for-treating-neurodegenerative-diseases
Article - 17/05/2016 Innovative biochip for discovering drugs for treating neuronal conditions Parkinson’s, Alzheimer’s and epilepsy are three prominent examples of neuronal conditions (disorders affecting the nerve cells) for which drugs for treatment are intensively sought. Paolo Cesare from the NMI in Reutlingen has developed an innovative 3D system for testing drugs that does not require animal testing. In 2015, the MEAFLUIT system was awarded first prize in BioRegio STERN Management GmbH's Science2Start idea competition. https:////www.gesundheitsindustrie-bw.de/en/article/news/innovative-biochip-for-discovering-drugs-for-treating-neuronal-conditions
Article - 02/05/2016 Biopolymers – raw materials for innovative medical products Polyhydroxyalkanoates (PHA) are biodegradable biopolymers that are becoming increasingly important. Bioplastics are now used not only in everyday objects such as plastic bags and yogurt pots but also increasingly in the field of medicine, which is why intensive research into medical devices made from biodegradable polymers such as PHA has been going on for quite some time. https:////www.gesundheitsindustrie-bw.de/en/article/news/biopolymers-raw-materials-for-innovative-medical-products
Article - 13/01/2016 New approach for treating depression Depression is the most common mental health condition; it must be taken seriously and requires treatment. Exactly how and where therapies work is still unclear. Prof. Dr. Dietrich van Calker and Prof. Dr. Knut Biber from Freiburg University Medical Center have been looking into mechanisms of action and have discovered a molecule that appears to be implicated in numerous neuropsychiatric disorders and the effect of various anti-depression…https:////www.gesundheitsindustrie-bw.de/en/article/news/new-approach-for-treating-depression
Article - 07/01/2016 New protein helps B cells generate an effective immune response The human immune system plays a key role for human health. Dr. Gina Fiala, a scientist in Prof. Dr. Wolfgang Schamel’s team in the Department of Immunology at Freiburg University, has discovered Kidins220/ARMS in B cells. Kidins220/ARMS is part of the adaptive immune system where it plays a key role in the maturation of B cells.https:////www.gesundheitsindustrie-bw.de/en/article/news/kidins220-hilft-b-zellen-bei-der-immunabwehr
Article - 07/12/2015 Microglial cells – the health police of Alzheimer’s It starts with memory loss and disorientation. Alzheimer’s disease is the most common type of dementia and is characterised by the loss of neurons and synapses in the brain resulting from the aggregation of beta amyloid protein fragments into fibrils and plaques. Prof. Dr. Knut Biber and his team from the Division of Molecular Psychiatry at Freiburg University Medical Center have analysed these plaques in an in vivo-like cell culture system. They…https:////www.gesundheitsindustrie-bw.de/en/article/news/microglial-cells-the-health-police-of-alzheimers
Press release - 01/04/2015 Migrating immune cells promote nerve cell demise in the brain The slow death of dopamine-producing nerve cells in a certain region of the brain is the principal cause underlying Parkinson's disease. In mice, it is possible to simulate the symptoms of this disease using a substance that selectively kills dopamine-producing neurons. Scientists from the German Cancer Research Center (DKFZ) have now shown for the first time in mouse experiments that after this treatment, cells of the peripheral immune…https:////www.gesundheitsindustrie-bw.de/en/article/press-release/migrating-immune-cells-promote-nerve-cell-demise-in-the-brain
Article - 17/11/2014 About synapses and learning You can’t teach an old dog new tricks – the old proverb is not totally true. It is now known that the modulation of synaptic functions, including the formation of new neurons, still takes place in old age, although to a lesser extent than in childhood. The human brain stores memories in the form of neural activity patterns. Structural plasticity appears to be the basis for all learning processes. Physician Thomas Hainmüller and Prof. Dr. Marlene…https:////www.gesundheitsindustrie-bw.de/en/article/news/about-synapses-and-learning
Dossier - 10/11/2014 Cell and gene therapies: from bench to bedside While cell therapy has become standard treatment for a number of blood cancers, most cell and gene therapy approaches for the treatment of hereditary and metabolic diseases, neurodegenerative disorders and cancer are still in the experimental phases or early clinical trials. However, recent successes give rise to the hope that cell and gene therapies will in future make important contributions to previously incurable diseases.https:////www.gesundheitsindustrie-bw.de/en/article/dossier/cell-and-gene-therapies-from-bench-to-bedside
Article - 10/11/2014 Alzheimer: amyloid-beta triggers mitochondrial dysfunction Neurons are very sensitive to disturbances and many different functions are no longer able to work efficiently when the power supply is impaired. Prof. Dr. Chris Meisinger and his team at the Institute of Biochemistry and Molecular Biology at the University of Freiburg have found that amyloid-beta peptides block important enzymes in the mitochondria resulting in mitochondrial dysfunction.https:////www.gesundheitsindustrie-bw.de/en/article/news/alzheimer-amyloid-beta-triggers-mitochondrial-dysfunction
Article - 16/06/2014 In vitro models for Parkinson’s research The death of dopamine-producing neurons leads to Parkinson’s disease, but the cause of this selective cell degeneration is unknown. Dr. Stefan Schildknecht from the University of Konstanz is therefore developing human cell culture models to investigate the early molecular processes in the development of Parkinson’s disease. The models can also be used to develop new approaches for the treatment of Parkinson’s.https:////www.gesundheitsindustrie-bw.de/en/article/news/in-vitro-models-for-parkinson-s-research
Article - 31/03/2014 Lsd1 – a gatekeeper for differentiation onset of embryonic mouse stem cells Epigenetics is an emerging field of research that studies heritable changes in gene expression that are not caused by changes in the underlying DNA sequence. Prof. Dr. Roland Schüle, Director of Central Clinical Research at the Freiburg University Medical Centre, and his team are specifically focused on epigenetic modifiers that regulate the timely development of placental mouse tissue. Schüle and his team have discovered in mouse embryos that a…https:////www.gesundheitsindustrie-bw.de/en/article/news/lsd1-a-gatekeeper-for-differentiation-onset-of-embryonic-mouse-stem-cells
Dossier - 20/01/2014 Optogenetics: switching cell activity on and off with light What still sounds like science fiction to the general public has long been within reach for many years scientists have been able to manipulate neural activity selectively with light. They use different wavelengths to turn cells on and off as if they were a standard switch. Optogenetics is an emerging technology that combines optics and genetics. The technology is already used in many different ways for many different purposes by numerous research…https:////www.gesundheitsindustrie-bw.de/en/article/dossier/optogenetics-switching-cell-activity-on-and-off-with-light
Article - 20/01/2014 Microarray copier – for copying DNA, RNA and protein arrays Dr. Günter Roth from the Centre for Biological Systems Analysis at the University of Freiburg is working on the development of a microarray copier that can almost at the push of a button copy arrays of any type of molecule DNA RNA and proteins from next-generation sequencing chips onto standard slides thereby combining the world of microarrays with the sequencing world. The approach has a huge application potential for the production of…https:////www.gesundheitsindustrie-bw.de/en/article/news/microarray-copier-for-copying-dna-rna-and-protein-arrays
Article - 16/12/2013 Tools of the future Optogenetics is a relatively new technique that enables scientists to manipulate nature with light. Light-sensitive proteins coupled to enzymes or channelrhodopsins embedded in membranes that guide ions across plasma membranes all of these can be used to modulate cell behaviour. Researchers around the world are working on the emerging technique in order to refine and optimise it for application in their research projects. Optogenetics seems to…https:////www.gesundheitsindustrie-bw.de/en/article/news/tools-of-the-future
Article - 16/12/2013 Light-activated enzymes for novel optogenetic approaches In a project funded by the German Research Foundation (DFG), researchers from the Max Planck Institute for Medical Research in Heidelberg are studying algal and bacterial photoreceptors that can be used as optogenetic tools for studying regulatory and metabolic pathways. Through the insertion of a light-activated bacterial enzyme into zebrafish, the researchers have been able to visualise a hormonal reaction chain that is induced by stress…https:////www.gesundheitsindustrie-bw.de/en/article/news/light-activated-enzymes-for-novel-optogenetic-approaches
Article - 09/12/2013 Photoreceptors added to optogenetic toolbox After light-gated ion channels in nerve cells had successfully paved the way for optogenetics numerous tools have been added to the optogenetic toolbox. Photoreceptors are novel optogenetic tools which when coupled to enzymes and kinases can trigger certain cell functions upon illumination with light. Prof. Dr. Wilfried Weber synthetic biologist at BIOSS Centre for Biological Signalling Studies at the University of Freiburg is one of the…https:////www.gesundheitsindustrie-bw.de/en/article/news/photoreceptors-added-to-optogenetic-toolbox
Article - 02/12/2013 ERC Starting Grant for spectral fingerprints of neuronal interactions Dr. Markus Siegel from the Centre for Integrative Neuroscience (CIN) at the University of Tübingen deals with fingerprints, but rather than those used to solve crime, he is interested in fingerprints of nerve cell activity in the brain. Siegel uses these fingerprints to explore the mechanisms that coordinate the interactions between different brain regions, which is what enables humans to learn, perceive and decide. He was recently awarded one of…https:////www.gesundheitsindustrie-bw.de/en/article/news/erc-starting-grant-for-spectral-fingerprints-of-neuronal-interactions