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  • Press release - 25/01/2021

    Protein anchors as a newly discovered key molecule in cancer spread and epilepsy

    Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases. They published their results in the journal Cell.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/protein-anchors-newly-discovered-key-molecule-cancer-spread-and-epilepsy
  • Press release - 08/10/2020

    New class of highly effective inhibitors protects against neurodegeneration

    Heidelberg neurobiologists decode central mechanism of degenerative processes in the brains of mouse models and develop new principle for therapeutic agents.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/new-class-highly-effective-inhibitors-protects-against-neurodegeneration
  • Press release - 29/11/2018

    Hattrick in Freiburg

    Three researchers at the MPI for Immunobiology and Epigenetics receive millions in funding from the European Research Council. Dominic Grün, Nicola Iovino and Ritwick Sawarkar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg will each be awareded one of the prestigious Consolidator Grants of the European Research Council. This means that 6 million euros in funding will go to fundamental research in Freiburg over the next…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/hattrick-in-freiburg
  • Article - 21/08/2018 Cells stained blue and red.

    Parkinson's disease: vitamin B3 has a positive effect on nerve cells

    Parkinson's disease is one of the most common neurodegenerative diseases in the world. There are around 4.1 million sufferers worldwide. It is characterised by motor impairments that result from the death of certain nerve cells in the brain. Researchers at the University of Tübingen have now discovered that vitamin B3 has a positive effect on damaged nerve cells and can boost their energy metabolism.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/parkinsons-disease-vitamin-b3-has-a-positive-effect-on-nerve-cells
  • Article - 14/12/2016 Slow-Waves-EEG.jpg

    Transcranial brain stimulation to counteract chronic tiredness

    You may well be familiar with the ”leaden” feeling associated with lack of sleep. However, chronic tiredness lasting many months might be a sign of a serious disease. Dr. Lukas Frase, together with Prof. Dr. Christoph Nissen’s team at the Freiburg University Medical Center’s Department of Psychiatry and Psychotherapy, has come up with a method to help patients with abnormally high sleep needs. The method uses weak electrostimulation and has the…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/transcranial-brain-stimulation-to-counteract-chronic-tiredness
  • Article - 02/08/2016 Huntington_Eiweiss_Abb_Dr_Katrin_Lindenberg_Neurologie_UK_Ulm.jpg

    Can the ticking Huntington clock be stopped?

    An early phase clinical study involving thirty-six Huntington’s disease (HD) patients is currently underway to investigate whether a method called gene silencing can cure the disease. If the gene that causes the disease can be turned off, it would be the first step towards a treatment that not only fights symptoms but actually treats the causes of HD, hence providing a cure.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/can-the-ticking-huntington-clock-be-stopped
  • Company profile - 14/07/2016 Schematic showing how the neurostimulator leads to the stimulation of the vagus nerve lowers the blood pressure.

    neuroloop GmbH: how the manipulation of neuronal information can lower blood pressure

    Millions of people worldwide suffer from high blood pressure. However, taking medicines to control high blood pressure does not work for everyone. Dr. Dennis Plachta and Prof. Dr. Thomas Stieglitz from IMTEK have now developed a neurostimulator to control blood pressure. Together with Dr. Michael Lauk, an experienced company founder, the two researchers set up a company called neuroloop, which is funded by Aesculap AG and aims to turn the…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/neuroloop-gmbh-how-the-manipulation-of-neuronal-information-can-lower-blood-pressure
  • Article - 27/06/2016 Bading_Hilmar.jpg

    A nasal spray for treating neurodegenerative diseases

    Neuroscientists from Heidelberg have created the scientific foundations for a nasal spray that can stabilise the dendrites of nerve cells, thus reducing nerve damage and brain function losses following a stroke. Prof. Dr. Hilmar Bading and his team received the 2016 German BioRegions Innovation Prize for their invention and have set up a company called FundaMental Pharma to further accelerate the development of a marketable medicinal product.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/a-nasal-spray-for-treating-neurodegenerative-diseases
  • Article - 17/05/2016 Schematic of the entire chip and an amplified sector showing the central area of the square chip along with the round seeding areas and microchannels.

    Innovative biochip for discovering drugs for treating neuronal conditions

    Parkinson’s, Alzheimer’s and epilepsy are three prominent examples of neuronal conditions (disorders affecting the nerve cells) for which drugs for treatment are intensively sought. Paolo Cesare from the NMI in Reutlingen has developed an innovative 3D system for testing drugs that does not require animal testing. In 2015, the MEAFLUIT system was awarded first prize in BioRegio STERN Management GmbH's Science2Start idea competition.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/innovative-biochip-for-discovering-drugs-for-treating-neuronal-conditions
  • Article - 02/05/2016 hv_PhaZd1__C_WT.jpg

    Biopolymers – raw materials for innovative medical products

    Polyhydroxyalkanoates (PHA) are biodegradable biopolymers that are becoming increasingly important. Bioplastics are now used not only in everyday objects such as plastic bags and yogurt pots but also increasingly in the field of medicine, which is why intensive research into medical devices made from biodegradable polymers such as PHA has been going on for quite some time.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/biopolymers-raw-materials-for-innovative-medical-products
  • Article - 13/01/2016 Drawing from the book "Max and Moritz" showing teacher Lämpel about to go to bed. A prohibition sign is    drawn across the bed.

    New approach for treating depression

    Depression is the most common mental health condition; it must be taken seriously and requires treatment. Exactly how and where therapies work is still unclear. Prof. Dr. Dietrich van Calker and Prof. Dr. Knut Biber from Freiburg University Medical Center have been looking into mechanisms of action and have discovered a molecule that appears to be implicated in numerous neuropsychiatric disorders and the effect of various anti-depression…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/new-approach-for-treating-depression
  • Article - 07/01/2016 Schematic showing a B-cell receptor in the plasma membrane and the protein Kidins220.

    New protein helps B cells generate an effective immune response

    The human immune system plays a key role for human health. Dr. Gina Fiala, a scientist in Prof. Dr. Wolfgang Schamel’s team in the Department of Immunology at Freiburg University, has discovered Kidins220/ARMS in B cells. Kidins220/ARMS is part of the adaptive immune system where it plays a key role in the maturation of B cells.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/kidins220-hilft-b-zellen-bei-der-immunabwehr
  • Article - 07/12/2015 Fluorescence image where plaques are clearly visible.

    Microglial cells – the health police of Alzheimer’s

    It starts with memory loss and disorientation. Alzheimer’s disease is the most common type of dementia and is characterised by the loss of neurons and synapses in the brain resulting from the aggregation of beta amyloid protein fragments into fibrils and plaques. Prof. Dr. Knut Biber and his team from the Division of Molecular Psychiatry at Freiburg University Medical Center have analysed these plaques in an in vivo-like cell culture system. They…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/microglial-cells-the-health-police-of-alzheimers
  • Press release - 01/04/2015 23155_de.jpg

    Migrating immune cells promote nerve cell demise in the brain

    The slow death of dopamine-producing nerve cells in a certain region of the brain is the principal cause underlying Parkinson's disease. In mice, it is possible to simulate the symptoms of this disease using a substance that selectively kills dopamine-producing neurons. Scientists from the German Cancer Research Center (DKFZ) have now shown for the first time in mouse experiments that after this treatment, cells of the peripheral immune…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/migrating-immune-cells-promote-nerve-cell-demise-in-the-brain
  • Article - 17/11/2014 Microscope image of two nerve cells that are connected with each other.<br />

    About synapses and learning

    You can’t teach an old dog new tricks – the old proverb is not totally true. It is now known that the modulation of synaptic functions, including the formation of new neurons, still takes place in old age, although to a lesser extent than in childhood. The human brain stores memories in the form of neural activity patterns. Structural plasticity appears to be the basis for all learning processes. Physician Thomas Hainmüller and Prof. Dr. Marlene…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/about-synapses-and-learning
  • Dossier - 10/11/2014 22065_de.jpg

    Cell and gene therapies: from bench to bedside

    While cell therapy has become standard treatment for a number of blood cancers, most cell and gene therapy approaches for the treatment of hereditary and metabolic diseases, neurodegenerative disorders and cancer are still in the experimental phases or early clinical trials. However, recent successes give rise to the hope that cell and gene therapies will in future make important contributions to previously incurable diseases.

    https:////www.gesundheitsindustrie-bw.de/en/article/dossier/cell-and-gene-therapies-from-bench-to-bedside
  • Article - 10/11/2014 22262_de.jpg

    Alzheimer: amyloid-beta triggers mitochondrial dysfunction

    Neurons are very sensitive to disturbances and many different functions are no longer able to work efficiently when the power supply is impaired. Prof. Dr. Chris Meisinger and his team at the Institute of Biochemistry and Molecular Biology at the University of Freiburg have found that amyloid-beta peptides block important enzymes in the mitochondria resulting in mitochondrial dysfunction.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/alzheimer-amyloid-beta-triggers-mitochondrial-dysfunction
  • Article - 16/06/2014 The photo shows Hanne Gerding, Dr. Christiaan Karreman and Dr. Stefan Schildknecht in the laboratory standing close to/sitting at a clean bench.

    In vitro models for Parkinson’s research

    The death of dopamine-producing neurons leads to Parkinson’s disease, but the cause of this selective cell degeneration is unknown. Dr. Stefan Schildknecht from the University of Konstanz is therefore developing human cell culture models to investigate the early molecular processes in the development of Parkinson’s disease. The models can also be used to develop new approaches for the treatment of Parkinson’s.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/in-vitro-models-for-parkinson-s-research
  • Article - 31/03/2014 Microscopic image in which the nuclei and cytoskeleton are strained.

    Lsd1 – a gatekeeper for differentiation onset of embryonic mouse stem cells

    Epigenetics is an emerging field of research that studies heritable changes in gene expression that are not caused by changes in the underlying DNA sequence. Prof. Dr. Roland Schüle, Director of Central Clinical Research at the Freiburg University Medical Centre, and his team are specifically focused on epigenetic modifiers that regulate the timely development of placental mouse tissue. Schüle and his team have discovered in mouse embryos that a…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/lsd1-a-gatekeeper-for-differentiation-onset-of-embryonic-mouse-stem-cells
  • Dossier - 20/01/2014

    Optogenetics: switching cell activity on and off with light

    What still sounds like science fiction to the general public has long been within reach for many years scientists have been able to manipulate neural activity selectively with light. They use different wavelengths to turn cells on and off as if they were a standard switch. Optogenetics is an emerging technology that combines optics and genetics. The technology is already used in many different ways for many different purposes by numerous research…

    https:////www.gesundheitsindustrie-bw.de/en/article/dossier/optogenetics-switching-cell-activity-on-and-off-with-light
  • Article - 20/01/2014 The photo shows a small metal device with wires and standing in a mount.

    Microarray copier – for copying DNA, RNA and protein arrays

    Dr. Günter Roth from the Centre for Biological Systems Analysis at the University of Freiburg is working on the development of a microarray copier that can almost at the push of a button copy arrays of any type of molecule DNA RNA and proteins from next-generation sequencing chips onto standard slides thereby combining the world of microarrays with the sequencing world. The approach has a huge application potential for the production of…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/microarray-copier-for-copying-dna-rna-and-protein-arrays
  • Article - 16/12/2013 Network with red glowing neurons.

    Tools of the future

    Optogenetics is a relatively new technique that enables scientists to manipulate nature with light. Light-sensitive proteins coupled to enzymes or channelrhodopsins embedded in membranes that guide ions across plasma membranes all of these can be used to modulate cell behaviour. Researchers around the world are working on the emerging technique in order to refine and optimise it for application in their research projects. Optogenetics seems to…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/tools-of-the-future
  • Article - 16/12/2013 20758_de.jpg

    Light-activated enzymes for novel optogenetic approaches

    In a project funded by the German Research Foundation (DFG), researchers from the Max Planck Institute for Medical Research in Heidelberg are studying algal and bacterial photoreceptors that can be used as optogenetic tools for studying regulatory and metabolic pathways. Through the insertion of a light-activated bacterial enzyme into zebrafish, the researchers have been able to visualise a hormonal reaction chain that is induced by stress…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/light-activated-enzymes-for-novel-optogenetic-approaches
  • Article - 09/12/2013 Cell culture dish on a mobile phone screen.

    Photoreceptors added to optogenetic toolbox

    After light-gated ion channels in nerve cells had successfully paved the way for optogenetics numerous tools have been added to the optogenetic toolbox. Photoreceptors are novel optogenetic tools which when coupled to enzymes and kinases can trigger certain cell functions upon illumination with light. Prof. Dr. Wilfried Weber synthetic biologist at BIOSS Centre for Biological Signalling Studies at the University of Freiburg is one of the…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/photoreceptors-added-to-optogenetic-toolbox
  • Article - 02/12/2013 Network of brain areas.

    ERC Starting Grant for spectral fingerprints of neuronal interactions

    Dr. Markus Siegel from the Centre for Integrative Neuroscience (CIN) at the University of Tübingen deals with fingerprints, but rather than those used to solve crime, he is interested in fingerprints of nerve cell activity in the brain. Siegel uses these fingerprints to explore the mechanisms that coordinate the interactions between different brain regions, which is what enables humans to learn, perceive and decide. He was recently awarded one of…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/erc-starting-grant-for-spectral-fingerprints-of-neuronal-interactions

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