Healthcare industry

Dossier - 24/04/2008

Contract manufacture: the order books remain full

The market for therapeutic proteins is continuing to grow in double figures. Current estimates of the total market value are in the range of 60 to 70 billion US dollars and the market is estimated to grow by 13 per cent p.a. up until 2010. Biopharmaceutical contract manufacturers have established themselves on the market and market observers estimate that the number of biopharmaceutical medicines will grow from 100 2005 to approx. 150 until 2010.

Almost half of the veins transplanted to restore blood flow in the heart become clogged again within ten years after surgery. Gene therapy pre-treatment of the vein fragments that prevents the muscle cells from entering the vascular wall might decrease the risk of this happening.

It began as a service laboratory for DNA sequencing and within a few years became a worldwide network of highly specialised biotech companies for molecular biology products. Investments in platform technologies play a key role in this development. Since then the team at Stuttgart-based BioLux GmbH has found that the production of antibodies is its highest revenue business activity.

Professor Roland Schuele from the University Womens Hospital in Freiburg originally studied biochemistry. Nowadays Schuele is researching the development of prostate cancer. During his scientific career he has learnt that research cannot be steered in a particular direction. It develops and we follow it said Schuele who has been able to gain astonishing insights into the molecular processes in tumour cells.

Researchers at the German Cancer Research Center have discovered a key molecule that is responsible for the immature structure of blood vessels in malignant tumors. If this molecule is switched off in mice vessels normalize so that immune cells are better able to get to the tumor tissue.

The neurogeneticists in the group of Professor Karl-Friedrich Fischbach at the University of Freiburg are investigating how the complex optical areas of the brain are organised. They found that proteins form a functional unit.

Article - 06/04/2008

Molecular chaperons in algal chloroplasts

Michael Schroda from the Department of Plant Biochemistry at the University of Freiburg is examining the role of HSP70B a chaperon in the chloroplasts of Chlamydomonas reinhardtii algae which is important for protecting the algae against high light intensity.

Article - 30/03/2008

Small air bubbles with a huge impact

Scientists from the Max Planck Institute for Metal Research in Stuttgart and their colleagues from Chicago and Miami have identified a physical mechanism that gives a new explanation as to how ion channels work.

Scientists from the Max Planck Institute for Developmental Biology in Tübingen and their colleagues from the International Rice Research Institute in the Philippines succeeded in accelerating rice plant breeding by using artificial small RNA molecules.

Working with colleagues from the Harvard Medical School in Boston USA researchers from Freiburg University have discovered a previously unknown role of insulin in ageing and lifespan. Insulin inhibits a master stress regulator protein known as SKN-1.

GATC Biotech announced that it has added to its facilities with a wholly owned subsidiary in Stockholm Sweden building on the Companys existing presence in Europe with offices in Germany France and England.

Article - 24/03/2008

Successful cooperation between science and industry

At the recent Science meets Business Day four tandem teams of the German BioValley Platform presented their projects. These will be introduced in two articles. The first article focuses on natural substances with a pharmaceutical potential.

The paper by Lohmueller et al. 2008 shows that there is proportionally more deleterious genetic variation in European than in African populations. This revelation enables conclusions to be made on the group that emigrated from Africa several thousand years ago.

Article - 16/03/2008

New indication for lead compound of Apogenix

Isolated tumour cells use to invade healthy brain tissue during the development and growth of glioblastoma multiforme GBM. This mechanism involves the CD95CD95L death system. These results supports the therapeutic potential of Apogenix APG101 for the treatment of glioblastomas.

The directors of the Tübingen Max Planck Institute MPI for Developmental Biology are pleased to have a Leibniz prizewinner in their ranks for the second year running. Dr. Elisa Izaurralde and her colleague Dr. Elena Conti have both been awarded the 2008 prize for their outstanding work in the field of RNA research.

Nils Johnssons work focuses on communication research involving living objects. The 48-year-old biochemist is investigating how proteins manage the complicated process of cytokinesis the division of the cell plasma. Thanks to a specific method Johnsson is able to detect when proteins are interacting with each other.

Christiane Pelzer and Ingrid Kassner biologists at the University of Constance recently discovered a previously unknown protein that plays a role in the binding of ubiquitin to target proteins. This discovery is a milestone in the research of basic enzymatic processes.

Red biotechnology became commercially successful because process engineering succeeded in expressing foreign genes in microorganisms and got a grip on cells tissue cells were not only cultivated using technical methods but also purified for medical application on an industrial scale. However the biopharmaceutical industry is now facing rising costs.

The history of Bt-maize is a strange mix of opportunities risks scientific contradictions market authorisations and recalls. It is also an excellent example of why the public scepticism towards genetically modified organisms GMO is growing.

The Dietmar Hopp Foundation has donated one million euro for a new small-animal tomograph at the University Hospital in Heidelberg. The new system is suitable for small animals such as rats and mice and can be used to investigate diseases and therapies.

Holger Barth works with a special kind of Trojan horses. The toxicologist from Ulm is investigating bacterial toxins. These proteins manage in a similar way to the ancient Greeks before them to open the barricaded portal of the cells with a trick whereupon they start wreaking destruction.

Dr. Gilbert Gorr has been fascinated by the moss Physcomitrella patens for many years in fact it occupies a great deal of his waking moments. The enthusiasm with which the CSO of greenovation Biotech GmbH talks about the key object of his work is both intoxicating and contagious. The latest discovery The moss produces a therapeutic antibody that is far more effective than its predecessors created in animal cell cultures.

Biametrics Marken and Rechte GmbH has developed new analytical devices based on reflectometric interference spectroscopy thus adopting the trend of label-free detection methods. This is because labelling tends to interfere with the natural activity of the biomolecules under investigation.

The forensic scientist Dr. Frank Wehner from the University of Tübingen has developed a method that enables him to determine the time of death to within a few days. The method is based on the degradation of proteins like insulin or cystatin C.

Article - 21/02/2008

The females choose their mates

The team of researchers led by evolutionary biologist Dr. Gerrit Begemann at Constance University is using swordtails to investigate the development of traits that evolved by sexual selection. Their major focus is the molecular mechanism of growth control in the caudal fin. Or put more simply why do these fish have swords?