Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors.

A new network has been set up in Baden-Württemberg aimed at reducing animal experiments as well as further improving animal welfare. It combines new approaches and measures at the state’s biomedical research locations, which are expected to limit stress in laboratory animals and steadily reduce the number of animals used in research in line with the 3R principles of Replacement, Reduction, and Refinement.

Expert interview - 03/03/2021

Healthcare movers – the future of Baden-Württemberg's healthcare industry

The 'Healthcare Movers 2020 - Baden-Württemberg Report' reveals the potentials and challenges Baden-Württemberg healthcare companies encounter as the digital transformation of the healthcare market progresses. In an interview with Dr. Ariane Pott from BIOPRO, the authors of the report, Beatus Hofrichter and Dr. Ursula Kramer, explain what is required to take the major step towards becoming a digital avant-garde company.

On 8 February, the European Parliament adopted its Own Initiative Report on the Circular Economy which recognised the role of bioplastics for the future. Amongst other issues highlighted, the MEPs emphasised the potential role of bio–based and biodegradable and compostable plastics in the circular economy whilst noting that bio-based and/or biodegradable plastics alone will not provide a solution to the environmental concerns related to plastics.

So-called silent mutations have no effect on the composition of a protein. They are therefore not considered to promote cancer. However, scientists from the German Consortium for Translational Cancer Research (DKTK), partner site Essen, now describe in a case of kidney cancer an overlooked silent mutation with a major impact on prognosis.

Neuroblastoma can spread relentlessly or shrink spontaneously. Scientists from the Hopp Children’s Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg and the National Center for Tumor Diseases (NCT) Heidelberg have shown that some malignant neuroblastomas employ a trick to avoid cell death: they use a special mechanism to lengthen the telomeres at the end of their chromosomes.

The European Commission agreed on the successor of BBI JU – the Circular Bio-based Europe Joint Undertaking (CBE JU) in a legislative proposal adopted today. The new partnership between the EU and the Bio-based Industries Consortium (BIC) is expected to build on the success of BBI JU while stepping up its contribution to the EU’s climate targets, in line with the European Green Deal. The European Parliament and Council will now study the…

Agrivoltaics enables the dual use of arable land: Photovoltaic modules, which are mounted on a structure, generate renewable electricity and underneath agricultural crops grow. The approach increases land efficiency and could mitigate conflicts over the use of arable land in the future. A new guideline provides up-to-date information on the technology, its potential and the current state of development.

Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics.

Article - 17/02/2021

Whole blood model enables development of early warning system for sepsis

Sepsis is a life-threatening disease that can be treated all the more successfully the faster therapy is initiated. It is not just the infection itself that is so dangerous, but a dysregulated response of the immune system. Physicians at Ulm University Hospital have now developed an animal-free test system that can be used to research the disease and develop innovative diagnostic tools to quickly assess a patient's sepsis risk and optimise…

An international research team involving the universities of Paraná and Tübingen has developed a rapid test that can reliably identify Covid-19 antibodies in the blood within minutes. As the researchers report in the journal ACS Sensors, the new process is based on a simple measuring principle making it easy to carry out without expensive instruments, and is therefore suitable for use at mobile testing centers or by laboratories.

Textiles can be coated with the biopolymer chitosan and thus made water-repellent by binding hydrophobic molecules. The good thing is that this can also replace toxic and petroleum-based substances that are currently used for textile finishing. In the last few years Fraunhofer IGB and partners have developed technology to provide fibers with the desired properties using biotechnological processes and chitosan.

University of Hohenheim project contributes to maintaining valuable biotopes: Autonomous robot to help prune fruit trees so they stay healthy.

From field to socket - 03/02/2021

Energy park & Donau-Silphie: a symbiosis that benefits nature

Biogas plants that produce non-fossil fuels are very much in vogue at the moment. In the Swabian hamlet of Hahnennest, four family farms have joined forces to form an energy park and operate a local biogas plant, covering everything from substrate production to the sale of energy.

Microbiologists at the University of Tübingen modify bacteria to produce climate-neutral and rapidly degradable bioplastics.

In a so-called inactivated or killed vaccine, the virus particles it contains are first rendered inactive by means of the toxic chemical formaldehyde. A better way of achieving this, however, is to irradiate the pathogens with low-energy electrons. Four Fraunhofer Institutes have now developed a new method of vaccine production based on this technique that is not only quicker but also guarantees a higher quality of product.

For quite some time now, the European Commission (EC) is putting a special focus on biodegradable and compostable polymers when assessing the general role of bioplastics.

Can interconnected digital assistance systems enhance the quality of life of people in older age? Scientists in an interdisciplinary research project at Heidelberg University are exploring this question in a representative practice study. The participating researchers want to investigate how well these technical aids can be used and what benefit they achieve.

The University of Warmia and Mazury in Olsztyn, Polish partner of the BalticBiomass4Value project, published a report which maps biomass value chains for improved sustainable energy use in the Baltic Sea Region countries. The research focuses on the 9 Baltic Sea Region (BSR) countries: Denmark, Germany, Estonia, Finland, Latvia, Lithuania, Poland, Sweden, and Norway.

Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases. They published their results in the journal Cell.

Paper production from plant fibres - 20/01/2021

In one cycle: ecopaper, energy and fertiliser made from Silphium perfoliatum

Many consumers don't care about exactly how their paper packaging is made and what it is made of as long as it is "eco". But even producing recycled paper, trees need to be felled. An alternative could be paper made from cup plant. Together with partners, a company called Silphie Paper has developed concept for obtaining fibres for a new type of grass paper, while also producing heat, energy and nutrients for natural fertilisers.

A specific variant of the surface protein VSG of African trypanosomes, the causative agents of sleeping sickness, is associated with resistance to the important drug Suramin. Scientists at the German Cancer Research Center have now been able to find a possible explanation for the formation of resistance based on the crystal structure of this protein variant.

Biobased building materials - 14/01/2021

Chitin for the development of sustainable materials for use in the construction and other industries

Pliable and robust, light and stable - it sounds like an ideal material for the construction and many other industries. A team of researchers at the University of Stuttgart is researching what purposes the naturally good properties of chitin can serve.

Article - 14/01/2021

Newly discovered RNA as growth driver in liver cancer

Non-coding RNA (ncRNAs) molecules that do not encode proteins have many different functions, and some are associated with certain diseases. Prof. Dr. Sven Diederichs from the German Consortium for Translational Cancer Research and the German Cancer Research Center in Heidelberg has been conducting research into these molecules at the Freiburg University Medical Centre and discovered a ncRNA that regulates cell proliferation in cancer cells.

CureVac N.V., a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), today announced the publication of preclinical data demonstrating the induction of robust antibody and T cell responses of its COVID-19 vaccine candidate, CVnCoV, in non-human primates.

Hier werden die abgeschlossenen Projekte gesammelt.

Bayer has signed a collaboration and services agreement with CureVac, a biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid. Under the terms of the agreement, Bayer will support the further development, supply and key territory operations of CureVac´s COVID-19 vaccine candidate CVnCoV.

Infection control - 07/01/2021

Gene accordions as potential markers for pathogenic properties

Bacteria must react to changes in the environment in order to survive. This is partly done by adapting genetic material, for example by multiplying and shortening individual genome segments. The research group led by Dr. Simon Heilbronner from the Interfaculty Institute of Microbiology and Infection Medicine at the University of Tübingen has shown that these so-called gene accordions are frequently found in the bacterium Staphylococcus aureus.

As healthy and tasty as mushrooms might be, they are good for much more than just the dinner plate. The Fraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT has now teamed up with the Fraunhofer Institute for Building Physics IBP to investigate the use of fungus-based materials for the fabrication of eco-friendly sound absorbers.

Natural substance with herbicide potential - 10/12/2020

The same but different: What makes sugar 7Sdh a better herbicide?

The sugar 7-deoxy-sedoheptulose (7dSh) is produced by cyanobacteria and inhibits the same metabolic pathway as the broad-spectrum herbicide glyphosate, thus making it an excellent herbicide candidate. Despite this amazing similarity, the microbiologist who discovered 7dSh, Prof. Dr. Karl Forchhammer, believes that this sugar has clear ecological advantages over glyphosate.

Digitalisation in Medicine - 08/12/2020

DiHeSys takes steps towards application

Digital Health Systems GmbH (DiHeSys) has completed its founding phase and entered a new stage of development. This is reflected in the arrival of a new managing director, a strategic cooperation and its first pilot projects.

Development of the genomDE genome database - 04/12/2020

Whole genome sequencing for diagnosing rare diseases

Grouped together, rare diseases are by no means a rare phenomenon; however, they are rarely correctly diagnosed and rarely properly treated. In most cases, there is no effective medication available. Rare disease centres staffed by experts have been set up in many German cities to speed up the often long and painful search for the right diagnosis and treatment. Whole genome sequencing is a component of general healthcare, used to identify…

Outlook on the future of agriculture - 30/11/2020

Agriculture 4.0 - ultramodern and without harmful plant protection products

The demand for organic products is continuing to grow; at the same time nature is being preserved – so why not switch completely to organic farming? The answer is simple: because not everyone can afford it, and with current consumption patterns not everyone would get enough to eat. A cooperative project is researching an an agricultural system that falls between conventional and organic farming.

New method for analysing blood samples - 26/11/2020

Personalised therapy monitoring for malignant melanomas

Immunotherapy has greatly improved the survival chances of patients with malignant melanoma. A study has now begun at the Department of Dermatology at the University Hospital of Tübingen to develop a way to monitor the course of treatment as effectively as possible. It involves personalised monitoring using liquid biopsies in addition to conventional PET/CT examinations. This analysis procedure of blood samples could enable closer monitoring of…

Development of biogenic packaging - 16/11/2020

Sustainable packaging - the devil is in the detail

Modern packaging often boils down to a tick list of biogenic origin and/or biodegradability. But comprehensive sustainable packaging concepts need more than just that. Perishable foods, for example, require special barrier properties. The Albstadt-Sigmaringen University of Applied Sciences is researching packaging concepts for their sustainability.

Lab-on-a-chip - 11/11/2020

Microfluidic platform for the best possible cancer therapy

Every tumour and every patient is different, and there are individual reactions to drugs as well as the problem of resistance. Patient-specific cancer treatments require innovative and cost-effective approaches. The TheraMe! consortium has developed a novel instrument: a combination of microfluidic experiments and mathematical modelling for use in cancer precision medicine to prevent incorrect therapy options.

Dossier - 09/11/2020

Packaging of the future

What will the packaging of the future look like, and what will be required of it? Can packaging be biobased, recyclable, sustainable and economic? In Baden-Württemberg, there are various approaches to developing packaging with the above properties from various sources including agricultural residual and side streams as well as municipal waste.

Article - 04/11/2020

Rapid coronavirus test delivers results in 43 minutes

The Hahn-Schickard Institute and Spindiag GmbH in Freiburg im Breisgau have joined forces to develop a rapid test used at the point of care. The test takes just 43 minutes to show whether a patient is infected with the coronavirus SARS-CoV-2. The rapid test is expected to be given market approval in Germany and the EU during the final quarter of 2020.

Inside the fight against COVID-19 - 28/10/2020

A new immunotherapeutic agent for treating severe COVID-19 cases

Apogenix, a Heidelberg-based biopharmaceutical company specialising in innovative immunotherapeutics, has initiated a Phase II clinical trial with asunercept, the company’s lead drug candidate for treating severe cases of COVID-19. The fusion protein blocks the CD95-ligand-mediated death of epithelial cells in the lung and thus prevents damage to the organ.

Phosphorus recovery from sewage sludge - 21/10/2020

Bacteria help to recycle phosphorus

Biotechnology for the bioeconomy: in something known as the P-bac process, sulphur bacteria extract phosphorus from sewage sludge ash. Phosphorus is one of the key building blocks of life and an essential nutrient for plant growth. When there is not enough phosphorus in the soil, farmers apply it via organic or mineral fertilisers.

Atriva Therapeutics - 21/10/2020

COVID-19 pioneer drug in Phase II clinical trial - with double the power

The effective treatment of people with severe COVID-19 is a major goal during the corona pandemic. ATR-002, an oral small molecule that targets RNA viruses such as influenza virus and SARS-CoV-2, has a dual effect: it impairs viral propagation and also has an immunomodulatory effect. And what’s more, due to its unique cellular mechanism of action, the efficacy of Atrivia Therapeutics’ drug candidate is not reduced by virus mutations and…