European project with participation of the University of Hohenheim investigates how unprofitable fields can be used sustainably while adding value with renewable raw materials.

Press release - 01/04/2021

Joint Masterplan on bioeconomy in the Alpine macro-region unveiled

AlpLinkBioEco Interreg project presents one of its main results.

CureVac N.V., a biopharmaceutical company developing a new class of transformative medicines based on mRNA and Celonic Group, a premium biopharmaceutical Contract Development and Manufacturing Organization specializing in the development and production of Advanced Therapy Medicinal Products and mammalian cell line-expressed bio-therapeutics, announced their partnership for the production of CureVac’s mRNA-based COVID-19 vaccine candidate, CVnCoV.

Tumor vaccines can help the body fight cancer. Mutations in the tumor genome often lead to protein changes that are typical of cancer. A vaccine can alert the patients' immune system to these mutated proteins. For the first time, physicians and cancer researchers from Heidelberg and Mannheim have now carried out a clinical trial to test a mutation-specific vaccine against malignant brain tumors.

Immunotherapy using checkpoint inhibitors is effective in around a quarter of patients with liver cancer. However, to date, physicians have been unable to predict which patients would benefit from this type of treatment and which would not. Researchers from the German Cancer Research Center have now discovered that liver cancer caused by chronic inflammatory fatty liver disease does not respond to this treatment. On the contrary: in an…

Microfluidics in medical technology - 24/03/2021

Ultra-compact: valves with shape memory actuators

Karlsruhe-based company memetis shows that this is possible. Intelligent components for controlling fluids open up huge potential in the medical technology and biotechnology sectors - from vaccine development and cell line analysis to drug research and point-of-care solutions.

AFYREN secures procurement of sugar beet co-products, major feedstock for industrial- scale production of its sustainable chemicals.

CureVac N.V., a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), today announced the publication of preclinical data demonstrating that their COVID-19 vaccine candidate, CVnCoV, protects against challenge infections with the SARS-CoV-2 Variant of Concern B.1.351 and a strain of the original SARS-CoV-2 B1 lineage (BavPat1) in a transgenic mouse model.

A new method allows stem cells and cancer stem cells to be studied at the single cell level and the resulting cell clones to be traced directly. Studying thousands of individual cells in parallel, the researchers combined the analysis of the genomic cancer mutations with the associated expression profiles.

Systematically prepared and easily accessible research data can provide an essential basis for decision-making for a wide range of stakeholders from politics, science and industry. The resource database developed by the DBFZ, which contains a wealth of information on various biomass potentials and their current use, has been extensively expanded and is now also available in two languages (DE/EN) with a variety of new functionalities.

Article - 17/03/2021

Epigenetic switches in bacteria as biosensors

The analysis of pathogen biomarkers and biomarkers for the diagnosis of diseases can be crucial for health. However, the detection of pathogens and diseases depends on a sensitive and reliable method that delivers rapid results. Biosensors have such properties. Researchers at the Institute of Biochemistry and Technical Biochemistry (IBTB) at Stuttgart University have constructed an epigenetic circuit composed of plasmids that might make it…

Do BMMFs, the novel infectious agents found in dairy products and bovine sera, play a role in the development of colorectal cancer? Scientists led by Harald zur Hausen detected the pathogens in colorectal cancer patients in close proximity to tumors. The researchers show that the BMMFs trigger local chronic inflammation, which can cause mutations via activated oxygen molecules and thus promote cancer development in the long term.

Women have an increased risk of breast cancer if they have a family history of this disease. However, the risk may also be higher if first-degree family members have another type of cancer, according to a study by a team of scientists and physicians from the National Center for Tumor Diseases (NCT) Heidelberg, the German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), as well as international colleagues.

Article - 10/03/2021

Faster to single cells using miniature grinder

Tissue cells are needed for medical diagnostics, cell therapies and tissue engineering, among other things. A novel tissue grinder gently and automatically dissociates cells from tissue. In November 2020, the newly founded biotech company Fast Forward Discoveries GmbH (FFX) delivered its first tissue grinders to customers.

Paper technology - 10/03/2021

PLAFCO – a sustainable plastic substitute made from paper

Plastic is indispensable: it is cheap and practical and found in many disposable products such as drinking straws, disposable tableware or even packaging like bonded beverage cartons or bags – and it has a disastrous effect on the environment. The start-up company Plafco Fibertech Oy has developed a sustainable plastic substitute made of paper that could replace many disposable plastic products in the future.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), and Novartis AG announced today that they have signed an initial agreement for the manufacturing of CureVac’s COVID-19 vaccine candidate, CVnCoV. Preparations for the start of production, technology transfers and test runs are already underway.

Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors.

A new network has been set up in Baden-Württemberg aimed at reducing animal experiments as well as further improving animal welfare. It combines new approaches and measures at the state’s biomedical research locations, which are expected to limit stress in laboratory animals and steadily reduce the number of animals used in research in line with the 3R principles of Replacement, Reduction, and Refinement.

Expert interview - 03/03/2021

Healthcare movers – the future of Baden-Württemberg's healthcare industry

The 'Healthcare Movers 2020 - Baden-Württemberg Report' reveals the potentials and challenges Baden-Württemberg healthcare companies encounter as the digital transformation of the healthcare market progresses. In an interview with Dr. Ariane Pott from BIOPRO, the authors of the report, Beatus Hofrichter and Dr. Ursula Kramer, explain what is required to take the major step towards becoming a digital avant-garde company.

On 8 February, the European Parliament adopted its Own Initiative Report on the Circular Economy which recognised the role of bioplastics for the future. Amongst other issues highlighted, the MEPs emphasised the potential role of bio–based and biodegradable and compostable plastics in the circular economy whilst noting that bio-based and/or biodegradable plastics alone will not provide a solution to the environmental concerns related to plastics.

So-called silent mutations have no effect on the composition of a protein. They are therefore not considered to promote cancer. However, scientists from the German Consortium for Translational Cancer Research (DKTK), partner site Essen, now describe in a case of kidney cancer an overlooked silent mutation with a major impact on prognosis.

Neuroblastoma can spread relentlessly or shrink spontaneously. Scientists from the Hopp Children’s Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg and the National Center for Tumor Diseases (NCT) Heidelberg have shown that some malignant neuroblastomas employ a trick to avoid cell death: they use a special mechanism to lengthen the telomeres at the end of their chromosomes.

The European Commission agreed on the successor of BBI JU – the Circular Bio-based Europe Joint Undertaking (CBE JU) in a legislative proposal adopted today. The new partnership between the EU and the Bio-based Industries Consortium (BIC) is expected to build on the success of BBI JU while stepping up its contribution to the EU’s climate targets, in line with the European Green Deal. The European Parliament and Council will now study the…

Agrivoltaics enables the dual use of arable land: Photovoltaic modules, which are mounted on a structure, generate renewable electricity and underneath agricultural crops grow. The approach increases land efficiency and could mitigate conflicts over the use of arable land in the future. A new guideline provides up-to-date information on the technology, its potential and the current state of development.

Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics.

Article - 17/02/2021

Whole blood model enables development of early warning system for sepsis

Sepsis is a life-threatening disease that can be treated all the more successfully the faster therapy is initiated. It is not just the infection itself that is so dangerous, but a dysregulated response of the immune system. Physicians at Ulm University Hospital have now developed an animal-free test system that can be used to research the disease and develop innovative diagnostic tools to quickly assess a patient's sepsis risk and optimise…

An international research team involving the universities of Paraná and Tübingen has developed a rapid test that can reliably identify Covid-19 antibodies in the blood within minutes. As the researchers report in the journal ACS Sensors, the new process is based on a simple measuring principle making it easy to carry out without expensive instruments, and is therefore suitable for use at mobile testing centers or by laboratories.

Textiles can be coated with the biopolymer chitosan and thus made water-repellent by binding hydrophobic molecules. The good thing is that this can also replace toxic and petroleum-based substances that are currently used for textile finishing. In the last few years Fraunhofer IGB and partners have developed technology to provide fibers with the desired properties using biotechnological processes and chitosan.

University of Hohenheim project contributes to maintaining valuable biotopes: Autonomous robot to help prune fruit trees so they stay healthy.

From field to socket - 03/02/2021

Energy park & Donau-Silphie: a symbiosis that benefits nature

Biogas plants that produce non-fossil fuels are very much in vogue at the moment. In the Swabian hamlet of Hahnennest, four family farms have joined forces to form an energy park and operate a local biogas plant, covering everything from substrate production to the sale of energy.

Microbiologists at the University of Tübingen modify bacteria to produce climate-neutral and rapidly degradable bioplastics.

In a so-called inactivated or killed vaccine, the virus particles it contains are first rendered inactive by means of the toxic chemical formaldehyde. A better way of achieving this, however, is to irradiate the pathogens with low-energy electrons. Four Fraunhofer Institutes have now developed a new method of vaccine production based on this technique that is not only quicker but also guarantees a higher quality of product.

For quite some time now, the European Commission (EC) is putting a special focus on biodegradable and compostable polymers when assessing the general role of bioplastics.

Can interconnected digital assistance systems enhance the quality of life of people in older age? Scientists in an interdisciplinary research project at Heidelberg University are exploring this question in a representative practice study. The participating researchers want to investigate how well these technical aids can be used and what benefit they achieve.

The University of Warmia and Mazury in Olsztyn, Polish partner of the BalticBiomass4Value project, published a report which maps biomass value chains for improved sustainable energy use in the Baltic Sea Region countries. The research focuses on the 9 Baltic Sea Region (BSR) countries: Denmark, Germany, Estonia, Finland, Latvia, Lithuania, Poland, Sweden, and Norway.

Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders. Scientists from the German Cancer Research Center (DKFZ) and the University of Innsbruck, together with a Europe-wide research network, discovered this molecular mechanism, which could open up new opportunities for personalized therapies for cancer and neuronal diseases. They published their results in the journal Cell.

Paper production from plant fibres - 20/01/2021

In one cycle: ecopaper, energy and fertiliser made from Silphium perfoliatum

Many consumers don't care about exactly how their paper packaging is made and what it is made of as long as it is "eco". But even producing recycled paper, trees need to be felled. An alternative could be paper made from cup plant. Together with partners, a company called Silphie Paper has developed concept for obtaining fibres for a new type of grass paper, while also producing heat, energy and nutrients for natural fertilisers.

A specific variant of the surface protein VSG of African trypanosomes, the causative agents of sleeping sickness, is associated with resistance to the important drug Suramin. Scientists at the German Cancer Research Center have now been able to find a possible explanation for the formation of resistance based on the crystal structure of this protein variant.

Biobased building materials - 14/01/2021

Chitin for the development of sustainable materials for use in the construction and other industries

Pliable and robust, light and stable - it sounds like an ideal material for the construction and many other industries. A team of researchers at the University of Stuttgart is researching what purposes the naturally good properties of chitin can serve.

Article - 14/01/2021

Newly discovered RNA as growth driver in liver cancer

Non-coding RNA (ncRNAs) molecules that do not encode proteins have many different functions, and some are associated with certain diseases. Prof. Dr. Sven Diederichs from the German Consortium for Translational Cancer Research and the German Cancer Research Center in Heidelberg has been conducting research into these molecules at the Freiburg University Medical Centre and discovered a ncRNA that regulates cell proliferation in cancer cells.

CureVac N.V., a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), today announced the publication of preclinical data demonstrating the induction of robust antibody and T cell responses of its COVID-19 vaccine candidate, CVnCoV, in non-human primates.

Hier werden die abgeschlossenen Projekte gesammelt.