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  • Press release - 17/01/2023

    Blood stem cells: not in charge in an emergency!

    After infections or blood loss, the body must compensate for the loss of blood cells as quickly as possible. This has long been considered the task of the hematopoietic stem cells in the bone marrow. But scientists at the German Cancer Research Center (DKFZ) have now discovered in mice that a certain population of progenitor cells takes over this task: This accelerates the regeneration of the blood cells.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/blood-stem-cells-not-charge-emergency
  • Press release - 17/01/2023

    Endogenous molecule protects from life-threatening complications after stem-cell transplantation

    Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation i.e. the transplantation of cells from another person. GvHD occurs when the transplanted immune cells are overly active and damage the receiving patient's healthy tissue. Researchers found that an endogenous molecule can mitigate this misdirected immune response.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/koerpereigenes-molekuel-schuetzt-vor-lebensbedrohlichen-komplikationen-nach-stammzelltransplantation
  • Press release - 14/11/2022

    Neurotoxicological hazard assessment without animal testing

    Using animal-free methods to assess the hazard potential of chemicals to the nervous system of unborn children? An international research team including toxicologists from Konstanz and Düsseldorf has developed a testing battery based on human cells that has the potential to replace traditional methods for assessing developmental neurotoxicity.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/neurotoxicological-hazard-assessment-without-animal-testing
  • Press release - 02/11/2022

    How Cells Find the Right Partners

    During the growth and development of living organisms, different types of cells must come into contact with each other in order to form tissues and organs together. A small team working with Prof. Dr. Anne Classen of the Excellence Cluster CIBSS of the University of Freiburg has discovered that complex changes in form, or morphogenesis, during development are driven exclusively via the affinity of cells to each other.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/how-cells-find-right-partners
  • Press release - 24/10/2022

    How tumors suppress the development of metastases

    Why do metastases often only appear after the original tumor has been surgically removed? Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim Medical Faculty of Heidelberg University have now published an explanation for this phenomenon. They were able to identify a messenger substance of the cancer cells that locally promotes the growth of the primary tumor.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/wie-tumoren-die-entstehung-von-metastasen-unterdruecken
  • Press release - 18/03/2022

    Lung Tissue form the Lab

    Laboratory studies of lung tissue usually require the removal of large amounts of human or animal tissue. Now scientists from the University of Freiburg’s Faculty of Medicine have succeeded in collaboration with American researchers in generating tiny quantities of lung tissue, so-called organoids, from just a few body cells in the lab.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/lung-tissue-lab
  • 3R-Center - 18/08/2021 Map showing the eight locations of the 3R-Netzwerk Baden-Württemberg: Mannheim, Heidelberg, Stuttgart, Reutlingen, Ulm, Freiburg and Konstanz.

    Putting alternatives to animal testing into practice

    Animal experiments are still central to biomedical research. However, it has become increasingly clear that not all of them are absolutely necessary. Alternative techniques exist. The new 3R-Netzwerk Baden-Württemberg is now seeking to promote these more vigorously - and improve animal welfare in cases where alternatives to animal testing are not available.

    https://www.gesundheitsindustrie-bw.de/en/article/news/putting-alternatives-animal-testing-practice
  • Press release - 03/03/2021

    New Baden-Württemberg network to reduce animal experiments

    A new network has been set up in Baden-Württemberg aimed at reducing animal experiments as well as further improving animal welfare. It combines new approaches and measures at the state’s biomedical research locations, which are expected to limit stress in laboratory animals and steadily reduce the number of animals used in research in line with the 3R principles of Replacement, Reduction, and Refinement.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-baden-wuerttemberg-network-reduce-animal-experiments
  • Organ failure due to fatty liver - 24/09/2020 AdobeStock_9729015_SciePro_Leber_Mensch.jpg

    HepaRegeniX develops an active substance for liver regeneration

    When the liver stops regenerating on its own, it might be possible in future for doctors to intervene with a chemical agent. Tübingen-based HepaRegeniX GmbH is developing a promising candidate with the aim of improving the treatment of both acute and chronic liver failure.

    https://www.gesundheitsindustrie-bw.de/en/article/news/heparegenix-develops-active-substance-liver-regeneration
  • Biochip systems - 02/09/2020 Hand hält einen Fett-Chip (Organ-on-a-Chip) in die Kamera. Gut zu sehen sind die Kammern und Kapillaren auf dem Mikrofluidik-System.

    Miniature organs with great potential

    Dr. Peter Loskill and his team at the Fraunhofer Institute in Stuttgart and the University Hospital of Tübingen are developing what is known as an "organ-on-a-chip" (OoC). An OoC is a microfluidic system that simulates small functional units of organ tissue. OoCs can be used in different ways: in basic and pharmaceutical research as well as in clinical research and application, where they might render many animal experiments…

    https://www.gesundheitsindustrie-bw.de/en/article/news/miniature-organs-great-potential
  • Expert interview - 08/08/2018 Das Bild zeigt das Brustbild des ALS-Forschers, und Ärztlichen Direktors der Neurologischen Klinik der Uni Ulm, Prof. Albert Ludolph. Der Neurologe ist Sprecher des DZNE-Standorts Ulm.

    Ludolph: diagnosing and treating neurodegenerative disorders

    Ulm has long been a world leader in diagnosing and treating rare neurological disorders, notably amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington's disease (HD). We spoke with Professor Albert C. Ludolph, spokesperson for the Ulm DZNE site, medical director of the Clinic for Neurology at the RKU (University and Rehabilitation Clinics of Ulm) and world-renowned ALS researcher.

    https://www.gesundheitsindustrie-bw.de/en/article/news/ludolph-diagnosing-and-treating-neurodegenerative-disorders
  • Alternative to animal experiments - 21/03/2018 The long-term expectation is to be able to several organs on a single chip.

    Drug tests using miniature organs

    At present, potential new drugs have to be tested on animals before they can be used on humans. However, results obtained from animals are not always transferrable to the situation in humans, which is why researchers around the world have long been seeking alternatives. Miniature human organs that can be used to test the efficacy of potential human drugs might provide a solution.

    https://www.gesundheitsindustrie-bw.de/en/article/news/drug-tests-using-miniature-organs
  • Press release - 05/09/2017 PET-Gerat-Uni-Tubingen.jpg

    Cell marking opens up a window into the body

    A new and particularly reliable method for marking cells can simplify research into diseases such as myocardial infarction, diabetes or Alzheimer's and reduce the use of test animals: Scientists from the University of Tübingen have developed a method by which they can target specific cell types in mice and monitor their behavior using positron emission tomography (PET). PET-based cell tracking allows scientists to observe complex life…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cell-marking-opens-up-a-window-into-the-body
  • Article - 22/08/2017 Two microscope images of fibroblasts of an transgenic mouse carrying the MxA gene. On the right: fibroblast nuclei. On the left: Alpha interferon treatment triggers MxA protein production. These proteins are now located around the cell nuclei.

    Transgenic mice in influenza research – risk assessment and vaccine development

    A research team from Freiburg is developing a method for identifying human influenza viruses of animal origin. This could potentially improve measures taken to prevent imminent pandemics. The researchers are working with genetically modified mice. Transgenic mice also play a role in the development of a ’universal’ influenza vaccine.

    https://www.gesundheitsindustrie-bw.de/en/article/news/transgenic-mice-in-influenza-research-risk-assessment-and-vaccine-development
  • Article - 19/06/2017 The photo shows the scientists in front of a computer screen with green cell cultures.

    Eric Gottwald: innovative 3D cell culture systems for pharmaceutical testing

    Realistic alternatives to animal testing are more in demand than ever, especially in the drug development field. One possible solution is 3D cell cultures that possess the characteristics of the tissue from which they originate. Such systems were already developed at the Karlsruhe Institute of Technology (KIT) many years ago. Due to the huge demand for such systems, Prof. Dr. Eric Gottwald and two of his colleagues founded a company called…

    https://www.gesundheitsindustrie-bw.de/en/article/news/eric-gottwald-innovative-3d-cell-culture-systems-for-pharmaceutical-testing
  • Article - 07/06/2017 The fruit fly Drosophila is used as obesity model. The fat tissue has been visualised by way of GFP (green fluorescent protein) expression.

    A gene that regulates body heat and fat storage

    Researchers from Heidelberg have shown that the organismal balance between heat production and energy storage is regulated by a gene called THADA. In animal experiments, knocking out the THADA gene leads to excessive food intake, obesity and sensitivity to cold. As humans spread throughout the world and settled in different climate zones, THADA was exposed to high selection pressure due to evolutionary adaptation. This explains why human…

    https://www.gesundheitsindustrie-bw.de/en/article/news/a-gene-that-regulates-body-heat-and-fat-storage
  • 24.04.2017

    World Day for Laboratory Animals

    On 24 April 2017 is "World Day for Laboratory Animals" – the BIOPRO provides information about this topic. In Baden-Württemberg alone, up to 600,000 animals are used for scientific purposes every year. In order to reduce their pain and suffering as much as possible, researchers all over the world are working on the development of innovative methods to replace animal experiments, including cell culture methods for drug analysis,…

    https://www.gesundheitsindustrie-bw.de/en/article/news/world-day-for-laboratory-animals
  • Article - 21/12/2016 Signatope GmbH’s founding team (from left to right) Prof. Dr. Hugo Hämmerle, Dr. Oliver Pötz, Dr. Hannes Planatscher, Dr. Octavian Schatz and Dr. Thomas Joos.

    For all types of tests: Signatope’s biomarker assays

    Signatope is a new biotech company that has been offering innovative biomarker assays for application in drug discovery since August 2016. The company’s assays can be used in all phases of drug development to detect potential adverse drug effects on the kidneys, liver and other organs in any species whatsoever using minute amounts of sample.

    https://www.gesundheitsindustrie-bw.de/en/article/news/for-all-types-of-tests-signatopes-biomarker-assays
  • Article - 17/05/2016 Schematic of the entire chip and an amplified sector showing the central area of the square chip along with the round seeding areas and microchannels.

    Innovative biochip for discovering drugs for treating neuronal conditions

    Parkinson’s, Alzheimer’s and epilepsy are three prominent examples of neuronal conditions (disorders affecting the nerve cells) for which drugs for treatment are intensively sought. Paolo Cesare from the NMI in Reutlingen has developed an innovative 3D system for testing drugs that does not require animal testing. In 2015, the MEAFLUIT system was awarded first prize in BioRegio STERN Management GmbH's Science2Start idea competition.

    https://www.gesundheitsindustrie-bw.de/en/article/news/innovative-biochip-for-discovering-drugs-for-treating-neuronal-conditions
  • Article - 21/03/2016 Schematic presentation before and after treatment showing the effect of the therapy. Blood vessel density improves considerably.

    Shock wave therapy gives hope to many men

    Although the approval of vasodilatory drugs made available an effective medicine for treating erectile dysfunction, not all men respond to this type of treatment. MTS Medical UG from Konstanz has developed a therapeutic device that means that these men can now get help too. What's more, the device has no adverse health effects.

    https://www.gesundheitsindustrie-bw.de/en/article/news/shock-wave-therapy-gives-hope-to-many-men
  • Article - 11/01/2016 Microscope image showing several intestinal cells. Pink-coloured spots indicate specific gene expression events.

    Study shows correlation between intestinal gene activity and obesity

    People with obesity suffer from more than just health problems related to their weight. They often feel socially stigmatised because their disease is often seen as a self-inflicted condition. A new study by the University of Hohenheim in cooperation with the eSwiss Medical and Surgical Center in St. Gallen now shows that severe obesity is closely associated with gene activity in the intestinal tissue. This activity is responsible for producing…

    https://www.gesundheitsindustrie-bw.de/en/article/news/studie-zeigt-zusammenhang-zwischen-gen-aktivitaet-im-darm-und-uebergewicht
  • Article - 29/06/2015 23436_de.jpg

    3D cell culture model for more efficient tumour research

    The development of anti-cancer drugs is a lengthy process because results obtained in vitro in the laboratory often differ from what then occurs in a living organism. A group of researchers led by Prof. Dr. Margareta Müller at the Furtwangen University of Applied Sciences is therefore developing a new cell culture model that adjusts in vitro to real conditions.

    https://www.gesundheitsindustrie-bw.de/en/article/news/3d-cell-culture-model-for-more-efficient-tumour-research
  • Article - 22/06/2015 The schematic shows how the blood vessel-containing printed tissue will look like.

    3D bioprinting: replicating the shape of bone parts

    Prof. Dr. Günter Finkenzeller, head of the Research and Tissue Engineering Laboratory in the Department of Plastic and Hand Surgery at the Freiburg University Medical Centre, and Dr. Peter Koltay from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg, are being given German Research Foundation (DFG) funds for a period of three years to develop a 3D printing technique for functional bone tissue containing blood…

    https://www.gesundheitsindustrie-bw.de/en/article/news/3d-bioprinting-replicating-the-shape-of-bone-parts
  • Article - 21/07/2014 Schematic representation of multi-scale modelling: images of a molecule, cell, lung tissue and whole body, all connected with each other by arrows.<br />

    Predicting the efficiency of cancer drugs using mathematical models

    A research consortium was established at the Stuttgart Research Center Systems Biology SRCSB at the University of Stuttgart in January 2013 with the goal of establishing models that help predict the action of targeted therapeutics. The scientists combine molecular biology experiments with complex mathematical models in order to achieve a holistic understanding of disease and therapy.

    https://www.gesundheitsindustrie-bw.de/en/article/news/predicting-the-efficiency-of-cancer-drugs-using-mathematical-models
  • Article - 19/05/2014 21459_de.jpg

    Alcoholism: the molecular basis of addiction and deprivation

    Scientists at the Central Institute of Mental Health in Mannheim use rats and mice to study the genetic basis and neurobiological mechanisms of alcohol addiction, the changes that occur during alcohol deprivation and the factors that favour a relapse. In translational research, the results from animal experiments are reviewed using alcohol-dependent patients in order to turn them quickly into preventive strategies and therapies.

    https://www.gesundheitsindustrie-bw.de/en/article/news/alcoholism-the-molecular-basis-of-addiction-and-deprivation

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