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  • Organ failure due to fatty liver - 24/09/2020 AdobeStock_9729015_SciePro_Leber_Mensch.jpg

    HepaRegeniX develops an active substance for liver regeneration

    When the liver stops regenerating on its own, it might be possible in future for doctors to intervene with a chemical agent. Tübingen-based HepaRegeniX GmbH is developing a promising candidate with the aim of improving the treatment of both acute and chronic liver failure.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/heparegenix-develops-active-substance-liver-regeneration
  • Biochip systems - 02/09/2020 Hand hält einen Fett-Chip (Organ-on-a-Chip) in die Kamera. Gut zu sehen sind die Kammern und Kapillaren auf dem Mikrofluidik-System.

    Miniature organs with great potential

    Dr. Peter Loskill and his team at the Fraunhofer Institute in Stuttgart and the University Hospital of Tübingen are developing what is known as an "organ-on-a-chip" (OoC). An OoC is a microfluidic system that simulates small functional units of organ tissue. OoCs can be used in different ways: in basic and pharmaceutical research as well as in clinical research and application, where they might render many animal experiments…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/miniature-organs-great-potential
  • Expert interview - 08/08/2018 Das Bild zeigt das Brustbild des ALS-Forschers, und Ärztlichen Direktors der Neurologischen Klinik der Uni Ulm, Prof. Albert Ludolph. Der Neurologe ist Sprecher des DZNE-Standorts Ulm.

    Ludolph: diagnosing and treating neurodegenerative disorders

    Ulm has long been a world leader in diagnosing and treating rare neurological disorders, notably amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington's disease (HD). We spoke with Professor Albert C. Ludolph, spokesperson for the Ulm DZNE site, medical director of the Clinic for Neurology at the RKU (University and Rehabilitation Clinics of Ulm) and world-renowned ALS researcher.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/ludolph-diagnosing-and-treating-neurodegenerative-disorders
  • Alternative to animal experiments - 21/03/2018 The long-term expectation is to be able to several organs on a single chip.

    Drug tests using miniature organs

    At present, potential new drugs have to be tested on animals before they can be used on humans. However, results obtained from animals are not always transferrable to the situation in humans, which is why researchers around the world have long been seeking alternatives. Miniature human organs that can be used to test the efficacy of potential human drugs might provide a solution.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/drug-tests-using-miniature-organs
  • Press release - 05/09/2017 PET-Gerat-Uni-Tubingen.jpg

    Cell marking opens up a window into the body

    A new and particularly reliable method for marking cells can simplify research into diseases such as myocardial infarction, diabetes or Alzheimer's and reduce the use of test animals: Scientists from the University of Tübingen have developed a method by which they can target specific cell types in mice and monitor their behavior using positron emission tomography (PET). PET-based cell tracking allows scientists to observe complex life…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/cell-marking-opens-up-a-window-into-the-body
  • Article - 22/08/2017 Two microscope images of fibroblasts of an transgenic mouse carrying the MxA gene. On the right: fibroblast nuclei. On the left: Alpha interferon treatment triggers MxA protein production. These proteins are now located around the cell nuclei.

    Transgenic mice in influenza research – risk assessment and vaccine development

    A research team from Freiburg is developing a method for identifying human influenza viruses of animal origin. This could potentially improve measures taken to prevent imminent pandemics. The researchers are working with genetically modified mice. Transgenic mice also play a role in the development of a ’universal’ influenza vaccine.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/transgenic-mice-in-influenza-research-risk-assessment-and-vaccine-development
  • Article - 19/06/2017 The photo shows the scientists in front of a computer screen with green cell cultures.

    Eric Gottwald: innovative 3D cell culture systems for pharmaceutical testing

    Realistic alternatives to animal testing are more in demand than ever, especially in the drug development field. One possible solution is 3D cell cultures that possess the characteristics of the tissue from which they originate. Such systems were already developed at the Karlsruhe Institute of Technology (KIT) many years ago. Due to the huge demand for such systems, Prof. Dr. Eric Gottwald and two of his colleagues founded a company called…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/eric-gottwald-innovative-3d-cell-culture-systems-for-pharmaceutical-testing
  • Article - 07/06/2017 The fruit fly Drosophila is used as obesity model. The fat tissue has been visualised by way of GFP (green fluorescent protein) expression.

    A gene that regulates body heat and fat storage

    Researchers from Heidelberg have shown that the organismal balance between heat production and energy storage is regulated by a gene called THADA. In animal experiments, knocking out the THADA gene leads to excessive food intake, obesity and sensitivity to cold. As humans spread throughout the world and settled in different climate zones, THADA was exposed to high selection pressure due to evolutionary adaptation. This explains why human…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/a-gene-that-regulates-body-heat-and-fat-storage
  • 24.04.2017

    World Day for Laboratory Animals

    On 24 April 2017 is "World Day for Laboratory Animals" – the BIOPRO provides information about this topic. In Baden-Württemberg alone, up to 600,000 animals are used for scientific purposes every year. In order to reduce their pain and suffering as much as possible, researchers all over the world are working on the development of innovative methods to replace animal experiments, including cell culture methods for drug analysis,…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/world-day-for-laboratory-animals
  • Article - 21/12/2016 Signatope GmbH’s founding team (from left to right) Prof. Dr. Hugo Hämmerle, Dr. Oliver Pötz, Dr. Hannes Planatscher, Dr. Octavian Schatz and Dr. Thomas Joos.

    For all types of tests: Signatope’s biomarker assays

    Signatope is a new biotech company that has been offering innovative biomarker assays for application in drug discovery since August 2016. The company’s assays can be used in all phases of drug development to detect potential adverse drug effects on the kidneys, liver and other organs in any species whatsoever using minute amounts of sample.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/for-all-types-of-tests-signatopes-biomarker-assays
  • Article - 17/05/2016 Schematic of the entire chip and an amplified sector showing the central area of the square chip along with the round seeding areas and microchannels.

    Innovative biochip for discovering drugs for treating neuronal conditions

    Parkinson’s, Alzheimer’s and epilepsy are three prominent examples of neuronal conditions (disorders affecting the nerve cells) for which drugs for treatment are intensively sought. Paolo Cesare from the NMI in Reutlingen has developed an innovative 3D system for testing drugs that does not require animal testing. In 2015, the MEAFLUIT system was awarded first prize in BioRegio STERN Management GmbH's Science2Start idea competition.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/innovative-biochip-for-discovering-drugs-for-treating-neuronal-conditions
  • Article - 21/03/2016 Schematic presentation before and after treatment showing the effect of the therapy. Blood vessel density improves considerably.

    Shock wave therapy gives hope to many men

    Although the approval of vasodilatory drugs made available an effective medicine for treating erectile dysfunction, not all men respond to this type of treatment. MTS Medical UG from Konstanz has developed a therapeutic device that means that these men can now get help too. What's more, the device has no adverse health effects.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/shock-wave-therapy-gives-hope-to-many-men
  • Article - 11/01/2016 Microscope image showing several intestinal cells. Pink-coloured spots indicate specific gene expression events.

    Study shows correlation between intestinal gene activity and obesity

    People with obesity suffer from more than just health problems related to their weight. They often feel socially stigmatised because their disease is often seen as a self-inflicted condition. A new study by the University of Hohenheim in cooperation with the eSwiss Medical and Surgical Center in St. Gallen now shows that severe obesity is closely associated with gene activity in the intestinal tissue. This activity is responsible for producing…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/studie-zeigt-zusammenhang-zwischen-gen-aktivitaet-im-darm-und-uebergewicht
  • Article - 29/06/2015 23436_de.jpg

    3D cell culture model for more efficient tumour research

    The development of anti-cancer drugs is a lengthy process because results obtained in vitro in the laboratory often differ from what then occurs in a living organism. A group of researchers led by Prof. Dr. Margareta Müller at the Furtwangen University of Applied Sciences is therefore developing a new cell culture model that adjusts in vitro to real conditions.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/3d-cell-culture-model-for-more-efficient-tumour-research
  • Article - 22/06/2015 The schematic shows how the blood vessel-containing printed tissue will look like.

    3D bioprinting: replicating the shape of bone parts

    Prof. Dr. Günter Finkenzeller, head of the Research and Tissue Engineering Laboratory in the Department of Plastic and Hand Surgery at the Freiburg University Medical Centre, and Dr. Peter Koltay from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg, are being given German Research Foundation (DFG) funds for a period of three years to develop a 3D printing technique for functional bone tissue containing blood…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/3d-bioprinting-replicating-the-shape-of-bone-parts
  • Article - 21/07/2014 Schematic representation of multi-scale modelling: images of a molecule, cell, lung tissue and whole body, all connected with each other by arrows.<br />

    Predicting the efficiency of cancer drugs using mathematical models

    A research consortium was established at the Stuttgart Research Center Systems Biology SRCSB at the University of Stuttgart in January 2013 with the goal of establishing models that help predict the action of targeted therapeutics. The scientists combine molecular biology experiments with complex mathematical models in order to achieve a holistic understanding of disease and therapy.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/predicting-the-efficiency-of-cancer-drugs-using-mathematical-models
  • Article - 19/05/2014 21459_de.jpg

    Alcoholism: the molecular basis of addiction and deprivation

    Scientists at the Central Institute of Mental Health in Mannheim use rats and mice to study the genetic basis and neurobiological mechanisms of alcohol addiction, the changes that occur during alcohol deprivation and the factors that favour a relapse. In translational research, the results from animal experiments are reviewed using alcohol-dependent patients in order to turn them quickly into preventive strategies and therapies.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/alcoholism-the-molecular-basis-of-addiction-and-deprivation
  • Article - 31/03/2014 21202_de.jpg

    Cell culture reactor – a mechanical lung as an alternative to animal experiments

    When people breathe, not only do they inhale oxygen, but they also ingest harmful substances into the lung. Animal experiments still need to be carried out in order to assess the potential effects of air-borne pollutants, but alternatives are being sought in order to reduce the number of animal tests. In cooperation with Cultex Laboratories GmbH, Askea Feinmechanik GmbH from Amtzell has developed a cell culture reactor for conducting in vitro…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/cell-culture-reactor-a-mechanical-lung-as-an-alternative-to-animal-experiments
  • Article - 31/03/2014 21168_de.jpg

    The growing significance of peptide therapeutics

    The therapeutic use of peptides lags behind that of proteins. And there are good reasons for this. However, it seems that this is beginning to change and that peptide therapeutics are growing in significance. As a matter of fact, peptides have become rather popular candidates for drugs.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/the-growing-significance-of-peptide-therapeutics
  • Article - 24/03/2014 Section of a malignant skin tumour in Mastomys coucha. Dividing tumour cells are stained red.

    Vaccine against papillomaviruses protects from skin cancer

    Papillomaviruses are thought to cause non-melanoma skin cancer in people exposed to UV radiation, especially those who have suppressed immune systems. Researchers from the German Cancer Research Center (DKFZ) and the Charité University Hospital in Berlin have developed a vaccine that protects mice against such skin tumours. The vaccine is even effective in mice that have previously been infected with papillomaviruses and that have suppressed…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/vaccine-against-papillomaviruses-protects-from-skin-cancer
  • Article - 07/08/2013 20000_de.jpg

    New regulations covering the use of laboratory animals

    The new directive of the European Parliament and of the Council on the protection of animals used for scientific purposes was adopted on 22nd September 2010 and was implemented into the German Animal Welfare Act which came into force in February 2013. These regulations have implications for companies and researchers alike. In recent years a growing number of alternative methods to animal testing have been developed. Dr. Nina Hasiwa CEO of…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/new-regulations-covering-the-use-of-laboratory-animals
  • Press release - 22/07/2013 The photo shows the Medicyte company building.

    BIOPRO Baden-Württemberg's international relations bring Heidelberg-based Medicyte GmbH in contact with new distribution partner

    BIOPRO Baden-Württembergs business development activities have led to the establishment of a new distribution partnership between Heidelberg-based Medicyte GmbH and Dutch Westburg BV. When BIOPRO searches for international partners for Baden-Württemberg companies the state agency often makes use of its international network partners and in this case BIOPROs contact with the Netherlands Business Support Office Stuttgart NBSO brought the desired…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/biopro-baden-wuerttemberg-s-international-relations-bring-heidelberg-based-medicyte-gmbh-in-contact
  • Article - 24/06/2013 19893_de.jpg

    Cloned human beings are not to be feared

    An international team of scientists led by Dr. Shoukhrat Mitalipov at the Oregon Health & Science University, USA, succeeded for the first time ever in cloning human embryonic stem cells by somatic cell nuclear transfer. This breakthrough raises questions about the potentials and dangers of creating human stem cells by cloning. Prof. Dr. Marcel Leist from the University of Konstanz, who uses human embryonic stem cells for his research, gives…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/cloned-human-beings-are-not-to-be-feared
  • Article - 10/06/2013 Dr. Tanja Waldmann (right) and her doctoral student Nina Balmer are developing cell culture systems with human embryonic stem cells. The photo shows the two scientists working in the laboratory.

    Stem-cell tests to provide protection to unborn babies

    The development of unborn babies may already be impaired in the womb by pollutants from the environment food and drugs to which their mothers are exposed. Reliable and informative toxicity tests are necessary in order to assess and prevent the effects toxic substances may have on unborn babies. Biologist Dr. Tanja Waldmann from Konstanz University is developing toxicity test systems based on human embryonic stem cells which contribute to improved…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/stem-cell-tests-to-provide-protection-to-unborn-babies
  • Article - 07/01/2013 19006_de.jpg

    HepaChip: a promising tool for assessing adverse drug effects

    Liver damage is one of the most common adverse drug effects. Since results obtained with animal experiments can only be transferred to the situation in humans to a limited extent, there is a need for cell-based systems that model human organ function as closely as possible. The new HepaChip, developed by researchers at the NMI in Reutlingen on the basis of human liver and endothelial cells is able to do just this.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/hepachip-a-promising-tool-for-assessing-adverse-drug-effects

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