Article - 25/03/2013 SHENC – shear flow regulation of hemostasis The first step in closing wounds is the aggregation of the von Willebrand factor glycoprotein with blood platelets, which plugs the hole in the blood vessel and stops blood from leaking out. Using computer simulations and artificial blood vessel experiments, researchers from Mannheim have shown that this aggregation is a reversible process that depends on the shear forces resulting from the flow of the blood. This also prevents the clogging of…https://www.gesundheitsindustrie-bw.de/en/article/news/shenc-shear-flow-regulation-of-hemostasis
Article - 28/01/2013 Epigenetics and childhood blood cancer Juvenile myelomonocytic leukaemia JMML is the most common chronic cancer of the blood in children and tends to have a poor response to chemotherapy. Prof. Dr. Christian Flotho and his team from the Centre of Paediatric and Adolescent Medicine in Freiburg have shown that epigenetic mechanisms play a key role in the pathogenesis of JMML. As part of a German Research Foundation priority programme the researchers from Freiburg are working on…https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-and-childhood-blood-cancer
Article - 07/08/2013 New regulations covering the use of laboratory animals The new directive of the European Parliament and of the Council on the protection of animals used for scientific purposes was adopted on 22nd September 2010 and was implemented into the German Animal Welfare Act which came into force in February 2013. These regulations have implications for companies and researchers alike. In recent years a growing number of alternative methods to animal testing have been developed. Dr. Nina Hasiwa CEO of…https://www.gesundheitsindustrie-bw.de/en/article/news/new-regulations-covering-the-use-of-laboratory-animals
Press release - 15/07/2011 HITS Participates in a new DFG Research Unit on Blood Coagulation Scientists from the Heidelberg Institute for Theoretical Studies participate in a new Research Unit on blood coagulation sponsored by the German Research Foundation (DFG). The aim of the DFG funding is to support a successful existing cooperation between scientists over several years.https://www.gesundheitsindustrie-bw.de/en/article/press-release/hits-participates-in-a-new-dfg-research-unit-on-blood-coagulation
Article - 13/05/2008 Just follow your nose Sharks can sense a few drops of blood in water. In fact they are able to smell blood in dilutions of as little as one to 10 billion. Is it just sharks or piranhas that have such an acute sense of smell? The answer is no - all fish have a highly developed sense of smell.https://www.gesundheitsindustrie-bw.de/en/article/news/just-follow-your-nose
Press release - 17/12/2011 Rapid identification of blood poisoning Does the patient have blood poisoning? In order to find out, the doctor takes a blood sample and sends it to a central laboratory for testing. Valuable time is lost, which could cost the patient his or her life. In future, doctors will be able to analyse blood in their surgery and results will be available within twenty minutes. This is made possible by a biochip developed by scientists at the Fraunhofer Institute for Physical Measurement…https://www.gesundheitsindustrie-bw.de/en/article/press-release/rapid-identification-of-blood-poisoning
Article - 19/05/2009 What makes blood vessels sprout? Calcified arteries or capillaries – this is often associated with blood stasis, reduced oxygen supply, and subsequent cardiac strain that compensates these deficiencies. Dr. Sebastian Grundmann from the Department of Cardiology and Angiology at the University Medical Centre Freiburg and his team are investigating how the growth of blood vessels is triggered, and potentially find ways to naturally deviate the site of congestion. https://www.gesundheitsindustrie-bw.de/en/article/news/what-makes-blood-vessels-sprout
Company profile - 14/07/2016 neuroloop GmbH: how the manipulation of neuronal information can lower blood pressure Millions of people worldwide suffer from high blood pressure. However, taking medicines to control high blood pressure does not work for everyone. Dr. Dennis Plachta and Prof. Dr. Thomas Stieglitz from IMTEK have now developed a neurostimulator to control blood pressure. Together with Dr. Michael Lauk, an experienced company founder, the two researchers set up a company called neuroloop, which is funded by Aesculap AG and aims to turn the…https://www.gesundheitsindustrie-bw.de/en/article/news/neuroloop-gmbh-how-the-manipulation-of-neuronal-information-can-lower-blood-pressure
Article - 11/02/2010 Johanna Schanz: Liver model as an alternative to animal experiments Blood vessels of a piece of pig’s intestine are used as carrier material for the IGB’s liver model and the cells seeded on the blood vessels stem from human biopsies. Dr. Johanna Schanz from the Fraunhofer IGB used this combination to produce her doctoral thesis which led to impressive results: a functional system of blood vessels in a biological carrier structure. Schanz’s outstanding thesis results have led to the creation of a liver model for…https://www.gesundheitsindustrie-bw.de/en/article/news/johanna-schanz-liver-model-as-an-alternative-to-animal-experiments
Article - 16/04/2019 Tumour monitoring using liquid biopsy Liquid biopsy, the analysis of cancer biomarkers and circulating tumour cells in body fluids such as blood, is revolutionising the diagnosis and monitoring of cancer. It has also been possible to expand circulating tumour cells from the blood under laboratory conditions. It is expected that in the future, liquid biopsy will be able to precisely characterise tumour cells at every stage of a cancer.https://www.gesundheitsindustrie-bw.de/en/article/news/tumour-monitoring-using-liquid-biopsy
Press release - 08/09/2010 Gene doping detectable with a simple blood test Scientists at the universities of Tübingen and Mainz have developed a blood test that is able to provide conclusive proof of gene doping. The test is still effective even if the actual doping took place some time before the test. The new test is based on a procedure developed in Tübingen in 2006 that enables transgenic DNA to be detected in the blood. The efficiency of this procedure has now been proven for the first time in laboratory mice. https://www.gesundheitsindustrie-bw.de/en/article/press-release/gene-doping-detectable-with-a-simple-blood-test
Press release - 07/08/2009 Silenced genes as a warning sign of blood cancer Important growth inhibitors are often switched off in the genetic material of cancer cells by specific chemical DNA modifications. Scientists of the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ), in collaboration with colleagues from Ohio State University in the United States, have investigated how this happens. They discovered, in mice, that cancer-typical DNA methylation occurs long before the first symptoms of…https://www.gesundheitsindustrie-bw.de/en/article/press-release/silenced-genes-as-a-warning-sign-of-blood-cancer
Article - 25/02/2013 Molecular monitoring of premature infants Premature births are not uncommon in Germany where around seven percent of newborns are born before week 37 of pregnancy. The WHO estimates that the numbers of preterm births are growing due to the increasing age of mothers. Doctors caring for the tiny patients are faced with a dilemma because regular blood samples required for the clinical monitoring of important blood parameters cannot be taken due to the infants low body volume.https://www.gesundheitsindustrie-bw.de/en/article/news/molecular-monitoring-of-premature-infants
Article - 07/07/2010 Excellent vascular research in Baden-Württemberg The fact that the DFG are continuing to fund the only collaborative research centre (SFB, Sonderforschungsbereich) in Germany that is exclusively focused on vascular research underlines the concentrated expertise found in Mannheim and Heidelberg in the field of vascular biology.https://www.gesundheitsindustrie-bw.de/en/article/news/excellent-vascular-research-in-baden-wuerttemberg
Article - 28/04/2008 A milestone in the treatment of leukaemia Blood cancer experts in the team of Professor Peter Dreger Head of the Section of Allogeneic Stem Cell Transplantation at the University Hospital of Heidelberg have achieved a major success in the treatment of leukaemia. For the 500th time the physicians from the Department of Haematology Oncology and Rheumatology transferred blood stem cells from a healthy donor to a patient suffering from leukaemia or lymphoma.https://www.gesundheitsindustrie-bw.de/en/article/press-release/a-milestone-in-the-treatment-of-leukaemia
Article - 25/06/2012 From blood samples to granulate The issue of proper nutrition has become more centred on the individual there is growing recognition that nutrition needs to be adapted to an individuals specific way of life and requirements. In cooperation with its subsidiary the Institut für Angewandte Biochemie AG IABC Hepart AG a company based in the city of Kreuzlingen on Lake Constance develops dietary products food to help people lose weight and micronutrient preparations adapted to…https://www.gesundheitsindustrie-bw.de/en/article/news/from-blood-samples-to-granulate
Article - 23/04/2012 Vascular grafts: biomolecules to prevent blood vessels from reclosing Obstructed blood vessels can be operated on and adequate blood flow restored. However, stents and bypasses are often subject to high reclosure rates. Excessive immune reactions close to where the intervention took place might prevent the regeneration of adjacent vessel walls and even lead to reclosure. New interventions involving RNA interference seem to be a way out of this dilemma.https://www.gesundheitsindustrie-bw.de/en/article/news/vascular-grafts-biomolecules-to-prevent-blood-vessels-from-reclosing
Article - 18/10/2017 Testing a new antibody therapy for treating blood cancer The fight against acute myeloid leukaemia is a long one. Cancer cells that cause the disease to recur may remain despite initially successful destruction of the tumour with chemotherapy drugs. Now researchers from Tübingen have identified an antibody that could potentially prevent cancer recurrence.https://www.gesundheitsindustrie-bw.de/en/article/news/testing-a-new-antibody-therapy-for-treating-blood-cancer
Article - 03/03/2014 Taking a drug taxi across the blood-brain barrier The central nervous system CNS which integrates the information it receives from all parts of the body is perhaps the most sensitive organ we have. As toxic compounds are able to disturb brain function enormously the brain is separated from circulating blood by a highly selective permeability barrier known as the blood-brain barrier. However the downside of this protection is that 98 percent of all drugs targeting the CNS cannot pass the barrier.…https://www.gesundheitsindustrie-bw.de/en/article/news/taking-a-drug-taxi-across-the-blood-brain-barrier
Press release - 12/03/2009 New strategy for the investigation of haematopoietic stem cells With the newly developed mouse model irradiation is no longer required. While the mutation in the growth factor receptor Kit KitWWv weakens the recipients stem cell compartment and makes room for the incoming donor cells the other two mutations are known to prevent rejection of donor haematopoietic stem cells by the recipients immune system. Thus these mice appear to accept all blood stem cells regardless of the mouse strain origin of the…https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-strategy-for-the-investigation-of-haematopoietic-stem-cells
Article - 27/04/2009 Interaction mechanisms between tumours and blood vessels In recognition of the growing importance of angiogenesis research in the field of oncology the German Research Foundation has established two new research consortia as part of its Angiogenesis research priority programme one project focuses on the mechanisms of vascular differentiation and the second on the interaction between tumour cells and cells of the vascular wall which are prerequisites for tumour growth and metastasis.https://www.gesundheitsindustrie-bw.de/en/article/news/interaction-mechanisms-between-tumours-and-blood-vessels
Article - 08/08/2017 N2B-patch: circumventing the blood-brain barrier There are many medications for treating central nervous system diseases. However, only a fraction of the active pharmaceutical ingredients actually reaches the site where they are needed. The reason for this is the blood-brain barrier that protects the brain and thus prevents many drugs used to treat neurological diseases from effectively penetrating the brain. Researchers from the Fraunhofer Institute for Interfacial Engineering and…https://www.gesundheitsindustrie-bw.de/en/article/news/n2b-patch-circumventing-the-blood-brain-barrier
Press release - 27/05/2010 Systems biology helps to understand haematopoiesis Following any major blood loss, large amounts of the hormone EPO flood the haematopoietic system in the bone marrow. Scientists from the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg and the University of Freiburg have published an article in Science that reveals how a rapid turnover of EPO receptor molecules on haematopoietic cells ensures that the cells maintain their state of readiness. The body can thus…https://www.gesundheitsindustrie-bw.de/en/article/press-release/systems-biology-helps-to-understand-haematopoiesis
Article - 04/07/2011 The adhesion of cells to the endothelium and to artificial surfaces Professor Stefan W. Schneider from the Mannheim Medical Faculty is investigating the function of the vascular endothelium and its interaction with blood and tumour cells using microfluidics methods that enable him to measure the adhesion of cells to the walls of blood vessels under physiological flow conditions. As part of an interdisciplinary project, he is investigating the characteristics of wafer-thin surfaces covered with living cells, which…https://www.gesundheitsindustrie-bw.de/en/article/news/the-adhesion-of-cells-to-the-endothelium-and-to-artificial-surfaces
Article - 21/04/2008 Human blood system in mice Scientists from Mannheim Heidelberg an Freiburg working together in the cooperative research area Vascular Biology have developed a method that can be used to create a human vascular system in mice which stays functional even after several months.https://www.gesundheitsindustrie-bw.de/en/article/news/human-blood-system-in-mice