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  • Press release - 24/05/2023

    Epigenetic profiling identifies potential COPD treatment targets

    Impaired function of lung fibroblast is considered causative for symptoms of the incurable lung disease COPD (Chronic Obstructive Pulmonary Disease). Using high-resolution epigenetic profiling, German and British scientists have now identified potential targets for COPD treatment. The team detected early epigenetic changes in the genome of COPD fibroblasts, providing new insights into the disease pathogenesis and potential therapeutic avenues.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/epigenetic-profiling-identifies-potential-copd-treatment-targets
  • Press release - 09/05/2023

    New strategy for clinically relevant protein sequencing

    Proteins have characteristic amino acid sequences, the analysis of which is fundamental for research and medicine. These can be decoded; however, so-called protein sequencing is expensive and time-consuming. A large-scale research project led by Prof. Dr. Jan Behrends from the Institute of Physiology at the University of Freiburg now aims to establish a new technology for protein sequencing using nanopores, which will be rapid and cost-effective.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-strategy-clinically-relevant-protein-sequencing
  • Review - 09/02/2023 Ausschnitt von DNA-Doppelhelix

    5th Gene Technology Report – a critical observation of a cutting-edge technology

    The societal importance of genetic technologies was demonstrated during the coronavirus pandemic, when it was possible to rapidly develop suitable vaccines thanks to genetic engineering methods. As a result, the Fifth Gene Technology Report published in autumn 2021 reads like a validation of many years of work, as well as making it clear that the will to continue the detailed long-term monitoring is very much present.

    https://www.gesundheitsindustrie-bw.de/en/article/news/5th-gene-technology-report-critical-observation-cutting-edge-technology
  • Press release - 09/12/2022

    Epigenetic emergency switch improves defense against infections

    During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against the pathogens. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found an epigenetic switch in blood stem cells and progenitor cells of mice that can trigger the switch from one mode to the other.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/epigenetic-emergency-switch-improves-defense-against-infections
  • Press release - 02/11/2022

    The guardian of the (epi-)genome

    Toxicologists from the University of Konstanz have found that the protein p53 continuously protects our cells from tumorigenesis by coordinating important metabolic processes that stabilize their genomes.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/guardian-epi-genome
  • Press release - 31/08/2022

    Using nanopores to detect epigenetic changes faster

    Changes known as epigenetic modifications play an important role in cancer development, among other things. Being able to analyze them quickly and reliably could, for example, contribute significantly to the further development of personalized therapy.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/using-nanopores-detect-epigenetic-changes-faster
  • Press release - 31/01/2022

    Cancer research learns from space travel

    Researchers use epigenetic factors to investigate the role of stress in the development of tumor diseases. Experts believe that stress plays a major role in the development of tumors. One occupational group, for example, that experiences extreme stress over a short period of time is astronauts.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cancer-research-learns-space-travel
  • Press release - 18/12/2021

    WHO publishes first classification of childhood tumors

    The International Agency for Research on Cancer (IARC), an agency of the World Health Organization (WHO), will soon publish the first edition of its classification of childhood cancers. The new WHO classification forms the basis of modern, precise cancer diagnostics for physicians and pediatric oncologists worldwide and is based on the latest international research findings.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/who-publishes-first-classification-childhood-tumors
  • Gene regulation as a starting point for cancer therapies - 02/12/2021 Schematische Darstellung der verschiedenen Stadien der Genexpression. Nukleinsäurestränge sind durch farbige Linien, Proteine durch farbige Ellipsen und die Methylierung durch kleine Kreise dargestellt.

    New investigation method for deciphering complex epigenetic networks

    The development and maintenance of uncontrolled cell division in tumours is often due to the unbalanced, complex interplay of regulatory epigenetic networks. Researchers at the Institute of Biochemistry and Technical Biochemistry in Stuttgart have developed a new screening system to identify essential components that can serve as targets for anticancer drugs.

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-investigation-method-deciphering-complex-epigenetic-networks
  • Cluster of the future - 25/11/2021 NanodiagBW_Teaser.png

    nanodiagBW: using nanopores to create completely new diagnostic possibilities

    Modern medicine has a wide range of molecular diagnostics at hand. In the next decade, this will increasingly be supplemented by prognostic methods. The BMBF Cluster of the Future finalist, nanodiag BW, is developing prognostic methods to identify epigenetic factors for diseases through a new type of bioanalytics – single molecule analysis in nanopores – which would make it possible to take personalised prevention approaches.

    https://www.gesundheitsindustrie-bw.de/en/article/news/nanodiagbw-using-nanopores-create-completely-new-diagnostic-possibilities
  • Press release - 25/11/2021

    New Collaborative Research Centre at Ulm University Focusing on the factors that influence human aging

    After a highly competitive process Ulm University has been awarded its fifth Collaborative Research Centre (CRC). The new CRC 1506 ‘Aging at Interfaces’ addresses one of the most urgent medical challenges of our time: the aging of the human body and the diseases and constraints that are frequently associated with the aging process.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-collaborative-research-centre-ulm-university-focusing-factors-influence-human-aging
  • Press release - 18/11/2021

    Overcoming resistance to treatment for breast, bowel, and pancreatic cancer

    As cancer progresses, the tumor cells continually change, ultimately resulting in a tumor consisting of a large number of different cell clones with different characteristics. This is referred to as "tumor heterogeneity". In many cases, the cancer cells become resistant to the treatments available.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/overcoming-resistance-treatment-breast-bowel-and-pancreatic-cancer
  • Press release - 18/11/2021

    Overcoming resistance to cancer treatment: bone and soft tissue tumors in adolescents as a model system

    Treatment resistance is a central problem in the treatment of cancer. Bone and soft tissue tumors – known as sarcomas – in adolescents and young adults often stop responding to treatment too. This is because cancer cells develop a large number of new characteristics as the disease progresses and often become resistant to drugs that were originally effective.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/overcoming-resistance-cancer-treatment-bone-and-soft-tissue-tumors-adolescents-model-system
  • Press release - 16/11/2021

    Cystic fibrosis & COPD: Mucus reprograms immune cells and promotes airway inflammation

    Scientists of the Translational Lung Research Center Heidelberg (TLRC) and the German Cancer Research Center (DKFZ) have discovered a new link between excessive airway mucus and chronic airway inflammation that is characteristic of cystic fibrosis and chronic obstructive pulmonary disease (COPD). The researchers showed that mucus in the airways reprograms certain cells of the immune system.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cystic-fibrosis-copd-mucus-reprograms-immune-cells-and-promotes-airway-inflammation
  • Gene regulation - 20/07/2021 Vor schwarzem Hintergrund ist ein gelb leuchtendes Chromosom zwischen blau gefärbten Chromosomen sichtbar.

    The many faces of the epigenetic regulator MOF

    Epigenetic modifications play a crucial role in coordinated gene transcription, and are required for a fertilised egg cell to be able to develop into an organism with different cell types. Dr. Asifa Akhtar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been studying the essential epigenetic regulator protein MOF for 20 years.

    https://www.gesundheitsindustrie-bw.de/en/article/news/die-vielen-gesichter-des-epigenetischen-regulators-mof
  • Press release - 06/07/2021

    High-throughput metabolic profiling of single cells

    Scientists from the EMBL and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells. The method, which combines fluorescence microscopy and a specific form of mass spectroscopy, can analyze over a hundred metabolites and lipids from more than a thousand individual cells per hour. Researchers expect the method to better answer a variety of biomedical questions in the future.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/high-throughput-metabolic-profiling-single-cells
  • Press release - 17/05/2021

    New findings in genome research

    The working group around Dr. Philipp Rathert at the Institute for Biochemistry and Technical Biochemistry investigates the regulation of epigenetic networks of certain cancers and ways of treating them. The working group published its new findings in April.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-findings-genome-research
  • Article - 17/03/2021 Schematische Abbildung des Tetracyclin-induzierbaren epigenetischen Gedächtnissystems in einem Escherichia coli Bakterium.

    Epigenetic switches in bacteria as biosensors

    The analysis of pathogen biomarkers and biomarkers for the diagnosis of diseases can be crucial for health. However, the detection of pathogens and diseases depends on a sensitive and reliable method that delivers rapid results. Biosensors have such properties. Researchers at the Institute of Biochemistry and Technical Biochemistry (IBTB) at Stuttgart University have constructed an epigenetic circuit composed of plasmids that might make it…

    https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetic-switches-bacteria-biosensors
  • Press release - 24/02/2021

    Disease progression in childhood cancer: Lengthening of telomeres promotes relapse

    Neuroblastoma can spread relentlessly or shrink spontaneously. Scientists from the Hopp Children’s Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg and the National Center for Tumor Diseases (NCT) Heidelberg have shown that some malignant neuroblastomas employ a trick to avoid cell death: they use a special mechanism to lengthen the telomeres at the end of their chromosomes.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/disease-progression-childhood-cancer-lengthening-telomeres-promotes-relapse
  • Press release - 02/11/2020

    Juvenile myelomonocytic leukemia: International classification model allows for customized treatment

    Juvenile myelomonocytic leukemia (JMML) is a rare blood cancer of early childhood. Previous research activities have shown that JMML patients can be divided into three groups based on certain genetic markers, DNA methylation. Depending on the subgroup, statements can be made about the course of the disease.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/juvenile-myelomonocytic-leukemia-international-classification-model-allows-customized-treatment
  • Article - 09/10/2019 Der Kopf eines Wissenschaftlers vor einem Computerbildschirm mit Molekülmodell.

    Epigenomics from the Cyber Valley

    Cyber Valley Stuttgart-Tübingen is a European hotspot for artificial intelligence and home to many renowned experts and scientists. They are now joined by Gabriele Schweikert, who heads up the Computational Epigenomics research group in the Cyber Valley’s Division of Computational Biology. Schweikert is interested in exploring epigenetic mechanisms using machine learning methods.

    https://www.gesundheitsindustrie-bw.de/en/article/news/epigenomik-aus-dem-cyber-valley
  • Press release - 29/11/2018

    Hattrick in Freiburg

    Three researchers at the MPI for Immunobiology and Epigenetics receive millions in funding from the European Research Council. Dominic Grün, Nicola Iovino and Ritwick Sawarkar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg will each be awareded one of the prestigious Consolidator Grants of the European Research Council. This means that 6 million euros in funding will go to fundamental research in Freiburg over the next…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/hattrick-in-freiburg
  • Press release - 27/09/2018

    One hundred percent success

    Two Clusters of Excellence for the University of Freiburg: Biological Signalling Studies and Bioinspired Materials Research. It is a major boost to cutting-edge research in Freiburg: in the current Excellence Strategy competition, scientists at the University of Freiburg have been granted two Clusters of Excellence, CIBSS – Centre for Integrative Biological Signalling Studies, and livMatS – Living, Adaptive and Energy-autonomous Materials…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/one-hundred-percent-success
  • Press release - 03/04/2018 Simon Raffel, Lars Velten and Simon Haas.

    Double success for Heidelberg stem cell researchers

    Two awards at once, both carrying high monetary prizes, go to young researchers from the Heidelberg Institute for Stem Cell Research and Experimental Medicine (HI-STEM) at the German Cancer Research Center (DKFZ): Simon Raffel will receive the 2018 Walter Schulz Prize. Simon Haas will share the 2018 Otto Schmeil Prize with his colleague Lars Velten from EMBL.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/double-success-for-heidelberg-stem-cell-researchers
  • Article - 28/03/2018 Fluorescent microscope image of a human cell nucleus in the bottom right-hand corner. The nucleus contains numerous yellow dots. These represent signals that are emitted by methylated DNA sequences. The molecular structure of the sensor components is shown schematically in the top left-hand corner. We can see an anchor domain (orange) bound to DNA, a detector domain bound to a chromatin modification (red), and the active fluorophore (green).

    New method for analysing epigenetic modifications - in the service of medical progress

    It is not just genetic factors that influence developmental processes and diseases; it is becoming increasingly evident that epigenetic changes play a major role too. Thanks to a new method developed at the University of Stuttgart, epigenetic processes can now be investigated in living cells.

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-method-for-analysing-epigenetic-modifications-in-the-service-of-medical-progress
  • Article - 01/02/2018 The photo shows the dentate gyrus of a rat (part of the hippocampus). The nuclei of the nerve cells that run like a ribbon from the left-hand to the right-hand side of the photo, are stained red; immature, newly formed nerve cells are white.

    Combined test systems to advance the development of drugs for treating Alzheimer’s

    Which substances are suitable for treating neurodegenerative diseases such as Alzheimer's? Due to complex biochemical relationships, testing suitable drug candidates is difficult, especially in the early drug development phase. Many predictive test systems only cover individual aspects. A team from Baden-Württemberg and France is now combining different models to develop a new approach.

    https://www.gesundheitsindustrie-bw.de/en/article/news/combined-test-systems-to-advance-the-development-of-drugs-for-treating-alzheimers
  • Article - 11/12/2017 The photo shows a man with glasses holding a blue cord with flags and marks in his hands.

    KDM4 – an efficient target for the therapy of triple-negative breast cancer

    While breast cancer survival has clearly improved in recent years, women with triple-negative breast cancer have benefitted very little from progress in cancer medicine. Targeted therapies aimed at inhibiting epigenetic regulators might offer a potential new option for the treatment of breast cancer. Prof. Dr. Roland Schüle and Dr. Jochen Maurer have discovered an epigenetic enzyme called KDM4 and come up with a new cell model that significantly…

    https://www.gesundheitsindustrie-bw.de/en/article/news/kdm4-an-efficient-target-for-the-therapy-of-triple-negative-breast-cancer
  • Transregional research cooperation - 11/10/2017 Schematic representation of liver and gall bladder. Hepatitis C viruses are depicted in the background as round orange particles with white surface proteins. Some HC viruses are highlighted in the top left-hand corner of the image.

    New research consortium to develop new liver cancer treatments

    The causes, signs and symptoms of liver cancer are extremely complex. Investigating them requires the collaboration of many experts across university and regional boundaries. A new transregional research group is now studying the complex overall mechanisms at the cellular, genetic and molecular level in order to develop new concepts and drugs for treating liver and bile duct cancers.

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-research-consortium-to-develop-new-liver-cancer-treatments
  • Article - 01/06/2017 Woman in a blue lab coat pipetting a blue liquid into an electrophoresis system.

    Biotechnology – key technology of the 21st century

    According to a study published by the German National Academy of Science and Engineering (acatech) on 5th April, biotechnology is a key technology of the 21st century and has huge innovation potential. What are the trends within the industry and what are the challenges we face?

    https://www.gesundheitsindustrie-bw.de/en/article/news/biotechnology-key-technology-of-the-21st-century
  • Article - 08/09/2016 Computer image of gold molecules to which a diamondoid and a DNA molecule are bound.

    A diamond might make sequencing more accurate

    DNA sequencing techniques have been developed along the lines of faster, further, cheaper. State-of-the-art methods make it possible to handle large projects in a relatively short period of time. However, the error rate is still very high. Dr. Maria Fyta and her team at the Institute for Computational Physics at the University of Stuttgart have carried out quantum-transport calculations which suggested that specific chemical modifications in the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/a-diamond-might-make-sequencing-more-accurate
  • Article - 04/07/2016 The schematic shows how oesophageal cells develop into the two major types of oesophageal cancer.

    Epigenetic modifications for the treatment of oesophageal cancer

    Oesophageal cancer is a rare but highly aggressive type of cancer with a rather poor prognosis. Dr. Theresa Ahrens, a researcher in a group led by Prof. Dr. Silke Laßmann and Prof. Dr. Martin Werner at the Institute of Clinical Pathology at the Freiburg University Medical Centre, has tested a variety of epigenetic drugs that can interfere with the development of oesophageal cancer.

    https://www.gesundheitsindustrie-bw.de/en/article/news/modifikation-epigenetic-modifications-for-the-treatment-of-oesophageal-cancer-als-therapie-bei-speiseroehrenkrebs
  • Dossier - 18/04/2016 nucleosome_Rippe_DKFZ.jpg

    Epigenetics – heritable traits without changing the DNA sequence

    Epigenetics, i.e. the inheritance of traits that does not involve a change in the DNA sequence, was once a controversial subject that has since become a central focus of biological research. Epigenetic inheritance is now studied by numerous national and international research programmes. Many cellular regulatory and differentiation processes are controlled by epigenetic mechanisms that take place on different levels, including the DNA, histone,…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/epigenetics-heritable-traits-without-changing-the-dna-sequence
  • Article - 17/12/2015 Microscope image showing how stem cells stay close together.

    Inhibition of bromodomain affects stem cell differentiation

    DNA methylation and histone modification are epigenetic mechanisms that affect gene transcription. Moreover, protein complexes can regulate gene expression by modifying chromatin structure and function. Dr. Thomas Günther and his team from the Center for Clinical Research at the Freiburg University Medical Center are studying the effect of the inhibitor PFI-3 on the BAF complex. This protein complex modifies chromatin structure and controls the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/nhibition-of-bromodomain-affects-stem-cell-differentiation
  • Article - 16/11/2015 Erhardt_Sylvia_UniHD_Tobias_Schwerdt.jpg

    Centromere regulation and cancer

    Dr. Sylvia Erhardt from the ZMBH in Heidelberg is specifically focused on the function of the centromere, the part of the chromosome indispensable for correct segregation of the chromosomes during cell division. Malfunctioning centromeres lead to changes in chromosome number, which is a hallmark of many types of cancer.

    https://www.gesundheitsindustrie-bw.de/en/article/news/centromere-regulation-and-cancer
  • Researcher profile - 09/11/2015 Boutros_Michael_2015_2.jpg

    Michael Boutros – from the study of social gene networks to the management of the DKFZ

    Deregulation of cell signalling pathways is a major driver of cancer. Prof. Dr. Michael Boutros has pioneered the development of new methods for the analysis of genetic interactions in such complex networks. He has been acting Chairman and Scientific Member of the Management Board of the German Cancer Research Center (DKFZ) since September 1st 2015.

    https://www.gesundheitsindustrie-bw.de/en/article/news/michael-boutros-from-the-study-of-social-gene-networks-to-the-management-of-the-dkfz
  • Epigenetics - 10/08/2015 jeltsch2.jpg

    Reading domains detect and identify histone modifications

    Prof. Dr. Albert Jeltsch from the Institute of Biochemistry at the University of Stuttgart and his team of researchers have now presented an alternative method to detect and identify changes in the post-translational modifications of histones. They envisage that their new method, which uses parts of natural proteins, so-called reading domains, will make such tests cheaper and simpler, and experimental data more reliable.

    https://www.gesundheitsindustrie-bw.de/en/article/news/reading-domains-detect-and-identify-histone-modifications
  • Article - 26/05/2015 The photo shows two scientists looking into the camera.

    Novel effect of B-Raf inhibitors against bowel cancer discovered

    Colorectal carcinoma is the most frequent type of bowel cancer and the second most common tumour disease in men and women in Germany. A particularly aggressive form occurs when a mutation is present in the proto-oncogene BRAF. As part of the Collaborative Research Centre 850 at the Institute of Molecular Medicine and Cell Research at the University of Freiburg, Dr. Ricarda Herr and Dr. Tilman Brummer are trying to find out how a mutated BRAF gene…

    https://www.gesundheitsindustrie-bw.de/en/article/news/novel-effect-of-b-raf-inhibitors-against-bowel-cancer-discovered
  • Overview

    Basic research

    The latest articles, press releases and dossiers on basic research in Baden-Württemberg

    https://www.gesundheitsindustrie-bw.de/en/article/research
  • Overview

    Diagnostics

    The latest articles, press releases and dossiers on diagnostics in Baden-Württemberg

    https://www.gesundheitsindustrie-bw.de/en/article/diagnostics
  • Article - 02/03/2015 22850_de.jpg

    EU supports biophysicists from Ulm to elucidate the structure of chromatin

    Human DNA consists of three billion base pairs, which corresponds to a total length of approximately two metres. DNA must be compressed 200,000-fold in order to fit into the tiny nuclei of mammalian cells. The thread-like complex of DNA and proteins is called chromatin. Although chromatin has been widely studied, relatively little is yet known about the spatial and temporal organisation of chromatin in interphase cells.

    https://www.gesundheitsindustrie-bw.de/en/article/news/eu-supports-biophysicists-from-ulm-to-elucidate-the-structure-of-chromatin
  • Article - 26/01/2015 22698_de.jpg

    A biomarker as indicator for the likelihood of developing aggressive prostate cancer

    Overexpression of the protein BAZ2A, which leads to alterations in epigenetic patterns, increases the malignant properties of tumour cells, including their mobility and their ability to form metastases. The findings of a team of researchers from Heidelberg, Zurich and Hamburg may have led to the discovery of an urgently needed prognostic biomarker that would make it possible to differentiate aggressive prostate cancer from the less malignant…

    https://www.gesundheitsindustrie-bw.de/en/article/news/a-biomarker-as-indicator-for-the-likelihood-of-developing-aggressive-prostate-cancer
  • Guest article - 19/01/2015 The photo shows a clothes line with clothes and shoes in a small street. Skyscrapers can be seen in the distance.

    Rich in contrasts – three research months in Shanghai

    After graduating, Johannes Zang applied for a Baden-Württemberg Ministry of Science, Research and the Arts China Scholarship to spend three months in Shanghai before going on to do his PhD. At the Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, he was, amongst other things, involved in elucidating the crystal structures of proteins. He also had time to learn about the city of Shanghai, China and the Chinese…

    https://www.gesundheitsindustrie-bw.de/en/article/news/rich-in-contrasts-three-research-months-in-shanghai
  • Article - 15/12/2014 Schematic showing how cardiac muscle cells are prepared, and how cell nuclei and the genetic material are isolated.

    Heart muscle cell 1.0 and 2.0 – two epigenetic programmes in one cell

    All the cells in an organism have to adapt to changing requirements as they develop and grow - including muscle cells in the heart. Crucial to this process are the cells’ growth in size and epigenetic factors that play a role in modulating the expression of various genes. The role of epigenetics in cancer development has been the focus of research for quite some time. The question is, what role do epigenetic factors play in the development of the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/heart-muscle-cell-1-0-and-2-0-two-epigenetic-programmes-in-one-cell
  • Article - 08/09/2014 21988_de.jpg

    Thomas Boehm – pushing back the frontiers of knowledge

    The comparison of different animal species enables us to understand the crucial principle of immune defence on condition that the right investigative approach is chosen. Prof. Dr. Thomas Boehm director of the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been doing just this for many years. Based on insights into fundamental immune system functions Boehms research is aimed at developing new strategies for the diagnosis…

    https://www.gesundheitsindustrie-bw.de/en/article/news/thomas-boehm-pushing-back-the-frontiers-of-knowledge
  • Article - 14/07/2014 The photo shows Andreas Marx and Martin Scheffner in the laboratory and evaluating a Petri dish.

    Andreas Marx – “Chemical Biology” of DNA polymerases

    Whether inside the cell or in molecular biology laboratories, the synthesis of DNA would not be possible without DNA polymerases. The regulation and application of this versatile enzyme family is the subject of research carried out by Prof. Dr. Andreas Marx at the University of Konstanz in Southern Germany. In addition to basic research into naturally occurring DNA polymerases, Marx deals with the development of novel polymerases that can be used…

    https://www.gesundheitsindustrie-bw.de/en/article/news/andreas-marx-chemical-biology-of-dna-polymerases
  • Article - 30/06/2014 The photo shows Dr. Summerer and two of his colleagues in the laboratory.

    Targeting epigenetic DNA modifications for the diagnosis of cancer

    Epigenetic DNA modifications have been shown to play a role in carcinogenesis and are therefore a promising target for the early detection of cancer. Dr. Daniel Summerer and his research group at the University of Konstanz have developed a method that enables the direct and site-specific identification of epigenetic changes. The method represents a new approach in the field of epigenetic analysis as well as a major step towards simpler cancer…

    https://www.gesundheitsindustrie-bw.de/en/article/news/targeting-epigenetic-dna-modifications-for-the-diagnosis-of-cancer
  • Article - 31/03/2014 Microscopic image in which the nuclei and cytoskeleton are strained.

    Lsd1 – a gatekeeper for differentiation onset of embryonic mouse stem cells

    Epigenetics is an emerging field of research that studies heritable changes in gene expression that are not caused by changes in the underlying DNA sequence. Prof. Dr. Roland Schüle, Director of Central Clinical Research at the Freiburg University Medical Centre, and his team are specifically focused on epigenetic modifiers that regulate the timely development of placental mouse tissue. Schüle and his team have discovered in mouse embryos that a…

    https://www.gesundheitsindustrie-bw.de/en/article/news/lsd1-a-gatekeeper-for-differentiation-onset-of-embryonic-mouse-stem-cells
  • Dossier - 10/03/2014 20939_de.jpg

    Cancer therapy and cancer diagnostics

    Thanks to improved diagnostics and therapy, today’s cancer patients can live considerably longer than patients several years ago. Nevertheless, some cancers, especially the strongly metastatic ones, are difficult to treat. Therapies targeting immune cells or cancer stem cells could potentially improve the current situation. The early detection and classification of tumours is crucial for the successful treatment of the disease, and molecular…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/cancer-therapy-and-cancer-diagnostics
  • Article - 29/07/2013 20141_de.jpg

    ‘Go back to start’ in the field of meiosis

    Researchers have long thought they knew exactly how meiosis, meiosis regulators and the complex that forms between homologous chromosomes during meiosis work. The research group headed by Dr. Andrea Pichler from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has now discovered a new mechanism that plays an important role in meiosis. The study carried out by Pichler and her colleague Dr. Helene Klug has shown why it is…

    https://www.gesundheitsindustrie-bw.de/en/article/news/go-back-to-start-in-the-field-of-meiosis
  • Article - 10/06/2013 Dr. Tanja Waldmann (right) and her doctoral student Nina Balmer are developing cell culture systems with human embryonic stem cells. The photo shows the two scientists working in the laboratory.

    Stem-cell tests to provide protection to unborn babies

    The development of unborn babies may already be impaired in the womb by pollutants from the environment food and drugs to which their mothers are exposed. Reliable and informative toxicity tests are necessary in order to assess and prevent the effects toxic substances may have on unborn babies. Biologist Dr. Tanja Waldmann from Konstanz University is developing toxicity test systems based on human embryonic stem cells which contribute to improved…

    https://www.gesundheitsindustrie-bw.de/en/article/news/stem-cell-tests-to-provide-protection-to-unborn-babies
  • Article - 13/05/2013 19672_de.jpg

    Cardiomyopathies and epigenetic inheritance

    Epigenetic mechanisms, along with gene mutations, have been shown to play important roles in the development of heart diseases. Researchers from Heidelberg have discovered that the methylation of two specific genes has an impact on the development of dilated cardiomyopathy. These epigenetic modifications have the potential to be used as molecular markers and improve the diagnosis and therapy of these particular heart diseases.

    https://www.gesundheitsindustrie-bw.de/en/article/news/cardiomyopathies-and-epigenetic-inheritance
  • Dossier - 13/05/2013 19501_de.jpg

    The human proteome – the next major goal

    The “Human Proteome Project”, a ten-year global initiative that is making a systematic effort to map all human proteins, has moved from the planning to the experimental stage. How significant and how effective the project will be depends on how much the resources offered are used by proteome researchers and on the data that the researchers bring into the project.

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/the-human-proteome-the-next-major-goal
  • Article - 15/04/2013 19500_de.jpg

    Price pressure requires new product developments – the "Bioactive Plant Foods" network

    The Bioactive Plant Foods network which is coordinated by the Steinbeis-Europa-Zentrum in Stuttgart is focused on developing innovative products that have a positive effect on human health and placing them on the market. Research resolves around the health-promoting effect of amaranth a short-lived plant with catkin-like cymes of densely packed red flowers. More than 20 partners from industry science and marketing have been working together since…

    https://www.gesundheitsindustrie-bw.de/en/article/news/price-pressure-requires-new-product-developments-the-bioactive-plant-foods-network
  • Article - 25/03/2013 19369_de.jpg

    Epigenetics for personalised cancer care for women

    Every year in the EU, 45,300 women are diagnosed with ovarian cancer and 330,000 with breast cancer. Ovarian cancer has a mortality rate of around 64% and breast cancer around 27%*. The EU-funded research project EpiFemCare aims at improving cancer detection and subsequent patient care. The research project aims to develop blood tests based on epigenetic DNA modifications, i.e. the methylation of the base cytosine, for the identification of…

    https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-for-personalised-cancer-care-for-women
  • Article - 28/01/2013 19105_de.jpg

    Epigenetics and childhood blood cancer

    Juvenile myelomonocytic leukaemia JMML is the most common chronic cancer of the blood in children and tends to have a poor response to chemotherapy. Prof. Dr. Christian Flotho and his team from the Centre of Paediatric and Adolescent Medicine in Freiburg have shown that epigenetic mechanisms play a key role in the pathogenesis of JMML. As part of a German Research Foundation priority programme the researchers from Freiburg are working on…

    https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-and-childhood-blood-cancer
  • Article - 19/11/2012 18680_de.jpg

    Uncovering the genetics of prostate cancer

    The prostate genome project, which is part of the International Cancer Genome Consortium, is focused on the genetic and epigenetic causes of the development and progression of this highly variable cancer and finding markers that enable the reliable diagnosis of the disease. The German research groups involved in the project are coordinated by the German Cancer Research Center and concentrate on prostate cancer patients under 50 years of age, as…

    https://www.gesundheitsindustrie-bw.de/en/article/news/uncovering-the-genetics-of-prostate-cancer
  • Press release - 12/11/2012 16634_de.jpg

    Searching for new strategies against prostate cancer

    The European Research Council (ERC) has announced that Roland Schüle, Scientific Director at the Department of Urology, University of Freiburg Medical Centre has been awarded an ERC Advanced Grant. Professor Schüle will receive €2.5 million for a period of 5 years for his research proposal to identify and characterize the molecular and physiological functions of the epigenetic enzyme LSD1 and to explore its role in prostate cancer.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/searching-for-new-strategies-against-prostate-cancer
  • Dossier - 05/11/2012 18550_de.jpg

    Cancer – basic research, successes and trends

    Science is approaching cancer treatment by using new systems biology approaches and setting up large-scale multidisciplinary projects such as the International Cancer Genome Consortium. Progress in genome, epigenome and gene expression analyses of cancer cells, new insights into the regulation and interaction of cells gained in cooperation with stem cell research and virus research contributes to gaining a causal understanding of cancer. This…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/cancer-basic-research-successes-and-trends
  • Article - 15/10/2012 18357_de.jpg

    ERC Starting Grants 2012: Baden-Württemberg achieves above-average success

    On September 10th 2012, the European Research Council (ERC) announced the results of the fifth funding round of its Starting Grants. Baden-Württemberg was awarded 13 grants, and is the state with the largest number of a total of 34 grants awarded to German life sciences researchers. Baden-Württemberg life sciences researchers will be receiving Starting Grants worth around 20 million euros.

    https://www.gesundheitsindustrie-bw.de/en/article/news/erc-starting-grants-2012-baden-wuerttemberg-achieves-above-average-success
  • Article - 17/09/2012 The photo shows a rosette-like structure consisting of differently coloured subunits.

    Biochemisty and the assembly of ammonium machines

    Researchers who intend to build enzymes in the laboratory need detailed knowledge about the function of the respective enzymes. Using modern biochemistry methods researchers led by Prof. Dr. Oliver Einsle from the University of Freiburg have in the last few years clarified the atomic structure of a complex bacterial protein that converts atmospheric nitrogen into a form that can be readily used by other organisms. The researchers have recently…

    https://www.gesundheitsindustrie-bw.de/en/article/news/biochemisty-and-the-assembly-of-ammonium-machines
  • Article - 06/08/2012 17713_de.jpg

    varionostic: specialist in epigenetic analyses

    Ulm-based varionostic helps epigenetics researchers to obtain information on gene activity. The company is specifically focused on the analysis of methyl groups (-CH3) that are attached to DNA and turn genes on and off. Just as the field of epigenetics, previously only known to insiders, has emerged as a biomedical area of research, the University of Ulm spin-off has matured and grown over the past six years since it was set up.

    https://www.gesundheitsindustrie-bw.de/en/article/news/varionostic-specialist-in-epigenetic-analyses
  • Press release - 03/08/2012 17813_de.jpg

    Dosage compensation in male flies: Balance between sexes

    The sex of many organisms is determined by the number of X chromosomes. In humans women have two X chromosomes whereas men have only one but also have an additional Y chromosome. Why this does not result in an imbalance in the expression of important genes on the X chromosome is what researchers at the Max Planck Institute in Freiburg have examined in collaboration with researcher in Cambridge UK. They have been able to show that the initiation…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/dosage-compensation-in-male-flies-balance-between-sexes
  • Press release - 04/06/2012 12300_de.jpg

    DFG establishes 20 new Collaborative Research Centres

    The support ranges from new therapies for multiple sclerosis via the heroic tradition in ancient time to functional microgels. Attached is a selection of research approaches in science in Baden-Württemberg.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/dfg-establishes-20-new-collaborative-research-centres
  • Article - 21/05/2012 17201_de.jpg

    Interactions between the genome and the environment

    Parental neglect appears to lead to epigenetic changes in children, which result in behavioural problems in later years. This is one issue amongst the many that were addressed at the colloquium “Gene und Umwelt – Wie wir werden, was wir sind” (Genes and the environment – how we become what we are) recently organized by the Daimler and Benz Foundation in Berlin.

    https://www.gesundheitsindustrie-bw.de/en/article/news/interactions-between-the-genome-and-the-environment
  • Article - 23/04/2012 16983_de.jpg

    Iris-Tatjana Kolassa – extreme stress takes a toll on cells

    Molecular psychology has huge potential for the future. The discipline has used imaging methods for diagnostic purposes for a long time, but Iris-Tatjana Kolassa, a 33-year-old psychologist from Ulm, is convinced that in future it will increasingly use molecular biology and medicine methods. The idea of remaining blinkered in her own discipline is a notion that is utterly foreign to Kolassa; whenever she senses synergies, whether it be with…

    https://www.gesundheitsindustrie-bw.de/en/article/news/iris-tatjana-kolassa-extreme-stress-takes-a-toll-on-cells
  • Article - 05/03/2012 The photo shows nine people standing on a staircase.

    Ubiquitin and related molecules do more than just degrade and recycle cellular waste

    The proteins of the ubiquitin family have long been regarded as cellular Post-its with to be discarded written on them. However over the last ten years it has become increasingly clear that the proteins of the ubiquitin family that cells use to label defective or unneeded proteins also regulate a broad range of important cellular processes. It has also been found that they are involved in the pathogenesis of cancer and neurodegenerative diseases…

    https://www.gesundheitsindustrie-bw.de/en/article/news/ubiquitin-and-related-molecules-do-more-than-just-degrade-and-recycle-cellular-waste
  • Press release - 01/02/2012 Logo DKFZ, blue letters "DKFZ"

    Defects in the packaging of genetic material in malignant brain tumors

    Glioblastomas are regarded as particularly aggressive brain tumors. In children with glioblastoma, Heidelberg scientists have now discovered genetic alterations that affect the function of DNA packaging proteins known as histones. In a cell, histones serve as coils around which the DNA wraps. At the same time, histones regulate gene activity. Mutations in histone genes have never before been tied to a disease. The group comprising scientists of…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/defects-in-the-packaging-of-genetic-material-in-malignant-brain-tumors
  • Article - 16/01/2012 The photo shows fifteen people standing in front of a building.

    Manfred Jung: drug discovery and the epigenetic code

    Prof. Dr. Manfred Jungs team at the University of Freiburg are chemical epigeneticists whose research involves the development of methods that enable them to identify and optimise new therapeutic drugs which are able to alter the epigenetic code of cancer and other cell types. The team use a perfidious worm for their research.

    https://www.gesundheitsindustrie-bw.de/en/article/news/manfred-jung-drug-discovery-and-the-epigenetic-code
  • Article - 19/12/2011 16054_de.jpg

    Patrick Heun: The DNA tangle and how it is organised

    Dr. Patrick Heun and his group of researchers at the Max Planck Institute MPI of Immunobiology and Epigenetics in Freiburg are working on elucidating the spatial organisation of cell nuclei and how the structure of chromosomes is passed on to daughter cells during the division of cells. The researchers have come up with clear proof that the formation of centromeres depends on a single molecule.

    https://www.gesundheitsindustrie-bw.de/en/article/news/patrick-heun-the-dna-tangle-and-how-it-is-organised
  • Article - 12/12/2011 16001_de.jpg

    Comprehensive Biomarker Center GmbH – next-generation biomarkers

    Biomarker research has moved on from proteins to nucleic acids where one of the main priorities is the use of microRNA expression profiles. The Heidelberg-based biotech company Comprehensive Biomarker Center GmbH (CBC, formerly febit) has state-of-the-art technologies and the skills and knowledge to advance the development of new nucleic acid biomarkers for complex diseases in cooperation with partners from research and industry.

    https://www.gesundheitsindustrie-bw.de/en/article/news/comprehensive-biomarker-center-gmbh-next-generation-biomarkers
  • Press release - 05/12/2011 10163_de.JPG

    Cellzome founder wins EU women innovators award

    Cellzome announces 5 December 2011 that Dr. Gitte Neubauer has received the highly esteemed EU Women Innovators Award. The award recognizes her outstanding contribution in translating academic research into a commercial venture through the foundation of Cellzome. The prize value of 100.000 euros awarded by the European Commission Innovation Union was presented by Jos Manuel Barroso in a ceremony as part of the Innovation Convention 2011 in…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cellzome-founder-wins-eu-women-innovators-award
  • Article - 14/11/2011 15790_de.jpg

    Marina Freudenberg and Chris Galanos – more than 40 years of bacterial defence research

    This years Nobel Prize in Medicine or Physiology was awarded to three renowned scientists one of whom is the American Bruce Beutler who was instrumental in clarifying the structure of the mammalian Toll-like 4 TLR4 receptor. Prof. Dr. med. Marina Freudenberg and Dr. Dr. h.c. Chris Galanos from the Freiburg-based Max Planck Institute MPI of Immunobiology and Epigenetics have co-authored the key publication that led to the award of the Nobel Prize…

    https://www.gesundheitsindustrie-bw.de/en/article/news/marina-freudenberg-and-chris-galanos-more-than-40-years-of-bacterial-defence-research
  • Press release - 21/09/2011 15391_de.jpg

    Epigenetic changes don’t last

    First comprehensive inventory of epigenetic changes over several generations shows that these often do not last and therefore probably have limited effects on long-term evolution. The team around Detlef Weigel, director of the Department for Molecular Biology, focused on one of the most important epigenetic marks, methylation of DNA.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/epigenetic-changes-don-t-last
  • Article - 25/07/2011 14841_de.jpg

    Silke Brüderlein has “green fingers” for cell cultures

    Many researchers in the biosciences work with cell cultures, but not all of them seem to understand them at a deeper level. The biologist Silke Brüderlein from the Institute of Pathology in Ulm is a specialist in cell culture and is well aware of the problems that might arise when working with cell cultures.

    https://www.gesundheitsindustrie-bw.de/en/article/news/silke-bruederlein-has-green-fingers-for-cell-cultures
  • Press release - 13/07/2011 14775_de.jpg

    Kinetochores prefer the “silent” DNA sections of the chromosome

    The centromere is a specialized region of the chromosome, on which a protein complex known as the kinetochore is assembled. During cell division, the kinetochore provides a point of attachment for molecules of the cytoskeleton, thereby mediating the segregation of chromosomes to the two opposing cell poles. Scientists from the Max Planck Institute of Immunobiology and Epigenetics and BIOSS in Freiburg have investigated the factors that play an…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/kinetochores-prefer-the-silent-dna-sections-of-the-chromosome

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