Article - 04/07/2016 Epigenetic modifications for the treatment of oesophageal cancer Oesophageal cancer is a rare but highly aggressive type of cancer with a rather poor prognosis. Dr. Theresa Ahrens, a researcher in a group led by Prof. Dr. Silke Laßmann and Prof. Dr. Martin Werner at the Institute of Clinical Pathology at the Freiburg University Medical Centre, has tested a variety of epigenetic drugs that can interfere with the development of oesophageal cancer. https://www.gesundheitsindustrie-bw.de/en/article/news/modifikation-epigenetic-modifications-for-the-treatment-of-oesophageal-cancer-als-therapie-bei-speiseroehrenkrebs
Dossier - 18/04/2016 Epigenetics – heritable traits without changing the DNA sequence Epigenetics, i.e. the inheritance of traits that does not involve a change in the DNA sequence, was once a controversial subject that has since become a central focus of biological research. Epigenetic inheritance is now studied by numerous national and international research programmes. Many cellular regulatory and differentiation processes are controlled by epigenetic mechanisms that take place on different levels, including the DNA, histone,…https://www.gesundheitsindustrie-bw.de/en/article/dossier/epigenetics-heritable-traits-without-changing-the-dna-sequence
Press release - 20/07/2009 University Medical Centre Freiburg coordinates popular DFG priority programme The German Research Foundation (DFG) has granted the Medical Hospital in Freiburg and the German Cancer Research Centre in Heidelberg funding for a proposal applying to become one of the DFG’s 18 priority programmes in 2009. https://www.gesundheitsindustrie-bw.de/en/article/press-release/university-medical-centre-freiburg-coordinates-popular-dfg-priority-programme
Article - 17/03/2021 Epigenetic switches in bacteria as biosensors The analysis of pathogen biomarkers and biomarkers for the diagnosis of diseases can be crucial for health. However, the detection of pathogens and diseases depends on a sensitive and reliable method that delivers rapid results. Biosensors have such properties. Researchers at the Institute of Biochemistry and Technical Biochemistry (IBTB) at Stuttgart University have constructed an epigenetic circuit composed of plasmids that might make it…https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetic-switches-bacteria-biosensors
Press release - 17/05/2021 New findings in genome research The working group around Dr. Philipp Rathert at the Institute for Biochemistry and Technical Biochemistry investigates the regulation of epigenetic networks of certain cancers and ways of treating them. The working group published its new findings in April. https://www.gesundheitsindustrie-bw.de/en/article/press-release/new-findings-genome-research
Press release - 15/02/2011 Cellzome Announces Achievement of Second Milestone in Epigenetics Collaboration with GSK Cellzome announced today that it has achieved the second milestone in its epigenetics alliance with GlaxoSmithKline. The milestone triggers a payment of an undisclosed amount from GSK and follows only two months after the first milestone was achieved. https://www.gesundheitsindustrie-bw.de/en/article/press-release/cellzome-announces-achievement-of-second-milestone-in-epigenetics-collaboration-with-gsk
Article - 11/10/2010 Cow sheds and asthma genetics Many genes are known to play a role in the development of the chronic lung disease bronchial asthma. Dr. Andrea Heinzmanns team at the University Medical Centre Freiburg has investigated some of these genes and is also interested in epigenetic factors. It is known that asthma is not only caused by genetic factors but can also be triggered by mechanisms that affect the genes without changing the genetic code.https://www.gesundheitsindustrie-bw.de/en/article/news/cow-sheds-and-asthma-genetics
Press release - 29/11/2018 Hattrick in Freiburg Three researchers at the MPI for Immunobiology and Epigenetics receive millions in funding from the European Research Council. Dominic Grün, Nicola Iovino and Ritwick Sawarkar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg will each be awareded one of the prestigious Consolidator Grants of the European Research Council. This means that 6 million euros in funding will go to fundamental research in Freiburg over the next…https://www.gesundheitsindustrie-bw.de/en/article/press-release/hattrick-in-freiburg
Article - 11/12/2017 KDM4 – an efficient target for the therapy of triple-negative breast cancer While breast cancer survival has clearly improved in recent years, women with triple-negative breast cancer have benefitted very little from progress in cancer medicine. Targeted therapies aimed at inhibiting epigenetic regulators might offer a potential new option for the treatment of breast cancer. Prof. Dr. Roland Schüle and Dr. Jochen Maurer have discovered an epigenetic enzyme called KDM4 and come up with a new cell model that significantly…https://www.gesundheitsindustrie-bw.de/en/article/news/kdm4-an-efficient-target-for-the-therapy-of-triple-negative-breast-cancer
Gene regulation - 20/07/2021 The many faces of the epigenetic regulator MOF Epigenetic modifications play a crucial role in coordinated gene transcription, and are required for a fertilised egg cell to be able to develop into an organism with different cell types. Dr. Asifa Akhtar from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg has been studying the essential epigenetic regulator protein MOF for 20 years.https://www.gesundheitsindustrie-bw.de/en/article/news/die-vielen-gesichter-des-epigenetischen-regulators-mof
Article - 16/01/2012 Manfred Jung: drug discovery and the epigenetic code Prof. Dr. Manfred Jungs team at the University of Freiburg are chemical epigeneticists whose research involves the development of methods that enable them to identify and optimise new therapeutic drugs which are able to alter the epigenetic code of cancer and other cell types. The team use a perfidious worm for their research.https://www.gesundheitsindustrie-bw.de/en/article/news/manfred-jung-drug-discovery-and-the-epigenetic-code
Article - 28/03/2018 New method for analysing epigenetic modifications - in the service of medical progress It is not just genetic factors that influence developmental processes and diseases; it is becoming increasingly evident that epigenetic changes play a major role too. Thanks to a new method developed at the University of Stuttgart, epigenetic processes can now be investigated in living cells.https://www.gesundheitsindustrie-bw.de/en/article/news/new-method-for-analysing-epigenetic-modifications-in-the-service-of-medical-progress
Article - 15/12/2014 Heart muscle cell 1.0 and 2.0 – two epigenetic programmes in one cell All the cells in an organism have to adapt to changing requirements as they develop and grow - including muscle cells in the heart. Crucial to this process are the cells’ growth in size and epigenetic factors that play a role in modulating the expression of various genes. The role of epigenetics in cancer development has been the focus of research for quite some time. The question is, what role do epigenetic factors play in the development of the…https://www.gesundheitsindustrie-bw.de/en/article/news/heart-muscle-cell-1-0-and-2-0-two-epigenetic-programmes-in-one-cell
Press release - 11/03/2010 Cellzome Announces Second Alliance with GlaxoSmithKline Cellzome today announced that it has formed a second strategic alliance with GlaxoSmithKline (GSK). This new collaboration gives GSK exclusive access to Cellzome’s proprietary Episphere™ technology in the emerging field of epigenetics as applied to immunoinflammatory disease. Epigenetic mechanisms play a key role in controlling immune cell differentiation and inflammatory gene expression during an excessive inflammatory response. https://www.gesundheitsindustrie-bw.de/en/article/press-release/cellzome-announces-second-alliance-with-glaxosmithkline
Press release - 26/01/2011 ‘Complexes Matter’ in How Epigenetic Inhibitors Interact with Their Drug Targets Cellzome Scientists Publish First Chemoproteomic Characterization of HDAC Inhibitors in Nature Biotechnology. Results of the first ever chemoproteomic study of inhibition of HDAC Histone Deacetylase complexes opens up the potential for a new way of studying potency and selectivity for inhibitors of epigenetic drug targets such as HDACs. https://www.gesundheitsindustrie-bw.de/en/article/press-release/complexes-matter-in-how-epigenetic-inhibitors-interact-with-their-drug-targets
Overview Diagnostics The latest articles, press releases and dossiers on diagnostics in Baden-Württemberghttps://www.gesundheitsindustrie-bw.de/en/article/diagnostics
Article - 30/06/2014 Targeting epigenetic DNA modifications for the diagnosis of cancer Epigenetic DNA modifications have been shown to play a role in carcinogenesis and are therefore a promising target for the early detection of cancer. Dr. Daniel Summerer and his research group at the University of Konstanz have developed a method that enables the direct and site-specific identification of epigenetic changes. The method represents a new approach in the field of epigenetic analysis as well as a major step towards simpler cancer…https://www.gesundheitsindustrie-bw.de/en/article/news/targeting-epigenetic-dna-modifications-for-the-diagnosis-of-cancer
Article - 21/05/2012 Interactions between the genome and the environment Parental neglect appears to lead to epigenetic changes in children, which result in behavioural problems in later years. This is one issue amongst the many that were addressed at the colloquium “Gene und Umwelt – Wie wir werden, was wir sind” (Genes and the environment – how we become what we are) recently organized by the Daimler and Benz Foundation in Berlin.https://www.gesundheitsindustrie-bw.de/en/article/news/interactions-between-the-genome-and-the-environment
Article - 25/03/2013 Epigenetics for personalised cancer care for women Every year in the EU, 45,300 women are diagnosed with ovarian cancer and 330,000 with breast cancer. Ovarian cancer has a mortality rate of around 64% and breast cancer around 27%*. The EU-funded research project EpiFemCare aims at improving cancer detection and subsequent patient care. The research project aims to develop blood tests based on epigenetic DNA modifications, i.e. the methylation of the base cytosine, for the identification of…https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-for-personalised-cancer-care-for-women
Overview Basic research The latest articles, press releases and dossiers on basic research in Baden-Württemberghttps://www.gesundheitsindustrie-bw.de/en/article/research
Press release - 07/08/2009 Silenced genes as a warning sign of blood cancer Important growth inhibitors are often switched off in the genetic material of cancer cells by specific chemical DNA modifications. Scientists of the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ), in collaboration with colleagues from Ohio State University in the United States, have investigated how this happens. They discovered, in mice, that cancer-typical DNA methylation occurs long before the first symptoms of…https://www.gesundheitsindustrie-bw.de/en/article/press-release/silenced-genes-as-a-warning-sign-of-blood-cancer
Article - 26/01/2015 A biomarker as indicator for the likelihood of developing aggressive prostate cancer Overexpression of the protein BAZ2A, which leads to alterations in epigenetic patterns, increases the malignant properties of tumour cells, including their mobility and their ability to form metastases. The findings of a team of researchers from Heidelberg, Zurich and Hamburg may have led to the discovery of an urgently needed prognostic biomarker that would make it possible to differentiate aggressive prostate cancer from the less malignant…https://www.gesundheitsindustrie-bw.de/en/article/news/a-biomarker-as-indicator-for-the-likelihood-of-developing-aggressive-prostate-cancer
Press release - 20/05/2008 Bookmarks in the human book of life Histone acetyltransferases HATs and their antagonists the histone deacetylases are important enzymes in epigenetic gene regulation. Scientists discovered new HAT inhibitors that are now being investigated for their potential as anti-cancer drugs.https://www.gesundheitsindustrie-bw.de/en/article/press-release/bookmarks-in-the-human-book-of-life
Article - 17/12/2015 Inhibition of bromodomain affects stem cell differentiation DNA methylation and histone modification are epigenetic mechanisms that affect gene transcription. Moreover, protein complexes can regulate gene expression by modifying chromatin structure and function. Dr. Thomas Günther and his team from the Center for Clinical Research at the Freiburg University Medical Center are studying the effect of the inhibitor PFI-3 on the BAF complex. This protein complex modifies chromatin structure and controls the…https://www.gesundheitsindustrie-bw.de/en/article/news/nhibition-of-bromodomain-affects-stem-cell-differentiation
Article - 06/08/2012 varionostic: specialist in epigenetic analyses Ulm-based varionostic helps epigenetics researchers to obtain information on gene activity. The company is specifically focused on the analysis of methyl groups (-CH3) that are attached to DNA and turn genes on and off. Just as the field of epigenetics, previously only known to insiders, has emerged as a biomedical area of research, the University of Ulm spin-off has matured and grown over the past six years since it was set up.https://www.gesundheitsindustrie-bw.de/en/article/news/varionostic-specialist-in-epigenetic-analyses