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  • Cancer immunotherapy - 06/09/2018 Schematic showing the so-called breakthrough event as well as the expansion and invasion stages of cells during carcinogenesis.

    The immunogenicity of tumours and the development of new cancer medicines

    Microsatellite-unstable cancers are characterised by a large number of mutations within short repetitive DNA sequence regions, and can form novel peptides that the human immune system recognises as neoantigens. These cancers represent a starting point for the development of vaccines to prevent them appearing at an early stage of development. Microsatellite instability is particularly frequent in colon and cervical cancers.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-immunogenicity-of-tumours-and-the-development-of-new-cancer-medicines
  • Press release - 02/09/2021

    Award-winning science: Cancer-promoting metabolic pathways as targets of new therapies

    Christiane Opitz, scientist at the German Cancer Research Center, is being awarded this year's Ita Askonas Prize of the European Federation of Immunological Societies. Opitz has discovered how tumor cells use certain metabolites to protect themselves against the immune system. Her research findings may provide important clues for the development of new therapeutic concepts.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/award-winning-science-cancer-promoting-metabolic-pathways-targets-new-therapies
  • Press release - 16/11/2021

    Cystic fibrosis & COPD: Mucus reprograms immune cells and promotes airway inflammation

    Scientists of the Translational Lung Research Center Heidelberg (TLRC) and the German Cancer Research Center (DKFZ) have discovered a new link between excessive airway mucus and chronic airway inflammation that is characteristic of cystic fibrosis and chronic obstructive pulmonary disease (COPD). The researchers showed that mucus in the airways reprograms certain cells of the immune system.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/cystic-fibrosis-copd-mucus-reprograms-immune-cells-and-promotes-airway-inflammation
  • Macrophages interacting with cytomegaloviruses - 22/02/2022 Graphik_CMV_Makrophagen_Teaser.jpg

    Cytomegaloviruses subvert macrophage identity

    Cytomegaloviruses are basically harmless. However, if they occur along with other pathogens, they can trigger serious diseases. They can manipulate our immune system and encourage resident defence cells to migrate. Researchers at the Centre for Chronic Immunodeficiency (CCI) at the Freiburg University Medical Centre have discovered which mechanisms underlie the behavioural changes in macrophages that make it easier for other pathogens to attack.

    https://www.gesundheitsindustrie-bw.de/en/article/news/cytomegaloviruses-subvert-macrophage-identity
  • Article - 20/12/2007

    Viruses are the major cause of myocardial diseases

    About 500000 people in Germany suffer from dilatative cardiomyopathy DCM. Viral infections are the major cause of this myocardial disease. Its molecular and cellular mechanisms are being investigated in a transregional SFB project at the University of Tübingen.

    https://www.gesundheitsindustrie-bw.de/en/article/news/viruses-are-the-major-cause-of-myocardial-diseases
  • Article - 28/02/2011 13779_de.jpg

    Development of food allergies

    Allergic reactions to certain types of food can, in extreme cases, lead to life-threatening anaphylactic shock. People with peanut allergies are particularly at risk. Allergic reactions can also gradually develop into chronic intolerances such as coeliac disease, for example. The causes of food allergies nearly always originate in early childhood.

    https://www.gesundheitsindustrie-bw.de/en/article/news/development-of-food-allergies
  • Article - 11/06/2010 Dr. Christoph Mayer in the microbiology laboratory at the University of Constance. He is holding a test tube over a gas burner.<br /> <br />

    Recycling of bacterial cell wall constituents

    Bacterial cells are focused on growth and proliferation. These processes are initiated by cellular enzymes that break up the cell wall material murein introduce new material and degrade material that is no longer needed. And all this in large amounts about 50 per cent of murein are degraded and newly formed turnover per cell generation. Dr. Christoph Mayer and his team from the University of Constance have shown that the cells carry out effective…

    https://www.gesundheitsindustrie-bw.de/en/article/news/recycling-of-bacterial-cell-wall-constituents
  • Article - 13/05/2008

    Just follow your nose

    Sharks can sense a few drops of blood in water. In fact they are able to smell blood in dilutions of as little as one to 10 billion. Is it just sharks or piranhas that have such an acute sense of smell? The answer is no - all fish have a highly developed sense of smell.

    https://www.gesundheitsindustrie-bw.de/en/article/news/just-follow-your-nose
  • Press release - 30/11/2011 15922_de.jpg

    Researchers are challenging a common model of immunology

    Up to now, scientists have assumed that mast cells, a certain type of immune cells, play a central role in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Current studies conducted at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now provided evidence to refute this assumption. Now it is only the mast cells’ central function in allergies that remains undisputed.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/researchers-are-challenging-a-common-model-of-immunology
  • Article - 01/08/2010 11984_de.jpg

    Manfred Kist – 25 years of fascination for a stomach bacterium

    Helicobacter pylori is a genus of bacteria that inhabits the human stomach. The bacteria can cause duodenal and gastric ulcers and are also linked to the development of gastric cancer. Prof. Dr. Manfred Kist from the Freiburg University Medical Centre has spent around 25 years of his scientific career on investigating H. pylori a bent rod-shaped bacterium.

    https://www.gesundheitsindustrie-bw.de/en/article/news/manfred-kist-25-years-of-fascination-for-a-stomach-bacterium
  • Press release - 01/02/2021

    Targeting a rapid market breakthrough for new vaccine production method

    In a so-called inactivated or killed vaccine, the virus particles it contains are first rendered inactive by means of the toxic chemical formaldehyde. A better way of achieving this, however, is to irradiate the pathogens with low-energy electrons. Four Fraunhofer Institutes have now developed a new method of vaccine production based on this technique that is not only quicker but also guarantees a higher quality of product.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/targeting-rapid-market-breakthrough-new-vaccine-production-method
  • Press release - 21/05/2010 11423_de.jpg

    The road to individualized tumour vaccines

    What are the typical cancer cell characteristics that our immune system is directed against? Using a new biochemical method, scientists from the Neurosurgery Department of the Heidelberg University Hospital and the German Cancer Research Centre (Deutsches Krebsforschungszentrum, DKFZ) are now able to answer this question for each individual patient. The method is expected to help identify new target structures for individualized tumour vaccines.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/the-road-to-individualized-tumour-vaccines
  • Article - 20/12/2010 13269_de.jpg

    Michael Reth – Immunobiological discoveries that meet resistance

    Dr Michael Reth professor at the Max Planck Institute of Immunobiology and the University of Freiburg and some of his colleagues have recently uncovered the mechanism that foreign substances use to activate B cells of the immune system. The researchers were using synthetic biology methods long before this particular branch of science existed in its present form. Their results require a paradigm change and a revision of the reference books.

    https://www.gesundheitsindustrie-bw.de/en/article/news/michael-reth-immunobiological-discoveries-that-meet-resistance
  • Article - 10/02/2014 20950_de.jpg

    HOT Screen GmbH - models for studying diseases

    HOT Screen GmbH from Reutlingen Germany develops human organotypical HOT cell culture models related to the human immune system for the assessment of drug activity profiles and the selection of suitable drug candidates. The sophisticated models are made with differentiated cells and can be adapted to a broad range of different diseases - including rheumatoid arthritis osteoarthritis Crohns disease neurodermatitis COPD asthma and many others.

    https://www.gesundheitsindustrie-bw.de/en/article/news/hot-screen-gmbh-models-for-studying-diseases
  • Mosses for pharmaceutical production - 16/09/2020 Eleva_Bild_1.jpg

    Factor H as a therapeutic option for viral diseases - including COVID-19

    The search for drug candidates for COVID-19 diseases is well underway. Factor H, which is part of the innate immune system, might also be a future therapeutic option. The Freiburg-based biotech company eleva has developed a technology for producing this human protein in moss cells. The active ingredient, which might also have a regulatory effect in other diseases, is currently undergoing preclinical testing.

    https://www.gesundheitsindustrie-bw.de/en/article/news/factor-h-therapeutic-option-viral-diseases-including-covid-19
  • Overview

    Pharmaceutics

    The latest articles, press releases and dossiers on pharmaceutics in Baden-Württemberg

    https://www.gesundheitsindustrie-bw.de/en/article/pharma
  • Article - 15/10/2012 18361_de.jpg

    Vegetables help fend off bacteria in the intestines

    Their discovery in the human intestines came as quite a surprise up until a few years ago LTi lymphoid tissue inducer - cells were only known to be involved in the embryonic development of the immune system. A team of researchers led by Prof. Dr. Andreas Diefenbach from the University of Freiburg Medical Centre has since been able to show the protective role played by LTi cells in fortifying the intestinal wall as a reaction to nutrients found…

    https://www.gesundheitsindustrie-bw.de/en/article/news/vegetables-help-fend-off-bacteria-in-the-intestines
  • Article - 20/03/2011 13917_de.jpg

    Non-pathogenic bacteria for the treatment and prevention of allergies

    Researchers and physicians from the Department of Dermatology at Tübingen University Hospital are investigating huge numbers of non-pathogenic bacteria with the aim of shedding light on their potential for the prevention and treatment of allergies. The mode of action of highly promising candidates is being investigated in further detail.

    https://www.gesundheitsindustrie-bw.de/en/article/news/non-pathogenic-bacteria-for-the-treatment-and-prevention-of-allergies
  • Article - 19/01/2016 The photo shows different intestinal cells. The Paneth cells (red) are stimulated by monocytes (blue) to produce defensins (red spots).

    Innate immune defence: using peptides against fungi and bacteria

    Part of the human immune defence relies on antimicrobial peptides. These peptides, so-called defensins, are present in the gastrointestinal tract where they play a role in the pathogenesis of Crohn’s disease. Prof. Jan Wehkamp and his team of researchers at the University Hospital in Tübingen study how this knowledge can be put to good use for the treatment of Crohn’s and other diseases.

    https://www.gesundheitsindustrie-bw.de/en/article/news/innate-immune-defence-using-peptides-against-fungi-and-bacteria
  • Article - 07/03/2011 Prof. Dr. Thomas Brunner

    Thomas Brunner: steroid synthesis in the intestine

    A research team led by Prof. Dr. Thomas Brunner at the University of Konstanz has found out that intestinal epithelial cells are able to synthesise anti-inflammatory steroids glucocorticoids following immunological stress which makes a considerable contribution to the maintenance of local immune homoeostasis. Brunner plans to use his findings to develop a therapeutic approach for the treatment of inflammatory bowel diseases.

    https://www.gesundheitsindustrie-bw.de/en/article/news/thomas-brunner-steroid-synthesis-in-the-intestine
  • Article - 03/07/2010 The photo shows the ingredients of Paramirum, including high-quality oils and plant essences.<br />

    Erbasens: Using the power of nature

    Before setting up her own company biologist Dr. Elke Schulz amassed a wealth of knowledge in the pharmaceutical industry. Now she harnesses the power of plants to develop and sell dietary supplements and natural cosmetics. Her company Erbasens specialises in combining high-quality oils and plant essences to create products such as Paramirum that safeguards the effectiveness of the immune system and promotes the bodys defence systems.

    https://www.gesundheitsindustrie-bw.de/en/article/news/erbasens-using-the-power-of-nature
  • Article - 02/07/2012 The photo shows a CT image of pink and red human organs. The liver is shown in pink.

    Together against liver failure

    Medicines that are usually effective in treating diseases can sometimes be associated with severe adverse effects. This can occur when the liver which normally metabolizes drugs and renders them harmless becomes overburdened and even collapses completely. Prof. Dr. Jens Timmer from the University of Freiburg and Prof. Dr. Ursula Klingmüller from the German Cancer Research Center DKFZ in Heidelberg have joined forces in a huge European research…

    https://www.gesundheitsindustrie-bw.de/en/article/news/together-against-liver-failure
  • Article - 19/11/2015 Brain slice of an Alzheimer’s disease mouse model. The immune cells are black, the plaques red and have a star-like shape.

    Immune cells are reprogrammed in Alzheimer’s brains

    Scientists from the Hertie Institute for Clinical Brain Research at the University of Tübingen are pursuing an innovative treatment approach for Alzheimer’s disease using immune cells to eliminate the protein deposits that are the hallmark of Alzheimer’s. Dr. Jonas Neher and his team tested whether exchanging brain-specific immune cells with fresh, more active cells has a positive effect on the disease.

    https://www.gesundheitsindustrie-bw.de/en/article/news/immune-cells-are-reprogrammed-in-alzheimers-brains
  • Press release - 12/10/2011 15552_de.jpg

    Dioxin-like Chemical Messenger Makes Brain Tumors More Aggressive

    Scientists from German Cancer Research Center and Heidelberg University have discovered a new dioxin receptor-coupled metabolic pathway which weakens the immune system and promotes the growth of malignant gliomas. Glioma is the most frequent and most malignant brain tumor in adults. In Germany, about 4,500 people are newly diagnosed with glioma every year.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/dioxin-like-chemical-messenger-makes-brain-tumors-more-aggressive
  • Press release - 26/07/2021

    Vaccination against hereditary colorectal cancer successful in mice

    Scientists from the German Cancer Research Center and Heidelberg University Hospital have for the first time been able to delay the development of hereditary colorectal cancer with a protective vaccination. Mice with a hereditary predisposition to colorectal cancer survived significantly longer after vaccination than unvaccinated animals. Combining the vaccination with an anti-inflammatory drug increased the protective effect.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/vaccination-against-hereditary-colorectal-cancer-successful-mice

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