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  • Assay to support the diagnosis of autoimmune diseases - 22/06/2022 Immunkomplexe_sIC-assay_Teaser.jpg

    Tracking down pathogenic immune complexes

    Soluble complexes of antibodies and their target structures circulating in the blood can trigger serious systemic inflammations. Dr. Philipp Kolb and Haizhang Chen from the Institute of Virology at the Freiburg University Medical Centre have developed a sensitive, cell-based test system for detecting these immune complexes. The system can be used to diagnose systemic autoimmune diseases, and also severe cases of COVID-19.

    https://www.gesundheitsindustrie-bw.de/en/article/news/tracking-down-pathogenic-immune-complexes
  • Press release - 18/11/2021

    Overcoming resistance to treatment for breast, bowel, and pancreatic cancer

    As cancer progresses, the tumor cells continually change, ultimately resulting in a tumor consisting of a large number of different cell clones with different characteristics. This is referred to as "tumor heterogeneity". In many cases, the cancer cells become resistant to the treatments available.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/overcoming-resistance-treatment-breast-bowel-and-pancreatic-cancer
  • Article - 31/05/2021 Das Foto zeigt einen Gewebeschnitt, auf dem immunhistologisch angefärbte angefärbte Pankreaskarzinomzellen zu sehen sind.

    Tracking down tumour-associated pain in pancreatic cancer

    Pancreatic cancer comes along quietly: unnoticed for a long time, it often triggers excruciating pain as the tumour progresses. This pain is associated with cancer cells invading pancreatic nerves. Dr. Michael Hirth from Mannheim University Hospital has shed some light on the complex communication between cancer cells and nerve cells. His findings could eventually be used for personalised pain therapies.

    https://www.gesundheitsindustrie-bw.de/en/article/news/tracking-down-tumour-associated-pain-pancreatic-cancer
  • Press release - 15/10/2020

    Pancreatic cancer: Subtypes with different aggressiveness discovered

    Tumors of the pancreas are particularly feared. They are usually discovered late and mortality is high. Until now, no targeted and personalized therapies exist. Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* (HI-STEM) have now succeeded for the first time in defining two differently aggressive molecular subtypes of pancreatic carcinoma.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/pancreatic-cancer-subtypes-different-aggressiveness-discovered
  • Press release - 10/12/2018 Trumpp_Andreas.jpg

    High distinction for stem cell researcher Andreas Trumpp

    This year's State Research Prize of Baden-Württemberg awarded for outstanding achievements in applied research goes to Andreas Trumpp from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM). Theresia Bauer, State Minister of Science, Research and the Arts, presented the award, which carries a monetary prize of €100.000, at a festive ceremony on December 10, 2018.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/high-distinction-for-stem-cell-researcher-andreas-trumpp
  • Article - 14/02/2018 The photo shows the biologist in front of the microscope with cell cultures in pink culture medium.

    Animal-free diabetes research with the pancreas chip

    Quite a number of promising drug candidates for the treatment of diabetes are currently in the pharmaceutical pipeline, including innovative drugs that can stimulate the regeneration of insulin-producing pancreatic cells. However, they will have to be safety tested in animals. Scientists from Ulm University Hospital have now begun to develop a pancreatic chip from stem cells.

    https://www.gesundheitsindustrie-bw.de/en/article/news/animal-free-diabetes-research-with-the-pancreas-chip
  • Article - 29/08/2016 B/w microscope image of pancreas organoids of different sizes. They are round and hollow.

    Cellendes and EU partners develop cell therapy for treating type 1 diabetes

    Cells derived from suitable donor stem cells that can do the work defective insulin-producing cells can no longer do are the central focus of a European cell therapy project involving Reutlingen-based Cellendes GmbH as one of the partners. Cellendes develops a biomaterial that facilitates the mass production of cells and could potentially be approved for therapeutic use in humans.

    https://www.gesundheitsindustrie-bw.de/en/article/news/cellendes-und-eu-partner-entwickeln-zelltherapie-fuer-diabetes-typ-1
  • Article - 25/04/2016 Trumpp_Andreas.jpg

    Pancreatic cancer and its resistance to therapy

    Pancreatic tumours are among the cancers with the worst prognosis. In many cases they are resistant to treatment. Prof. Dr. Andreas Trumpp and his colleagues from the DKFZ and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI-STEM have discovered that the reason why some pancreatic tumours are so resistant to treatment is down to larger quantities of the enzyme CYP3A5 in subtypes of pancreatic cancer. Molecular…

    https://www.gesundheitsindustrie-bw.de/en/article/news/pancreatic-cancer-and-its-resistance-to-therapy
  • Article - 27/07/2015 Zender_Lars_Prof.jpg

    Looking for the Achilles’ heel of the tumour

    Although medicines that inhibit the growth of cancer cells are available, the prognosis for patients with solid tumours is generally still rather poor. The reason for this is that tumour cells develop resistance to therapy during treatment, and the tumour can continue to grow. However, tumours are vulnerable – if only more robust medicines were available. Prof. Dr. Lars Zender, senior physician and head of the Division of Translational…

    https://www.gesundheitsindustrie-bw.de/en/article/news/looking-for-the-achilles-heel-of-the-tumour
  • Article - 29/04/2013 19551_de.jpg

    Bioactive plant foods: plant substances against cancer stem cells

    Many findings indicate that the consumption of cruciferous vegetable plants rich in mustard oil glycosides has a cancer-inhibiting effect. Researchers from Heidelberg have now shown that sulforaphane, a broccoli mustard oil, blocks a signalling pathway that makes tumour stem cells resistant to cytotoxic drugs. The administration of sulforaphane can prevent therapy resistance and metastasis of pancreatic cancer in animal models.

    https://www.gesundheitsindustrie-bw.de/en/article/news/bioactive-plant-foods-plant-substances-against-cancer-stem-cells
  • Article - 02/07/2012 17568_de.jpg

    amcure GmbH is working on a new compound against pancreatic cancer

    amcure GmbH has identified a new compound with a new efficacy profile against pancreatic cancer. Animal experiments have shown promising results: the drug candidate successfully prevents tumour growth and destroys existing metastases. The company, which was spun out from the Karlsruhe Institute of Technology (KIT) in 2011, is now working on its first financing round and is looking for new investors. At the same time it is carefully planning its…

    https://www.gesundheitsindustrie-bw.de/en/article/news/amcure-gmbh-is-working-on-a-new-compound-against-pancreatic-cancer
  • Press release - 12/10/2011 Logo DKFZ, blue letters "DKFZ"

    Autoimmune Diseases Affect Cancer Risk

    In a recently published study, scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have calculated the interrelations between autoimmune diseases and cancer of the digestive tract. They discovered that many autoimmune diseases increase the cancer risk, while others, such as rheumatism, are associated with a significantly lower bowel cancer risk. These differing impacts on cancer risk may be attributable to the…

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/autoimmune-diseases-affect-cancer-risk
  • Article - 06/03/2011 13837_de.jpg

    Heidelberg Translational Lung Research Centre

    University and non-university research institutions in Heidelberg that carry out research into lung diseases have established an expert network – the Heidelberg Translational Lung Research Centre – which is part of the new BMBF-funded German Centre for Lung Research. In Heidelberg, research focuses on the development and treatment of cystic fibrosis, chronic obstructive pulmonary diseases and lung cancer.

    https://www.gesundheitsindustrie-bw.de/en/article/news/heidelberg-translational-lung-research-centre
  • Article - 24/11/2010

    Choosing natural drugs is not without risk

    Germans like natural solutions and show a marked preference for medicines made from St. John’s wort, valerian, devil’s claw or Marian Thistle. However, when taking herbal medicines people are well advised to be cautious: "herbal" does not automatically mean safe, warns Thomas Simmet, pharmacologist from the University Hospital of Ulm.

    https://www.gesundheitsindustrie-bw.de/en/article/news/choosing-natural-drugs-is-not-without-risk
  • Article - 12/07/2010 11759_de.jpg

    TET Systems: Controlled gene expression in eukaryotes

    The most common and most successful system used for the experimental regulation of gene expression in eukaryotes is based on a gene switch that regulates the resistance of bacteria to tetracycline. The Tet technology also provides researchers with a tool that enables them to specifically, quantitatively and reversibly control the activity of individual genes in vivo and in vitro. The Heidelberg-based company TET Systems sells licences for the Tet…

    https://www.gesundheitsindustrie-bw.de/en/article/news/tet-systems-controlled-gene-expression-in-eukaryotes
  • Press release - 14/06/2010

    Substance in broccoli supports pancreatic cancer therapy

    The new cancer medication sorafenib inhibits resistant tumour stem cells in pancreatic cancer and is especially effective when combined with sulforaphane, an organic compound found in broccoli and cauliflower.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/substance-in-broccoli-supports-pancreatic-cancer-therapy
  • Article - 15/03/2010 10842_de.jpg

    Cystic fibrosis therapy is making good progress

    Thirty years ago cystic fibrosis CF formerly also known as mucoviscidosis was considered to be a disease that only affected children. Hardly any children with this hereditary metabolic disease ever reached early adulthood. Since then both the therapy and the life expectancy of CF patients have improved considerably. Dr. Gerd Döring from Tübingen is investigating the occurrence of respiratory tract defects that are common in CF patients.

    https://www.gesundheitsindustrie-bw.de/en/article/news/cystic-fibrosis-therapy-is-making-good-progress
  • Dossier - 22/02/2010 10749_de.jpg

    Respiratory disease - congestion in the respiratory system

    Lung diseases are by far the most frequent cause of death worldwide. Every year three million people die from chronic obstructive pulmonary diseases 2.3 million die from lung cancer and 1.5 die from tuberculosis WHO World Health Organisation. There is no improvement in sight and experts believe that the number of deaths will continue to rise particularly in the case of chronic obstructive pulmonary diseases COPD lung cancer and tuberculosis TB.…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/respiratory-disease-congestion-in-the-respiratory-system
  • Article - 12/05/2009 Prof. Dr. Martin Wabitsch was head of a weight reduction programme (Obeldicks) for children. The photo shows him together with oecotrophologist Maleika Fuchs.

    Fatal relatives: adiposity and diabetes

    Martin Wabitsch was the first German pediatrician to investigate adiposity back when it was seen as a strange subject to study. Nowadays, in Germany the attitude towards adiposity has completely changed. More and more people are suffering from adiposity and diabetes and are consequently at risk of contracting other severe diseases as a result. In children and young adults the situation is alarming; many children are at risk of contracting…

    https://www.gesundheitsindustrie-bw.de/en/article/news/fatal-relatives-adiposity-and-diabetes
  • Article - 12/05/2009 A great deal of experience is necessary to prepare pancreatic islet cells.

    Islet cell transplantation gives new hope to diabetics

    Establishing a medical therapy requires a great deal of patience. An interdisciplinary group of researchers at the University Hospital Tübingen knows this from experience. It took more than three years before researchers succeeded in transplanting insulin-producing cells. However, the huge effort has paid off two-fold: the diabetes sufferer feels well after the intervention and secondly, Tübingen became the first German centre to receive the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/islet-cell-transplantation-gives-new-hope-to-diabetics
  • Dossier - 11/05/2009 08594_de.jpg

    Diabetes, a danger that is still underestimated

    In 2010 there will be 10 million diabetes patients in Germany and nearly 33 millions in Europe. The diabetes avalanche is rolling and what is Germany doing? So far so little say experts. There is a lot happening at the same time in different places little is evaluated and a lot is lost in the maelstrom of individual interests. The figures are clear The metabolic disease known as diabetes has reached the proportions of a worldwide epidemic. It not…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/diabetes-a-danger-that-is-still-underestimated
  • Article - 11/05/2009 08552_de.jpg

    Can stem cells treat diabetes?

    Stem cells are seen as the miracle cure of the future for many degenerative diseases. Scientists and physicians also hope that stem cells will exert their regenerative effect in the treatment of diabetes type 1 which is caused by damaged tissue.

    https://www.gesundheitsindustrie-bw.de/en/article/news/can-stem-cells-treat-diabetes
  • Article - 11/05/2009 The cancer stem cell (CSC) hypothesis

    Metastasis-inducing cancer stem cells

    Just a small subpopulation of cancer cells namely metastasis-inducing cancer stem cells MICs is potentially responsible for the formation of distant malignant tumour metastases. The characterisation of MICs and the clarification of mechanisms that lead to their reactivation from a dormant state opens up new strategies for the development of new effective therapies against metastasising tumours.

    https://www.gesundheitsindustrie-bw.de/en/article/news/metastasis-inducing-cancer-stem-cells
  • Article - 07/04/2009 08360_de.jpg

    All-rounders that export cancer

    Migrating stem cells have been the focus of attention for some years now opening up potential new strategies for cancer research and therapy. Professor Dr. Thomas Brabletz and his team at the University Medical Centre in Freiburg are working on these stem cells that have an ability to generate new tumours anywhere in the body.

    https://www.gesundheitsindustrie-bw.de/en/article/news/all-rounders-that-export-cancer
  • Press release - 04/03/2009 08136_de.jpg

    Federal funding for new stem cell project at the ZRM

    Researchers in Tübingen have successfully cultivated germ cells of adult men to create pluripotent stem cells with a therapeutic potential similar to that of embryonic stem cells, but with much less potential for ethical conflict. Now, with funding from the German Federal Ministry of Education and Research, a new project has been launched to characterize these cells in depth and to explore their therapeutic application in regenerative medicine.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/federal-funding-for-new-stem-cell-project-at-the-zrm

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