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  • Article - 26/09/2011 Diagram of a light path in a microscope in which the laser beam hits an object at a flat angle of incidence. The photo on the right shows many white spots against a black background.<br />

    A close look at individual membrane receptors

    The majority of research groups around the world working on membrane receptors are concentrating on the interactions between the receptors and the signalling molecules in the interior of cells and each individual receptor tends to be seen as a black box. The independent research group led by junior professor Dr. Maximilian Ulbrich of the BIOSS excellence cluster at the University of Freiburg has developed a high-resolution real-time method for…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/a-close-look-at-individual-membrane-receptors
  • Press release - 10/08/2009

    How do immune cells recognise infectious pathogens?

    Scientists of the University of Heidelberg and the German Cancer Research Centre have clarified the functional principles of an important receptor for bacterial infections: immune cells recognise bacterial and viral pathogens with a receptor known as toll-like receptor 9 (TLR9), which mediates biochemical reaction chains in order to fend off intruders. This discovery made by the Heidelberg researchers paves the way to develop new anti-infective…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/how-do-immune-cells-recognise-infectious-pathogens
  • Article - 29/11/2010 12950_de.jpg

    CYP2D6 and the oestrogen receptor

    The medicinal adjuvant therapy of breast cancer is a good example of how important it is being aware that different patients metabolise drugs differently. This knowledge plays a key role in the prescription of effective drugs at the correct dose and in preventing adverse reactions and interactions with concomitant drugs.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/cyp2d6-and-the-oestrogen-receptor
  • Press release - 17/08/2009 09349_de.jpg

    Death Receptor Regulates Brain Regeneration

    The so-called death receptor is well known among experts – it induces programmed cell death. In brain stem cells, however, this molecule has an entirely different function, as shown by scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in an article published in CELL Stem Cell. Here, signals to the death receptor cause the formation of new nerve cells (neurons). When the researchers switched off the receptor…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/death-receptor-regulates-brain-regeneration
  • Press release - 23/04/2010 11187_de.jpg

    Previously unknown protein subunits of GABAB receptors identified

    Neurobiologists from the Universities of Freiburg and Basel have published a report on previously unknown subunits of GABAB receptors of the central nervous system in the renowned scientific journal Nature. GABAB receptors are transmembrane proteins in nerve cells that are of crucial importance for brain function as well as playing a vital role in therapy and pharmaceutics.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/previously-unknown-protein-subunits-of-gabab-receptors-identified
  • Article - 29/10/2008

    Cannabinoids - important for memory?

    Cannabis intoxication is certainly not the original purpose of the cannabinoid receptors in the human brain. Nowadays there are known body substances which dock to the receptor molecules of nerve cells in a similar way to cannabis. A group of researchers led by pharmacologist Prof. Dr. med. Bela Szabo at the University of Freiburg is investigating the role of this molecular system in the human brain.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/cannabinoids-important-for-memory
  • Article - 17/12/2012 18972_de.jpg

    rent-a-lab – the bioassay specialist

    rent-a-lab has been offering services to detect and determine the quantity of biomolecules for around ten years. The company is mainly focused on studies related to the binding of biomolecules to GTP-binding protein-coupled receptors, a field that has attracted a great deal of attention following the award of the Nobel Prize in Chemistry 2012 for the identification of this important class of receptors.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/rent-a-lab-the-bioassay-specialist
  • Article - 13/04/2008

    Scientists discover a genetic dependence to nicotine

    Scientists have shown that a particular variant of a receptor gene impacts smoking behaviour and hence confers a 30 increase in risk of lung cancer and a 20 increase in risk of peripheral artery disease PAD.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/scientists-discover-a-genetic-dependence-to-nicotine
  • Article - 25/06/2012 17478_de.jpg

    Cannabidiol for the treatment of schizophrenic psychoses

    A hemp compound has been shown to increase the effect of the endogenous cannabinoid anandamide in the human brain, thus reducing the delusions associated with psychotic diseases. Studies carried out by Prof. Markus Leweke from the Central Institute of Mental Health in Mannheim involving patients with acute schizophrenic attacks show that the plant compound is better tolerated than currently approved antipsychotic drugs.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/cannabidiol-for-the-treatment-of-schizophrenic-psychoses
  • Press release - 23/03/2012

    Communication channels in the brain

    Jakob von Engelhardt leads a new Junior Research Group, “Synaptic Communication and Neurodegeneration”, established by the German Center for NeurodegenerativeDiseases (DZNE) at the German Cancer Research Center (DKFZ) with the aim of combining the competencies of the two institutes. Research topics of the group include the cellular foundations of learning and memory as well as the molecular causes of neurodegenerative diseases.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/communication-channels-in-the-brain
  • Dossier - 29/10/2008 import_00148_de.jpg

    Signal transduction - exciting research with huge potential for the future

    Signal transduction is one of the most innovative fields of research in the life sciences. Although the scientists are far from being able to understand and decipher everything the signal researchers nevertheless have a good deal of knowledge about the transduction of signals and the different signalling pathways.

    https:////www.gesundheitsindustrie-bw.de/en/article/dossier/signal-transduction-exciting-research-with-huge-potential-for-the-future
  • Press release - 18/09/2009

    Why don’t brain tumours respond to drugs?

    Malignant brain tumours do not often respond to promising new drugs. Researchers from Heidelberg have now uncovered a mechanism and a tumour marker that are linked to the development of this resistance. A “death receptor” might possibly indicate the chances of success of chemotherapy at the same time as providing new approaches for developing a new therapy for the successful treatment of brain tumours.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/why-don-t-brain-tumours-respond-to-drugs
  • Article - 23/06/2016 Microscopig image of immune cells, stained red, attacking green biofilms.

    The body’s immune system loosens artificial joints

    Hip and knee endoprostheses are not nearly as long-lasting as their natural counterparts. Dr. Ulrike Dapunt from the University Hospital Heidelberg’s Department of Orthopaedics and Traumatology has now discovered that it is not the bacterial activity or secretions that lead to the degradation of bone during chronic inflammation, but rather local host defence mechanisms.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/the-bodys-immune-system-loosens-artificial-joints
  • Press release - 28/08/2008

    Günther Schütz and the regulation of gene expression by nuclear receptors

    Professor Dr. Günther Schützs work on the cell- and development-specific gene regulation using nuclear receptors has led amongst other things to new insights into the steroid hormone-dependent early development and differentiation of the nervous system the molecular mechanisms of learning and the development and regulation of drug addiction. Schütz has now been appointed Helmholtz professor which will enable him to continue his work beyond…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/guenther-schuetz-and-the-regulation-of-gene-expression-by-nuclear-receptors
  • Press release - 08/10/2020

    New class of highly effective inhibitors protects against neurodegeneration

    Heidelberg neurobiologists decode central mechanism of degenerative processes in the brains of mouse models and develop new principle for therapeutic agents.

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/new-class-highly-effective-inhibitors-protects-against-neurodegeneration
  • Article - 16/06/2014 Glioblastoma cells with a granular appearance that indicates that they have undergone apoptosis. Cell death can be induced by the addition of methadone.

    Methadone – the last step to becoming an anti-cancer drug

    It all began several years ago with a surprising discovery in the laboratory. Claudia Friesen, a chemist at Ulm University, discovered that leukaemia cells that were exposed to methadone died within a relatively short period of time. Seven years on and many papers later, what was once a rather exotic substance is now undergoing clinical testing in cancer patients.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/methadone-the-last-step-to-becoming-an-anti-cancer-drug
  • Article - 05/09/2016 Glioblastom_MRT.jpg

    Apogenix: immuno-oncological protein drugs for the treatment of malignant diseases

    Apogenix AG, a biopharmaceutical company from Heidelberg that specialises in immuno-oncology, develops protein drugs that target central signalling pathways involved in regulating the growth, migration and apoptosis of malfunctioning cells and thus offer novel treatment options for cancer and other malignant diseases.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/apogenix-immunonkologische-proteinwirkstoffe-gegen-maligne-erkrankungen
  • Article - 17/11/2014 Microscope image of two nerve cells that are connected with each other.<br />

    About synapses and learning

    You can’t teach an old dog new tricks – the old proverb is not totally true. It is now known that the modulation of synaptic functions, including the formation of new neurons, still takes place in old age, although to a lesser extent than in childhood. The human brain stores memories in the form of neural activity patterns. Structural plasticity appears to be the basis for all learning processes. Physician Thomas Hainmüller and Prof. Dr. Marlene…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/about-synapses-and-learning
  • Article - 13/12/2008

    Insights into the perception of light

    Rhodopsin mediates between the visual world and our brain. Biophysicists at Freiburg have used infrared spectroscopy to gain detailed insights into the rhodopsin centre to find out how the molecular side chains of the proteins have to interact in order for the brain to understand the visual environment.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/insights-into-the-perception-of-light
  • Article - 14/03/2011 Loop model of an EGF molecule with a blue area. Next to the EGF are three tryptophane molecules that differ from each other by the insertion of an N atom at different locations of the molecule.<br />

    Synthesising proteins from non-natural building blocks?

    Dr. Birgit Wiltschi from the University of Freiburg has been awarded funding from the Baden-Württemberg Ministry of Science Research and the Arts under the Biotechnology and Medical Technology Idea Competition for a highly ambitious project she wants to learn how proteins can be modified using non-natural building blocks that will enable the engineered proteins to specifically target receptors on cancer cells amongst other things.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/synthesising-proteins-from-non-natural-building-blocks
  • Press release - 21/05/2010 11414_de.jpg

    The molecular network of “death receptors” on trial

    The international ApoNET research project, which is part of a European-wide systems biology initiative, is coordinated by the Mannheim Medical Faculty at the University of Heidelberg. ApoNET researchers use modern genome sequencing methods and computer models to gain a better understanding of apoptosis networks in liver cells. The project is funded by the German Federal Ministry of Education and Research and the European Union with 1.7 million…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/the-molecular-network-of-death-receptors-on-trial
  • Microstructure Technology - 17/07/2020 eNase_Bild_4.jpg

    An electronic nose for many applications

    Sensory organs are sophisticated masterpieces of nature. That is why humans have often tried to copy them. Be it cameras or microphones - there are technical objects that have always been based on natural models such as the eye or the ear. For a long time, however, no artificial sense of smell has featured in the technical repertoire. Now researchers at the Karlsruhe Institute of Technology (KIT) have developed an electronic nose. It can…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/electronic-nose-many-applications
  • Press release - 22/04/2010 The virally expressed Cre recombinase can highly specifically modify the genome of transgenic mice. In the present case, a glutamate receptor was removed from the majority of granule cells, which resulted in the enhanced inhibition of the specific olfactory bulb cells and led to the accelerated discrimination of odours.<br />

    How nerve cells discriminate olfactory clues

    Whether different odours can be quickly discriminated depends on whether certain synapses in the brain are able to inhibit neuronal information processing. Scientists led by Professor Dr. Thomas Kuner at the Institute of Anatomy and Cell Biology at the Heidelberg Medical Faculty and Dr. Andreas Schäfer at the Max Planck Institute of Medical Research have shown that mice lacking a certain receptor in the olfactory bulb are able to discriminate…

    https:////www.gesundheitsindustrie-bw.de/en/article/press-release/how-nerve-cells-discriminate-olfactory-clues
  • Article - 04/03/2010 The photo shows a greenish-yellowish cell against a dark blue background; three red rods are located close to the cell.<br />

    Asthma and COPD – how to control centres of inflammation

    In today’s world, not all asthma patients benefit from adequate treatment. There is no cure at all for people who suffer from COPD, chronic obstructive pulmonary disease. A group of researchers led by Dr. Marco Idzko at the Freiburg University Medical Centre are looking for new strategies to treat lung diseases such as these. They have already discovered that ATP, which is the major energy currency molecule in the body, has an effect on the…

    https:////www.gesundheitsindustrie-bw.de/en/article/news/asthma-and-copd-how-to-control-centres-of-inflammation
  • Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB - 24/04/2020 Das Foto zeigt den Immustick, wobei eine Lösung auf das Auftragsfenster pipettiert wird.

    A rapid pyrogen test: the human immune system as model

    Every year, around 11 million people die of sepsis (blood poisoning) caused by microorganisms or microbial residues, known as pyrogens, entering the bloodstream. The smallest amounts can trigger fever. Researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart have developed a pyrogen test that does not require a laboratory and is not tested on animals. It is expected to be placed on the market soon.

    https:////www.gesundheitsindustrie-bw.de/en/article/news/A-rapid-pyrogen-test-the-human-immune-system-as-model

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