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Basic research

The latest articles, press releases and dossiers on basic research in Baden-Württemberg

  • Article - 20/09/2016

    Since 2012, a DFG-funded research group called FOR1680 has been studying CRISPR-Cas, an immune system that unicellular bacteria and arachaea use to protect themselves against attacks from viruses and plasmids. Prof. Dr. Anita Marchfelder, a molecular biologist at Ulm University and coordinator of the FOR1680 research group, and many other researchers were surprised to find that prokaryotes incorporate the genetic material of enemies as a kind of…

  • Article - 12/09/2016

    Hepatocellular carcinoma is the second most common cause of cancer deaths worldwide. If the tumour is at an advanced stage, doctors have few treatment options. Researchers led by Prof. Dr. Lars Zender from the University of Tübingen have now identified one of the cancer's Achilles' heels, namely, the interaction between C-MYC and AURKA proteins, which can be destabilised with a drug, thus killing cancer cells.

  • Article - 08/09/2016

    In recent years, there has been huge technological progress in the analysis of genetic material: DNA sequencing techniques have been developed along the lines of faster, further, cheaper. State-of-the-art methods make it possible to handle large projects in a relatively short period of time. However, the error rate is still very high, and samples need to be sequenced several times to determine the correct DNA sequence. Along with research teams…

  • Article - 29/08/2016

    Cells derived from suitable donor stem cells that can do the work defective insulin-producing cells can no longer do are the central focus of a European cell therapy project involving Reutlingen-based Cellendes GmbH as one of the partners. Cellendes develops a biomaterial that facilitates the mass production of cells and could potentially be approved for therapeutic use in humans.

  • Article - 18/08/2016

    Proteins either remain in a cell or leave it, and which they do depends on their function. However, the mechanism underlying the export of biomolecules from cells remains unknown. Prof. Dr. Friedrich Götz and his team of researchers at the Institute of Microbial Genetics at the University of Tübingen have found out that staphylococci can turn into dangerous pathogens by excreting normally harmless enzymes. The researchers believe that the…

  • Article - 18/08/2016

    Hepatitis B and hepatitis C are two of the most common infectious diseases in the world. They often take a chronic course and carry a high risk of progressing to cirrhosis and hepatocellular carcinoma. A new transregional collaborative research centre involving scientists from Heidelberg and Freiburg is looking into how hepatitis B and hepatitis C viruses, which have different symptoms and treatments, are able to evade the immune system and allow…

  • Article - 02/08/2016

    An early phase clinical study involving thirty-six Huntington’s disease (HD) patients is currently underway to investigate whether a method called gene silencing can cure the disease. If the gene that causes the disease can be turned off, it would be the first step towards a treatment that not only fights symptoms but actually treats the causes of HD, hence providing a cure. Prof. Dr. G. Bernhard Landwehrmeyer, a neurologist from Ulm who is…

  • Article - 27/07/2016

    Danger identified, danger averted – the better the dynamic changes of the viral genome are understood, the better the spread of the pathogens can be predicted, thus enabling more efficient countermeasures to be taken. A team of researchers from Tübingen and Seattle is developing an open source online platform that maps the evolution of viruses and identifies dangerous developments.

  • Article - 25/07/2016

    What happens in tissues and organs and how do they react to pharmaceutical substances? Three-dimensional cell cultures can reproduce reality far better than a single-cell layer can. With good reason. Reality is far from two-dimensional. A company called 300MICRONS GmbH develops films with tiny indentations that provide optimal conditions for cells to grow into 3D cell aggregates.

  • Article - 21/07/2016

    Secondary hop compounds appear to have a positive effect on the immune system and therefore have the potential to be used for the treatment and prevention of cancer. However, the bioavailability of hop compounds in the human body is relatively poor. Researchers from Hohenheim and Tübingen are therefore looking for a way to increase their absorption rate.

  • Press release - 14/07/2016

    Tübingen, Germany, July 14, 2016 – CureVac AG, the most clinically advanced mRNA company, today announced that a study of its RNActive® technology was published in the renowned, peer-reviewed journal Vaccine. The study, titled, “Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity,” demonstrated a mechanistic insight into the mode of action and rationale for the use of messenger…

  • Article - 11/07/2016

    The oxidation state of the cells in our body is very important for us: if the normal balance of the distribution of endogenous oxidants is disturbed or if they attack cellular structures, cells are either unable or only partially able to fulfil their functions, and diseases develop. Knowing the oxidation state and one day also having the capacity to modify it with pharmaceuticals, is therefore of crucial importance when disease-related changes…

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