Within biological cells, molecules are constantly in motion. Investigating these motions, however, is still difficult, due to the fact that these processes occur on very small length and time scales. To overcome these challenges, researchers from HITS and MPI-P have developed a simulation method that works rapidly and can predict chemical processes in cells with high precision. Their findings have been published in Nature Communications.

A novel biomimetic tissue substitute combines precisely tunable mechanical properties with biological functionality and is now ready for applications in medical technology. The material was developed in the »PolyKARD« project by Fraunhofer IAP and the NMI Natural and Medical Sciences Institute. From 20.-24.04, 2026, the material will be presented together with further developments at the Hannover Messe, Fraunhofer joint booth.

How can you charge electric cars without plugging them into the power grid for hours on end? How can industrial robots be “refueled” during operation? And how does wireless energy transfer improve medical technology? These questions have occupied Prof. Nejila Parspour, Director of the Institute of Electrical Energy Conversion (IEW) at the University of Stuttgart, for more than twenty years.

Can Aztekin and his team have discovered how oxygen-sensing explains why amphibians regenerate limbs and mammals do not.

Traumatic brain injuries often lead to complications with long-lasting consequences on memory, concentration and movement control. Detrimental secondary inflammatory reactions at the injured tissue sites are often responsible for this. Researchers from Ulm have now shown that a transcription factor plays a key role in reactions to TBI. When this gene regulator is activated, an elevated neuroimmune response promotes inflammation.

Immunotherapies have greatly improved the treatment of metastatic melanoma, but they can cause serious side effects. A study led by researchers from Heidelberg University's Medical Faculty, the Heidelberg University Hospital, and the NCT in Heidelberg now shows that autoantibodies detected in the blood before the start of therapy could help to better assess the individual risk of side effects in patients.

A severe side effect of radiation therapy can be debilitating fibrotic skin damage. Scientists at the German Cancer Research Center (DKFZ) have now identified a key factor in the development of this radiation damage. Modulating this factor could potentially prevent this severe adverse effect.

Tenderness can literally get under your skin: An international research group led by Heidelberg University's Medical Faculty and Heidelberg University Hospital has found that small skin wounds heal significantly faster in couples who are particularly affectionate with each other in everyday life and who also receive the hormone oxytocin. At the same time, they had lower stress levels.

With victims numbering in the millions, malaria is an infectious disease caused by the bite of a mosquito carrying the malaria parasite. After penetrating the skin, the pathogen moves with helical trajectories. It almost always turns toward the right, as a team of physicists and malaria researchers from Heidelberg University recently discovered.

A joint team from the University of Stuttgart in Germany and the University of Melbourne in Australia has developed a new method for the straightforward analysis of tiny nanoplastic particles in environmental samples. One needs only an ordinary optical microscope and a newly developed test strip—the optical sieve. The research results have now been published in “Nature Photonics

When embryos grow, cells and tissue are constantly bumping into each other. This creates mechanical tensions that could endanger their development. A team from University of Hohenheim and the Japanese RIKEN Center have discovered that fly embryos have strategies to deal with this pressure. The different species have developed two different solutions. This ability to control mechanical tension could be a key to why so many body plans have evolved.

Until now, the early phase of drug discovery for the development of new therapeutics has been cost- and time-intensive. Researchers at KIT have developed a platform on which extremely miniaturized nanodroplets with a volume of 200 nanoliters per droplet and containing 300 cells per test can be arranged. This platform enables the researchers to synthesize and test thousands of therapeutic agents on the same chip, saving time and resources.

Sepsis is one of the most dangerous medical emergencies. The condition is the result of a misdirected immune response to an infection, which can quickly lead to organ failure and death. Every hour counts – but early detection is difficult. A new study from Heidelberg now presents an innovative approach: artificial intelligence (AI) and hyperspectral imaging of the skin enable immediate and non-invasive sepsis diagnosis directly at the bedside.

Computer tool opens up new ways to address antibiotic resistance - 02/07/2025

PhARIS identifies effective phages against multi-resistant bacteria

Bacteriophages - viruses that specifically attack and destroy bacteria - are emerging as promising alternatives to antibiotics in the fight against drug-resistant infections. To speed this effort, researchers have created PhARIS, a computational tool that mines genomic data to pinpoint phages that are effective against S. aureus. By rapidly matching phage and pathogen, PhARIS can accelerate the development of targeted phage therapies.

Scientists at the German Cancer Research Center (DKFZ) have shown in an international eye-tracking study that dermatologists not only improve their diagnostic accuracy by using explainable artificial intelligence, but also show significantly less fatigue when assessing challenging cases. The researchers were able to demonstrate this by measuring a reduction in cognitive stress indicators.

A research team led by PD Dr. Justus Marquet and from the Hertie Institute for Clinical Brain Research has developed two methods that allow muscle activity and training-induced adaptations to be measured completely contactlessly. The studies demonstrate that magnetic fields generated during muscle activity can be captured using highly sensitive quantum sensors - without the need for electrodes or skin contact.

Animal-free testing of chemicals and cosmetics - 07/05/2025

Human reporter skin for visualsing skin reactions

Before new cosmetics can be placed on the market, all ingredients must undergo rigorous testing for safety and efficacy. Dr. Anke Burger-Kentischer of the Fraunhofer IGB has long been at the forefront of animal-free research and has developed an innovative method to quickly and reliably test cosmetics and other chemicals without using animals. She was awarded the 2024 Hamburg Research Prize for her groundbreaking ‘reporter skin’ in vitro model.

The Max Planck Society and the Dieter Schwarz Foundation (DSS) have embarked on a groundbreaking initiative. On March 13, 2025, they signed an agreement through which the foundation will support an innovative approach by the Max Planck Institute for Medical Research in Heidelberg to translate basic research findings into practical applications. As part of this endeavour, two new departments of the institute will be established in Heilbronn.

Zebrafish can completely replace damaged heart muscle cells: The affected organ becomes fully functional again. Researchers at Ulm University have discovered that a specific cell-to-cell communication signal helps them to cope better with replication stress. This stress inhibits tissue regeneration in humans and mammals as they age. In Zebrafish a signalling protein ensures that the cells of the damaged organ continue to divide and thus multiply.

New polymer for wound care - 09/01/2025

Thermoresponsive adhesive for pain-free removal of wound dressings

Plasters or wound dressings can only perform their intended function if they adhere securely to the skin. However, they are often painful to remove, and in some cases, damage delicate newly formed tissue. Researchers at the University of Freiburg have developed an innovative polymer that adheres reliably at body temperature but can be easily and painlessly removed, leaving no residue, after being cooled.

A quantum sensor that can register nerve impulses without contact opens up new possibilities in prosthetics. Researchers at Fraunhofer IPA are developing together with the industrial partner Q.ANT the prototype of one Prosthetic arm that is controlled by neural commands like healthy limbs.

At the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, a three-dimensional skin model has now been set up for the first time that directly displays the skin's reaction to substances: The reporter skin. Thanks to the built-in reporter, the cellular response can be measured precisely and quickly – using a living model.

Research teams from the Universities of Konstanz and Potsdam are analyzing how proteins work together to enable our cells to both stick and move. The marker protein paxillin is at the centre of their interest.

The "Friends of the German Cancer Research Center" association supports the DKFZ and aims to help strengthen its position in international competition. With the DKFZ Innovation Award presented at this year's DKFZ annual reception, the association honored Titus Brinker as a researcher whose highly innovative work builds a bridge from research to practical application with commercialization potential.

Collagen has been used in ophthalmology since the 1990s, particularly in the treatment of corneal defects. However, why and how this technique works was only known in theory. Researchers at the NMI Natural and Medical Sciences Institute in Reutlingen led by Lu Fan have found the necessary evidence and can now reliably explain how this technique works.