Healthcare industry

Using new microscopic methods in combination with machine learning-based image analysis, researchers from Freiburg have discovered new structures on the surface of living B cells that affect the distribution and possibly the function of their antigen receptors. The researchers' study has been published in The EMBO Journal.

Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease. The new technology can trace which populations of breast cancer cells are responsible for the spread of the disease, and for the first time highlights how the location of cancer cells could be as important as mutations in tumor growth The new study is…

Researchers of the University of Freiburg have discovered a previously unknown function of septins in defending cells against dangerous hospital pathogens.

Researchers from Freiburg and Harvard publish the three-dimensional structure of the B cell antigen receptor, shedding new light on its composition.

Microrobots have the potential to revolutionize medicine. Researchers at the Max Planck ETH Centre for Learning Systems have now developed an imaging technique that for the first time recognises cell-sized microrobots individually and at high resolution in a living organism. This is an important step towards precise control of the robots and their clinical translation.

Laboratory automation - 29/11/2021

Reaching the goal quickly and efficiently with the help of artificial intelligence

Medical research is slow, costly and time-consuming. The system developed by the start-up LABMaiTE could soon change that. With the help of artificial intelligence, it will be possible to automate laboratory experiments and collect and analyse data at the same time.

Nanoparticles are omnipresent in our environment: Viruses in ambient air, proteins in the body, as building blocks of new materials for electronics, or in surface coatings. Visualizing these smallest particles is a problem: They are so small that they can hardly be seen under an optical microscope.

International research collaboration explores the properties of different neuron types in the brain motor cortex of mice, monkeys and humans using novel experimental and data analysis techniques.

A pioneering technique developed by the Prevedel Group at EMBL allows neuroscientists to observe live neurons deep inside the brain – or any other cell hidden within an opaque tissue. The technique is based on two state-of-the-art microscopy methods, three-photon microscopy and adaptive optics. The paper reporting on this advancement was published on 30th September 2021 in Nature Methods.

Scientists use super-resolution microscopy to study previously undiscovered cellular worlds, revealing nanometer-scale details inside cells. This method revolutionized light microscopy and earned its inventors the 2014 Nobel Prize in Chemistry. In an international collaboration, AI researchers from Tübingen have now developed an algorithm that significantly accelerates this technology.

Under certain conditions, our immune system can efficiently fight off infectious diseases and cancer. T cells, especially the gamma delta T cell type, play an important role in this. The issue is that this cell type is extremely infrequent in the human body. Researchers at the University Hospital Tübingen, the University of Heidelberg and the European Molecular Biology Laboratory (EMBL) have now succeeded in finding the cause for the formation of…

Scientists from the EMBL and the German Cancer Research Center have presented a new method for generating metabolic profiles of individual cells. The method, which combines fluorescence microscopy and a specific form of mass spectroscopy, can analyze over a hundred metabolites and lipids from more than a thousand individual cells per hour. Researchers expect the method to better answer a variety of biomedical questions in the future.

Article - 10/03/2021

Faster to single cells using miniature grinder

Tissue cells are needed for medical diagnostics, cell therapies and tissue engineering, among other things. A novel tissue grinder gently and automatically dissociates cells from tissue. In November 2020, the newly founded biotech company Fast Forward Discoveries GmbH (FFX) delivered its first tissue grinders to customers.

AI-based evaluation of medical imaging data usually requires a specially developed algorithm for each task. Scientists from the German Cancer Research Center (DKFZ) have now presented a new method for configuring self-learning algorithms for a large number of different imaging datasets – without the need for specialist knowledge or very significant computing power.

“Molecular glue degraders” are a new class of cancer drugs, which “glue” cancer growth-promoting proteins directly to the molecular machinery of a cell’s disposal system, leading to the subsequent degradation of the cancer-driving proteins and anti-tumor activity. Scientists from Heidelberg and USA have now deciphered another mechanism whereby a small molecule can degrade a cancer protein.

Sometimes an image is just an image. Sometimes it gives those who can read it correctly a deeper insight into what they can see. In many scientific disciplines, the key to extracting meaningful information from large three-dimensional images, obtained from X-ray tomography or optical microscopy, is segmentation, a tedious and time-consuming – and therefore error-prone – task if done manually.

International study in which Freiburg scientists are participating maps molecular targets for possible therapy for MERS, SARS-CoV1, and SARS-CoV2.

Expert interview - 13/05/2019

Innovation management in the life sciences – Inova DE provides insights

Personalized medicine, medical technology, digital health and artificial intelligence are revolutionizing diagnostics and product development. Analyses are becoming faster and more precise, and data volumes can now be networked and used effectively. The goal of improving people's quality of life is within reach, and this will also strengthen Germany’s future viability. However, not every good idea can be turned into a marketable commodity.…

Article - 26/04/2017

Chaperones disassemble Parkinson’s disease-specific amyloid fibrils

Amyloid fibrils consisting of clumped α-synuclein protein are characteristic of Parkinson's disease. Chaperones, which ensure the correct folding of newly synthesised polypeptides, can inhibit α-synuclein aggregation and, as a consequence, prevent fibrils from forming. Researchers from Heidelberg have shown that a specific combination of human molecular chaperones is able to disassemble fibrils and transform them into non-toxic α-synuclein…

Article - 12/04/2017

Imaging flow cytometry – introducing a new era of imaging

High-resolution images or quantifiable results? Up until now, researchers usually had to choose. All this has now changed thanks to a single device known as an imaging flow cytometer that combines fluorescence microscopy and flow cytometry. The new device gives new insights into complex biological phenomena in cells. It is available for research purposes at the Research Centre for Women’s Health at the University Hospital of Tübingen, which…

Press release - 31/01/2017

Background Suppression for Super-resolution Light Microscopy

Researchers of Karlsruhe Institute of Technology (KIT) have developed a new fluorescence microscopy method: STEDD (Stimulation Emission Double Depletion) nanoscopy produces images of highest resolution with suppressed background. The new method yields an enhanced image quality, which is advantageous when analyzing three-dimensional, densely arranged subcellular structures. STEDD, a further development of the STED method, is now presented in…

Article - 11/07/2016

Endogenous oxidants: biosensor monitoring of metabolic conditions in living organisms

The oxidation state of the cells in our body is very important for us: if the normal balance of the distribution of endogenous oxidants is disturbed or if they attack cellular structures, cells are either unable or only partially able to fulfil their functions, and diseases develop. Dr. Tobias Dick and his team of researchers at the German Cancer Research Center (DKFZ) in Heidelberg have now developed a biosensor that facilitates real-time…

Company profile - 05/07/2016

HS-Analysis GmbH – using digital histology to develop new drugs

The idea of analysing tissue samples automatically sounds more of a pipe dream than anything else. However, it already happens. HS-Analysis GmbH's ability to interpret tissue samples automatically is driving new drug development a decisive step forward.

Article - 26/10/2015

Ultrafast STED nanoscopy

Nobel Laureate Stefan Hell and his team at the German Cancer Research Center in Heidelberg have achieved yet another milestone in super-resolved optical microscopy. The team have developed an ultrafast STED (stimulation emission depletion) nanoscope that now makes it possible to study molecular processes and transport processes in living cells in millisecond time steps.