CRISPR base editing for tailored tumour detection - 16/07/2026

Targeted genetic manipulation of signal transduction pathways in CAR T cells enhances anti-tumour potency

Chimeric antigen receptor (CAR) T cell therapy has emerged as a highly promising treatment modality but has so far been used almost exclusively for advanced haematologic malignancies. Researchers at the iFIT cluster of excellence in Tübingen have now used CRISPR base-editing technology to introduce precise point mutations into key signalling pathways of CAR T cells, significantly enhancing their long-term persistence and anti-tumour potency.

With the aid of physical forces it is possible to actively steer the formation of engineered tissue. For example, sound waves can be used to create functional vascular networks with blood vessel-like structures in vitro. Scientists at the Center for Molecular Biology of Heidelberg University have demonstrated this through their methodology for acoustic manipulation.

The Friends of the German Cancer Research Center (DKFZ) support the DKFZ and aim to help strengthen its position in the international arena. With the DKFZ Innovation Award, presented at this year’s annual reception, the association honors Helmut Salih, a researcher whose innovative work bridges the gap between immunological research and patient care.

The University of Freiburg is strengthening its European collaboration in the field of Artificial Intelligence by having been accepted into the Virtual Centre of Excellence of the European AI initiative ELIAS. The Freiburg researchers contribute their expertise to the European network in areas including machine learning, computer vision, robot learning, automated reasoning, intelligent systems and neurotechnologies, as well as responsible AI.

Robots that can learn and adapt require not only data, AI tools, and algorithms but also direct communication with their users. Jens Kober would like to improve this interaction and as the new head of a research team at Fraunhofer IPA, he is focusing in particular on construction robotics.