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  • Article - 04/07/2013 19902_de.jpg

    Experimental evidence of stem cells for metastasis

    For the first time, scientists from Heidelberg have characterised cancer cells that initiate metastasis in the blood of breast cancer patients using an in-vivo xenograft mouse model. These cells have the properties of cancer stem cells and are characterised by three surface molecules that can be used as biomarkers for disease progression.

    https://www.gesundheitsindustrie-bw.de/en/article/news/experimental-evidence-of-stem-cells-for-metastasis
  • Article - 17/06/2013 19818_de.jpg

    New software systems for patient-friendly cancer radiotherapy

    The new large-scale cooperative project SPARTA is aimed at developing adaptive, intelligent and flexibly expandable software systems for the improved radiotherapy of cancer. The Heidelberg Institute of Radiation Oncology (HIRO), which integrates the common research interests of all institutions in Heidelberg active in the field of radiotherapy, plays a pivotal role in the project.

    https://www.gesundheitsindustrie-bw.de/en/article/news/new-software-systems-for-patient-friendly-cancer-radiotherapy
  • Article - 21/05/2013 Photo of an apple, also showing the formula of ethyl 2-methylbutyrate

    Green gold: bioactive plant foods

    Nowadays everything must be good for something must have a direct noticeable or tangible effect. The ever topical issue of nutrition is no exception. All this makes functional food a promising and inexhaustible market. Teams of scientists around the world are focussing on how unhealthy food can be made healthy. Bioactive plant foods are expected to close a gap that should not have existed in the first place.

    https://www.gesundheitsindustrie-bw.de/en/article/news/green-gold-bioactive-plant-foods
  • Dossier - 13/05/2013 19501_de.jpg

    The human proteome – the next major goal

    The “Human Proteome Project”, a ten-year global initiative that is making a systematic effort to map all human proteins, has moved from the planning to the experimental stage. How significant and how effective the project will be depends on how much the resources offered are used by proteome researchers and on the data that the researchers bring into the project.

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/the-human-proteome-the-next-major-goal
  • Article - 09/05/2013 19543_de.jpg

    Immunoproteasome Drug Targeting: Immunoproteasome inhibitors allow control of autoimmune diseases

    Marcus Groettrup is the chair of immunology at the University of Konstanz and has been active in the field of immunology for many years. In 2009 Groettrup made a discovery that led to him setting up a company. His analysis of immunoproteasomes whose main function is to degrade unneeded or damaged proteins showed that these protein complexes also play a major role in the development of autoimmune diseases. Based on this knowledge Groettrup…

    https://www.gesundheitsindustrie-bw.de/en/article/news/immunoproteasome-drug-targeting-immunoproteasome-inhibitors-allow-control-of-autoimmune-diseases
  • Article - 06/05/2013 19644_de.jpg

    HeLa, a human bauplan in the Petri dish

    Scientists from EMBL have recently sequenced the genome of HeLa cells, which are the world’s most commonly used human cell line. They found that the HeLa genome and that of normal human cells reveal striking differences, caused by chromothripsis and other aberrations. Some evolutionary researchers believe that HeLa cells are developing a new human bauplan as they adapt to cultivation in the Petri dish.

    https://www.gesundheitsindustrie-bw.de/en/article/news/hela-a-human-bauplan-in-the-petri-dish
  • Press release - 30/04/2013 19630_de.jpg

    Impressions from the 2013 BIO International Convention in Chicago

    A trade fair turns 20 and an industrial sector is coming of age. Where does BIO stand today? The number of exhibitors has slightly decreased the conference is characterised by general themes and trends and partnering has become the most important and indispensable part of the global event for biotechnology. What was once a gold rush atmosphere has given way to an experienced self-confidence about the economic importance of biotechnology.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/impressions-from-the-2013-bio-international-convention-in-chicago
  • Article - 29/04/2013 19551_de.jpg

    Bioactive plant foods: plant substances against cancer stem cells

    Many findings indicate that the consumption of cruciferous vegetable plants rich in mustard oil glycosides has a cancer-inhibiting effect. Researchers from Heidelberg have now shown that sulforaphane, a broccoli mustard oil, blocks a signalling pathway that makes tumour stem cells resistant to cytotoxic drugs. The administration of sulforaphane can prevent therapy resistance and metastasis of pancreatic cancer in animal models.

    https://www.gesundheitsindustrie-bw.de/en/article/news/bioactive-plant-foods-plant-substances-against-cancer-stem-cells
  • Dossier - 15/04/2013 19496_de.jpg

    Bioactive plant foods – more than just filling

    The increasing demand for functional foods clearly shows that the role of food is no longer just to meet an essential need. Food that offers additional nutritional benefits is becoming increasingly important for example food that is able to prevent or treat diseases. This kind of food is therefore interesting for consumers the food industry and the healthcare sector alike. Products based on plant raw materials are particularly in demand due to…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/bioactive-plant-foods-more-than-just-filling
  • Article - 08/04/2013 19469_de.jpg

    The first major cell migration

    It is of crucial importance that cells stick tightly together where their function requires them to do so for example in organs such as the heart and the liver to name but two examples. However it is equally crucial that cells start to migrate at some stage during embryonic development in order to form such organs. Prof. Dr. Wolfgang Driever from the Institute of Biology I at the University of Freiburg and his team have elucidated the molecular…

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-first-major-cell-migration
  • Article - 08/04/2013 19437_de.jpg

    Integrated infrastructures for medical science

    The annual TMF conference in Heidelberg dealt with the need for integrated science infrastructures for the advancement of medical research. The major focus was on quality criteria for medical biomaterial banks and the establishment of the German Biobank Registry as the core of a central IT infrastructure, with the overall aim of creating the right conditions for resource-saving medical research excellence in Germany.

    https://www.gesundheitsindustrie-bw.de/en/article/news/integrated-infrastructures-for-medical-science
  • Dossier - 01/04/2013 19423_de.jpg

    Retroviruses: from infectious agent to therapeutic assistant

    Viruses are infectious particles that use the machinery and metabolism of a host cell to replicate. Despite some similarities with accepted forms of life viruses are not considered as such. The family of retroviruses is particularly known for its most notorious representative i. e. the human immunodeficiency virus HIV which leads to AIDS and for which no cure or effective vaccine is currently available. However retroviruses are not only of…

    https://www.gesundheitsindustrie-bw.de/en/article/dossier/retroviruses-from-infectious-agent-to-therapeutic-assistant
  • Article - 25/03/2013 19369_de.jpg

    Epigenetics for personalised cancer care for women

    Every year in the EU, 45,300 women are diagnosed with ovarian cancer and 330,000 with breast cancer. Ovarian cancer has a mortality rate of around 64% and breast cancer around 27%*. The EU-funded research project EpiFemCare aims at improving cancer detection and subsequent patient care. The research project aims to develop blood tests based on epigenetic DNA modifications, i.e. the methylation of the base cytosine, for the identification of…

    https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-for-personalised-cancer-care-for-women
  • Article - 04/03/2013 Diagram showing how CARL® works: the drug is distributed in the body and part of it is removed with two filters.

    TellTargeting Medical GmbH – targeted chemotherapy using CARL®

    The needs of cancer patients are clear chemotherapies that are as gentle as possible associated with minimal adverse effects and have a rapid effect. This is often difficult to achieve because the drug that stops tumour growth needs to remain in the body for a certain amount of time during which time it damages cancerous as well as healthy structures. Dr. Gerhard Pütz and Dr. Jürgen Eckes founded the company TellTargeting Medical GmbH Co. KG…

    https://www.gesundheitsindustrie-bw.de/en/article/news/telltargeting-medical-gmbh-targeted-chemotherapy-using-carl
  • Article - 04/03/2013 19277_de.jpg

    Genomic structural variations can cause cancer

    Genome-wide sequencing analyses show that comprehensive structural variations of chromosomes can play a key role in the pathogenesis of many types of cancer. Dr. Jan Korbel’s research group at the European Molecular Biology Laboratory in Heidelberg has been investigating chromosomal aberrations in paediatric brain tumours and early-onset prostate cancer.

    https://www.gesundheitsindustrie-bw.de/en/article/news/genomic-structural-variations-can-cause-cancer
  • Article - 22/02/2013 19239_de.jpg

    Malte Drescher provides insights into cells

    Electron spin resonance (ESR) spectroscopy can deliver information about the structure and dynamics of large molecules and was used by Dr. Malte Drescher from the University of Konstanz to develop a method for the structural analysis of biological macromolecules inside cells. It provides insights into the complex structure of molecules under physiological conditions and is a promising approach for the development of cancer drugs.

    https://www.gesundheitsindustrie-bw.de/en/article/news/malte-drescher-provides-insights-into-cells
  • Article - 18/02/2013 19216_de.jpg

    Dickkopf deficiency improves cognitive performance

    Scientists from the German Cancer Research Center have shown that the Dickkopf gene, which regulates head development during embryogenesis, prevents the regeneration of nerve cells in the mouse hippocampus. This also leads to the loss of learning capacity in advanced age. Animals in advanced adult age whose Dickkopf gene had been silenced showed no age-related decline in cognitive performance.

    https://www.gesundheitsindustrie-bw.de/en/article/news/dickkopf-deficiency-improves-cognitive-performance
  • Article - 11/02/2013 19172_de.jpg

    REGiNA – the health region for regenerative medicine

    REGiNA is a users’ centre for regenerative medicine in the area bordered by the cities of Stuttgart and Tübingen and the Neckar-Alb region. It was established with the aim of translating a variety of advanced regenerative methods into broad clinical application. Providing a diverse and broad range of information, REGiNA is focused on making new treatment possibilities and the opportunities created by regenerative medicine known to doctors,…

    https://www.gesundheitsindustrie-bw.de/en/article/news/regina-the-health-region-for-regenerative-medicine
  • Article - 04/02/2013 19110_de.jpg

    DKFZ-HIPO – the Heidelberg Center for Personalised Oncology

    The German Cancer Research Center (DKFZ) and the National Center for Tumour Diseases (NCT) have jointly initiated the Heidelberg Center for Personalised Oncology (HIPO) which provides cancer patients with high-throughput genetic and molecular analyses. In anticipation of the upcoming World Cancer Day on 4th February 2013, the potential of high-throughput genetic and molecular analyses in improving cancer therapy was presented at a workshop held…

    https://www.gesundheitsindustrie-bw.de/en/article/news/dkfz-hipo-the-heidelberg-center-for-personalised-oncology
  • Article - 04/02/2013 19136_de.jpg

    G protein-coupled receptors and their importance for research and development

    Brian Kobilka and Robert Lefkowitz were awarded the 2012 Nobel Prize in Chemistry for their groundbreaking discoveries of the inner workings of G protein-coupled receptors (GPCRs). These transmembrane receptors play a key role in the processing of odours and the recognition of hormones. The work of the two American scientists has had an impact on many researchers around the world. In the following interview, Professor Dr. Daniel Legler, head of…

    https://www.gesundheitsindustrie-bw.de/en/article/news/g-protein-coupled-receptors-and-their-importance-for-research-and-development
  • Article - 28/01/2013 19105_de.jpg

    Epigenetics and childhood blood cancer

    Juvenile myelomonocytic leukaemia JMML is the most common chronic cancer of the blood in children and tends to have a poor response to chemotherapy. Prof. Dr. Christian Flotho and his team from the Centre of Paediatric and Adolescent Medicine in Freiburg have shown that epigenetic mechanisms play a key role in the pathogenesis of JMML. As part of a German Research Foundation priority programme the researchers from Freiburg are working on…

    https://www.gesundheitsindustrie-bw.de/en/article/news/epigenetics-and-childhood-blood-cancer
  • Article - 21/01/2013 19076_de.jpg

    Early warning signals of ageing in stem cells

    The large international project SyStemAge is specifically focused on the role of stem cells in ageing and age-related diseases. Coordinated by the European Molecular Biology Laboratory and the Heidelberg University Hospital the SyStemAge consortium seeks to identify the causes and molecular pathways associated with the processes of ageing on the stem-cell level as well as developing novel strategies for the early treatment of age-related…

    https://www.gesundheitsindustrie-bw.de/en/article/news/early-warning-signals-of-ageing-in-stem-cells
  • Article - 14/01/2013 19037_de.jpg

    Boehringer takes a deep breath: a look into the company’s respiratory R&D pipeline

    At its 3rd International Research & Development (R&D) press conference, Boehringer Ingelheim gave journalists insights into its R&D pipeline. Around 200 scientists at the company’s site in Biberach are investigating new treatment options for patients with COPD (chronic obstructive pulmonary disease), asthma, idiopathic lung fibrosis, lung cancer and other respiratory diseases. In addition, the researchers are also focusing on the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/boehringer-takes-a-deep-breath-a-look-into-the-company-s-respiratory-r-d-pipeline
  • Article - 07/01/2013 How a reporter gene works: microRNA-mediated regulation can be measured using fluorescent proteins. The photo shows numerous cells whose nuclei appear blue under the fluorescence microscope. Some cells have red edges, others green ones.

    Small RNAs and immunological reactions

    Patients with common variable immunodeficiency CVID lack antibodies that would protect them against infections. Only a handful of patients develop the disease because of a single defect in any of the genes involved in CVID pathogenesis. A group of researchers led by Dr. Ulrich Salzer at the Centre for Chronic Immunodeficiency CCI at the University of Freiburg Medical Centre investigates how small RNA molecules control B-lymphocyte development as…

    https://www.gesundheitsindustrie-bw.de/en/article/news/small-rnas-and-immunological-reactions
  • Article - 18/12/2012 18996_de.jpg

    Gene therapy medicinal products: the first gene therapy product has been approved – where does the future lie?

    Is gene therapy close to broad clinical application? Following negative headlines at the end of the 1990s gene therapy had almost disappeared from the public radar to become an issue almost exclusively dealt with by research laboratories. Gene therapy has now reappeared in the public domain since the European Medicines Agency EMA gave the Dutch biotech company uniQure the go-ahead for the application of somatic gene therapy for the treatment of a…

    https://www.gesundheitsindustrie-bw.de/en/article/news/gene-therapy-medicinal-products-the-first-gene-therapy-product-has-been-approved-where-does-the-futu

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