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  • Article - 08/12/2009 Immunofluorescence image of two dendritic mouse cells with MHC complexes (labelled with red-fluorescent antibodies) on their surface.

    Sentinels against microbial invaders

    Dendritic cells are sentinels of the innate immune system that activate the adaptive immune system when infectious microorganisms enter the body. Prof. Dr. Klaus Heeg and his team from the Department of Infectiology at the University of Heidelberg are focusing on the complex signalling pathways that link the innate and adaptive immune systems.

    https://www.gesundheitsindustrie-bw.de/en/article/news/sentinels-against-microbial-invaders
  • Article - 03/09/2009 The colour drawing shows a spherical structure with pearls of different colour in the outer layer. Different letters, T and C, are located in the centre of the sphere.<br />

    The lipid metabolism and the immune system

    What has the lipid metabolism of the human body got to do with inflammation? Scientists in Dr. Petra May’s group at the Centre for Neuroscience at the University of Freiburg recently found that molecules which normally regulate the availability of cholesterol and other water-insoluble substances, also interact with the signalling networks of the immune system. According to their findings, a receptor which mediates the uptake of certain…

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-lipid-metabolism-and-the-immune-system
  • Article - 28/04/2008

    Mast cells of the immune system

    Immune cells sometimes kick over the traces. This could lead to allergic reactions. At the Freiburg Max Planck Institute of Immunobiology a group of researchers led by Professor Michael Huber is investigating the mechanisms that can prevent this from happening.

    https://www.gesundheitsindustrie-bw.de/en/article/news/mast-cells-of-the-immune-system
  • Article - 28/02/2011 13773_de.jpg

    The regulation of the intestinal immune system

    If the interplay of factors that regulate the intestinal immune system tips out of balance, this could result in allergic reactions or serious inflammatory intestinal diseases. Professor Dr. med. Stefan Meuer, Managing Director of the Institute for Immunology at the University Hospital in Heidelberg, is focusing on the molecular mechanisms of mucosal immune regulation.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-regulation-of-the-intestinal-immune-system
  • Article - 15/12/2009 10453_de.jpg

    Arming the immune system against cancer

    The theory that immune cells are able to attack tumours has long been a theory with only a minority of supporters. However, this theory is currently experiencing a renaissance. In the future, it might even be possible to specifically alter T-lymphocytes in order to improve their ability to identify and destroy certain tumour types. Prof. Dr. Hanspeter Pircher and his team at the Freiburg University Medical Centre are focusing on the development…

    https://www.gesundheitsindustrie-bw.de/en/article/news/arming-the-immune-system-against-cancer
  • Article - 09/03/2015 22905_de.jpg

    Treating cancer by activating the immune system

    Vaccines that prevent infection with cancer-causing viruses are already available. Moreover, the development of therapeutic vaccines for the treatment of a number of other cancers is well under way. These vaccines not only prevent the development of cancer, but also treat early stages of cancer. Antigen-armed antibodies have long been used in vaccines against infectious diseases, and can now also be used for treating cancer.

    https://www.gesundheitsindustrie-bw.de/en/article/news/treating-cancer-by-activating-the-immune-system
  • Article - 30/03/2015 The photo shows Dr. Sommershof in the laboratory, using a flow cytometer.<br />

    How psychological stress weakens the immune system

    Too much stress makes you sick – this is the widely held opinion. But exactly how chronic psychological stress affects our body is not yet fully understood. This is the question Dr. Annette Sommershof and her team from the University of Konstanz are trying to answer. The scientists are exploring stress-related changes in the immune system and have found evidence for the observation that long-term stress weakens the immune system, resulting in…

    https://www.gesundheitsindustrie-bw.de/en/article/news/how-psychological-stress-weakens-the-immune-system
  • Press release - 01/09/2020

    Strengthening the immune system with small molecules

    Infections pose an increasing risk to hospitalized patients. In collaboration with a number of partners, the Fraunhofer IGB has developed a new therapeutic approach as part of the InnateFun project. Their strategy is to improve cells’ ability to defend themselves against harmful microorganisms by acting on their immune receptors. The researchers’ work on this therapeutic approach has reached the animal model stage.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/strengthening-immune-system-small-molecules
  • Press release - 07/08/2010 12055_de.jpg

    Light into the darkness of the human immune system

    Scientists from the Department of Molecular Immunology at the Faculty of Biology and the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg have discovered a new mechanism that regulates the development of B-lymphocytes in the human bone marrow.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/light-into-the-darkness-of-the-human-immune-system
  • Article - 11/02/2013 Schematic with two artificial liposomes. The membrane on the left contains phospholipids and the receptors are positioned far away from each other. The membrane of the liposome on the right also contains cholesterol and sphingomyelin, which makes the receptors aggregate into clusters.<br />

    Cholesterol boosts the memory of the immune system

    Cholesterol has been demonised for a long time as high cholesterol levels are seen as major risk factors for atherosclerosis myocardial infarction and gallstones. However cholesterol is an essential component of mammalian cell membranes and is required for proper membrane function. It exists in huge quantities in the human body. In addition to being essential for cell survival and hence all animal life in general cholesterol also plays a crucial…

    https://www.gesundheitsindustrie-bw.de/en/article/news/cholesterol-boosts-the-memory-of-the-immune-system
  • Article - 18/11/2019 Messung_Immunantwort_Elispot2_Kopie.jpg

    Researchers successfully rejuvenate the immune system in animal models

    It is well known that stem cells age. Even the human immune system loses its power with age. Since all immune cells are derived from blood-forming stem cells, it is quite natural to associate the weakening of the immune system (immune senescence) with the ageing of blood-forming stem cells. Stem cell researchers and immunologists from the University of Ulm have now demonstrated the important role that blood-forming cells play in the ageing of the…

    https://www.gesundheitsindustrie-bw.de/en/article/news/Researchers-successfully-rejuvenate-the-immune-system-in-animal-models
  • Press release - 30/06/2009 08933_de.jpg

    Gentle rather than radical: ways to improve the treatment of autoimmune diseases

    Autoimmune diseases are usually treated with drugs that block the entire immune system rendering the body very susceptible to all kinds of infections. A team of Constance researchers under the leadership of Prof. Marcus Groettrup has developed a treatment method that only targets part of the immune system and is therefore far better tolerated by patients.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/gentle-rather-than-radical-ways-to-improve-the-treatment-of-autoimmune-diseases
  • Article - 07/01/2016 Schematic showing a B-cell receptor in the plasma membrane and the protein Kidins220.

    New protein helps B cells generate an effective immune response

    The human immune system plays a key role for human health. Dr. Gina Fiala, a scientist in Prof. Dr. Wolfgang Schamel’s team in the Department of Immunology at Freiburg University, has discovered Kidins220/ARMS in B cells. Kidins220/ARMS is part of the adaptive immune system where it plays a key role in the maturation of B cells.

    https://www.gesundheitsindustrie-bw.de/en/article/news/kidins220-hilft-b-zellen-bei-der-immunabwehr
  • Article - 23/06/2016 Microscopig image of immune cells, stained red, attacking green biofilms.

    The body’s immune system loosens artificial joints

    Hip and knee endoprostheses are not nearly as long-lasting as their natural counterparts. Dr. Ulrike Dapunt from the University Hospital Heidelberg’s Department of Orthopaedics and Traumatology has now discovered that it is not the bacterial activity or secretions that lead to the degradation of bone during chronic inflammation, but rather local host defence mechanisms.

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-bodys-immune-system-loosens-artificial-joints
  • Affimed GmbH - 01/07/2020 Schematische Darstellung der Kommunikation zwischen den Zellen der angeborenen und erworbenen Immunität. „innate cell engager“ aktivieren NK-Zellen und Makrophagen, die wiederum tumorspezifische T-Zellen stimulieren.

    "Innate cell engagers" to fight cancer

    In the fight against tumour cells, d Affimed GmbH from Heidelberg relies entirely on the weapons of the innate immune system. Affimed has developed special innate cell engagers, which are bispecific antibodies that recognise tumour cells and bring them together with natural killer cells and macrophages of the innate immune system, which then kill the tumour cells. Clinical trials using the AFM13 molecule are ongoing.

    https://www.gesundheitsindustrie-bw.de/en/article/news/innate-cell-engager-fighting-against-cancer
  • Article - 05/10/2008

    DFG to fund Traumatology Clinical Research Unit

    A new Clinical Research Unit at the University of Ulm is to investigate the early inflammation response and the positive impact on the immune system in casualty injuries. The insights gained will be transferred to patients.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/dfg-to-fund-traumatology-clinical-research-unit
  • Press release - 30/03/2011 14050_de.jpg

    Scientists Find Cause of Fatal Inflammation of the Heart Muscle

    Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues in the United States, have found out that inflammations of the heart muscle are caused by attacks of a specific type of immune cells. These immune cells attack the body’s own tissue because during their maturation they did not have the chance to develop tolerance against a protein that is only found in the heart muscle.

    https://www.gesundheitsindustrie-bw.de/en/article/press-release/scientists-find-cause-of-fatal-inflammation-of-the-heart-muscle
  • Article - 20/06/2016 NCT_Heidelberg.jpg

    Activation of the innate immune system against metastatic colorectal cancer

    Researchers from Heidelberg have shown that instead of fighting cancer cells, macrophages of the innate immune system promote the growth of metastases in people with metastatic colorectal cancer. They have also shown that a signal inhibitor used to treat HIV infections reactivates macrophages so that they gain the ability to destroy cancer cells. A clinical phase I study has confirmed the antitumoral effects of this drug.

    https://www.gesundheitsindustrie-bw.de/en/article/news/activation-of-the-innate-immune-system-against-metastatic-colorectal-cancer
  • Article - 05/12/2008

    Secret biological recipes for a long life

    Staying healthy as you get older that is probably what many people would wish for. As part of the European research network LifeSpan 130 scientists are now looking into how to make this wish come true. Prof. Dr. Graham Pawelec from the University Hospital of Tübingen UKT is one of the 130 scientists and his principal focus is immunological ageing processes.

    https://www.gesundheitsindustrie-bw.de/en/article/news/secret-biological-recipes-for-a-long-life
  • Article - 22/02/2010 10746_de.jpg

    Immune system discovers mould fungi through surface structures

    Mould fungus spores which are found in air aerosols are constantly being taken up in the air we inhale. As a rule this poses no danger to healthy people. However depending on the quantity of spores inhaled and the duration of exposure mould fungi could possibly lead or contribute to lung diseases and allergies. Dr. Mardas Daneshian and his team at the University of Constance are focusing on the immunostimulatory capacity of fungal spores. The…

    https://www.gesundheitsindustrie-bw.de/en/article/news/immune-system-discovers-mould-fungi-through-surface-structures
  • Article - 29/04/2021 aufbau-antikoerper.jpg

    Nanobodies for determining neutralising antibodies after corona infection

    After contact with a pathogen, ideally our immune system generates neutralising antibodies to prevent a future infection. With NeutrobodyPlex, scientists from Reutlingen and Tübingen have developed a highly specific test procedure based on single-domain antibodies (nanobodies) that can be used to easily and reliably determine the quality of the immune response against the novel coronavirus.

    https://www.gesundheitsindustrie-bw.de/en/article/news/nanobodies-determining-neutralising-antibodies-after-corona-infection
  • Article - 22/12/2014 Schematic showing T-cell activation without and without CTLA4.

    The immune system – both weak and overreactive in the absence of CTLA4

    The ability to recognise a pathogen and combat it effectively is certainly one of the most complex and sophisticated processes the human body has evolved. People with an immunodeficiency or autoimmune disease may have a genetic defect in one of the genes involved in the immune response. Working with immunologists from London scientists Desire Schubert and Prof. Dr. Bodo Grimbacher from the Centre for Chronic Immunodeficiency CCI at the Freiburg…

    https://www.gesundheitsindustrie-bw.de/en/article/news/the-immune-system-both-weak-and-overreactive-in-the-absence-of-ctla4
  • Article - 24/03/2014 Section of a malignant skin tumour in Mastomys coucha. Dividing tumour cells are stained red.

    Vaccine against papillomaviruses protects from skin cancer

    Papillomaviruses are thought to cause non-melanoma skin cancer in people exposed to UV radiation, especially those who have suppressed immune systems. Researchers from the German Cancer Research Center (DKFZ) and the Charité University Hospital in Berlin have developed a vaccine that protects mice against such skin tumours. The vaccine is even effective in mice that have previously been infected with papillomaviruses and that have suppressed…

    https://www.gesundheitsindustrie-bw.de/en/article/news/vaccine-against-papillomaviruses-protects-from-skin-cancer
  • Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB - 24/04/2020 Das Foto zeigt den Immustick, wobei eine Lösung auf das Auftragsfenster pipettiert wird.

    A rapid pyrogen test: the human immune system as model

    Every year, around 11 million people die of sepsis (blood poisoning) caused by microorganisms or microbial residues, known as pyrogens, entering the bloodstream. The smallest amounts can trigger fever. Researchers from the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart have developed a pyrogen test that does not require a laboratory and is not tested on animals. It is expected to be placed on the market soon.

    https://www.gesundheitsindustrie-bw.de/en/article/news/A-rapid-pyrogen-test-the-human-immune-system-as-model
  • Article - 23/08/2010 12137_de.jpg

    Antibiotics for the prevention of malaria

    Researchers from Heidelberg and Berlin have shown that if malaria-infected mice are administered an antibiotic, no parasites appear in the blood and the mice are protected from this life-threatening disease. The scientists believe that antibiotics also have the potential to strengthen the human immune system as well as making it possible to provide a natural needle-free vaccination against malaria.

    https://www.gesundheitsindustrie-bw.de/en/article/news/antibiotics-for-the-prevention-of-malaria

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