Composite materials provide stability in aircraft parts, sports equipment, and everyday household items. However, most of these materials have a poor carbon footprint and are not naturally degradable. A more sustainable alternative has been developed by a team from the University of Stuttgart. This completely bio-based composite material is made of flax fibers and the biopolymer chitosan.

Inovedis GmbH’s innovative implant - 28/03/2023

Next-generation minimally invasive shoulder surgery

The treatment of shoulder injuries such as rotator cuff tears is one of the most common orthopaedic interventions. It is therefore quite surprising that the surgical procedure has not changed much for decades - although it is relatively complicated. The start-up Inovedis has now developed a completely new surgical technique based on an implant that can be performed simply, safely, quickly and cost-effectively with minimal stress for patients.

Sustainable construction - 28/03/2023

Digital manufacturing processes enable buildings to be constructed with flax and willow

A switch to sustainable and circular construction concepts is needed to significantly reduce greenhouse gas emissions in the construction sector. At the German National Garden Show (Bundesgartenschau) in Mannheim, FibR GmbH, together with researchers from the Karlsruhe Institute of Technology, will be showcasing two innovative buildings made from flax and willow, renewable raw materials that exemplify possible building concepts of the future.

Effective drugs against viral diseases like COVID-19 are urgently needed now and in the future. The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. The DZIF scientist and bioinformatician Andreas Dräger from the University of Tübingen is working on a computer-based method that can help to accelerate the time-consuming identification and development of antiviral agents. Using a novel analysis technique that…

Development of anti-tumour agents - 20/03/2023

Targeting the protective shield of cancers

Cancer cells have different mechanisms to help them escape destruction by the immune system. Solid tumours, for example, are often surrounded by a protective layer of lactate, which has a strong immunosuppressive effect. WMT AG from Heidelberg is developing small drug molecules that reduce lactate production and thus make cancer cells vulnerable to immune system attacks.

Residual materials with potential - 16/03/2023

PeePower™ – energy from urine

The objective of the PeePower™ BUGA 2023 collaborative research project is to produce green hydrogen and platform chemicals from wastewater. This fits in nicely with BUGA 2023’s (German National Garden Show) four major themes, namely, climate, energy, environment and food security.

How can camera images be used during minimally invasive surgeries to assess whether the operated organ is sufficiently perfused with blood? Scientists from the German Cancer Research Center (DKFZ) and the Städtisches Klinikum Karlsruhe have now succeeded in automatic monitoring of ischemia during a kidney surgery using only the optical properties of the tissue and not relying on injection of contrast agent.

A novel, both environmentally friendly and cost-saving process for the production of carbon fibers from lignin has been developed at DITF. It is characterized by high energy-saving potential. The avoidance of solvents and the use of natural raw materials make the process environmentally friendly.

Expert interview - 08/03/2023

How do new active substances from university research reach patients?

Access to capital remains one of the biggest challenges in the life sciences sector. Over the last two years, the Baden-Württemberg Center for Academic Drug Discovery (BWCAD2) has successfully implemented a model of cooperation between academic drug research and industry for the development and validation of therapeutic concepts. Dr. Barbara Jonischkeit spoke with the initiator and leading figure behind the BWCAD2 project, Prof. Dr. Stefan Laufer

In February, the Estonian-based startup New Standard Oil successfully commissioned their first industrial-scale prototype for drying and torrefaction of biogenic feedstock operating with superheated steam at atmospheric pressure.

Bacteria of the species Pseudomonas aeruginosa are antibiotic-resistant hospital germs that can enter blood, lungs and other tissues through wounds and cause life-threatening infections. In a joint project, researchers from the Universities of Freiburg and Strasbourg in France have discovered a mechanism that likely contributes to the severity of P. aeruginosa infections.

Researchers at the University of Freiburg have examined how mulching at different times affects insect flower-visitors and larvae.

Immune complexes in COVID-19 - 01/03/2023

Vicious circle of hyperinflammation

Whether a person experiences only a mild malaise or a critical course of disease after a coronavirus infection apparently depends on the antigen-antibody complexes that form in our body. The discovery of these immune complexes set a group of researchers, headed up by Prof. Dr. Hartmut Hengel from the Freiburg University Medical Centre, on the trail of a vicious circle of constantly escalating inflammation.

The Tech4Biowaste database will be showcased online by its developers on 30 March 2023

Start for an EU-wide collaborative project: Under the leadership of the French company Fairbrics SAS, 17 project partners from 7 European countries are coming together. The common goal is to produce end products from polyester in a closed cycle using industrial CO2 emissions and to bring them to market maturity. The DITF produce synthetic fibers from plastics of non-fossil origin.

nova-Institute’s take on the recently published EU proposal for a Packaging and Packaging Waste Regulation as well as the new policy framework for biobased, biodegradable and compostable plastics.

On February 16, 2023, Baden-Württemberg’s Minister of Science, Research and the Arts, Petra Olschowski, visited the University of Freiburg. The focus of her visit was on sustainability and the transfer of knowledge. The minister learned all about how the day-to-day running of the university is becoming sustainable, and the wide-ranging climate protection and environmental safety measures. She also visited the livMatS pavilion.

Think Tank FYI: Agriculture 5.0 - 16/02/2023

Agriculture 5.0: fighting the climate crisis with agrophotovoltaics and biochar

Climate protection, agriculture and biodiversity are closely intertwined. Agriculture 5.0 provides positive guidance, as the Offenburg University of Applied Sciences has demonstrated: agrophotovoltaics (or agrivoltaics), which is currently in vogue in Germany, can be used to generate solar power on high-yield fields. Biomass strips and biochar remove CO2 from the atmosphere. All this improves soil quality and promotes biodiversity.

Around 7 million euros to promote more sustainable use of the world's limited phosphate supply: The German-Chinese Research Training Group AMAIZE-P can continue its research on phosphorus as one of the most important nutrient elements for plants. The German Research Foundation (DFG) has approved a second funding period of another 4.5 years.

Cytolytics GmbH - 14/02/2023

Bioinformatics meets medical diagnostics and drug development

The start-up company Cytolytics from Tübingen has developed a robust and user-friendly software platform that uses machine learning for the automated analysis of cells. This is beneficial in areas such as cancer diagnostics and the development of new pharmaceutically active substances.

Review - 09/02/2023

5th Gene Technology Report – a critical observation of a cutting-edge technology

The societal importance of genetic technologies was demonstrated during the coronavirus pandemic, when it was possible to rapidly develop suitable vaccines thanks to genetic engineering methods. As a result, the Fifth Gene Technology Report published in autumn 2021 reads like a validation of many years of work, as well as making it clear that the will to continue the detailed long-term monitoring is very much present.

Review - 09/02/2023

5th Gene Technology Report – a critical observation of a cutting-edge technology

The societal importance of genetic technologies was demonstrated during the coronavirus pandemic, when it was possible to rapidly develop suitable vaccines thanks to genetic engineering methods. As a result, the Fifth Gene Technology Report published in autumn 2021 reads like a validation of many years of work, as well as making it clear that the will to continue the detailed long-term monitoring is very much present.

This month marks the launch of an outstanding project integrating artificial intelligence (AI) and neuromedicine – the Hertie Institute for Artificial Intelligence in Brain Health (Hertie AI). Founded on February 1 at the Medical Faculty of the University of Tübingen, it will be the first institute in Germany to research the prevention and early diagnosis of diseases of the nervous system using artificial intelligence methods.

Patients have 30 percent fewer serious side effects when medication doses are tailored to their genetic profile. This is what an international research consortium has found out, including the Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology at the Bosch Health Campus. With an individual DNA medication pass, as used in the study, treatments can be made more effective and safer in the future.

Non-profit limited liability company creates institutional framework for interdisciplinary research collaboration, innovative technology development and outstanding healthcare in the Rhine-Neckar region.

Synergistic effects with microalgae and purple bacteria - 03/02/2023

Working towards a hydrogen economy with a wastewater biorefinery: the SmartBioH2-BW project

A biorefinery that uses industrial wastewater and residual material streams is being built in Rheinfelden (Baden). It will have two interlinking bioreactors and will synthesize biohydrogen as well as organic basic materials such as carotenoids and proteins. SmartBioH2-BW is a pilot project run by the Urban and Industrial Biorefineries initiative and funded by the Baden-Württemberg Ministry of the Environment, Climate Protection and Energy Sector.

Photon-counting technology - 01/02/2023

PC3 consortium: innovative computed tomography for Baden-Württemberg

The University Hospitals of Freiburg, Tübingen and Mannheim have been cooperating with each other since 2021 to test new types of computed tomography devices. With the help of photon-counting technology, the aim is not only to improve patient care, but also to encourage local companies to develop downstream data processing technologies.

In the 2022 allocation round for the award of the prestigious Consolidator Grants of the European Research Council, researchers of Karlsruhe Institute of Technology (KIT) have been successful. For their projects in the fields of photovoltaics and medical sensor technology, physicist Ulrich W. Paetzold and chemist Frank Biedermann will receive approximately two million euros over the next five years.

Resource efficiency, time and cost savings are essential topics in the textile and apparel industry. The advantages of digital manufacturing apply not only to fashion, but also to medical textiles. To this end, the German Institutes of Textile and Fiber Research Denkendorf (DITF) have developed a digital platform that can be used to produce precisely fitting flexible textile orthoses in a resource-, time- and cost-efficient manner.

Automated pain recognition - 25/01/2023

Using artificial intelligence to improve pain management

Psychologists from Ulm and their cooperation partners have developed algorithms for automated pain recognition in order to be able to dose painkillers more precisely. The researchers are now looking for industrial partners to take their project to application.

Cancer immunotherapies often fail because the immune cells are paralysed by immunosuppressive conditions in the tumor. Scientists from Heidelberg, Mannheim and Tel Aviv have now shown on tissue samples from patients as well as on tumor models in mice that the functionality of the immune defence depends decisively on certain helper cells.

Heidelberg scientists succeed in boosting the efficiency of CRISPR/Cas9 and related methods and modifying initially inaccessible DNA sequences.

Brain-computer interfaces are able to restore some mobility to paralyzed people by controlling exoskeletons. However, more complex control signals cannot yet be read from the head surface because conventional sensors are not sensitive enough. A collaboration of Fraunhofer IAF, Charité – Universitätsmedizin Berlin, University of Stuttgart and other industrial partners has taken up this challenge.

Vaccination for plants - 23/01/2023

Dialogue instead of a chemical maze – new strategy for sustainable crop protection

Climate change creates stress. This provides an opportunity for pests to exploit plant weaknesses and reproduce. For the infested plant, this can be catastrophic and often fatal. But instead of continuing to protect harvest yields with toxic substances as before, the transnational DialogProTec project is now taking a completely new approach: researchers want to intervene in the communication between plants and pests to keep them healthy.

With the "Česká Hlava" awards, the Czech government has been honoring the country's most brilliant minds every year since 2002 and recognizing exceptional achievements in research, development and innovation. Martina Benešová-Schäfer of the German Cancer Research Center was among the six laureates honored in 2022 at Charles University in Prague.

After infections or blood loss, the body must compensate for the loss of blood cells as quickly as possible. This has long been considered the task of the hematopoietic stem cells in the bone marrow. But scientists at the German Cancer Research Center (DKFZ) have now discovered in mice that a certain population of progenitor cells takes over this task: This accelerates the regeneration of the blood cells.

Acute Graft-versus-host disease (GvHD) is a life-threatening complication after leukemia treatment with allogeneic stem cell transplantation i.e. the transplantation of cells from another person. GvHD occurs when the transplanted immune cells are overly active and damage the receiving patient's healthy tissue. Researchers found that an endogenous molecule can mitigate this misdirected immune response.

The hospital pathogen Pseudomonas aeruginosa requires the sugar-binding proteins LecA and LecB to form biofilms as well as to attach to and penetrate host cells. These so-called lectins are therefore suitable targets for active substances to combat Pseudomonas infections. Researchers from Saarbrücken and Freiburg have now produced potent inhibitors for LecA and LecB that are more stable and soluble than previous drug candidates.

Press release - 16/01/2023

GoDanuBio’s contribution to the bioeconomisation of the Danube Region

GoDanuBio supported the set-up of policy frameworks and participative governance schemes in the participating regions. The main topics were circular bioeconomy, sustainable rural development and rural-urban interactions.

Researchers at the University of Freiburg Medical School led by Prof. Dr. Johannes Letzkus and the Max Planck Institute for Brain Research have discovered that a little-studied area of the brain, the "zone of uncertainty" or "zona incerta," communicates with the neocortex in unconventional ways to rapidly control memory formation.

Valorization of biological materials - 12/01/2023

ValBio-Urban brings bioeconomy research to users

Reducing carbon dioxide emissions and the capture and utilization of CO2 are important steps towards achieving a climate-neutral and sustainable economy. Accordingly, as part of the ValBio-Urban research project, an interdisciplinary team from the University of Stuttgart is developing bioeconomic approaches to solutions that will be implemented with companies from Baden-Württemberg.

Using new microscopic methods in combination with machine learning-based image analysis, researchers from Freiburg have discovered new structures on the surface of living B cells that affect the distribution and possibly the function of their antigen receptors. The researchers' study has been published in The EMBO Journal.

Value-based healthcare - 11/01/2023

High-quality healthcare pays off

High-quality medical treatment is not only worthwhile for ill persons. The Division of Health Economics at the German Cancer Research Center in Heidelberg, headed up by Prof. Dr. Michael Schlander, together with researchers from Dresden, has carried out a cost-effectiveness analysis that shows that certified colon cancer centres provide not only better but also more cost-effective care than other clinics.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (“mRNA”), today announced positive preliminary data from ongoing Phase 1 clinical programs in COVID-19 and seasonal flu, assessing both modified and unmodified mRNA technology. The tested vaccine candidates are being developed in collaboration with GSK.

Mitochondria are considered to be the power plants of cells and are essential for human metabolism. Dysfunction in 40 percent of mitochondrial proteins are associated with human diseases, which is why mitochondria also play an important role in medical research. A previously unexplained process in the complex mitochondria was the formation of their barrel pores.

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers led by scientists from the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim* and the University Medical Center Hamburg Eppendorf has now identified an enzyme that controls the activity of osteoblasts.

Heidelberg scientists decode the genetic foundations of rapid testicle evolution in mammals and humans. Evolutionary pressure across male mammals to guarantee the procreation of their own offspring led to a rapid evolution of the testicle.

Inhibition of a protein complex in cells of the immune system prevents rejection of transplanted organs – this has been shown in a study by immunologists from the University of Konstanz, the Biotechnology Institute Thurgau (BITg) and Chongqing Cancer University Hospital.

A polyester plastic of great mechanical stability, which is also easily recyclable and even compostable: Stefan Mecking, chemist at the University of Konstanz, and his research group present a new material.

A polyester plastic of great mechanical stability, which is also easily recyclable and even compostable: Stefan Mecking, chemist at the University of Konstanz, and his research group present a new material.

Start-up 'Innovation Matters' - 19/12/2022

Saffron cultivation in Germany - sustainable with support from robots

Saffron is one of the most expensive spices in the world, because picking it involves a complex manual process. This treasure therefore comes to us mostly from countries such as Iran with poor working conditions and low wages. A start-up company called Innovation Matters from Baden-Württemberg is now developing a robot-assisted, automated process that will make saffron cultivation attractive in Germany as well as ecological and fair.

The launch of the global Nature Positive Universities initiative was announced at the UN Biodiversity Conference (COP 15), held in Montreal, Canada, in December 2022. The University of Konstanz is one of more than one hundred universities from all five continents joining the initiative. The common goal is to address the university's own impact on nature and to identify and implement effective measures to halt and reverse the loss of…

On December 13, 2022, the European Commission granted approval to a drug against metastatic prostate cancer whose active ingredient was developed under the leadership of the German Cancer Research Center (DKFZ) in collaboration with Heidelberg University Hospital and Heidelberg University. The drug can significantly improve the survival chances of patients.

Neurodegenerative diseases - 12/12/2022

Blood-based biomarkers allow the early prediction of Alzheimer's risks

Most dementia diseases develop insidiously and are only detected at an advanced stage. Researchers at the University of Heidelberg and the German Cancer Research Center (DKFZ) have now identified the glial fibre acidic protein (GFAP) in the blood as a promising biomarker that can be used to determine an increased risk of developing Alzheimer's disease up to 17 years before diagnosis.

Project FuTuReS - 12/12/2022

Microalgae - high-quality products for domestic agriculture?

Algae are aquatic organisms that flourish in a huge variety of species. But that's not all: they are also small green mini-factories that can produce all kinds of valuable materials. All they need is water, light, CO2 and a few nutrients that can be recycled from biogas or sewage treatment plants. Researchers have now determined the optimal framework conditions and practicability of process methods for agricultural algae cultivation.

AI & robotics from the University of Hohenheim advance environmental protection & sustainability in agriculture / German Chancellor Scholz impressed by potential of Swabian multi-talent robot

During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against the pathogens. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found an epigenetic switch in blood stem cells and progenitor cells of mice that can trigger the switch from one mode to the other.

Tübingen biotechnologist Lars Angenent is being awarded the Leibniz Prize by the German Research Foundation (DFG) in appreciation of his outstanding work in the field of environmental biotechnology, it was announced in Bonn on Thursday. The DFG said: “In view of climate change and the resulting need to develop a sustainable food, chemistry and energy economy, his work is highly relevant.”

Tübingen biotechnologist Lars Angenent is being awarded the Leibniz Prize by the German Research Foundation (DFG) in appreciation of his outstanding work in the field of environmental biotechnology, it was announced in Bonn on Thursday. The DFG said: “In view of climate change and the resulting need to develop a sustainable food, chemistry and energy economy, his work is highly relevant.”

The German Research Foundation (DFG) has awarded the 2023 Gottfried Wilhelm Leibniz Prize to Prof. Achim Menges, head of the Institute for Computational Design and Construction at the University of Stuttgart. The award, which is endowed with EUR 2.5 million, is considered by many the most important research prize in Germany.

The German Research Foundation (DFG) has awarded the 2023 Gottfried Wilhelm Leibniz Prize to Prof. Achim Menges, head of the Institute for Computational Design and Construction at the University of Stuttgart. The award, which is endowed with EUR 2.5 million, is considered by many the most important research prize in Germany.

An interdisciplinary research team at the University of Freiburg has found important clues about the functioning of the sensorimotor cortex. The new findings on neuronal activities in this brain area could be helpful for the further development and use of so-called neuroprostheses. These have an interface with the nervous system and are intended to help compensate for neuronal dysfunctions.