Expert interview - 05/07/2023

Every tenth of a degree matters when it comes to mitigating the consequences of global warming: sustainability measures in the laboratory

The life sciences sector consumes huge quantities of energy and resources. This needs to change and we have to think differently. But how and where can sustainability measures be sensibly applied in the laboratory without compromising the quality of research results? Dr. Kerstin Hermuth-Kleinschmidt, owner of NIUB-Nachhaltigkeitsberatung, a company from Freiburg that focuses on sustainability in life sciences, tells BIOPRO how this can be done.

Climate change is causing temperatures to rise and storms to increase. In inner cities, summers are becoming a burden for people. Densification increases the amount of sealed surfaces. Green facades bring more green into cities. If textile storage structures are used, they can even actively contribute to flood protection. The German Institutes of Textile and Fiber Research (DITF) have developed a "Living Wall".

Expert interview - 28/06/2023

Money isn't all that is needed – knowledge and networking can also help start-ups move forward

Dr. Rolf Neuhaus is one of the driving forces behind PALATINA Business Angels Rhein-Neckar e.V., a business angels association in the Rhine-Neckar metropolitan region. In an interview with BIOPRO, Neuhaus describes the association’s activities and explains where there is still catching up to be done in terms of start-up support in Baden-Württemberg.

Astonishing results published from individual projects of the Tara Pacific expedition studying coral reefs – the entire dataset is made publicly available – coordinator is a biologist from the University of Konstanz

Researchers from Konstanz and Zurich have deciphered a biochemical mechanism that ensures that newly formed proteins are processed correctly when they leave the cell's own protein factories. This solves a decade-old puzzle in protein sorting.

The Institute for Technology Assessment and Systems Analysis of Karlsruhe Institute of Technology (KIT) has been entrusted with the continued operation of the Office of Technology Assessment at the German Bundestag (TAB) in the next five years until 2028. This unanimous decision was taken by the Parliament Committee for Education, Research, and Technology Assessment during today’s meeting (June 21, 2023).

Predicting the success of cancer treatment - 20/06/2023

Focusing on gut microbiome for CAR T-cell therapy

Cancer immunotherapies use the body's own defences to fight tumour cells. An international consortium of researchers from Germany and the USA led by the DKFZ in Heidelberg has demonstrated that the effectiveness of CAR T-cell therapies greatly depends on the composition of the gut microbiome. The researchers have also developed a model for predicting the long-term response to the treatment.

Scientists at the Max Planck Institute for Intelligent Systems in Stuttgart have developed a magnetically controlled soft medical robot with a unique, flexible structure inspired by the body of a pangolin. The robot is freely movable despite built-in hard metal components. Thus, depending on the magnetic field, it can adapt its shape to be able to move and can emit heat when needed.

CureVac N.V. today announced that it has dosed the first patient with its investigational cancer vaccine CVGBM in a Phase 1 study. CVGBM is based on CureVac’s proprietary second-generation mRNA backbone and features a single mRNA, encoding eight epitopes derived from known tumor-associated antigens with demon­strated relevance in glioblastoma. A first data readout is expected in the second half of 2024.

KIT and Research Center Borstel Present Nanoparticles with a High Antibiotic Concentration for Inhalation – Nanocarriers of Antibiotics Can Reduce Resistances and Enhance Compatibility.

In most cancers, it is not the growth of the primary tumor that determines the prognosis for the patient, but whether it will spread and form metastases. This process is very complex. There are often years between the development of the cancer and the aggressive growth of the metastases. Scientists from the DKFZ, the HI-STEM, the Ruhr University Bochum, Helmholtz Munich and ETH Zurich have studied and identified metastasis growth in breast cancer

Innovative materials - 14/06/2023

Reinventing ‘wood’ with programmable bacteria

Conserving wood by producing furniture and other objects from wood-based materials with the help of microorganisms? That is exactly what a team of researchers from the University of Freiburg and the Leibniz Institute for New Materials (INM) in Saarbrücken is working on in the DELIVER project. The aim is to create a database of materials with a broad range of controllable properties for various applications that can be produced from wood waste.

The AutoProNano German/French collaborative project involves developing a process for the automated production of nanoparticles for in vitro and in vivo diagnostics. The project is being launched within the smart analytics cooperation network. This international initiative has been funded by the Central Innovation Programme for SMEs (ZIM) of the German Federal Ministry for Economic Affairs and Climate Action (BMWK) since May 2020.

Researchers at the Faculty of Medicine at the University of Freiburg have gained significant new insights into metabolic processes in the kidney. The scientists from the Institute of Genetic Epidemiology at the Medical Center - University of Freiburg measured tiny molecules, so-called metabolites, which occur in blood and urine and reflect our metabolism, in samples from more than 5,000 study participants.

Reduced immunosuppression possible in transplantations - 05/06/2023

Modified immune cells produce donor-specific tolerance

Traditionally, transplant recipients have had to take immunosuppressive medication for life to prevent organ rejection. However, there are considerable side effects involved. Using modified immune cells (MICs), TolerogenixX GmbH from Heidelberg has now managed to generate donor-specific tolerance in recipients of living kidney transplants without suppressing the overall immune system.

Team of Freiburg researchers shows how information about the quantity of absorbed light passes from the leaves to the roots. Plant growth is driven by light and supplied with energy through photosynthesis by green leaves. It is the same for roots that grow in the dark – they receive the products of photosynthesis, in particular sucrose, i.e. sugar, via the central transportation pathways of phloem.

Detecting drug resistance of tumour cells - 25/05/2023

AI-assisted diagnostics declares war on lung cancer

Lung cancer is one of the most common cancers and has a particularly high mortality rate. A significant challenge in treating this disease lies in the resistance of lung tumours to conventional drug therapies, rendering chemotherapy ineffective. There is hope on the horizon as a team of experts from Baden-Württemberg has joined forces to develop an innovative AI-supported test procedure that paves the way for individualised therapy approaches.

Tübingen researchers describe connection between action and feeling of authorship - finding sheds light on delusions of external control in schizophrenia

Daisies, peas, canola, etc.: Researchers at the University of Hohenheim want to replace gluten protein with new alternatives. Instead of ovens, 3-D printers would be possible

Impaired function of lung fibroblast is considered causative for symptoms of the incurable lung disease COPD (Chronic Obstructive Pulmonary Disease). Using high-resolution epigenetic profiling, German and British scientists have now identified potential targets for COPD treatment. The team detected early epigenetic changes in the genome of COPD fibroblasts, providing new insights into the disease pathogenesis and potential therapeutic avenues.

Inflammatory fatty liver disease (NASH, non alcoholic steatohepatitis ) and the resulting liver cancer are driven by autoaggressive T cells. Scientists from the German Cancer Research Center (DKFZ) now show what ist behind this destructive behavior. In both mice and humans with NASH, they found increased numbers of activated B cells in the gastrointestinal tract.

Along with sugar reallocation, a basic molecular mechanism within plants controls the formation of new lateral roots. An international team of plant biologists has demonstrated that it is based on the activity of a certain factor, the target of rapamycin (TOR) protein.

Volkswagen Foundation to fund international research project with around 1.5 million euros. Interdisciplinary team led by the Institute for Global Health at Heidelberg University Hospital to research the transmission of pathogens from animals to humans in Thailand and Laos. Long-term goal is to develop sustainable preventive measures against future pandemics.

Centromeres, the DNA sections often found at the center of the chromosomes, display enormous interspecies diversity, despite having the same vital role during cell division across almost the entire tree of life. An international team of researchers has discovered that the variation in centromere DNA regions can be strikingly large even within a single species. The findings, now published in the journal Nature, shed light on the molecular…

3D-Thermocell project - 17/05/2023

Paper instead of plastic: sustainable packaging with a good conscience

Replacing plastic – for example in packaging – is not that easy but nevertheless urgently needed. In the 3D-Thermocell project, researchers at DHBW Karlsruhe are currently developing new plastic substitute products made of thermoformable paper as a renewable resource, which should be cheap and light and easy to dispose of along with waste paper. The characterisation and application of demonstration models will start soon.

This year's Venice Architecture Biennale sees itself as a "Laboratory of the Future". Bio-composites are not just dreams of the future in architecture. The German Institutes of Textile and Fiber Research (DITF) have developed a sustainable material for support profiles and connecting nodes, which will be on display at Palazzo Mora during the Biennale from May 20 to November 26.

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow. It mainly occurs in older individuals and represents about 20 percent of all adult leukemia cases. A research team from the Institute of Molecular Medicine and Cell Research at the University of Freiburg has now demonstrated for the first time that mast cells play a crucial role in the development of CML.

The recently established ITCC-P4 gGmbH provides academic institutions and pharmaceutical companies with a comprehensive repertoire of modern laboratory models of pediatric tumors. The aim is to systematically test new treatment options for children and adolescents with cancer and to contribute data to regulatory approval processes in order to make the development of new cancer therapies for children and adolescents more attractive.

Optogenetic cell analysis - 15/05/2023

opto biolabs: how frustration and inventiveness led to the establishment of a company

When she found she had no suitable illumination devices for her doctoral thesis, Dr. Kathrin Brenker simply created her own customised adapters and founded a company called opto biolabs. Now, Brenker and company co-founder Luis Köbele sell two different types of devices. The main goal is to equip laboratories with illumination technologies that allow optogenetics methods to be used to accelerate development of optogenetic therapeutics.

Proteins have characteristic amino acid sequences, the analysis of which is fundamental for research and medicine. These can be decoded; however, so-called protein sequencing is expensive and time-consuming. A large-scale research project led by Prof. Dr. Jan Behrends from the Institute of Physiology at the University of Freiburg now aims to establish a new technology for protein sequencing using nanopores, which will be rapid and cost-effective.

Researchers at the University of Konstanz publish image analysis software that automatically detects and classifies defects of animal development. Thanks to artificial intelligence, "EmbryoNet" outperforms human experts in terms of speed, accuracy and sensitivity.

Initial Phase 1 part started with multivalent modified mRNA influenza vaccine candidates. Candidates developed in collaboration with GSK within broad infectious disease vaccine program encode for antigens covering four WHO-recommended flu strains.

Diatoms as a biorefinery - 05/05/2023

Microalgae: sustainable chemical production in a mini factory

Renewable raw materials that can be used as alternatives to fossil resources already exist. However, to turn them into everyday products, plant oils and other renewable raw materials not only have to be extracted, but often have to undergo complex chemical processing. Researchers at the University of Konstanz have now converted microalgae cells into tiny refineries to produce and upgrade raw materials, creating a supply of sustainable chemicals.

Triple-negative breast cancer (TNBC) is the most aggressive and deadly form of breast cancer with limited treatment options. Tumor growth and relapse of TNBC are driven by breast cancer stem cells, and improved therapies that can eliminate those hardy cells are urgently needed. Researchers from the University of Frieburg discovered that coordinated differentiation and changes in the metabolism of breast cancer stem cells make them invisible for…

At the Fraunhofer Center for Chemical-Biotechnological Processes CBP in Leuna, Germany, representatives from politics, research and industry opened a novel pilot plant for the mild processing of rapeseed to increase the added-value potential of rape as a raw material.

Sustainability is a major challenge in the food and packaging industry. Plastic packaging is being replaced by organic-based and biodegradable materials, but it must still fulfill high functional requirements. A team of researchers at the University of Hohenheim has developed a new coating system that is both water-impermeable, heat-resistant, and mechanically durable as well as being suitable for consumption, and biodegradable at the same time.

Milana will strengthen the research of the Cluster of Excellence Living, Adaptive and Energy-autonomous Materials (livMatS) in the field and work closely with scientists from the Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT) and the Freiburg Materials Research Center (FMF).

Ready-made meals are ideal for quickly satisfying hunger. However, the quick snacks produce a lot of environmentally harmful plastic waste. To tackle this problem, the student team EDGGY from the University of Hohenheim in Stuttgart rolled up its sleeves and developed edible packaging made from eggshells and other plant-based raw materials. And even better: they simply dissolve in the hot water and can be eaten as an additional protein boost.

Roboticists at the Max Planck Institute for Intelligent Systems in Stuttgart have developed a jellyfish-inspired underwater robot with which they hope one day to collect waste from the bottom of the ocean. The almost noise-free prototype can trap objects underneath its body without physical contact, thereby enabling safe interactions in delicate environments such as coral reefs. Jellyfish-Bot could become a tool for environmental remediation.

"Programmable" polymer materials - 24/04/2023

Medicine of the future: intelligent 4D polymers from the printer

It is impossible to imagine medicine without 3D printing, which can be used to make implants or for culturing cells and tissues. It is now possible for 3D objects to be given an added dimension, namely an ability to make simple autonomous movements, by changing their size. Researchers at Heidelberg University have been able to produce microscopically small 4D structures from intelligent polymers that can be tailored to individual requirements.

Konstanz researchers discover the function of a previously unexplored protein: In three characteristic steps, "C12orf29" links the ends of RNA strands. Proteins that perform this kind of RNA ligation were previously unknown in humans. The results of the study suggest that it is important for RNA repair during cellular stress.

In collaboration with the project partners CG TEC, Cordenka, ElringKlinger, Fiber Engineering and Technikum Laubholz, the DITF are developing a new fiber composite material (CELLUN) with reinforcing fibers made of cellulose. The matrix of the material is a thermoplastic cellulose derivative. CELLUN made from renewable biopolymers enables the replacement of glass or carbon fibers in the production of industrial molded parts.

Heidelberg University is to acquire a research building to develop innovative engineering science strategies and technologies on the basis of life-inspired molecular systems. The German Science and Humanities Council has now expressed its backing for the idea with an outstanding rating. This recommendation is the crucial precondition for a new building on the university campus Im Neuenheimer Feld.

The Phytopharmaceuticals and Valuable Plant Ingredients initiative aims to further develop phytopharmaceuticals and valuable plant ingredients in Baden-Württemberg.

Tablet-based diagnostics - 12/04/2023

TuCAN - innovative diagnostic procedure for neuropsychiatric disorders

Neuropsychiatric disorders are often diagnosed late and have a negative impact on quality of life. Diagnosing the disease at an early stage is vital to be able to help those affected by offering them treatment adapted to their specific requirements. This is what the TuCAN project in Tübingen aims to achieve through the early and differential diagnosis of neuropsychiatric disorders.

A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown that with this oxidation, cells switch to an alternative sugar breakdown pathway and can thus escape oxidative stress. Cancer cells in particular benefit from this mechanism, which can also protect them from therapy-related damage.

City of the future - 04/04/2023

FamoS: climate protection on facades

Resource-efficient water management, photovoltaic modules and innovative facade greening - FamoS is all that. By combining proven elements, the ‘facade module with synergy’ makes a valuable contribution to combatting climate change and boosting climate resilience in cities.

Press release - 31/03/2023

Simulation of Miscanthus- and Sorghum-based resilient value chains in the Danube Region

Can the value chains in the Danube macro-region be more sustainable and resilient against disruptions such as pandemics? How modelling could help to simulate the economic viability of developing Miscanthus and Sorghum based value chains in that region?

Composite materials provide stability in aircraft parts, sports equipment, and everyday household items. However, most of these materials have a poor carbon footprint and are not naturally degradable. A more sustainable alternative has been developed by a team from the University of Stuttgart. This completely bio-based composite material is made of flax fibers and the biopolymer chitosan.

Inovedis GmbH’s innovative implant - 28/03/2023

Next-generation minimally invasive shoulder surgery

The treatment of shoulder injuries such as rotator cuff tears is one of the most common orthopaedic interventions. It is therefore quite surprising that the surgical procedure has not changed much for decades - although it is relatively complicated. The start-up Inovedis has now developed a completely new surgical technique based on an implant that can be performed simply, safely, quickly and cost-effectively with minimal stress for patients.

Sustainable construction - 28/03/2023

Digital manufacturing processes enable buildings to be constructed with flax and willow

A switch to sustainable and circular construction concepts is needed to significantly reduce greenhouse gas emissions in the construction sector. At the German National Garden Show (Bundesgartenschau) in Mannheim, FibR GmbH, together with researchers from the Karlsruhe Institute of Technology, will be showcasing two innovative buildings made from flax and willow, renewable raw materials that exemplify possible building concepts of the future.

Effective drugs against viral diseases like COVID-19 are urgently needed now and in the future. The emergence of viral mutants and yet unknown viruses could push vaccines to their limits. The DZIF scientist and bioinformatician Andreas Dräger from the University of Tübingen is working on a computer-based method that can help to accelerate the time-consuming identification and development of antiviral agents. Using a novel analysis technique that…

Development of anti-tumour agents - 20/03/2023

Targeting the protective shield of cancers

Cancer cells have different mechanisms to help them escape destruction by the immune system. Solid tumours, for example, are often surrounded by a protective layer of lactate, which has a strong immunosuppressive effect. WMT AG from Heidelberg is developing small drug molecules that reduce lactate production and thus make cancer cells vulnerable to immune system attacks.

Residual materials with potential - 16/03/2023

PeePower™ – energy from urine

The objective of the PeePower™ BUGA 2023 collaborative research project is to produce green hydrogen and platform chemicals from wastewater. This fits in nicely with BUGA 2023’s (German National Garden Show) four major themes, namely, climate, energy, environment and food security.

How can camera images be used during minimally invasive surgeries to assess whether the operated organ is sufficiently perfused with blood? Scientists from the German Cancer Research Center (DKFZ) and the Städtisches Klinikum Karlsruhe have now succeeded in automatic monitoring of ischemia during a kidney surgery using only the optical properties of the tissue and not relying on injection of contrast agent.

A novel, both environmentally friendly and cost-saving process for the production of carbon fibers from lignin has been developed at DITF. It is characterized by high energy-saving potential. The avoidance of solvents and the use of natural raw materials make the process environmentally friendly.

Expert interview - 08/03/2023

How do new active substances from university research reach patients?

Access to capital remains one of the biggest challenges in the life sciences sector. Over the last two years, the Baden-Württemberg Center for Academic Drug Discovery (BWCAD2) has successfully implemented a model of cooperation between academic drug research and industry for the development and validation of therapeutic concepts. Dr. Barbara Jonischkeit spoke with the initiator and leading figure behind the BWCAD2 project, Prof. Dr. Stefan Laufer

In February, the Estonian-based startup New Standard Oil successfully commissioned their first industrial-scale prototype for drying and torrefaction of biogenic feedstock operating with superheated steam at atmospheric pressure.

Bacteria of the species Pseudomonas aeruginosa are antibiotic-resistant hospital germs that can enter blood, lungs and other tissues through wounds and cause life-threatening infections. In a joint project, researchers from the Universities of Freiburg and Strasbourg in France have discovered a mechanism that likely contributes to the severity of P. aeruginosa infections.

Researchers at the University of Freiburg have examined how mulching at different times affects insect flower-visitors and larvae.

Immune complexes in COVID-19 - 01/03/2023

Vicious circle of hyperinflammation

Whether a person experiences only a mild malaise or a critical course of disease after a coronavirus infection apparently depends on the antigen-antibody complexes that form in our body. The discovery of these immune complexes set a group of researchers, headed up by Prof. Dr. Hartmut Hengel from the Freiburg University Medical Centre, on the trail of a vicious circle of constantly escalating inflammation.

The Tech4Biowaste database will be showcased online by its developers on 30 March 2023

Start for an EU-wide collaborative project: Under the leadership of the French company Fairbrics SAS, 17 project partners from 7 European countries are coming together. The common goal is to produce end products from polyester in a closed cycle using industrial CO2 emissions and to bring them to market maturity. The DITF produce synthetic fibers from plastics of non-fossil origin.

nova-Institute’s take on the recently published EU proposal for a Packaging and Packaging Waste Regulation as well as the new policy framework for biobased, biodegradable and compostable plastics.

On February 16, 2023, Baden-Württemberg’s Minister of Science, Research and the Arts, Petra Olschowski, visited the University of Freiburg. The focus of her visit was on sustainability and the transfer of knowledge. The minister learned all about how the day-to-day running of the university is becoming sustainable, and the wide-ranging climate protection and environmental safety measures. She also visited the livMatS pavilion.

Think Tank FYI: Agriculture 5.0 - 16/02/2023

Agriculture 5.0: fighting the climate crisis with agrophotovoltaics and biochar

Climate protection, agriculture and biodiversity are closely intertwined. Agriculture 5.0 provides positive guidance, as the Offenburg University of Applied Sciences has demonstrated: agrophotovoltaics (or agrivoltaics), which is currently in vogue in Germany, can be used to generate solar power on high-yield fields. Biomass strips and biochar remove CO2 from the atmosphere. All this improves soil quality and promotes biodiversity.

Around 7 million euros to promote more sustainable use of the world's limited phosphate supply: The German-Chinese Research Training Group AMAIZE-P can continue its research on phosphorus as one of the most important nutrient elements for plants. The German Research Foundation (DFG) has approved a second funding period of another 4.5 years.

Cytolytics GmbH - 14/02/2023

Bioinformatics meets medical diagnostics and drug development

The start-up company Cytolytics from Tübingen has developed a robust and user-friendly software platform that uses machine learning for the automated analysis of cells. This is beneficial in areas such as cancer diagnostics and the development of new pharmaceutically active substances.

Review - 09/02/2023

5th Gene Technology Report – a critical observation of a cutting-edge technology

The societal importance of genetic technologies was demonstrated during the coronavirus pandemic, when it was possible to rapidly develop suitable vaccines thanks to genetic engineering methods. As a result, the Fifth Gene Technology Report published in autumn 2021 reads like a validation of many years of work, as well as making it clear that the will to continue the detailed long-term monitoring is very much present.